Brownlee 2001 Nature

Brownlee M (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 414:813-20. https://doi.org/10.1038/414813a

» PMID:11742414 Open Access

Brownlee M (2001) Nature

Abstract: Diabetes-specific microvascular disease is a leading cause of blindness, renal failure and nerve damage, and diabetes-accelerated atherosclerosis leads to increased risk of myocardial infarction, stroke and limb amputation. Four main molecular mechanisms have been implicated in glucose-mediated vascular damage. All seem to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain. This integrating paradigm provides a new conceptual framework for future research and drug discovery.

Correction: FADH₂ and Complex II

FADH₂ is shown as the substrate feeding electrons into Complex II (CII). This is wrong and requires correction - for details see Gnaiger (2023).

Gnaiger E (2023) Complex II ambiguities ― FADH₂ in the electron transfer system. J Biol Chem. https://doi.org/10.1016/j.jbc.2023.105470 - »Bioblast link«