According to David Fell, "Elasticities are properties of individual enzymes and not the metabolic system. The elasticity of an enzyme to a metabolite is related to the slope of the curve of the enzyme's rate plotted against metabolite concentration, taken at the metabolite concentrations found in the pathway in the metabolic state of interest. It can be obtained directly as the slope of the logarithm of the rate plotted against the logarithm of the metabolic concentration. The elasticity will change at each point of the curve (s,v) and must be calculated for the specific concentration of the metabolite (s) that will give a specific rate (r) of the enzyme activity" (See Figure).
Reference: Flux control efficiency
Communicated by Iglesias-Gonzalez J 2018-11-08.
- 1. David Fell. Frontiers in metabolism 2. Understanding the control of metabolism. Portland Press. 1997.
- 2. Lehninger. Principles of Biochemistry. 5th Edition. 2008.