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Giaccia 2004 Genes Dev

From Bioblast
Publications in the MiPMap
Giaccia AJ, Simon MC, Johnson R (2004) The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease. Genes Dev 18(18):2183-94.

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Giaccia AJ, Simon MC, Johnson R (2004) Genes Dev

Abstract: The ability to sense and respond to changes in oxygen is essential for the survival of prokaryotic and eukaryotic organisms. Oxygen-sensing mechanisms have been developed to maintain cell and tissue homeostasis, as well as to adapt to the chronic low-oxygen conditions found in diseases such as cancer. This report on the first Keystone Meeting on the Biology of Hypoxia will summarize our current understanding of key genes and pathways involved in oxygen sensing that are required for normal development and that are dysregulated in disease states. It will also comment on future directions for this exciting field. β€’ Keywords: Hypoxia, HIF, hydroxylases, ion channels β€’ Bioblast editor: Sobotka O


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Stress:Oxidative stress;RONS, Hypoxia