Petrus 2019 Physiol Res
|Petrus AT, Lighezan DL, Dănilă MD, Duicu OM, Sturza A, Muntean DM, Ionită I (2019) Assessment of platelet respiration as emerging biomarker of disease. Physiol Res [Epub ahead of print].|
Abstract: Mitochondrial dysfunction is currently acknowledged as a central pathomechanism of most common diseases of the 21st century. Recently, the assessment of the bioenergetic profile of human peripheral blood cells has emerged as a novel research field with potential applications in the development of disease biomarkers. In particular, platelets have been successfully used for the ex vivo analysis of mitochondrial respiratory function in several acute and chronic pathologies. An increasing number of studies support the idea that evaluation of the bioenergetic function in circulating platelets may represent the peripheral signature of mitochondrial dysfunction in metabolically active tissues (brain, heart, liver, skeletal muscle). Accordingly, impairment of mitochondrial respiration in peripheral platelets might have potential clinical applicability as a diagnostic and prognostic tool as well as a biomarker in treatment monitoring. The aim of this minireview is to summarize current information in the field of platelet mitochondrial dysfunction in both acute and chronic diseases.
• Keywords: Blood platelets, Mitochondrial respiration, High-resolution respirometry, Extracellular flux analysis, Acute and chronic diseases • Bioblast editor: Plangger M • O2k-Network Lab: RO Timisoara Muntean DM
Labels: MiParea: Respiration