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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
Hansson Magnus J
MitoPedia topics: EAGLE
COST: Member
| Name | Hansson Magnus J, MD, PhD, CMO & VP Preclinical and Clinical Development |
|---|---|
| Institution |  Abliva AB |
| Address | Medicon Village, Scheelevägen 2, SE-223 81 |
| City | Lund |
| State/Province | |
| Country | Sweden |
| [email protected] | |
| Weblink | Abliva |
| O2k-Network Lab | SE Lund Elmer E |
Labels:
Publications
| Published | Reference | |
|---|---|---|
| Westerlund 2024 Heliyon | 2024 | Westerlund E, Marelsson SE, Karlsson M, Sjövall F, Chamkha I, Åsander Frostner E, Lundgren J, Fellman V, Eklund EA, Steding-Ehrenborg K, Darin N, Paul G, Hansson MJ, Ehinger JK, Elmér E (2024) Correlation of mitochondrial respiration in platelets, peripheral blood mononuclear cells and muscle fibers. Heliyon 10:e26745. https://doi.org/10.1016/j.heliyon.2024.e26745 |
| Aasander Frostner 2022 BEC | 2022 | Åsander Frostner E, Simón Serrano S, Chamkha I, Donnelly E, Elmér E, Hansson MJ (2022) Towards a treatment for mitochondrial disease: current compounds in clinical development. Bioenerg Commun 2022.4. https://doi.org/10.26124/bec:2022-0004 |
| Avram 2021 Int J Mol Sci | 2021 | Avram VF, Chamkha I, Åsander-Frostner E, Ehinger JK, Timar RZ, Hansson MJ, Muntean DM, Elmér E (2021) Cell-permeable succinate rescues mitochondrial respiration in cellular models of statin toxicity. Int J Mol Sci 22:424. |
| Piel 2020 PLoS One | 2020 | Piel S, Chamkha I, Dehlin AK, Ehinger JK, Sjövall F, Elmér E, Hansson MJ (2020) Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose. PLoS One 15:e0231173. |
| Karlsson 2018 J Neurotrauma | 2018 | Karlsson M, Pukenas B, Chawla S, Ehinger JK, Plyler R, Stolow M, Gabello M, Hugerth M, Elmér E, Hansson MJ, Margulies S, Kilbaugh T (2018) Neuroprotective effects of cyclosporine in a porcine pre-clinical trial of focal traumatic brain injury. J Neurotrauma 36:14-24. |
| Piel 2018 Intensive Care Med Exp | 2018 | Piel S, Ehinger JK, Chamkha I, Frostner EÅ, Sjövall F, Elmér E, Hansson MJ (2018) Bioenergetic bypass using cell-permeable succinate, but not methylene blue, attenuates metformin-induced lactate production. Intensive Care Med Exp 6:22. |
| Westerlund 2017 Pediatr Res | 2017 | Westerlund E, Marelsson SE, Ehinger JK, Sjövall F, Morota S, Åsander Frostner E, Oldfors A, Darin N, Lundgren J, Hansson MJ, Fellman V, Elmér E (2017) Oxygen consumption in platelets as an adjunct diagnostic method for pediatric mitochondrial disease. Pediatr Res 83:455-65. |
| Elmer 2017 US Patent | 2017 | Elmer E, Hansson MJ, Ehinger JK, Piel S, Moss S (2017) Succinate prodrugs for use in the treatment of lactic acidosis or drug-induced side-effects due to complex I-related impairment of mitochondrial oxidative phosphorylation. US Patent US20170100359 A1. |
| Karlsson 2016 Mitochondrion | 2016 | Karlsson M, Ehinger JK, Piel S, Sjövall F, Henriksnäs J, Höglund U, Hansson MJ, Elmér E (2016) Changes in energy metabolism due to acute rotenone-induced mitochondrial complex I dysfunction – an in vivo large animal model. Mitochondrion 31:56-62. |
| Kilbaugh 2016 Mitochondrion | 2016 | Kilbaugh TJ, Karlsson M, Duhaime AC, Hansson MJ, Elmer E, Margulies SS (2016) Mitochondrial response in a toddler-aged swine model following diffuse non-impact traumatic brain injury. Mitochondrion 26:19-25. |
