Oxidative phosphorylation

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Oxidative phosphorylation

Description

P.jpg Oxidative phosphorylation (OXPHOS) is the oxidation of reduced fuel substrates by electron transfer to oxygen, chemiosmotically coupled to the phosphorylation of ADP to ATP (P») and accompanied by an intrinsically uncoupled component of respiration. The OXPHOS state of respiration provides a measure of OXPHOS capacity (P), which is frequently corrected for residual oxygen consumption (ROX).

Abbreviation: OXPHOS

Reference: OXPHOS capacity


MitoPedia concepts: Respiratory state, Recommended 


MitoPedia methods: Respirometry 


MitoPedia topics: EAGLE 

Contributed by Gnaiger E 2010-09-10, edited 2014-11-02.
Energy transformation in coupled fluxes, J, and forces, F and Δp, of oxidative phosphorylation. 2[H] indicates the reduced hydrogen equivalents of CHO fuel substrates and electron transfer to oxygen. JH+out is coupled output flux. Proton leaks dissipate energy of translocated protons from low pH in the positive to the negative compartment (Gnaiger 2014 MitoPathways).

OXPHOS

Figure: Energy transformation in coupled fluxes, J, and forces, F and Δp, of oxidative phosphorylation. 2[H] indicates the reduced hydrogen equivalents of CHO fuel substrates and electron transfer to oxygen. JH+out is coupled output flux. Proton leaks dissipate energy of translocated protons from low pH in the positive to the negative compartment (from Gnaiger 2014).


Related terms in Bioblast

P.jpg OXPHOS; P
R.jpg ROUTINE; R
E.jpg ET-capacity; E
L.jpg LEAK; L
ROX.jpg ROX; Rox


SUITbrowser question: OXPHOS respiration

Work in progress

Physiological pathway control: protocols with substrates under the OXPHOS state, assessing mitochondrial respiration in conditions that approximate the physiological.