From Bioblast
MitoKit-CII
Description | Cell permeable compound - MitoKit-CII, 2 vials; 1 vial of NV118 (25 mg) + 1 vial of NV161 (10 mg) |
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Product ID | 60200-01 |
Type | O2k |
Link | MitoPedia: MitoFit-CII |
Image |
Compounds
The cell permeable compound MitoKit-CII is the first generation of NeuroVive Pharmaceutical AB's succinate/malonate prodrugs and was developed to stimulate and inhibit Complex II of the respiratory electron transfer system in intact cells, and will expand the toolbox for evaluating the role of mitochondria in disease.
Compounds of MitoKit-CII
- The MitoKit-CII is composed of equal quantities of the following Compounds:
- Cell permeable compound NV118
- Description: Succinate prodrug: C10H14O8, Molecular weight 262,2g.mol-1
- Aliquots per 25 mg
- Cell permeable compound NV161
- Description: Malonate prodrug: C9H12O8, Molecular weight 248,2g.mol-1
- Aliquots per 10 mg
- Reference:
- Ehinger JK, Piel S, Ford R, Karlsson M, SjΓΆvall F, Frostner EΓ , Morota S, Taylor RW, Turnbull DM, Cornell C, Moss SJ, Metzsch C, Hansson MJ, Fliri H, ElmΓ©r E (2016) Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency. Nat Commun 7:12317. Β»Bioblast linkΒ« - Original publication introducing Mito-CII.
Preparation
- NV118: Dissolved in DMSO for 1M concentration (MW= 262.2 g/mol): 100 mM stock solution) and stored in aliquots at -20.
- NV161: Dissolved in DMSO for 1M concentration ((MW = 248.2 g/mol): 10 mM stock solution) and stored in aliquots at -20.
Expiry date of MitoKit-CII compounds (according to NeuroVive)
Before preparation:
- 3 years in -80Β° C
- 1 year in -20Β° C
Prepared:
- In DMSO solution
- at room temperature: 24 hours.
- at -20Β° C: for weeks
CAS-Numbers:
- NV-118: 1592635-33-0
- NV-161: 1432752-62-9
Labels: MiParea: Instruments;methods
HRR: O2k-Protocol
O2k-chemicals and media