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| == ''MitoCom'' News ==
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| __TOC__
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| == ''MitoCom'' Track Record 2014 ==
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| === OROBOROS INSTRUMENTS at the Long Night of Research and Science in Innsbruck, AT, April 04 ===
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| The OROBOROS-Team (Christiane Bauer, Verena Marte, Mona Fontana-Ayoub, Sandra Fleischmann und Mario Fasching) was overwhelmed by the many visitors who came to the Long Night of Research and Science (Lange Nacht der Forschung). This event was the perfect opportunity to inform the locals about the MitoCom Tyrol project. We have received many good feedback for participating at this event and the whole team enjoyed the evening.
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| [[File: DSCN1364.JPG|right|200px|Prof. Ulrik Wisloff and Trine Karlsen (NTNU, Trondheim) are monitoring the body function after floating for 60 min in the arctic sea. Subject: Thor Oivind Hagen (Aclima AS, NO), photographer in the picture: Roger Tangvik (NTNU, Trondheim)]]
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| === O2k-Workshop on HRR and O2k-Fluorometry during [http://www.ntnu.edu/isb/enjoy-the-cold 'Enjoy the Cold'] in Spitsbergen, NO, March 27===
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| Dr. Erich Gnaiger and Mag. Verena Laner joined the course 'Enjoy the Cold', which was held from March 24-31 in Ny-Alesund, NO. Dr. Erich Gnaiger gave a presentation entitled ,Mitochondrial respiratory function in the cold‘ on March 26. Furthermore, in the course was an O2k-Workshop on Fluorometry integrated (IOC87). Some inpressions of this course and the O2k-Workshop can be found [http://www.oroboros.at/index.php?id=spitsbergen2014 here].
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| === Iditarod Alaska 2014 ===
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| Dr. Erich Gnaiger (Medical University of Innsbruck and OROBOROS INSTRUMENTS) and his collaborator Verena Laner (OROBOROS INSTRUMENTS) joined the project of [[Davis MS|Michael Davis]] (Oklahoma State University) in Big Lake, Alaska. Cumulative training effects on the mitochondrial function of alaskan sled dogs were studied in January and March 2014 at Happy Trails Kennel in Big Lake, Alaska. Further participants were [[Boushel RC|Robert Boushel]] (Institute for Sport and Health Sciences, Stockholm, SE) as well as Benjamin F. Miller and Karyn Hamilton (Colorado State University, Fort Collins, US). [http://www.oroboros.at/index.php?id=racing-dogs_alaska More info]
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| === O2k-Workshop, Mumbai, India, January 31 ===
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| === O2k-Workshop, Mahalabaleshwar, India, January 27-29 ===
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| Lectures on HRR and Fluorometry were given by Dr. Erich Gnaiger during the 38th Seminar in Mahalabaleshwar.
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| == ''MitoCom'' Track Record 2013 ==
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| === O2k-Workshop, Bangalore, India, Dec 18 prior SMRM2013 ===
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| * [[MiPNet18.17_IOC83|IOC83]]A one-day O2k-Workshop on HRR and Fluorometry was given by Dr. Erich Gnaiger.
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| === O2k-Fluorometry Workshop, Trondheim, Norway, Dec 10-11 ===
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| * [[MiPNet18.11_IOC82|IOC82]]
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| Dr. Erich Gnaiger and Verena Laner gave an O2k-Workshop, focused on the Fluorescence LED-2 Module prior the seminar 'Exercise in Medicine', which was organized by [http://www.ntnu.no/cerg CERG] of the NTNU University.
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| === O2k-Luncheon Seminar, Seoul, Korea, Nov 05 @ ASMRM2013 ===
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| * IOC81
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| Dr. Erich Gnaiger (Medical University of Innsbruck) followed the invitation of Prof. Hong Kyu Lee to give a talk at the ASMRM2013 meeting. Furthermore he took this opportunity to give an O2k-Luncheon Workshop on HRR and Fluorometry.
