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Courtes 2019 Biomed Pharmacother
Additional label Labels  + , 2019-02  + , Amplex UltraRed  +
Coupling states OXPHOS  +
Enzyme Complex II;succinate dehydrogenase  +
Has abstract Mitochondria play an important role in cel
Mitochondria play an important role in cell life and in the regulation of cell death. In addition, mitochondrial dysfunction contributes to a wide range of neuropathologies. The nucleoside Guanosine (GUO) is an endogenous molecule, presenting antioxidant properties, possibly due to its direct scavenging ability and/or from its capacity to activate the antioxidant defense system. GUO demonstrate a neuroprotective effect due to the modulation of the glutamatergic system and maintenance of the redox system. Thus, considering the few studies focused on the direct effects of GUO on mitochondrial bioenergetics, we designed a study to evaluate the ''in vitro'' effects of GUO on rat mitochondrial function, as well as against Ca<sup>2+</sup>-induced impairment. Our results indicate that GUO prevented mitochondrial dysfunction induced by Ca<sup>2+</sup> misbalance, once GUO was able to reduce mitochondrial swelling in the presence of Ca<sup>2+</sup>, as well as ROS production and hydrogen peroxide levels, and to increase manganese superoxide dismutase activity, oxidative phosphorylation and tricarboxylic acid cycle activities. Our study indicates for the first time that GUO could direct prevent the mitochondrial damage induced by Ca<sup>2+</sup> and that these effects were not related to its scavenging properties. Our data indicates that GUO could be included as a new pharmacological strategy for diseases linked to mitochondrial dysfunction.
eases linked to mitochondrial dysfunction.  +
Has editor [[Plangger M]]  +
Has info [https://www.sciencedirect.com/science/article/pii/S0753332218387559#! Open Access]  +
Has publicationkeywords Nucleoside  + , Guanine-based purine  + , Calcium  + , High-resolution respirometry  +
Has title Courtes AA, de Carvalho NR, Gonçalves DF,
Courtes AA, de Carvalho NR, Gonçalves DF, Hartmann DD, da Rosa PC, Dobrachinski F, Franco JL, de Souza DOG, Soares FAA (2019) Guanosine protects against Ca<sup>2+</sup>-induced mitochondrial dysfunction in rats. Biomed Pharmacother 111: 1438-46.
in rats. Biomed Pharmacother 111: 1438-46.  +
Instrument and method Oxygraph-2k  + , O2k-Fluorometer  +
Mammal and model Rat  +
MiP area Respiration  + , Pharmacology;toxicology  +
Pathways N  + , S  + , NS  + , ROX  +
Preparation Isolated mitochondria  +
Respiration and regulation Calcium  +
Tissue and cell Liver  +
Was published by MiPNetLab BR Sao Gabriel Franco JL +
Was published in journal Biomed Pharmacother +
Was published in year 2019  +
Was written by Courtes AA + , De Carvalho NR + , Goncalves DF + , Hartmann DD + , Da Rosa PC + , Dobrachinski F + , Franco JL + , De Souza DOG + , Soares FAA +
Categories Publications
Modification date
"Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki.
11:02:25, 5 February 2019  +
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