Gross 2023 MitoFit

Gross A (2023) A BID-MTCH2 love story: Energizing mitochondria until apoptosis do them part? MitoFit Preprints 2023.9. https://doi.org/10.26124/mitofit:2023-0009 — 2024-02-08 published in Bioenerg Commun 2024.1.

» MitoFit Preprints 2023.9.

A BID-MTCH2 love story: Energizing mitochondria until apoptosis do them part?

Gross Atan (2023) MitoFit Prep

Abstract: Mitochondrial carrier homolog 2 (MTCH2) is currently one of the most enigmatic mitochondrial proteins. MTCH2’s ligand is the pro-apoptotic BID protein, and the love story between these two proteins involves the regulation of diverse cellular processes including apoptosis, energy metabolism, mitochondrial dynamics, and protein insertion into the mitochondrial outer membrane. This review offers an updated progress report of these two proteins, and describes our hypotheses regarding their joint mechanism of action.
• Keywords: MTCH2; BID; energy metabolism; mitochondrial fusion; ER mitochondrial crosstalk; apoptosis; scramblase; insertase • Bioblast editor: Tindle-Solomon L

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