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Shulman GI

From Bioblast
Name Shulman GI,
Institution Departments of Internal Medicine

Cellular & Molecular Physiology, Pediatrics, Diagnostic Radiology and Biomedical Engineering

Howard Hughes Medical Institute

Yale University School of Medicine

Address ,
City New Haven
State/Province Connecticut (CT)
Country USA
O2k-Network Lab



Jelenik 2017 Diabetes2017Jelenik T, Kaul K, Séquaris G, Flögel U, Phielix E, Kotzka J, Knebel B, Fahlbusch P, Hörbelt T, Lehr S, Reinbeck AL, Müller-Wieland D, Esposito I, Shulman GI, Szendroedi J, Roden M (2017) Mechanisms of insulin resistance in primary and secondary nonalcoholic fatty liver. Diabetes 66:2241-53.
Pesta 2016 FASEB J2016Pesta DH, Tsirigotis DN, Befroy DE, Caballero D, Jurczak MJ, Rahimi Y, Cline GW, Dufour S, Birkenfeld AL, Rothman DL, Carpenter TO, Insogna K, Petersen KF, Bergwitz C, Shulman GI (2016) Hypophosphatemia promotes lower rates of muscle ATP synthesis. FASEB J 30:3378-87.
Johnson 2016 Diabetes2016Johnson ML, Distelmaier K, Lanza IR, Irving BA, Robinson MM, Konopka AR, Shulman GI, Nair KS (2016) Mechanism by which caloric restriction improves insulin sensitivity in sedentary obese adults. Diabetes 65:74-84.
Laursen 2015 Proc Natl Acad Sci USA2015Laursen WJ, Mastrotto M, Pesta D, Funk OH, Goodman JB, Merriman DK, Ingolia N, Shulman GI, Bagriantsev SN, Gracheva EO (2015) Neuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation. Proc Natl Acad Sci USA 112:1607-12.
Jelenik 2014 Diabetes2014Jelenik T, Séquaris G, Kaul K, Ouwens DM, Phielix E, Kotzka J, Knebel B, Weiß J, Reinbeck AL, Janke L, Nowotny P, Partke HJ, Zhang D, Shulman GI, Szendroedi J, Roden M (2014) Tissue-specific differences in the development of insulin resistance in a mouse model for type 1 diabetes. Diabetes 63:3856-67.
Camporez 2013 Endocrinology2013Camporez JP, Jornayvaz FR, Petersen M, Pesta D, Guigni BA, Serr J, Zhang D, Kahn M, Samuel VT, Jurczak MJ, Shulman GI (2013) Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice. Endocrinology 154:3099-109.
Lee 2010 Cell Metab2010Lee HY, Choi CS, Birkenfeld AL, Alves TC, Jornayvaz FR, Jurczak MJ, Zhang D, Woo DK, Shadel GS, Ladiges W, Rabinovitch PS, Santos JH, Petersen KF, Samuel VT, Shulman GI (2010) Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance. Cell Metab 12:668-74.
Pongratz 2007 J Biol Chem2007Pongratz RL, Kibbey RG, Shulman GI, Cline GW (2007) Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion. J Biol Chem 282:200-7.


Pesta 2014 Abstract MiP 20142014Dysregulation of muscle ATP synthesis in hypophosphatemic mouse models and in a patient with hypophosphatemia due to a mutation in NaPi2c.
Pesta 2012 Abstract Bioblast2012Pesta D, Jamison PR, Zhang D, Jurczak M, Manchem VP, Bhanot S, Samuel V, Shulman GI (2012) Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotides targeted to mIndy. Mitochondr Physiol Network 17.12.