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Li 2022 Hypertens Res

From Bioblast
Publications in the MiPMap
Li L, Ma L, Luo Z, Wei X, Zhao Y, Zhou C, Mou A, Lu Z, You M, He C, Ma H, Zhou Q, Wang L, Cao T, Gu Y, Gao P, Zhu Z (2022) Lack of TRPV1 aggravates obesity-associated hypertension through the disturbance of mitochondrial Ca2+ homeostasis in brown adipose tissue. https://doi.org/10.1038/s41440-021-00842-8

Β» Hypertens Res 45:789-801. PMID: 35043013 Open Access

Li Li, Ma Liqun, Luo Zhidan, Wei Xiao, Zhao Yu, Zhou Cui, Mou Aidi, Lu Zongshi, You Mei, He Chengkang, Ma Huan, Zhou Qing, Wang Lijuan, Cao Tingbing, Gu Yucun, Gao Peng, Zhu Zhiming (2022) Hypertens Res

Abstract: The combination of obesity and hypertension is associated with high morbidity and mortality; however, the mechanism underlying obesity-induced hypertension remains unclear. In this study, we detected the possible effects of TRPV1, a previously identified antihypertensive calcium (Ca2+) channel in adipose tissue, on the occurrence of obesity and hypertension in mice lacking UCP1, a spontaneously genetically manipulated obesity model, by generating TRPV1 and UCP1 double knockout mice. In these mice, obesity and hypertension appeared earlier and were more severe than in mice with the knockout of UCP1 or TRPV1 alone. The knockout of TRPV1 in UCP1 knockout mice further reduced functional brown adipose tissue (BAT) generation; decreased resting oxygen consumption, heat production, and locomotor activities; and was accompanied by severe mitochondrial respiratory dysfunction in BAT. Mechanistically, TRPV1, UCP1, and LETM1 acted as a complex to maintain an appropriate mitochondrial Ca2+ level, and TRPV1 knockout caused a compensatory increase in mitochondrial Ca2+ uptake via LETM1 activation. However, the compensatory response was blocked in UCP1-/- mice, resulting in dramatically reduced mitochondrial Ca2+ uptake and higher production of ATP and oxidative stress. This study provides in vivo evidence for the critical role of BAT mitochondrial Ca2+ homeostasis in obesity-associated hypertension and indicates that the TRPV1/UCP1/LETM1 complex may be an alternative intervention target. β€’ Keywords: Brown adipose tissue, Leucine zipper-EF-hand containing transmembrane protein 1, Mitochondrial Ca2+, Obesity-associated hypertension, Transient receptor potential vanilloid-1, Uncoupling protein 1 β€’ Bioblast editor: Plangger M β€’ O2k-Network Lab: CN Chongqing Zhu Z


Labels: MiParea: Respiration, Genetic knockout;overexpression 


Organism: Mouse 




HRR: Oxygraph-2k 

CN, 2022-01