Proton slip

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Bioblasts - Richard Altmann and MiPArt by Odra Noel
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Proton slip

Description

Proton slip is a property of the proton pumps (Complexes CI, CIII, and CIV) when the proton slips back to the matrix side within the proton pumping process. Slip is different from the proton leak, which depends on Δp and is a property of the inner mt-membrane (including the boundaries between membrane-spanning proteins and the lipid phase). Slip is an uncoupling process that depends mainly on flux and contributes to a reduction in the biochemical coupling efficiency of ATP production and oxygen consumption. Together with proton leak and cation cycling, proton slip is compensated for by LEAK respiration or LEAK oxygen flux, L. Compare: Proton leak.


Reference: Gnaiger 2014 MitoPathways


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MitoPedia methods: Respirometry 


MitoPedia topics: Uncoupler