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- Anaplerotic pathway control state + ('''Anaplerotic pathway control states''' a … '''Anaplerotic pathway control states''' are fuelled by single substrates which are transported into the mitochondrial matrix and increase the pool of intermediates of the [[tricarboxylic acid cycle]]. [[Malic enzyme]] (mtME), phosphoenopyruvate carboxykinase (PEPCK), propionyl-CoA carboxylase, and pyruvate carboxylase play important roles in [[anaplerosis]]. The [[glutamate-anaplerotic pathway control state]] and [[malate-anaplerotic pathway control state]] are the most important anaplerotic substrate control states (aN).anaplerotic substrate control states (aN).)