OctPGM pathway control state

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Bioblasts - Richard Altmann and MiPArt by Odra Noel
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MitoPedia

OctPGM pathway control state

Description

OctPGM: Octanoylcarnitine & Pyruvate & Glutamate & Malate.

MitoPathway control state: FN

SUIT protocols: SUIT-002

This substrate combination supports N-linked flux which is typically higher than FAO capacity (F/FN<1 in the OXPHOS state). In SUIT-RP1, PMOct is induced after PM(E), to evaluate any additive effect of adding Oct. In SUIT-RP2, FAO OXPHOS capacity is measured first, testing for the effect of increasing malate concentration (compare malate anaplerotic pathway control state, M alone), and pyruvate and glutamate is added to compare FAO as the background state with FN as the reference state.

Abbreviation: OctPGM

Reference: MiPNet21.06 SUIT reference protocol


MitoPedia concepts: SUIT state 






More details
» FN
» Additive effect of convergent electron flow
» Respiratory complexes - more than five
» OctGM
» Convergent electron flow

OctPGML

FN pathway in the LEAK state can be evaluated in the following SUIT protocols:

OctPGMP

FN pathway in the OXPHOS state can be evaluated in the following SUIT protocols:


OctPGME

FN pathway in the ET state can be evaluated in the following SUIT protocols:


1PM;2D;3U;4G;5S;6Oct;7Rot;8Gp-



SUIT RP2