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| === O2k-Fluorometry Workshop, Schroecken, Austria, Oct 09 - 14 ===
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| * [[MiPNet18.09_IOC80|IOC80]]
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| A new concept, integrating the Flurometry-Workshop into the Basic-O2k-Workshop, was celebrated at the 80th O2k-Workshop in Schroecken. Tutors: Dr. Erich Gnaiger, Mona Fontana-Ayoub, Verena Laner and Gerhard Krumschnabel.
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| === O2k-Fluorometry Workshop, Obergurgl, Austria, September 19-23 ===
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| * [[MiPNet18.07_IOC79|IOC79]]
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| Prior MiP2013, a O2k-Fluorometry Workshop was given in Obergurgl by Dr. Erich Gnaiger, Dr. Mario Fasching, Mona Fontana-Ayoub and Verena Laner. Hands-on sessions for ~30 participants on 6 O2ks.
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| === O2k-Workshop @ MiPsummer, Copenhagen, DK, August 27-29 ===
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| * IOC78 - Tutors: Dr. Erich Gnaiger and Verena Laner
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| === O2k-Luncheon Seminar @ UMDF, Newport Beach, CA, US, June 13 ===
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| * IOC77
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| === Prof. Gottfried Schatz ===
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| [https://www.i-med.ac.at/mypoint/thema/675045.html Article of the Medical University of Innsbruck]
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| === O2k-Workshop, Prague, Austria, May 28 - 29===
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| * [[MiPNet18.04_IOC76|IOC76]]
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| === O2k-Workshop, Schroecken, Austria, Apr 09 - 14 ===
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| * [[MiPNet18.03_IOC75|IOC75]]
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| === Xtreme Everst 2 - high-altitude research in Nepal===
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| [[File: Erich_EBC.jpg|right|200px|Erich Gnaiger with 3 Oxygraphs at the Everest Base Camp]]
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| [[File: KTM_Andrew_Verena.jpg|right|200px|Verena Laner assisted Andrew Murray in the Kathamandu Laboratory]]
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| Dr. Erich Gnaiger and Verena Laner participated at the Xtreme Everest 2 Expedition in Nepal.
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| '''Erich Gnaiger''' (Innsbruck, AT) joined the Xtreme Everest 2 mitochondrial team at Everest Base Camp (5,300 m) where acclimation to high altitude was studied using three O2k (March to May 2013). In Kathmandu (Nepal) at low altitude (1,400 m), Andrew Murray (Cambridge, UK) operated high-resolution respirometry on human musle biopsies with assistance by '''Verena Laner''' (Innsbruck, AT).
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| More infomation: [http://www.oroboros.at/?Xtreme-Everest2 Xtreme Everest 2]
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| Some impressions of the Expedition:
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| * [http://www.oroboros.at/?Everest-Base-Camp Everest Base Camp]
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| * [http://www.oroboros.at/?KTM Kathmandu Laboratory]
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| The participants from Innsbruck are supported by the K-Regio project ''MitoCom Tyrol'', D. Swarovski Research Laboratory (Medical University of Innsbruck), and OROBOROS INSTRUMENTS.
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| === O2k-TPP-Workshop, Innsbruck, Austria, Jan 22 - 25===
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| * [[MiPNet18.02_IOC74|IOC74]]
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| === O2k-Workshop, Kolkata, India, January 15 - 16===
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| *[[MiPNet18.01_IOC73|IOC73]]
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| == ''MitoCom'' Track Record 2012 ==
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| === O2k-Workshop, Schroecken, Austria, Dec 5 - 10 ===
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| * [[IOC72]]
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| === Bioblast 2012 - Conference on Mitochondrial Competence===
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| The Bioblast Conference 2012 took place in Hotel Grauer Bär from 10<sup>th</sup> to 12<sup>th</sup> December 2012.
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| With more than 70 participants from 19 nations the conference was a great success.
