Oxidative phosphorylation (OXPHOS) is the oxidation of reduced fuel substrates by electron transfer to oxygen, chemiosmotically coupled to the phosphorylation of ADP to ATP (P») and accompanied by an intrinsically uncoupled component of respiration. The OXPHOS state of respiration provides a measure of OXPHOS capacity (P), which is frequently corrected for residual oxygen consumption (ROX).
Reference: OXPHOS capacity
MitoPedia methods: Respirometry
MitoPedia topics: EAGLE
Contributed by Gnaiger E 2010-09-10, edited 2014-11-02.
Figure: Energy transformation in coupled fluxes, J, and forces, F and Δp, of oxidative phosphorylation. 2[H] indicates the reduced hydrogen equivalents of CHO fuel substrates and electron transfer to oxygen. JH+out is coupled output flux. Proton leaks dissipate energy of translocated protons from low pH in the positive to the negative compartment (from Gnaiger 2014).
Related terms in Bioblast
- OXPHOS; P
- ROUTINE; R
- ET-capacity; E
- LEAK; L
- ROX; Rox
SUITbrowser question: OXPHOS respiration
Work in progress
Physiological pathway control: protocols with substrates under the OXPHOS state, assessing mitochondrial respiration in conditions that approximate the physiological.