Noland Robert C
From Bioblast
| Name | Noland Robert C, Assistant Professor, PhD |
|---|---|
| Institution | Pennington Biomedical Research Center |
| Address | , LA 70808 |
| City | Baton Rouge |
| State/Province | |
| Country | USA |
| [email protected] | |
| Weblink | |
| O2k-Network Lab | US LA Baton Rouge Noland RC |
Labels:
Field of research: Basic
Publications
| Published | Reference | |
|---|---|---|
| Axelrod 2021 EMBO Mol Med | 2021 | Axelrod CL, King WT, Davuluri G, Noland RC, Hall J, Hull M, Dantas WS, Zunica ER, Alexopoulos SJ, Hoehn KL, Langohr I, Stadler K, Doyle H, Schmidt E, Nieuwoudt S, Fitzgerald K, Pergola K, Fujioka H, Mey JT, Fealy C, Mulya A, Beyl R, Hoppel CL, Kirwan JP (2021) BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. EMBO Mol Med 12:12088. |
| King 2021 J Biol Chem | 2021 | King WT, Axelrod CL, Zunica ERM, Noland RC, Davuluri G, Fujioka H, Tandler B, Pergola K, Hermann GE, Rogers RC, López-Domènech S, Dantas WS, Stadler K, Hoppel CL, Kirwan JP (2021) Dynamin-related protein 1 regulates substrate oxidation in skeletal muscle by stabilizing cellular and mitochondrial calcium dynamics. J Biol Chem 297:101196. |
Abstracts
| Published | Reference | |
|---|---|---|
| Axelrod 2019 Abstract IOC141 | 2019 | Axelrod CL, Davuluri G, Zunica ERM, Noland RC, Hoppel CL, Kirwan JP (2019) Administration of BAM15 to obese C57BL/6J mice increases skeletal muscle fatty acid oxidation independent of OXPHOS or ETC capacity. Mitochondr Physiol Network 24.02. |
- My research primarily focuses on exploring mechanisms linking dysregulation of lipid metabolism to pre-diabetes and diabetes. Chief among these are the potential role of aberrant mitochondrial and peroxisomal function contributing to the development of lipid-induced insulin resistance. Currently my laboratory assesses mitochondrial function by protein/gene expression, enzymatic activity, direct measurement of substrate metabolism using radiolabeled tracer technology, and metabolomic/lipidomic profiling. The OROBOROS-O2k ISE Multisensor System will greatly increase our ability to comprehensively test mitochondrial function which is anticipated to not only strengthen results obtained from our studies, but also provide novel insight that will guide future experimental exploration.