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| For the article of the Medical University Innsbruck, see: [https://www.i-med.ac.at/mypoint/news/668966.html MUI website]
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| More information: [[Bioblast 2012]]
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| === Padua Muscle Days, Nov 23 - 25===
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| After the satellite meeting in Vienna on October 17th, Prof. Dr. Gnaiger was invited by Prof. Dr. Ugo Carraro (University of Padua) to Padua for a talk on high-resolution respirometry in permeabilized fibers from small biopsies of human muscle.
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| === MCI Forum Technologie & Life Sciences, Innsbruck, Nov 6===
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| In her talk, Mag. Verena Laner will outline the development of the company OROBOROS INSTRUMENTS and will walk you through the early company days up to the current K-Regio Project ''MitoCom Tyrol''. [http://www.mci.edu/en/home/dokumentenverwaltung/category/164-pressemitteilung-20121115?download=3866%3Aprogrammflyer-forum-biotechnologie Programme]
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| === Satellite Meeting Vienna, Oct 17 ===
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| Dr. Erich Gnaiger participated at the Satellite Meeting in Vienna, which took place on 17th October.
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| Attendees of this meeting were Delegates of the University in Padua (Univ.-Prof. Dr. Ugo Carraro and Dr. Sandra Zampieri), University in Chieti (Univ.-Prof. Dr. Protasi) and University in Rome (Univ.-Prof. Dr. Andrea Musaro).
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| The meeting was organized by Dr. Kern from the Ludwig Boltzmann Institute in Vienna.
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| === Standort Lunch Vienna, 2012 Sep 27 ===
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| Dr. Erich Gnaiger presented the ''MitoCom'' project at the Standort Lunch in Vienna, organized by the Standortagentur Tirol. [http://www.standort-tirol.at/page.cfm?vpath=veranstaltungen/details&genericpageid=35834 More information].
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| The article of the STANDORT Tirol you can find in [http://www.standort-tirol.at/data.cfm?vpath=der_standort/standort-tirol_04-2012_final issue no. 15, page 8]
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| === Medizintechnikforum Hall, 2012 Sep 20 to 21 ===
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| OROBOROS INSTRUMENTS exhibited at the [http://www.jahrestagung-oegbmt-2012.at/uploads/Programm_OEGBMT_Final.pdf Medizintechnikforum Hall], showing latest developments in high-resolution respirometry in combination with the O2k-Fluorescence LED2-Module. ''MitoCom Tyrol'' was presented together with the Open Innovation project, both supported by the Government of Tyrol.
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| === Tiroltag, Europäisches Forum Alpbach, 2012 Aug 19 ===
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| Verena Laner, the project manager of MitoCom Tyrol, took part at the Tirolday, which was the "Opening" of the European Congress in Alpbach 2012. The main topic was "The future of sports in the Alps", which is an integral part of the ''MitoCom'' project. Additionally to the presentations and the award presentation ceremony for young scientists, there was a podium discussion with well-known experts such as the famous alpinist Reinhard Messner.
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| ===''MitoCom'' Cooperation AltitudeOmics 2012, 2012 July 20 to Aug 13 ===
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| Dr. Erich Gnaiger participated in the [http://www.oroboros.at/?Bolivia2012 AltitudeOmics2012] project in Bolivia and provided the scientists with two O2ks and his expertise. Aim of the study was to investigate the impacts of hypoxia/acclimatization onto molecular mechanisms of the human cells.
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| [[File:BabyJoseph Visit Innsbruck.JPG|right|350px|Prof. Dr. Fr. Baby Joseph und Prof. Dr. Erich Gnaiger]]
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| === Visiting scientist: Prof. Dr. Fr. Baby Joseph, July 19 ===
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| On July 19th, Prof. Dr. Fr. Baby Joseph visited the OROBOROS office.
