N-junction

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MitoPedia

N-junction

Description

N-junction

The N-junction is a junction for convergent electron flow in the electron transfer-pathway (ET-pathway) from type N substrates (further details »N-pathway control state) through the mt-NADH pool to Complex I (CI), and further transfer through the Q-junction to Complex III (CIII). Representative type N substrates are pyruvate (P), glutamate (G) and malate (M). The corresponding dehydrogenases (PDH, GDH, MDH) and some additional TCA cycle dehydrogenases (isocitrate dehydrogenase, oxoglutarate dehydrogenase generate NADH, the substrate of Complex I (CI). The concept of the N-junction and F-junction provides a basis for defining categories of SUIT protocols based on Electron transfer-pathway states.


Reference: N-pathway control state


MitoPedia concepts: MiP concept, SUIT concept 


MitoPedia methods: Respirometry 

Contributed by Gnaiger E 2016-02-12; edited 2016-08-28, 2017-01-03.