Hildyard 2003 Biochem J

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Hildyard JC, Halestrap AP (2003) Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevisiae. Biochem J 374: 607-611.


Hildyard JC, Halestrap AP (2003) Biochem J

Abstract: Mitochondrial pyruvate transport is fundamental for metabolism and mediated by a specific inhibitable carrier. We have identified the yeast mitochondrial pyruvate carrier by measuring inhibitor-sensitive pyruvate uptake into mitochondria from 18 different Saccharomyces cerevisiae mutants, each lacking an unattributed member of the mitochondrial carrier family (MCF). Only mitochondria from the YIL006w deletion mutant exhibited no inhibitor-sensitive pyruvate transport, but otherwise behaved normally. YIL006w encodes a 41.9 kDa MCF member with homologous proteins present in both the human and mouse genomes.

Keywords: Mitochondrial carrier family, Mitochondrial pyruvate transport, Pyruvate metabolism, Saccharomyces.

O2k-Network Lab: UK Bristol Halestrap AP


Organism: Saccharomyces cerevisiae, Fungi