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| [[Research_link_to_Prof_Baby_Joseph_India|Time schedule of the research visit]]
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| === Houska Award 2011 - First price for ''MitoCom Tyrol'', April 26 ===
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| * First price - Medical University of Innsbruck: http://www.oroboros.at/?Houska-Award_2011
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| * http://www.houskapreis.at/siegerprojekt-2011-licht-in-die-kraftwerke-der-zellen
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| * http://www.houskapreis.at
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| * http://www.tt.com/Nachrichten/4702341-6/houska-preise-an-universit%C3%A4ten-in-innsbruck-und-graz.csp
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| === Mitolab O2k-Fluorometry Workshop Madrid, Spain, May 7 ===
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| * [http://vmbacterio.cbm.uam.es/mitolab/Programa.aspx?Opcion=Mitolab Mitolab Workshop] by [[Gnaiger E|Erich Gnaiger]]
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| >> See also [[MitoCom_Tyrol - Report]] '''
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| === O2k-Workshop Schröcken, Austria, April 11 to 16 ===
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| * [[IOC68]]
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| === O2k-Workshop Sydney, Australia, April 2 to 4 ===
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| * [http://www.oroboros.at/?IO67 '''IOC67''' - an International O2k-Workshop of ''MitoCom Tyrol''].
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| === First O2k-Fluorometry Workshop, Innsbruck, March 15 to 16 ===
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| * [http://www.oroboros.at/?IOC66 IOC66 O2k-Fluorometry Workshop]. An International O2k-Workshop of ''MitoCom Tyrol''.
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| === Manuscript accepted for publication in PloS One, March 9 ===
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| * "'''[[Votion 2012 PLoS One|Physical fitness and mitochondrial respiratory capacity in horse skeletal muscle]]'''" (by Votion DM, Gnaiger E, Lemieux H, Mouithys-Mickalad A, Serteyn D) was accepted for publication in ''PloS One''.
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| * From the anonymous referee's comments:
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| ** Reviewer #1: "This is an original work performed with state of the art methodologies, as high-resolution respirometry. The results indicate that not only mitochondrial capacity is a limiting factor of horse performance but also the modalities of energy substrate utilization. Horse is an animal of choice for energetic studies since it shows a huge consumption of oxygen during muscle contraction, suggesting an positive adaptation of the mitochondrial system as compared to other animals. .. This article provides new findings on the link between mitochondrial capacity and whole animal body size and aerobic capacity. It also clarifies whether mitochondrial capacity is a controling factor for horse performance. An important finding is also that the control by the phosphorylation system is stable and does not vary with the performance of the horse. In contrast, the relative utilization of complex I versus complex II varies witht he performance, and this is a new finding which adds up to our knowledge of energy regulation. This work is of broad interest for sport physiology, metabolic researchers and aging research."
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| ** Reviewer #2: "The results could be described in a much easier way if utilizing classical definitions of mitochondrial respiratory parameters (from the late Britton Chance's milestones), such as state IV (or II), state III, uncoupled respiration, respiratory control ratio and so on." (''Comment:'' [[Glossary: Respiratory states]])
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| == ''MitoCom'' Track Record 2011 ==
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| * 2011-12-10 to 15: [http://www.oroboros.at/index.php?nextcourse#c3124 Internatl. O2k-Workshop on High-Resolution Respirometry, Schröcken, Austria]
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| * 2011-12-08: [http://www.oroboros.at/index.php?nextcourse#c3202 O2k-Workshop on High-Resolution Respirometry, Hyderabad, India]
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| * See also: [http://www.oroboros.at/index.php?calendar Science Calendar]
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| === 2011-11-29: 9. Tiroler Innovationstag ===
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| * 13:00-14:30 [http://www.standort-tirol.at/page.cfm?vpath=veranstaltungen/details&genericpageid=29311 Cluster-Partnertreffen LIFE SCIENCES Tirol]
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| :'''Programm'''
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| :ab 12.30 Uhr: Treffen im Congress Innsbruck, 3. Stock
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| ::13.00 Uhr: Begrüßung DDr. Petra Stöckl (Programm Managerin Life Sciences Tirol)
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| ::13.05 Uhr: Die neue Clusterstrategie. Vorstellung der Eckdaten
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| ::13.20 Uhr: Vorstellung der Clusterpartner und Diskussion der Clusterstrategie
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| ::* '''14.15 Uhr Vorstellung [[K-Regio MitoCom Tyrol|K-Regio MitoCom]]. Univ.-Prof. Dr. Erich Gnaiger (Oroboros)'''
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| :15:00 m [http://www.standort-tirol.at/page.cfm?vpath=veranstaltungen/details&genericpageid=25359 Tiroler Innovationstag - Programm]
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| === 2011-11-19: An extension of Bioblast ===
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| * In addition to the [[List of respirometry terms]], the [[List of fluorometry terms]] and [[List of spectrophotometry terms]] were initiated by [[Harrison DK|David Harrison]].
