|Coupling control state|
'''Coupling control states''' are defined …
'''Coupling control states''' are defined in [[mitochondrial preparations]] (isolated mitochondria, permeabilized cells, permeabilized tissues, homogenates) as [[LEAK]], [[OXPHOS]], and [[ET-pathway]] states, with corresponding respiration rates (''L, P, E'') in any [[electron transfer-pathway state]] which is competent for electron transfer. These coupling states are induced by application of specific inhibitors of the [[phosphorylation system]], titration of ADP and uncouplers. In [[living cells]], the coupling control states are [[LEAK]], [[ROUTINE]], and [[ET-pathway]] states of respiration (''L, R, E''), using membrane-permeable inhibitors of the [[phosphorylation system]] (e.g. [[oligomycin]]) and [[uncoupler]]s (e.g. [[CCCP]]). [[Coupling control protocol]]s induce these coupling control states sequentially at a constant [[electron transfer-pathway state]].stant [[electron transfer-pathway state]]. +
|Has abbr||''CCS'' +|
|Info||[[Gnaiger 2009 Int J Biochem Cell Biol]] +|
|MitoPedia concept||MiP concept + , Respiratory state + , SUIT concept + , SUIT state + , Recommended +|
|MitoPedia method||Respirometry +|
|MitoPedia topic||EAGLE +|
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|Coupling control state +|
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|08:18:04, 3 July 2019 +|
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|Coupling control state + , Coupling control state +||redirect page|