NS e-input: Difference between revisions

Revision as of 08:42, 14 September 2010

high-resolution terminology - matching measurements at high-resolution

NS e-input

Description

Electron input though Complexes CI plus CII simultaneously into the Q-junction corresponds to TCA cycle function in vivo, with convergent electron flow through the ETS. In mt-preparations, CI+II e-input requires addition not only of CI substrate (pyruvate+malate or glutamate+malate), but of succinate simultaneously, since metabolite depletion in the absence of succinate prevents a significant activity of CII.

Reference: MiPNet12.12; Gnaiger_2009_IJCBC

Labels:

Enzyme: Complex I, Complex II; Succinate Dehydrogenase"Complex II; Succinate Dehydrogenase" is not in the list (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, ...) of allowed values for the "Enzyme" property.

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-Electron input though Complexes [[CI]] plus [[CII]] simultaneously into the [[Q-junction]] corresponds to [[TCA cycle]] function in vivo, with [[convergent electron flow]] through the [[ETS]].  In [[mt-preparations]], CI+II e-input requires addition not only of CI substrate (pyruvate+malate or glutamate+malate), but of succinate simultaneously, since [[metabolite depletion]] in the absence of succinate prevents a significant activity of CII.
+{{MitoPedia
-==References==
+|description=Electron input though Complexes [[CI]] plus [[CII]] simultaneously into the [[Q-junction]] corresponds to [[TCA cycle]] function in vivo, with [[convergent electron flow]] through the [[ETS]].  In [[mt-preparations]], CI+II e-input requires addition not only of CI substrate (pyruvate+malate or glutamate+malate), but of succinate simultaneously, since [[metabolite depletion]] in the absence of succinate prevents a significant activity of CII.
-*Gnaiger E (2009) Mitochondrial pathways through Complexes I+II: Convergent electron transport at the Q-junction and additive effect of substrate combinations. [http://www.oroboros.at/index.php?compl-12-convergent Mitochondr. Physiol. Network 12.12: 1-20].
+|info=[[MiPNet12.12]]; [[Gnaiger_2009_IJCBC]]
-*Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCH-4W04KR1-3&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=a6456620daa0d8cca022b5f934f2cf30 Int. J. Biochem. Cell Biol. 41: 1837–1845].
+|type=Transport
+}}
-{{#set:keyword=Respiration|keyword=Mitochondrial pathways}}
+{{Labeling
-{{MitoPedia}}
+|discipline=Mitochondrial Physiology
+|enzymes=Complex I, Complex II; Succinate Dehydrogenase
+}}