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| === 2011-11-11: Bioblast alert ===
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| * [[Bioblast alert]] was launched, for information purposes, not intended to be an advertisement.
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| === 2011-11-04: Product news ===
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| * [[O2k-Fluorescence LED2-Module]]
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| === 2011-November: ''MitoCom Lectures'', Innsbruck ===
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| * [[MitoCom lectures|Introduction to mitochondrial respiratory physiology]]
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| === 2011-10-20 to 21: Targeting Mitochondria, Berlin, DE ===
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| * Invited lecture: Erich Gnaiger - [[Gnaiger 2011 Abstract-Berlin]]
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| * Exhibition of OROBOROS INSTRUMENTS and ''MitoCom Tyrol'': Katrin Stecher, Lyda Staudacher
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| === 2011-09-24: High-output to replace wasteful high-throughput? ===
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| * [[Talk:Rogers 2011 PlosOne|Discussion: OROBOROS O2k versus Seahorse XF]]
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| === 2011-09-05 to 04: MiP2011 Bordeaux, France ===
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| * [http://www.mitophysiology.org 8th Conference on Mitochondrial Physiology] - MiP2011. Bordeaux, France.
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| * Invited lecture: Erich Gnaiger - [[Sumbalova 2011 Abstract Bordeaux]]
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| * Poster: Erich Gnaiger - [[Lemieux_2011_Abstract Bordeaux]]
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| * Poster: Mario Fasching - [[Fasching_2011_Abstract Bordeaux]]
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| * Exhibition of OROBOROS INSTRUMENTS and ''MitoCom Tyrol'': Katrin Stecher, Lyda Staudacher
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| === 2011-08-31 to 09-04: KAGOSHIMA JAPAN ===
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| * 5th Biennial Meeting of Society for Free Radical Research (SFRR)-Asia, 8th Conference of Asian Society for Mitochondrial Research and Medicine (ASMRM), and [http://www.kagoshima2011.com 11th Conference of Japanese Society of Mitochondrial Research and Medicine (J-mit)]; Kagoshima Citizens´Culture Hall, Kagoshima, Japan. Chair: Prof. Hideyuki J. Majima; E-mail: [email protected] | |
| * Invited lecture: Erich Gnaiger - [[Sumbalova 2011 Abstract Kagoshima]]
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| * Exhibition of the OROBOROS Oxygraph-2k: Yoshiaki Nakayoshi, Sanyo Trading Co. Ltd., Tokyo, JP
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| === 2011-08-26 to 27: O2k-Workshop China ===
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| * [http://www.oroboros.at/index.php?nextcourse#c3191 O2k-Workshop on High-Resolution Respirometry, Beijing and Tianjin, China]
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| === 2011-08-12: Circular on MitoScore ===
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| '''[[MitoScore]]''' is an initiative of ''MitoCom'':
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| * [[File:Network MitoScore.pdf]]
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| === 2011-08-09: Manuscript accepted for publication in IJBCB ===
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| * "'''[[Lemieux 2011 IJBCB|Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heart]]'''" (by Lemieux H, Semsroth S, Antretter H, Höfer D, Gnaiger E) was accepted for publication in ''Intl. J. Biochem. Cell Biol''.
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| * From the anonymous referee's comments:
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| ** Reviewer #1: "''The manuscript by Lemieux and colleagues offers interesting '''insight into the bioenergetics of early phases of heart failure'''.''"
