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Asseburg 2016 Neuromolecular Med
Additional label 2016-11  +
Coupling states LEAK  + , OXPHOS  + , ET  +
Diseases Aging;senescence  +
Has abstract Dementia contributes substantially to the
Dementia contributes substantially to the burden of disability experienced at old age, and mitochondrial dysfunction (MD) was identified as common final pathway in brain aging and Alzheimer's disease. Due to its early appearance, MD is a promising target for nutritional prevention strategies and polyphenols as potential neurohormetic inducers may be strong neuroprotective candidates. This study aimed to investigate the effects of a polyphenol-rich grape skin extract (PGE) on age-related dysfunctions of brain mitochondria, memory, life span and potential hormetic pathways in C57BL/6J mice. PGE was administered at a dose of 200 mg/kg body weight/d in a 3-week short-term, 6-month long-term and life-long study. MD in the brains of aged mice (19-22 months old) compared to young mice (3 months old) was demonstrated by lower ATP levels and by impaired mitochondrial respiratory complex activity (except for mice treated with antioxidant-depleted food pellets). Long-term PGE feeding partly enhanced brain mitochondrial respiration with only minor beneficial effect on brain ATP levels and memory of aged mice. Life-long PGE feeding led to a transient but significant shift of survival curve toward higher survival rates but without effect on the overall survival. The moderate effects of PGE were associated with elevated SIRT1 but not SIRT3 mRNA expressions in brain and liver tissue. The beneficial effects of the grape extract may have been influenced by the profile of bioavailable polyphenols and the starting point of interventions.
s and the starting point of interventions.  +
Has info [ PMID: 27455862]  +
Has publicationkeywords Brain aging  + , Grape polyphenols  + , Hormesis  + , Life span  + , Memory  + , Mitochondria  +
Has title Asseburg H, Schäfer C, Müller M, Hagl S, Pohland M, Berressem D, Borchiellini M, Plank C, Eckert GP (2016) Effects of grape skin extract on age-related mitochondrial dysfunction, memory and life span in C57BL/6J mice. Neuromolecular Med 18:378-95.  +
Instrument and method Oxygraph-2k  +
Mammal and model Mouse  +
MiP area Respiration  + , Exercise physiology;nutrition;life style  +
Pathways N  + , S  + , CIV  + , NS  + , ROX  +
Preparation Isolated mitochondria  +
Tissue and cell Nervous system  +
Was published by MiPNetLab DE Giessen Eckert GP + , DE Frankfurt Eckert GP +
Was published in journal Neuromolecular Med +
Was published in year 2016  +
Was written by Asseburg H + , Silaidos C + , Mueller M + , Hagl S + , Pohland M + , Berressem D + , Borchiellini M + , Plank C + , Eckert GP +
Categories Publications
Modification date
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10:30:09, 16 January 2018  +
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