Rojas-Morales 2019 Free Radic Biol Med
|Rojas-Morales P, León-Contreras JC, Aparicio-Trejo OE, Reyes- Ocampo JG, Medina-Campos ON, Jiménez-Osorio AS, González-Reyes S, Marquina- Castillo B, Hernández-Pando R, Barrera-Oviedo D, Sánchez-Lozada LG, Pedraza-Chaverri J, Tapia E (2019) Fasting reduces oxidative stress, mitochondrial dysfunction and fibrosis induced by renal ischemia-reperfusion injury. Free Radic Biol Med [Epub ahead of print].|
Rojas-Morales P, Leon-Contreras JC, Aparicio-Trejo OE, Reyes- Ocampo JG, Medina-Campos ON, Jimenez-Osorio AS, Gonzalez-Reyes S, Marquina-Castillo B, Hernandez-Pando R, Barrera-Oviedo D, Sanchez-Lozada LG, Pedraza-Chaverri J, Tapia E (2019) Free Radic Biol Med
Abstract: Food deprivation protects against ischemia-reperfusion (IR) injury through unknown mechanisms. In an experimental rat model of acute IR injury, we found that preoperative fasting for 3 days protects rats from tubular damage and renal functional decline by increasing antioxidant protection independently of the NF-E2-related factor 2 (Nrf2), and by maintaining mitochondrial morphology and function. In addition, further analysis revealed that fasting protects against tubulointerstitial fibrosis. In summary, our results point out to fasting as a robust nutritional intervention to limit oxidative stress and mitochondrial dysfunction in early acute kidney injury and also to promote long-term protection against fibrosis.
• Keywords: Fasting, Oxidative stress, Mitochondrial dysfunction, Fibrosis, Ischemia-reperfusion injury, Acute kidney injury, Chronic kidney disease • Bioblast editor: Plangger M • O2k-Network Lab: MX Mexico City Pedraza Chaverri J
Labels: MiParea: Respiration, Exercise physiology;nutrition;life style
Stress:Ischemia-reperfusion, Oxidative stress;RONS Organism: Rat Tissue;cell: Kidney Preparation: Isolated mitochondria
Regulation: mt-Membrane potential Coupling state: LEAK, OXPHOS Pathway: N HRR: Oxygraph-2k