Robach 2018 Scand J Med Sci Sports

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Robach P, Hansen J, Pichon A, Meinild Lundby AK, Dandanell S, Slettaløkken Falch G, Hammarström D, Pesta DH, Siebenmann C, Keiser S, Kérivel P, Whist JE, Rønnestad BR, Lundby C (2018) Hypobaric live high-train low does not improve aerobic performance more than live low-train low in cross-country skiers. Scand J Med Sci Sports 28:1636-52.

» PMID: 29469995

Robach P, Hansen J, Pichon A, Meinild Lundby AK, Dandanell S, Slettaloekken Falch G, Hammarstroem D, Pesta DH, Siebenmann C, Keiser S, Kerivel P, Whist JE, Roennestad BR, Lundby C (2018) Scand J Med Sci Sports

Abstract: Live high - train low (LHTL) using hypobaric hypoxia was previously found to improve sea-level endurance performance in well-trained individuals, however confirmatory controlled data in athletes are lacking. Here we test the hypothesis that natural-altitude LHTL improves aerobic performance in cross-country skiers, in conjunction with expansion of total hemoglobin mass (Hbmass, carbon-monoxide rebreathing technique) promoted by accelerated erythropoiesis. Following duplicate baseline measurements at sea level over the course of two weeks, nineteen Norwegian cross-country skiers (three women, sixteen men, age 20±2 yr, maximal oxygen uptake (VO2 max) 69±5 ml.min-1.kg-1) were assigned to 26 consecutive nights spent either at low (1035m, Control, n=8) or moderate altitude (2207m, daily exposure 16.7±0.5 hours, LHTL, n=11). All athletes trained together daily at a common location ranging from 550-1500m (21.2% of training time at 550m, 44.2% at 550-800m, 16.6% at 800-1100m, 18.0% at 1100-1500m). Three test sessions at sea level were performed over the first three weeks after intervention. Despite the demonstration of nocturnal hypoxemia at moderate altitude (pulse oximetry), LHTL had no specific effect on serum erythropoietin, reticulocytes, Hbmass, VO2 max or 3000-m running performance. Also LHTL had no specific effect on i) running economy (VO2 assessed during steady-state submaximal exercise), ii) respiratory capacities or efficiency of the skeletal muscle (biopsy), and iii) diffusing capacity of the lung. The present study, showing similar physiological responses and performance improvements in the two groups following intervention, suggests that in young cross-country skiers, improvements in sea-level aerobic performance associated with LHTL may not be due to moderate altitude acclimatization. This article is protected by copyright. All rights reserved.

Keywords: Altitude training, Skeletal muscle mitochondrial function, Total red blood cell volume, Buffer z Bioblast editor: Kandolf G O2k-Network Lab: CH Zurich Lundby C, CH Zurich University of Zurich Physiology


Labels: MiParea: Respiration, Exercise physiology;nutrition;life style 

Stress:Hypoxia  Organism: Human  Tissue;cell: Skeletal muscle  Preparation: Permeabilized tissue 


Coupling state: OXPHOS, ET  Pathway: F, N, NS  HRR: Oxygraph-2k 

BMI, VO2max