OctPM pathway control state

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Bioblasts - Richard Altmann and MiPArt by Odra Noel
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MitoPedia

OctPM pathway control state

Description

OctPM: Octanoylcarnitine & Pyruvate & Malate.

MitoPathway control state: FN

SUIT protocol: SUIT-002, SUIT-005

This substrate combination supports N-linked flux which is typically higher than FAO capacity (F/FN<0 in the OXPHOS state). In SUIT-RP1, PMOct is induced after PM(E), to evaluate any additive effect of adding Oct. In SUIT-RP2, FAO OXPHOS capacity is measured first, testing for the effect of increasing malate concentration (compare malate anaplerotic pathway control state, M alone), and pyruvate is added to compare FAO as the background state with FN as the reference state.

Abbreviation: OctPM

Reference: MiPNet21.06 SUIT reference protocol


MitoPedia concepts: SUIT state 

More details
» FN
» Additive effect of convergent electron flow
» Respiratory complexes - more than five
» OctPGM pathway control state
» Convergent electron flow

OctPML

FN pathway in the LEAK state can be evaluated in the following SUIT protocols:

OctPMP

FN pathway in the OXPHOS state can be evaluated in the following SUIT protocols:


OctPME

FN pathway in the ET state can be evaluated in the following SUIT protocols:



1PM;2D;3U;4G;5S;6Oct;7Rot;8Gp-


SUIT RP2