Talk:MiPschool Obergurgl 2017

Tentative programme Version 01

Session A (morning) Introduction: coupling control in oxidative phosphorylation

• A1. The electron transfer system – mitochondrial pathways from fuel substrates to oxygen.
• A2. Coupling of the phosphorylation system to electron transfer and respiratory coupling control.
• A3. From Einstein's diffusion equation to Mitchell’s chemiosmotic equation: rates and states in the bioenergetics of oxidative phosphorylation.
• A4. Measurement of coupling in intact cells and mitochondrial preparations: biochemical coupling efficiency and ATP/O2 ratios.

Session B (afternoon) Posters and selected abstracts

• B1. Poster session.
• B2: Selected abstracts: measurement of coupling control in intact cells and mitochondrial preparations - open discussion.
• B3. Towards a data base on coupling control in intact cells.

• • • • 2017-07-25

Session C (morning) Introduction: from experimental design to data analysis

• C1. Respiratory pathway control in mitochondrial preparations.
• C2. Substrate-uncoupler-inhibitor titration (SUIT) protocols – fundamental principles.
• C3. Normalization of respiratory flux and flow.
• C4. Respiratory control ratios and control factors.

Session D (afternoon) Posters and selected abstracts

• D1. Selected abstracts: applications of SUIT protocols – open discussion.
• D2. SUIT protocols: design and limitations.
• D3. Towards a data base on mitochondrial respiratory control: diagnostic approaches and comparative mitochondrial physiology.

• • • • 2017-07-26

Session E (morning) Mitochondrial physiology: biomedical applications (possible titles, depending on keynote lecturers/selected abstracts)

• E1. The challenges of functional mitochondrial diagnosis.
• E2. Mitochondrial fitness in skeletal muscle (Pablo Garcia-Roves, University of Barcelona, ES).
• E3. Scope and limitations of functional mitochondrial diagnosis in blood cells.
• E4. Mitochondrial respiratory function and neuromuscular disease.
• E5. Mitochondrial function and dysfunction in cancer (Richard K Porter, Trinity College Dublin, IE).
• E6. Ischemia-reperfusion injury.
• E7. The metabolic syndrome (Hong Kyu Lee, Eulji University College of Medicine, Seoul, KR).
• E8. Mitochondrial function in aging and regeneration (Pidder Jansen-Duerr, University of Innsbruck, AT).

Session F (afternoon) Comparative mitochondrial physiology (possible titles, depending on keynote lecturers/selected abstracts)

• F1. Mitochondrial physiology in cell models versus primary tissue.
• F2. Mitochondrial physiology studies in mouse models.
• F3. Mitochondrial vertrebrate physiology – extreme performers.
• F5. Mitochondrial physiology of and beyond established animal models.
• F6. Mitochondrial physiology in plants and microbes.
• F7. Mitochondrial physiology and evolution.

Preliminary programme MiPschool (Jul 23-27) Version 02

• This MiPschool will focus on basic concepts on mitochondrial respiratory states and applications of substrate-uncoupler-inhibitor titration (SUIT) protocols.
• Mitochondrial respiratory control: MITOEAGLE recommendations 1

• • • • 2017-07-24

Session A (morning) Introduction: coupling control in oxidative phosphorylation

• A1. The electron transfer system – Q redox regulation and mitochondrial pathways to oxygen (Anthony L Moore, University of Sussex, UK).
• A2. Coupling of the phosphorylation system to electron transfer and respiratory coupling control (Vilma Borutaite, University of Health Sciences, LT).
• A3. From Einstein's diffusion equation to Mitchell’s chemiosmotic equation: rates and states in the bioenergetics of oxidative phosphorylation (Erich Gnaiger, Medical University of Innsbruck, AT).
• A4. Biochemical coupling efficiency and ATP/O₂ ratios (Charles L Hoppel, Case Western Reserve University School of Medicine, Ohio, US).

Session B (afternoon) Posters and selected abstracts

• B1. Poster session.
• B2: Selected abstracts: measurement of coupling control in intact cells and mitochondrial preparations - open discussion.
• B3. Towards a data base on coupling control in intact cells.

• • • • 2017-07-25

Session C (morning) Introduction: from experimental design to data analysis

• C1. Respiratory pathway control in mitochondrial preparations (Gnaiger Erich, Medical University of Innsbruck, AT).
• C2. Substrate-uncoupler-inhibitor titration (SUIT) protocols – fundamental principles (Carolina Doerrier, OROBOROS INSTRUMENTS, AT).
• C3. Normalization of respiratory flux and flow.
• C4. Respiratory control ratios and control factors (Gnaiger Erich, Medical University of Innsbruck, AT).

Session D (afternoon) Posters and selected abstracts

• D1. Selected abstracts: applications of SUIT protocols – open discussion.
• D2. SUIT protocols: design and limitations.
• D3. Towards a data base on mitochondrial respiratory control: diagnostic approaches and comparative mitochondrial physiology.

• • • • 2017-07-26

Session E (morning) Comparative mitochondrial physiology (possible titles, depending on keynote lecturers/selected abstracts)

• E1. Mitochondrial physiology and the scope of cryopreservation in blood cells. (Beata Velika, Pavol Jozef Šafárik University in Kosice, SK)
• E2. Mitochondrial physiology studies in mouse models.
• E3. Mitochondrial vertrebrate physiology – extreme performers.
• E4. Mitochondrial physiology of and beyond established animal models.
• E5. Mitochondrial physiology in plants (Anthony L Moore, University of Sussex, UK).
• E6. Mitochondrial physiology and evolution.

Session F (afternoon) Mitochondrial physiology: biomedical applications (possible titles, depending on keynote lecturers/selected abstracts)

• F1. The challenges of functional mitochondrial diagnosis (Charles L Hoppel, Case Western Reserve University School of Medicine, Ohio, US).
• F2. Mitochondrial fitness in skeletal muscle (Pablo Garcia-Roves, University of Barcelona, ES).
• F3. Scope and limitations of functional mitochondrial diagnosis in blood cells. (Anthony Molina,Department of Internal Medicine, US).
• F4. Mitochondrial function and dysfunction: ROS and Ca²⁺. (Werner Koopman, Radboud University Nijmegen Medical Centre, NL)
• F5. Mitochondrial function and dysfunction in cancer (Richard K Porter, Trinity College Dublin, IE).
• F6. Ischemia-reperfusion injury (Carlos Palmeira, University of Coimbra, PT).
• F7. The metabolic syndrome - dysmitochondrial syndrome and mitochondrial disruptors (Hong Kyu Lee, Eulji University College of Medicine, Seoul, KR).
• F8. Mitochondrial function in aging and regeneration (Pidder Jansen-Duerr, University of Innsbruck, AT).

Session G (evening) MITOEAGLE Early Career Investigators forum

• MITOEAGLE Early Career Investigators