DescriptionPyruvate & Glutamate & Malate & Succinate.
MitoPathway control state: NS-pathway control state
2-oxoglutarate is produced through the citric acid cycle from citrate by isocitrate dehydrogenase, from oxaloacetate and glutamate by the transaminase, and from glutamate by the glutamate dehydrogenase. If the 2-oxoglutarate carrier does not outcompete these sources of 2-oxoglutarate, then the TCA cycle operates in full circle with external pyruvate&malate&glutamate&succinate
Reference: Gnaiger 2014 MitoPathways - Chapter 5.6
MitoPedia concepts: SUIT state
PGMS pathway in the LEAK state can be evaluated in the following SUIT protocols:
PGMS pathway in the OXPHOS state can be evaluated in the following SUIT protocols:
PGMS pathway in the ET state can be evaluated in the following SUIT protocols:
- Recent studies showed that S- and NS-linked OXPHOS capacity is inhibited by 2 mM malate concentrations as applied in many SUIT protocols. This inhibition is less pronounced at higher succinate concentrations (10 mM up to 50 mM S).