Krumschnabel G

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Evolution-Age-Gender-Lifestyle-Environment  » COST Action CA15203 Mitochondrial fitness mapping

Krumschnabel G

MitoPedia topics: EAGLE 


Name Krumschnabel Gerhard, Univ. Doz. Mag. Dr.
Gerhard Krumschnabel


O2k high-resolution respirometry

Area of expertise:

  • Mitochondrial physiology specialist K-Regio MitoFit
  • Mitochondrial physiology
Address Schöpfstr. 18, 6020
City Innsbruck
Country Austria
O2k-Network Lab AT Innsbruck OROBOROS

Labels: Field of research: Basic 


Moll 2016 bioRxiv2016Moll CWI, Lindtner RA, Vogel GF, Brunner M, Gutleben K, Blauth M, Krumschnabel G, Ebner HL (2016) Bone marrow mesenchymal stem cells from osteoporotic patients do not show altered mitochondrial energetics or ultrastructure. bioRxiv
Makrecka-Kuka 2015 Biomolecules2015
O2k-Protocols contents
Makrecka-Kuka M, Krumschnabel G, Gnaiger E (2015) High-resolution respirometry for simultaneous measurement of oxygen and hydrogen peroxide fluxes in permeabilized cells, tissue homogenate and isolated mitochondria. Biomolecules 5:1319-38.
Bock 2015 Sci Rep2015Bock FJ, Tanzer MC, Haschka MD, Krumschnabel G, Sohm B, Goetsch K, Kofler R, Villunger A (2015) The p53 binding protein PDCD5 is not rate-limiting in DNA damage induced cell death. Sci Rep 5:11268. doi: 10.1038/srep11268.
Krumschnabel 2015 Methods Mol Biol2015
O2k-Protocols contents
Krumschnabel G, Fontana-Ayoub M, Sumbalova Z, Heidler J, Gauper K, Fasching M, Gnaiger E (2015) Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production. Methods Mol Biol 1264:245-61.
Krumschnabel 2014 Methods Enzymol2014
O2k-Protocols contents
Krumschnabel G, Eigentler A, Fasching M, Gnaiger E (2014) Use of safranin for the assessment of mitochondrial membrane potential by high-resolution respirometry and fluorometry. Methods Enzymol 542:163-81.
Bock 2013 Cell Death Differ2013Bock FJ, Krumschnabel G, Manzl C, Peintner L, Tanzer MC, Hermann-Kleiter N, Baier G, Llacuna L, Yelamos J, Villunger A (2013) Loss of PIDD limits NF-κB activation and cytokine production but not cell survival or transformation after DNA damage. Cell Death Differ 20:546-57.
Manzl 2013 Cell Death Dis2013Manzl C, Fava LL, Krumschnabel G, Peintner L, Tanzer MC, Soratroi C, Bock FJ, Schuler F, Luef B, Geley S, Villunger A (2013) Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome. Cell Death Dis 4:e942.
Tischner 2012 Apoptosis2012Tischner D, Manzl C, Soratroi C, Villunger A, Krumschnabel G (2012) Necrosis-like death can engage multiple pro-apoptotic Bcl-2 protein family members. Apoptosis 17: 1197-1209.
Manzl 2012 Cell Death Differ2012Manzl C, Peintner L, Krumschnabel G, Bock F, Labi V, Drach M, Newbold A, Johnstone R, Villunger A (2012) PIDDosome-independent tumor suppression by Caspase-2. Cell Death Differ 19:1722-32.
Chara 2011 J Exp Zool A Ecol Genet Physiol2011Chara O, Espelt MV, Krumschnabel G, Schwarzbaum PJ (2011) Regulatory volume decrease and P receptor signaling in fish cells: mechanisms, physiology, and modeling approaches. J Exp Zool A Ecol Genet Physiol 315: 175-202.
Schwarzbaum 2011 Comp Biochem Physiol A Mol Integr Physio2011Schwarzbaum PJ, Krumschnabel G (2011) Perspective--from describing to understanding environment-physiology relations: 50th birthday of a branch in ecophysiology. Comp Biochem Physiol A Mol Integr Physio 158: 9-11.
