Kaelin 2005 Cell Metab
From Bioblast
| Kaelin WG Jr (2005) ROS: really involved in oxygen sensing. Cell Metab 1(6):357-8. |
Kaelin WG Jr (2005) Cell Metab
Abstract: The role of reactive oxygen species (ROS) in the cellular response to cellular oxygen sensing has been controversial. Three papers in this issue of Cell Metabolism (Brunelle et al., Guzy et al., 2005; Mansfield et al., 2005) used genetic tools to establish that ROS produced by mitochondria are required for the normal induction of HIF (hypoxia-inducible factor), which is a master regulator of oxygen-sensitive gene expression, by low oxygen.
Comment on
Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation.
• Bioblast editor: Sobotka O
Cited by
- Komlódi T, Schmitt S, Zdrazilova L, Donnelly C, Zischka H, Gnaiger E. Oxygen dependence of hydrogen peroxide production in isolated mitochondria and permeabilized cells. MitoFit Preprints (in prep).
Labels:
Stress:Oxidative stress;RONS, Hypoxia
MitoFit 2021 AmR
