Burtscher 2022 Antioxid Redox Signal

From Bioblast
Publications in the MiPMap
Burtscher J, Mallet RT, Pialoux V, Millet GP, Burtscher M (2022) Adaptive responses to hypoxia and/or hyperoxia in humans. https://doi.org/10.1089/ars.2021.0280

Β» Antioxid Redox Signal PMID: 35102747 Open Access

Burtscher J, Mallet RT, Pialoux V, Millet GP, Burtscher M (2022) Antioxid Redox Signal

Abstract: Significance: Oxygen is indispensable for aerobic life, but its utilization exposes cells and tissues to oxidative stress; thus, tight regulation of cellular, tissue, and systemic oxygen concentrations is crucial. Here, we review the current understanding of how the human organism (mal-)adapts to low (hypoxia) and high (hyperoxia) oxygen levels and how these adaptations may be harnessed as therapeutic or performance enhancing strategies at the systemic level.

Recent Advances: Hyperbaric oxygen therapy is already a cornerstone of modern medicine, and the application of mild hypoxia, that is, hypoxia conditioning (HC), to strengthen the resilience of organs or the whole body to severe hypoxic insults is an important preparation for high-altitude sojourns or to protect the cardiovascular system from hypoxic/ischemic damage. Many other applications of adaptations to hypo- and/or hyperoxia are only just emerging. HC-sometimes in combination with hyperoxic interventions-is gaining traction for the treatment of chronic diseases, including numerous neurological disorders, and for performance enhancement.

Critical Issues: The dose- and intensity-dependent effects of varying oxygen concentrations render hypoxia- and/or hyperoxia-based interventions potentially highly beneficial, yet hazardous, although the risks versus benefits are as yet ill-defined.

Future Directions: The field of low and high oxygen conditioning is expanding rapidly, and novel applications are increasingly recognized, for example, the modulation of aging processes, mood disorders, or metabolic diseases. To advance hypoxia/hyperoxia conditioning to clinical applications, more research on the effects of the intensity, duration, and frequency of altered oxygen concentrations, as well as on individual vulnerabilities to such interventions, is paramount. β€’ Keywords: adaptation, conditioning, hormesis, hyperoxia, hypoxia, mitochondria, reactive oxygen species β€’ Bioblast editor: Gnaiger E

Labels: MiParea: Respiration 

Stress:Oxidative stress;RONS, Hypoxia  Organism: Human 

Preparation: Intact organism 


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