Cookies help us deliver our services. By using our services, you agree to our use of cookies. More information

Brown 2012 Mitochondrion

From Bioblast
Publications in the MiPMap
Brown GC, Borutaite V (2012) There is no evidence that mitochondria are the main source of reactive oxygen species in mammalian cells. Mitochondrion 12:1-4.

» PMID:21303703 Open Access

Brown GC, Borutaite V (2012) Mitochondrion

Abstract: It is often assumed that mitochondria are the main source of reactive oxygen species (ROS) in mammalian cells, but there is no convincing experimental evidence for this in the literature. What evidence there is suggests mitochondria are a significant source for ROS, which may have physiological and pathological effects. But quantitatively, endoplasmic reticulum and peroxisomes have a greater capacity to produce ROS than mitochondria, at least in liver. In most cells and physiological or pathological conditions there is a lack of evidence for or against mitochondria being the main source of cellular ROS. Mitochondria can rapidly degrade ROS and thus are potential sinks for ROS, but whether mitochondria act as net sources or sinks within cells in particular conditions is unknown.

Cited by

  • Komlódi T, Schmitt S, Zdrazilova L, Donnelly C, Zischka H, Gnaiger E (2022) Oxygen dependence of hydrogen peroxide production in isolated mitochondria and permeabilized cells. MitoFit Preprints 2022 (in prep).

Labels:






MitoFit 2021 AmR