Pafundo 2010 J Biol Chem2010Pafundo DE, Alvarez CL, Krumschnabel G, Schwarzbaum PJ (2010) A volume regulatory response can be triggered by nucleosides in human erythrocytes, a perfect osmometer no longer. J Biol Chem 285:6134-44.
Krumschnabel 2010 Aquat Toxicol2010Krumschnabel G, Ebner HL, Hess MW, Villunger A (2010) Apoptosis and necroptosis are induced in rainbow trout cell lines exposed to cadmium. Aquat Toxicol 99:73-85.
Grespi 2010 Cell Death Differ2010Grespi F, Soratroi C, Krumschnabel G, Sohm B, Ploner C, Geley S, Hengst L, Häcker G, Villunger A (2010) BH3-only protein Bmf mediates apoptosis upon inhibition of CAP-dependent protein synthesis. Cell Death Differ 17:1672-83.
Podrabsky 2010 Apoptosis2010Podrabsky JE, Krumschnabel G (2010) Cell death beyond worms, flies and humans: Unusual model systems for cell death research. Apoptosis 15:243-8.
Labi 2010 Genes Dev2010Labi V, Erlacher M, Krumschnabel G, Manzl C, Tzankov A, Pinon J, Egle A, Villunger A (2010) Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation. Genes Dev 24:1602-07.
Van Breukelen 2010 Apoptosis2010Van Breukelen F, Krumschnabel G, Podrabsky JE (2010) Vertebrate cell death in energy-limited conditions and how to avoid it: what we might learn from mammalian hibernators and other stress-tolerant vertebrates. Apoptosis 15:386-99.
Krumschnabel 2009 Oncogene2009Krumschnabel G, Manzl C, Villunger A (2009) Caspase-2: killer, savior and safeguard--emerging versatile roles for an ill-defined caspase. Oncogene 28:3093-6.
Manzl 2009 J Cell Biol2009Manzl C, Krumschnabel G, Bock F, Sohm B, Labi V, Baumgartner F, Logette E, Tschopp J, Villunger A (2009) Caspase-2 activation in the absence of PIDDosome formation. J Cell Biol 185:291-303.
Krumschnabel 2009 Apoptosis2009Krumschnabel G, Podrabsky JE (2009) Fish as model systems for the study of vertebrate apoptosis. Apoptosis 14: 1-21.
Krumschnabel 2009 Cell Death Differ2009Krumschnabel G, Sohm B, Bock F, Manzl C, Villunger A (2009) The enigma of caspase-2: the laymen's view. Cell Death Differ 16:195-207.
Espelt 2008 Comp Biochem Physiol B Biochem Mol Biol2008Espelt MV, Alleva K, Amodeo G, Krumschnabel G, Rossi RC, Schwarzbaum PJ (2008) Volumetric response of vertebrate hepatocytes challenged by osmotic gradients: a theoretical approach. Comp Biochem Physiol B Biochem Mol Biol 150: 103-111.
Pafundo 2008 Am J Physiol2008Pafundo DE, Chara O, Faillace MP, Krumschnabel G, Schwarzbaum PJ (2008) Kinetics of ATP release and cell volume regulation of hyposmotically challenged goldfish hepatocytes. Am J Physiol 294: R220-R233.
Krumschnabel 2007 Apoptosis2007Krumschnabel G, Maehr T, Nawaz M, Schwarzbaum PJ, Manzl C (2007) Staurosporine-induced cell death in salmonid cells: the role of apoptotic volume decrease, ion fluxes and MAP kinase signaling. Apoptosis 12: 1755-1768.
Ebner 2007 J Exp Biol2007Ebner HL, Blatzer M, Nawaz M, Krumschnabel G (2007) Activation and nuclear translocation of ERK in response to ligand-dependent and -independent stimuli in liver and gill cells from rainbow trout. J Exp Biol 210: 1036-1045.
Ebner 2006 Biochim Biophys Acta2006Ebner HL, Fiechtner B, Pelster B, Krumschnabel G (2006) Extracellular signal regulated MAP-kinase signalling in osmotically stressed trout hepatocytes. Biochim Biophys Acta 1760: 941-950.
Ahmed 2006 J Exp Biol2006Ahmed KH, Pelster B, Krumschnabel G (2006) Signalling pathways involved in hypertonicity- and acidification-induced activation of Na+/H+ exchange in trout hepatocytes. J Exp Biol 209: 3101-3113.
