Martin 2010 Proc Natl Acad Sci U S A
| Martin B, Ji S, Maudsley S, Mattson MP (2010) "Control" laboratory rodents are metabolically morbid: why it matters. Proc Natl Acad Sci U S A 107:6127-33. |
Martin B, Ji S, Maudsley S, Mattson MP (2010) Proc Natl Acad Sci U S A
Abstract: Failure to recognize that many standard control rats and mice used in biomedical research are sedentary, obese, glucose intolerant, and on a trajectory to premature death may confound data interpretation and outcomes of human studies. Fundamental aspects of cellular physiology, vulnerability to oxidative stress, inflammation, and associated diseases are among the many biological processes affected by dietary energy intake and exercise. Although overfed sedentary rodents may be reasonable models for the study of obesity in humans, treatments shown to be efficacious in these animal models may prove ineffective or exhibit novel side effects in active, normal-weight subjects. • Keywords: Cancer, Clinical trials, Exercise, Insulin resistance, Obesity
Labels:
Pathology: Aging;senescence, Cancer
Stress:Mitochondrial disease
Organism: Human, Mouse, Rat
Tissue;cell: Nervous system
Preparation: Intact organism
