Electron leak

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Electron leak

Description

Electrons that escape the electron transfer pathway without completing the reduction of oxygen to water at cytochrome c oxidase, causing the production of ROS. The rate of electron leak depends on the topology of the complex, the redox state of the moiety responsible of electron leakiness and usually on the protonmotive force (Δp). In some cases, the Δp dependance relies more on the ∆pH component than in the ∆Ψ.


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References

  1. Jastroch M, Divakaruni AS, MookerjeecS, Treberg JR, Brand MD (2010) Mitochondrial proton and electron leaks. Essays Biochemistry 47: 53–67 pp.


MitoPedia concepts: MiP concept 


MitoPedia methods: Respirometry, Fluorometry 



MitoPedia topics: EAGLE