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Brownlee 2001 Nature

From Bioblast
Publications in the MiPMap
Brownlee M (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 414:813-20.

» PMID:11742414 Open Access

Brownlee M (2001) Nature

Abstract: Diabetes-specific microvascular disease is a leading cause of blindness, renal failure and nerve damage, and diabetes-accelerated atherosclerosis leads to increased risk of myocardial infarction, stroke and limb amputation. Four main molecular mechanisms have been implicated in glucose-mediated vascular damage. All seem to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain. This integrating paradigm provides a new conceptual framework for future research and drug discovery.

Brownlee 2001 Nature CORRECTION.png

Correction: FADH2 and Complex II

Ambiguity alert.png
FADH2 is shown as the substrate feeding electrons into Complex II (CII). This is wrong and requires correction - for details see Gnaiger (2023).
Gnaiger E (2023) Complex II ambiguities ― FADH2 in the electron transfer system. J Biol Chem. - »Bioblast link«