Arya 2012 Cytokine

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Arya AK, Pokharia D, Bhan S, Tripathi R, Tripathi K (2012) Correlation between IL-7 and MCP-1 in diabetic chronic non healing ulcer patients at higher risk of coronary artery disease. Cytokine 60:767-71.

» PMID: 22921903

Arya AK, Pokharia D, Bhan S, Tripathi R, Tripathi K (2012) Cytokine

Abstract: Cytokines play an extremely important role in the pathogenesis of coronary artery disease (CAD) in which interleukin (IL)-7 is a major regulator of T-cell homeostasis which is conced in the stimulation of leukocyte–endothelial cell adhesion during inflammatory events. Circulating IL-7 is associated with activation of monocyte and natural killer cells, leading to enhanced production of inflammatory cytokines and chemokines observed in atherosclerosis and acute coronary syndromes. Plasma levels of IL-7, hs-CRP and monocyte chemoattractant protein (MCP)-1 were measured by an immunoenzymatic ELISA technique. Ninety neuropathic diabetic foot patients were divided into two groups: group B [those without CAD (n = 45)] and group C [those with higher risk of CAD (n = 45)]. Thirty-five healthy subjects were included as control (group H). Plasma concentration of IL-7, MCP-1 and hs-CRP were significantly higher in group C as compare with group H and B. Plasma IL-7 levels also showed significant positive correlations with plasma levels of hs-CRP and MCP-1. Abnormalities in lipid profile were also observed. In conclusion the positive correlation between plasma concentration of IL-7, MCP-1 and hs-CRP in diabetic foot patients observed herein, suggests a plausible role for IL-7 in the promotion of clinical instability in coronary artery disease.

Highlights ► Diabetic foot patients are at higher risk of coronary artery disease (CAD). ► IL-7, MCP-1 and hs-CRP promotes clinical instability towards CAD. ► IL-7 up regulating the expression of MCP-1; induces inflammatory processes. ► Abnormalities in lipid profile of diabetic foot patients shows higher risk of CAD.

Abbreviations T2DM, type 2 diabetes mellitus; SBP, systolic blood pressure; DBP, diastolic blood pressure; CAD, coronary artery disease; IL, interleukin; MCP, monocyte chemoattractant protein; hsCRP, high sensitive C-reactive protein

Keywords: Interleukin, Diabetes mellitus, Neuropathy, Diabetic foot, Coronary artery disease


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Organism: Human  Tissue;cell: Blood cells