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Dhillon 2014 Abstract IOC96

From Bioblast
Dhillon RS (2014) Acetylation and mitochondrial respiratory function in aging and calorie-restricted mice. Mitochondr Physiol Network 19.11.

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Dhillon R

Dhillon RS, Denu JM (2014)

Event: IOC96

Recent studies have demonstrated widespread reprogramming of the mitochondrial proteome via post-translational modifications (PTMs) in response to a number of treatments that can affect metabolism. However, little is known of how these PTMs modify electron transport chain function. The objectives of our research are to examine the global acetylome in aging and caloric restriction in wild-type and sirtuin 3 knockout mice. We hypothesize that hyperacetylation seen in sirtuin 3 knockout or control diet mice will adversely affect mitochondrial respiration, and that caloric restriction may offset mitochondrial defects due to aging. Previous studies in our lab have demonstrated an increase in sirtuin 3 protein expression in the livers of calorie-restricted mice. Furthermore, all tissues do not respond to calorie restriction in a similar manner, yet how this affects mitochondrial metabolism has not been determined. We aim to explore these questions and incorporate a comparative approach using aging models (naked mole rats) and caloric-restriction models (hibernating mammals) to further elucidate the evolutionary mechanisms involved in post-translational modifications and metabolic phenotypes.


β€’ O2k-Network Lab: US WI Madison Denu JM


Labels: MiParea: Respiration, Exercise physiology;nutrition;life style  Pathology: Aging;senescence 

Organism: Mouse  Tissue;cell: Liver 





Affiliation

Department of Biomolecular Chemistry

Epigenetics Theme - Wisconsin Institute for Discovery

University of Wisconsin