Kennedy 1949 J Biol Chem: Difference between revisions
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{{Publication | {{Publication | ||
|title=Kennedy EP, Lehninger A (1949) Oxidation of fatty acids and tricarboxylic acid cycle intermediates by isolated rat liver mitochondria. J Biol Chem 179: 957- | |title=Kennedy EP, Lehninger A (1949) Oxidation of fatty acids and tricarboxylic acid cycle intermediates by isolated rat liver mitochondria. J Biol Chem 179:957-72. | ||
|info=[http://www.jbc.org/content/179/2/957.full.pdf+html PMID: 18150026 Open Access] | |info=[http://www.jbc.org/content/179/2/957.full.pdf+html PMID: 18150026 Open Access] | ||
|authors=Kennedy EP, Lehninger A | |authors=Kennedy EP, Lehninger A | ||
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|journal=J Biol Chem | |journal=J Biol Chem | ||
|abstract=Morphologically homogeneous mitochondria ("large granules") separated from ratΒ liver dispersions by the hypertonic sucrose method of Hogeboom, Schneider, andΒ Pallade contain essentially all the measurable activity of the liver in the oxidation of fatty acids. Likewise, the integrated reactions of the Krebs tricarboxylic acid cycle are found in this fraction. Esterification of inorganic phosphate accompanies these oxidations in purified preparations of mitochondria. These bodies have insignificant glycolytic activity. "Mitochondria" prepared by other methods involving saline or water as the dispersing media are inactive in these reactions, possibly because of osmotic damage. | |abstract=Morphologically homogeneous mitochondria ("large granules") separated from ratΒ liver dispersions by the hypertonic sucrose method of Hogeboom, Schneider, andΒ Pallade contain essentially all the measurable activity of the liver in the oxidation of fatty acids. Likewise, the integrated reactions of the Krebs tricarboxylic acid cycle are found in this fraction. Esterification of inorganic phosphate accompanies these oxidations in purified preparations of mitochondria. These bodies have insignificant glycolytic activity. "Mitochondria" prepared by other methods involving saline or water as the dispersing media are inactive in these reactions, possibly because of osmotic damage. | ||
|keywords=[[O2k-Publications: | |keywords=[[O2k-Publications:_Topics#Preparations]] | ||
}} | }} | ||
{{Labeling | {{Labeling | ||
|organism=Rat | |organism=Rat | ||
|tissues= | |tissues=Liver | ||
|preparations=Isolated | |preparations=Isolated mitochondria | ||
|enzymes=TCA | |enzymes=TCA cycle and matrix dehydrogenases | ||
|topics=Fatty | |topics=Fatty acid | ||
|additional=Made history | |additional=Made history | ||
}} | }} |
Latest revision as of 12:58, 13 February 2015
Kennedy EP, Lehninger A (1949) Oxidation of fatty acids and tricarboxylic acid cycle intermediates by isolated rat liver mitochondria. J Biol Chem 179:957-72. |
Kennedy EP, Lehninger A (1949) J Biol Chem
Abstract: Morphologically homogeneous mitochondria ("large granules") separated from rat liver dispersions by the hypertonic sucrose method of Hogeboom, Schneider, and Pallade contain essentially all the measurable activity of the liver in the oxidation of fatty acids. Likewise, the integrated reactions of the Krebs tricarboxylic acid cycle are found in this fraction. Esterification of inorganic phosphate accompanies these oxidations in purified preparations of mitochondria. These bodies have insignificant glycolytic activity. "Mitochondria" prepared by other methods involving saline or water as the dispersing media are inactive in these reactions, possibly because of osmotic damage. β’ Keywords: O2k-Publications:_Topics#Preparations
Labels:
Organism: Rat
Tissue;cell: Liver
Preparation: Isolated mitochondria
Enzyme: TCA cycle and matrix dehydrogenases
Regulation: Fatty acid
Made history