| Karlsson 2016 Shock | 2016 | Karlsson M, Hara N, Morata S, Sjövall F, Kilbaugh T, Hansson MJ, Uchino H, Elmér E (2016) Diverse and tissue-specific mitochondrial respiratory response in a mouse model of sepsis-induced multiple organ failure. Shock 45:404-10. |
| Ehinger 2016 Nat Commun | 2016 | Ehinger JK, Piel S, Ford R, Karlsson M, Sjövall F, Frostner EÅ, Morota S, Taylor RW, Turnbull DM, Cornell C, Moss SJ, Metzsch C, Hansson MJ, Fliri H, Elmér E (2016) Cell-permeable succinate prodrugs bypass mitochondrial Complex I deficiency. Nat Commun 7:12317. https://doi.org/10.1038/ncomms12317 |
| Ehinger 2016 Mov Disord | 2016 | Ehinger JK, Morota S, Hansson MJ, Gesine P, Elmér E (2016) Mitochondrial respiratory function in peripheral blood cells from Huntington’s disease patients. Mov Disord doi:10.1002/mdc3.12308. |
| Kilbaugh 2015 J Am Heart Assoc | 2015 | Kilbaugh TJ, Sutton RM, Karlsson M, Hansson MJ, Naim MY, Morgan RW, Bratinov G, Lampe JW, Nadkarni VM, Becker LB, Margulies SS, Berg RA (2015) Persistently altered brain mitochondrial bioenergetics after apparently successful resuscitation from cardiac arrest. J Am Heart Assoc 4(9) pii: e002232. |
| Fliri 2015 US Patent | 2015 | Fliri HG, Ford RL, Scowen DA, Batcheller DG, Ehinger J, Elmér E, Hansson MJ, Sjövall F (2015) Protected succinates for enhancing mitochondrial atp-production. US Patent US20150259317 A1. |
| Sjoevall 2015 US Patent | 2015 | Sjövall F, Ehinger J, Hansson M, Elmer E, Batcheller DG (2018) Mitochondrial toxicity test. US Patent US20150253306 A1. |
| Kilbaugh 2015 Exp Neurol | 2015 | Kilbaugh TJ, Karlsson M, Byro M, Bebee A, Ralston J, Sullivan S, Duhaime AC, Hansson MJ, Elmér E, Margulies SS (2015) Mitochondrial bioenergetic alterations after focal traumatic brain injury in the immature brain. Exp Neurol 271:136-144. |
| Ehinger 2015 J Neurol | 2015 | Ehinger JK, Morota S, Hansson MJ, Paul G, Elmér E (2015) Mitochondrial dysfunction in blood cells from amyotrophic lateral sclerosis patients. J Neurol 262:1493-503. https://doi.org/10.1007/s00415-015-7737-0 |
| Hansson 2015 Eur J Pharmacol | 2015 | Hansson MJ, Llwyd O, Morin D, de Paulis D, Arnoux T, Gouarné C, Koul S, Engblom H, Bordet T, Tissier R, Arheden H, Erlinge D, Halestrap AP, Berdeaux A, Pruss RM, Schaller S (2015) Differences in the profile of protection afforded by TRO40303 and mild hypothermia in models of cardiac ischemia/reperfusion injury. Eur J Pharmacol 760:7-19. |
| Piel 2014 Acta Physiol (Oxf) | 2014 | Piel S, Ehinger JK, Elmér E, Hansson Magnus J (2014) Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial Complex I inhibition. Acta Physiol (Oxf) 213:171-80. |
| Sjoevall 2014 PLoS One | 2014 | Sjövall F, Morota S, Asander Frostner E, Hansson Magnus J, Elmer E (2014) Cytokine and nitric oxide levels in patients with sepsis - temporal evolvement and relation to platelet mitochondrial respiratory function. PLoS One 9:e97673. |
| Burguillos 2013 PLoS One | 2013 | Burguillos MA, Magnusson C, Nordin M, Lenshof A, Augustsson P, Hansson Magnus J, Elmér E, Lilja H, Brundin P, Laurell T, Deierborg T (2013) Microchannel acoustophoresis does not impact survival or function of microglia, leukocytes or tumor cells. PLoS One 8:e64233. |
