OctM pathway control state

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Bioblasts - Richard Altmann and MiPArt by Odra Noel
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OctM pathway control state

Description

OctM: Octanoylcarnitine & Malate.

MitoPathway control state: F

SUIT protocols: SUIT-002, SUIT-015, SUIT-016, SUIT-017

Respiratory stimulation of the FAO-pathway, F, by fatty acid, FA, in the presence of malate, M. Malate is a type N substrate (N), required for the FAO-pathway. In the presence of anaplerotic pathways (e.g., mitochondrial malic enzyme, mtME) FAO-pathway could be overestimated due to a contribution of NADH-linked respiration, F(N) (see SUIT-002). The FA concentration has to be optimized to saturate the FAO-pathway, without inhibiting or uncoupling respiration. Low concentration of malate, typically 0.1 mM, does not saturate the N-pathway; but saturates the F-pathway. High concentration of malate, typically 2 mM, saturates the F-pathway.

Abbreviation: OctM

Reference: MiPNet21.06 SUIT reference protocol, SUIT reference protocol


MitoPedia concepts: SUIT state 

More details
» Fatty acid oxidation pathway control state

OctML

FAO in the LEAK state can be evaluated in the following SUIT protocols:

OctMP

FAO in the OXPHOS state can be evaluated in the following SUIT protocols:

OctME

FAO in the ET state can be evaluated in the following SUIT protocols: