Krebs, Eggleston 1940 Biochem J
| Krebs HA, Eggleston LV (1940) The oxidation of pyruvate in pigeon breast muscle. Biochem J 34:442-59. https://doi.org/10.1042/bj0340442 |
Krebs HA, Eggleston LV (1940) Biochem J
Abstract: Pyruvate is very readily oxidized in animal tissues, yet little is known about the immediate products of its oxidation. Such oxidative reactions of pyruvate as are known to occur - dismutation, formation of succinate, acetate or ketone bodies - are side reactions whose significance varies from tissue to tissue: in no tissue can these reactions account for the total oxidation, and in some tissues, such as muscle or kidney, they account for even less than 20 %.
We have tried to elucidate the oxidation of pyruvate in pigeon breast muscle by studying in detail the factors governing the oxidation. We find that fumarate acts as catalyst in the oxidation of pyruvate and that malonate breaks the catalysis when one molecule of pyruvate has reacted with one molecule of fumarate.
• Bioblast editor: Gnaiger E
- 267 mg mw = 53 mg md; md/mw = 0.20
Labels: MiParea: Respiration
Organism: Birds
Tissue;cell: Skeletal muscle
Preparation: Homogenate
Enzyme: TCA cycle and matrix dehydrogenases
Pathway: N
Made history