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| ** Reviewer #2: "'''''This is a beautifully written work, replete with well-designed experiments and, within the space limitations, a nice review of the pertinent literature.''' The demonstration of impaired mitochondrial fatty acid oxidation in early stages of human failure is very important, as is the demonstration of defects in the phosphorylation system and Complex I-linked respiration.''"
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| ** Reviewer #3: "'''''The manuscript belongs literally to the symphony of bioenergetics''' and have mastered on a maximum thorough and detailed level a priority study of human heart disease bioenergetics in an intermediate state of heart disease, which was done only scarcely in medical sciences and for this orthodox approach this work deserves a high attention. It elegantly describes detailed oxidative phosphorylation parameters in heart disease compared to the control human heart. Using high-resolution respirometry of permeabilized human heart muscle fibres authors progressively describe distinct aspect of measured data in logical steps to present important differences of diminished mitochondrial function during heart failure. Using elegant protocols developed for years, authors distinguish between phosphorylating (OXPHOS) and non-phosphorylating (ETS) conditions with both complex I and II input using physiological substrates of glucose and lipid oxidation. With presented protocols, authors are able to provide conclusions regarding, e.g., complex I impairment, phosphorylation system limitation (3.2) mitochondrial content (3.3), leak respiration involvement, etc., besides OXPHOS and ETS capacities. Authors use their own terminology describing respiratory states. It would be useful to explain briefly their terminology also in terms of the canonical state 2 - 4 terminology. In spite of this, the methodology approach and presented data are well explained.''"
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| === 2011-07-18: Informal ''MitoCom-MiPArt'' 18:18 ===
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| * Monday, July 18 ● 18:18 h ● Schöpfstr. 18 – '''''we thank our guests for sharing a friendly 18:18 evening with us'''''.
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| ** Informal get-together at 'Oroboros' - science and art - celebrate a "''beautifully written work''" - a "''symphony of bioenergetics''" (see 2011-08-09).
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| ** Celebrate the official acceptance of [[MitoCom_K-Regio|K-Regio ''MitoCom Tyrol'']].
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| ** Explore future perspectives.
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| === 2011-07-12: The K-Regio MitoCom project - accepted ===
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| *The project application [[MitoCom_K-Regio|''MitoCom Tyrol'']] was officially accepted.
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| === 2011-07-12: Manuscript accepted in AJP ===
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| * "[[Pesta_2011_AJP|Similar qualitative and quantitative changes of mitochondrial respiration following strength and endurance training in normoxia and hypoxia in sedentary humans" by Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E]], was accepted for publication in ''Am. J. Physiol. Regul. Integr. Comp. Physiol.'' (http://www.ncbi.nlm.nih.gov/pubmed/21775647).
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| * From the anonymous referee's comments: ''This is really a superb revision; the MS has been improved substantially, particularly with reference to the theory and methods re: the HRR.''
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| === 2011-07-11 to 13: Introductory O2k-Workshop (IOC62) - MitoCom Tyrol ===
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| * Location: OROBOROS INSTRUMENTS, Schöpfstr. 18, Innsbruck, Austria.
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| * More informatio: [[IOC62]]
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| === 2011-06-15 to 18: UMDF Mitochondrial Medicine 2011 - Chicago, US ===
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| * Poster: Erich Gnaiger - [[Burtscher 2011 AbstractUMDFChicago]]
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| * Poster: Dominik Pesta - [[Pesta_2011_AbstractUMDFChicago-Training]]
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| * Poster: Dominik Pesta - [[Pesta_2011_AbstractUMDFChicago-Diagnosis]]
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| * Exhibition of OROBOROS INSTRUMENTS and ''MitoCom Tyrol'': Katrin Stecher, Dominik Pesta, Erich Gnaiger
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| === 2011-05-18: ''MiPArt'' - Mitochondria - the Aliens in our Cells ===
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| [http://www.mipart.at ''MiPArt'' - Mitochondria - the Aliens in our Cells]
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| *Exhibition (Odra Noel, Richard Altmann and others)
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| *Presentation of ''MitoCom Tyrol''
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|
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| === 2011-05-01: Start K-Regio Project ''MitoCom Tyrol'' ===
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