Difference between revisions of "NS e-input"

Revision as of 16:10, 26 August 2016

high-resolution terminology - matching measurements at high-resolution

NS e-input

Description

NS e-input or NS-pathway control (CI&II e-input) is electron input from a combination substrates for N-pathway control and S-pathway control through Complexes CI and CII simultaneously into the Q-junction corresponding to TCA cycle function in vivo, with convergent electron flow through the ETS. In mt-preparations, NS e-input requires addition not only of N (CI-linked) substrate types (pyruvate&malate or glutamate&malate), but of S (succinate) simultaneously, since metabolite depletion in the absence of succinate prevents a significant stimulation of S-linked respiration. For more details, see: Additive effect of convergent electron flow.

Abbreviation: NS, CI&II

Reference: Gnaiger 2014 MitoPathways, Gnaiger 2009 Int J Biochem Cell Biol

MitoPedia concepts: Respiratory state, SUIT state

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 {{MitoPedia
 |abbr=NS, CI<small>&</small>II
-|description='''NS e-input''' (CI<small>&</small>II e-input) is electron input from a combination of [[N]] and [[S]] substrates through Complexes [[CI]] and [[CII]] simultaneously into the [[Q-junction]] corresponding to [[TCA cycle]] function ''in vivo'', with [[convergent electron flow]] through the [[ETS]].  In [[Mitochondrial preparations|mt-preparations]], NS e-input requires addition not only of N (CI-linked) substrate (pyruvate&malate or glutamate&malate), but of S (succinate) simultaneously, since [[metabolite depletion]] in the absence of succinate prevents a significant stimulation of S-linked respiration. For more details, see: [[Additive effect of convergent electron flow]].
+|description='''NS e-input''' or [[NS-pathway control]] (CI<small>&</small>II e-input) is electron input from a combination substrates for [[N-pathway control]] and [[S-pathway control]] through Complexes [[CI]] and [[CII]] simultaneously into the [[Q-junction]] corresponding to [[TCA cycle]] function ''in vivo'', with [[convergent electron flow]] through the [[ETS]].  In [[Mitochondrial preparations|mt-preparations]], NS e-input requires addition not only of N (CI-linked) substrate types (pyruvate&malate or glutamate&malate), but of S (succinate) simultaneously, since [[metabolite depletion]] in the absence of succinate prevents a significant stimulation of S-linked respiration. For more details, see: [[Additive effect of convergent electron flow]].
 |info=[[Gnaiger 2014 MitoPathways]], [[Gnaiger 2009 Int J Biochem Cell Biol]]
 }}
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 |mitopedia concept=Respiratory state, SUIT state
 }}
-{{MitoPedia methods}}
-{{MitoPedia O2k and high-resolution respirometry}}
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