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Chatfield 2019 JACC Basic Transl Sci
Additional label 2019-05  + , Labels  +
Coupling states ET  + , LEAK  + , OXPHOS  +
Diseases Cardiovascular  +
Enzyme Complex I  + , Complex II;succinate dehydrogenase  + , Complex IV;cytochrome c oxidase  + , Complex V;ATP synthase  + , Supercomplex  +
Has abstract Negative alterations of mitochondria are k
Negative alterations of mitochondria are known to occur in heart failure (HF). This study investigated the novel mitochondrial-targeted therapeutic agent elamipretide on mitochondrial and supercomplex function in failing human hearts ''ex vivo''. Freshly explanted failing and nonfailing ventricular tissue from children and adults was treated with elamipretide. Mitochondrial oxygen flux, complex (C) I and CIV activities, and in-gel activity of supercomplex assembly were measured. Mitochondrial function was impaired in the failing human heart, and mitochondrial oxygen flux, CI and CIV activities, and supercomplex-associated CIV activity significantly improved in response to elamipretide treatment. Elamipretide significantly improved failing human mitochondrial function.
oved failing human mitochondrial function.  +
Has editor [[Plangger M]]  +
Has info [https://www.ncbi.nlm.nih.gov/pubmed/31061916 PMID: 31061916 Open Access]  +
Has publicationkeywords ADP  + , Adenosine diphosphate  + , BN-PAGE  + , Blue native polyacrylamide gel electrophoresis  + , C  + , Carbonyl cyanide p-trifluoromethoxyphenylhydrazone  + , FCCP  + , HF  + , Heart failure  + , High-resolution respirometry  + , Mitochondrial respiratory complex  + , Mitochondrial-targeted compounds  + , RCR  + , Respiratory control ratio  + , SC CCF  + , Supercomplex  + , Supercomplex coupling control factor  +
Has title Chatfield KC, Sparagna GC, Chau S, Phillips EK, Ambardekar AV, Aftab M, Mitchell MB, Sucharov CC, Miyamoto SD, Stauffer BL (2019) Elamipretide improves mitochondrial function in the failing human heart. JACC Basic Transl Sci 4:147-57.  +
Instrument and method Oxygraph-2k  +
Mammal and model Human  +
MiP area Pharmacology;toxicology  + , Respiration  +
Pathways N  + , NS  + , S  +
Preparation Permeabilized tissue  +
Tissue and cell Heart  +
Was published by MiPNetLab US CO Aurora Sparagna GC +
Was published in journal JACC Basic Transl Sci +
Was published in year 2019  +
Was written by Chatfield KC + , Sparagna GC + , Chau S + , Phillips EK + , Ambardekar AV + , Aftab M + , Mitchell MB + , Sucharov CC + , Miyamoto SD + , Stauffer BL +
Categories Publications
Modification date
"Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki.
11:01:52, 16 May 2019  +
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