Shrum 2016 J Kidney

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Shrum S, MacMillan-Crow LA, Parajuli N (2016) Cold storage exacerbates renal and mitochondrial dysfunction following transplantation. J Kidney 2 pii: 114.

» PMID: 27066594 Open Access

Shrum S, MacMillan-Crow LA, Parajuli N (2016) J Kidney

Abstract: Long-term renal function is compromised in patients receiving deceased donor kidneys which require cold storage exposure prior to transplantation. It is well established that extended cold storage induces renal damage and several labs, including our own, have demonstrated renal mitochondrial damage after cold storage alone. However, to our knowledge, few studies have assessed renal and mitochondrial function after transplantation of rat kidneys exposed to short-term (4 hr) cold storage compared to transplant without cold storage (autotransplantation). Our data reveal that cold storage plus transplantation exacerbated renal and mitochondrial dysfunction when compared to autotransplantation alone.

Keywords: Cold storage, Kidney, Mitochondria, Transplantation

O2k-Network Lab: US AR Little Rock MacMillan-Crow LA

Labels: MiParea: Respiration 

Stress:Temperature  Organism: Rat  Tissue;cell: Kidney  Preparation: Permeabilized tissue 

Coupling state: OXPHOS  Pathway: N, S, CIV  HRR: Oxygraph-2k