| Sjoevall 2013 Crit Care | 2013 | Sjoevall F, Morota S, Persson J, Hansson Magnus J, Elmer E (2013) Patients with sepsis exhibit increased mitochondrial respiratory capacity in peripheral blood immune cells. Crit Care 17:R152. |
| Hara 2013 Eur J Anaesthesiol | 2013 | Hara N, Karlsson M, Sjövall F, Hansson Magnus J, Elmér E, Uchino H (2013) Early brain mitochondrial dysfunction in a mouse model of sepsis: 7AP4‐9. Eur J Anaesthesiol 30,112-112. |
| Karlsson 2013 Int J Biochem Cell Biol | 2013 | Karlsson M, Hempel C, Sjövall F, Hansson Magnus J, Kurtzhals JA, Elmér E (2013) Brain mitochondrial function in a murine model of cerebral malaria and the therapeutic effects of rhEPO. Int J Biochem Cell Biol 45:151-5. |
| Sjoevall 2013 Mitochondrion | 2013 | Sjövall F, Ehinger JK, Marelsson SE, Morota S, Asander Frostner E, Uchino H, Lundgren J, Arnbjörnsson E, Hansson Magnus J, Fellman V, Elmér E (2013) Mitochondrial respiration in human viable platelets - methodology and influence of gender, age and storage. Mitochondrion 13:7-14. |
| Hansson 2010 J Biol Chem | 2010 | Hansson Magnus J, Morota S, Teilum M, Mattiasson G, Uchino H, Elmer E (2010) Increased potassium conductance of brain mitochondria induces resistance to permeability transition by enhancing matrix volume. J Biol Chem 285:741-50. |
| Sjoevall 2010 Crit Care | 2010 | Sjoevall F, Morota S, Hansson Magnus J, Friberg H, Gnaiger E, Elmer E (2010) Temporal increase of platelet mitochondrial respiration is negatively associated with clinical outcome in patients with sepsis. Crit Care 14:R214. |
| Morota 2009 Exp Neurol | 2009 | Morota S, Månsson R, Hansson Magnus J, Kasuya K, Shimazu M, Hasegawa E, Yanagi S, Omi A, Uchino H, Elmér E (2009) Evaluation of putative inhibitors of mitochondrial permeability transition for brain disorders-specificity vs. toxicity. Exp Neurol 218:353-62. |
| Hansson 2008 Free Radic Biol Med | 2008 | Hansson Magnus J, Månsson R, Morota S, Uchino H, Kallur T, Sumi T, Ishii N, Shimazu M, Keep MF, Jegorov A, Elmér E (2008) Calcium-induced generation of reactive oxygen species in brain mitochondria is mediated by permeability transition. Free Radic Biol Med 45:284-94. |
| Hansson 2007 Thesis | 2007 | Hansson MJ (2007) Mitochondrial permeability transition following calcium overload. - Its role in neuronal cell death and potential as a pharmacological target. Doctoral Thesis 78p. |
Abstracts
| Published | Reference | |
|---|---|---|
| Aasander Frostner 2022 Abstract Bioblast | 2022 | 8.1. «10+5»  »Bioenergetics Communications«  |
| Avram 2018 MiP2018 | 2018 |  |
| Aasander Frostner 2017 MiP2017 | 2017 | |
| Ehinger 2015 Abstract MiPschool London 2015 | 2015 | Cell-permeable mitochondrial complex II substrates – a new compound class for treatment of complex I-linked mitochondrial disease. |
| Piel 2015 Abstract MiPschool London 2015 | 2015 | The novel Cyclophilin D inhibitor NVP019 reduces mitochondrial permeability transition in isolated rat and human heart mitochondria. |
| Hansson Fatty Acid Oxidation O2k-Network Discussion Forum | 2015 | Hansson 2015 Fatty Acid Oxidation O2k-Network Discussion Forum |
| Aasander Frostner 2011 Abstract MiP2011 | 2011 | Is there a systemic mitochondrial biogenic response to aerobic training? Mitochondrial respiration in platelets from athletes forced to rest following a knee injury. |
