Karabatsiakis 2017 MiP2017
We therefore analyzed in a study cohort of 30 women with varying degrees of CM experiences whether mitochondrial respiratory activity was altered in intact peripheral blood mononuclear cells immune cells and was associated with increased levels of inflammatory signaling. The Childhood Trauma Questionaire (CTQ) was used to assess adverse experiences in childhood.
With increasingly severe CM experiences, study participants displayed higher levels of endogenous, bioactive molecules linked to oxidative stress and an increased immune cell mitochondrial activity, which was associated with a higher secretion of the pro-inflammatory cytokines IL-1beta, IL-6 and TNF-alpha.
Together these data support the hypothesis that alterations in immune cell mitochondrial functioning might be at the interface between the association of CM experiences and a state of chronic low-grade inflammation that persists until adulthood. The present findings further emphasize that the early prevention of child maltreatment, abuse and neglect warrants more attention, as affected individuals suffer not only from life-long consequences for mental, but also for physical health.
Labels: MiParea: Respiration, mt-Awareness
Organism: Human Tissue;cell: Blood cells Preparation: Intact cells
- Karabatsiakis A(1), Böck C(1), Koenig AM(1), Schury K(1), Geiger ML(1), Wilker S(1), Waller C(2), Gündel H(2), Fegert JM(3), Calzia E(4), Kolassa IT(1)
- Clinical & Biological Psychology, Inst Psychology Education, Ulm Univ
- Dept Psychosomatic Medicine Psychotherapy
- Dept Child Adolescent Psychiatry Psychotherapy
- Inst Anesthesiological Pathophysiology Process Engineering
- Univ Hosp Ulm, Germany. – firstname.lastname@example.org
- WHO fact sheet, revised September 2016.