Oxoglutarate

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Bioblasts - Richard Altmann and MiPArt by Odra Noel
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MitoPedia

Oxoglutarate

Description

2-Oxoglutaric acid

2-Oxoglutaric acid or alpha-ketoglutaric acid, C5H6O5, occurs under physiological conditions as the anion 2-Oxoglutarate2-, Og. 2-Oxoglutarate (alpha-ketoglutarate) is formed from isocitrate as a product of isocitrate dehydrogenase (IDH) in the TCA cycle, and is a substrate of oxoglutarate dehydrogenase (OgDH). The 2-oxoglutarate carrier exchanges malate2- for 2-oxoglutarate2- as part of the malate-aspartate shuttle. In the cytosol, oxoglutarate+aspartate are transaminated to form oxaloacetate+glutamate. Cytosolic malate dehydrogenase converts oxaloacetate+NADH to malate.

Abbreviation: Og

Reference: Gnaiger 2012 MitoPathways



MitoPedia topics: Substrate and metabolite 


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Enzyme:
"TCA Cycle and Matrix Dehydrogenases" is not in the list of possible values (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, Uncoupling protein) for this property.
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"Inner mtMembrane Transporter" is not in the list of possible values (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, Uncoupling protein) for this property.
  Regulation:
"Substrate; Glucose; TCA Cycle" is not in the list of possible values (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, Ion;substrate transport, mt-Membrane potential, Oxygen kinetics, PCr;Cr, pH, Phosphate, Redox state, Substrate, Temperature, Threshold;excess capacity, Uncoupler, Fatty acid, Amino acid, Q-junction effect) for this property.