Description
The Free ET-capacity, โE, is the ET-capacity corrected for LEAK respiration, โE = E-L. โE is the respiratory capacity potentially available for ion transport and phosphorylation of ADP to ATP. Oxygen consumption in the ET-pathway state, therefore, is partitioned into the free ET-capacity, โE, and LEAK respiration, LP, compensating for proton leaks, slip and cation cycling: E = โE+LP (see free OXPHOS capacity).
Abbreviation: โE
Reference: Gnaiger 2014 MitoPathways
MitoPedia concepts:
Respiratory state,
Recommended,
Ergodynamics
MitoPedia topics:
EAGLE
Communicated by Gnaiger E 2014-09-21, edited 2015-01-19.
Coupling control states for โE
- Reference state, ZX: ET-capacity; E = Eยด-Rox
- Background state, YX: LEAK respiration; L = Lยด-Rox
- Metabolic control variable, X=ZX-YX: Scope of uncoupler stimulation, Free ET-capacity; โE = E-L
Flux control factor
- ยป Flux control factor, FCF
- Coupling control factor, 1-YX/ZX: E-L coupling control factor, ET-coupling efficiency: jโE = โE/E =(E-L)/E = 1-L/E
Compare
- mt-Preparations Free OXPHOS capacity, โP = P-L
- Intact cells Free ROUTINE activity, โR = R-L