Soares 2017 Diab Vasc Dis Res
Soares RN, Reimer RA, Doyle-Baker PK, Murias JM (2017) Metabolic inflexibility in individuals with obesity assessed by near-infrared spectroscopy. Diab Vasc Dis Res 14:502-9. |
Soares RN, Reimer RA, Doyle-Baker PK, Murias JM (2017) Diab Vasc Dis Res
Abstract: To non-invasively evaluate differences in oxidative metabolism in individuals with obesity compared to normal weight using the near-infrared spectroscopy and vascular occlusion technique during hyperglycaemia.
In all, 16 normal-weight individuals (body mass index: 21.3βΒ±β1.7βkg/m2) and 13 individuals with obesity (body mass index: 34.4βΒ±β2.0βkg/m2) had five vascular occlusion tests (pre, 30, 60, 90 and 120βmin after glucose ingestion). Oxygen utilization was estimated from the area under the curve of the deoxyhemoglobin [HHb] signal during occlusion. Muscle reperfusion was derived from the area above the curve after cuff release.
The deoxyhemoglobin area under the curve during occlusion of the normal-weight individuals increased from 15,732βΒ±β2344β(% . s) at pre to 18,930βΒ±β3226β(% . s) ( pβ<β0.05) at 90βmin after glucose ingestion. The deoxyhemoglobin area under the curve during occlusion decreased significantly from 14,695βΒ±β3341β(% . s) at pre to 11,273βΒ±β1825β(% . s) ( pβ<β0.05) and 11,360βΒ±β1750β(% . s) ( pβ<β0.05) at 30 and 60βmin, respectively, after glucose ingestion. The area above the curve of deoxyhemoglobin during reperfusion decreased significantly from 6450βΒ±β765β(% . s) at pre to 4830βΒ±β963β(% . s) ( pβ<β0.05) at 60βmin and to 4210βΒ±β595β(% . s) ( pβ<β0.01) at 90βmin in normal-weight individuals after glucose ingestion, with no changes observed in individuals with obesity.
This study confirmed in vivo and non-invasively the metabolic inflexibility of skeletal muscle in individuals with obesity during hyperglycaemia. β’ Keywords: Glucose, Glucose metabolism, Glucose oxidation, Metabolic diseases, Obesity β’ Bioblast editor: Kandolf G
Labels:
Pathology: Obesity
Organism: Human