View source for Scandella 2023 Trends Endocrinol Metab

{{Publication
|title=Scandella V, Petrelli F, Moore DL, Braun SMG, Knobloch M (2023) Neural stem cell metabolism revisited: a critical role for mitochondria. Trends Endocrinol Metab 34:446-61. https://doi.org/10.1016/j.tem.2023.05.008
|info=[https://pubmed.ncbi.nlm.nih.gov/37380501/ PMID: 37380501 Open Access]
|authors=Scandella V, Petrelli F, Moore DL, Braun SMG, Knobloch M
|year=2023
|journal=Trends Endocrinol Metab
|abstract=Metabolism has emerged as a key regulator of stem cell behavior. Mitochondria are crucial metabolic organelles that are important for differentiated cells, yet considered less so for stem cells. However, recent studies have shown that mitochondria influence stem cell maintenance and fate decisions, inviting a revised look at this topic. In this review, we cover the current literature addressing the role of mitochondrial metabolism in mouse and human neural stem cells (NSCs) in the embryonic and adult brain. We summarize how mitochondria are implicated in fate regulation and how substrate oxidation affects NSC quiescence. We further explore single-cell RNA sequencing (scRNA-seq) data for metabolic signatures of adult NSCs, highlight emerging technologies reporting on metabolic signatures, and discuss mitochondrial metabolism in other stem cells.
|editor=Gnaiger E
}}
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|enzymes=Complex II;succinate dehydrogenase
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