Nawaz 2006 Toxicol Sci2006Nawaz M, Manzl C, Lacher V, Krumschnabel G (2006) Copper-induced stimulation of extracellular signal-regulated kinase in trout hepatocytes: the role of reactive oxygen species, Ca2+, and cell energetics and the impact of extracellular signal-regulated kinase signaling on apoptosis and necrosis. Toxicol Sci 92: 464-475.
Ebner 2005 Am J Physiol2005Ebner HL, Cordas A, Pafundo DE, Schwarzbaum PJ, Pelster B, Krumschnabel G (2005) Importance of cytoskeletal elements in volume regulatory responses of trout hepatocytes. Am J Physiol 289: R877-R890.
Krumschnabel 2005 Toxicol Appl Pharmacol2005Krumschnabel G, Manzl C, Berger C, Hofer B (2005) Oxidative stress, mitochondrial permeability transition, and cell death in Cu-exposed trout hepatocytes. Toxicol Appl Pharmacol 209:62-73.
Manzl 2004 Comp Biochem Physiol C Toxicol Pharmacol2004Manzl C, Krumschnabel G, Schwarzbaum PJ, Dallinger R (2004) Acute toxicity of cadmium and copper in hepatopancreas cells from the Roman snail (Helix pomatia). Comp Biochem Physiol C Toxicol Pharmacol 138:45-52.
Krumschnabel 2004 Aquat Toxicol2004Krumschnabel G, Nawaz M (2004) Acute toxicity of hexavalent chromium in isolated teleost hepatocytes. Aquat Toxicol 70:159-167.
Pafundo 2004 Am J Physiol2004Pafundo DE, Mut P, Pérez Recalde M, González-Lebrero RM, Fachino V, Krumschnabel G, Schwarzbaum PJ (2004) Effects of extracellular nucleotides and their hydrolysis products on regulatory volume decrease of trout hepatocytes. Am J Physiol 287: R833-R843.
Manzl 2004 J Exp Zool A2004Manzl C, Krumschnabel G, Schwarzbaum PJ, Chabicovsky M, Dallinger R (2004) Intracellular pH regulation in isolated hepatopancreas cells from the Roman snail (Helix pomatia). J Exp Zool A 301:75-84.
Rissanen 2003 Aquat Toxicol2003Rissanen E, Krumschnabel G, Nikinmaa M (2003) Dehydroabietic acid, a major component of wood industry effluents, interferes with cellular energetics in rainbow trout hepatocytes. Aquat Toxicol 62:45-53.
Krumschnabel 2003 J Exp Biol2003Krumschnabel G, Gstir R, Manzl C, Prem C, Pafundo D, Schwarzbaum PJ (2003) Metabolic and ionic responses of trout hepatocytes to anisosmotic exposure. J Exp Biol 206:1799-1808.
Manzl 2003 Toxicol Appl Pharmacol2003Manzl C, Ebner H, Köck G, Dallinger R, Krumschnabel G (2003) Copper, but not cadmium, is acutely toxic for trout hepatocytes: short-term effects on energetics and ion homeostasis. Toxicol Appl Pharmacol 191:235-244.
Manzl 2002 J Exp Zool2002Manzl C, Schubert M, Schwarzbaum PJ, Krumschnabel G (2002) Effects of chemical anoxia on adrenergic responses of goldfish hepatocytes and the contribution of alpha- and beta-adrenoceptors. J Exp Zool 292: 468-476..
Alleva 2002 Comp Biochem Physiol B Biochem Mol Biol2002Alleva KE, Espelt MV, Krumschnabel G, Schwarzbaum PJ (2002) Identification of two distinct E-NTPDases in liver of goldfish (Carassius auratus L.). Comp Biochem Physiol B Biochem Mol Biol 131: 725-731..
Krumschnabel 2001 J Exp Biol2001Krumschnabel G, Manzl C, Schwarzbaum PJ (2001) Regulation of intracellular pH in anoxia-tolerant and anoxia-intolerant teleost hepatocytes. J Exp Biol 204:3943-3951.
Krumschnabel 2001 Gen Comp Endocrinol2001Krumschnabel G, Manzl C, Schwarzbaum PJ (2001) Metabolic responses to epinephrine stimulation in goldfish hepatocytes: evidence for the presence of alpha-adrenoceptors. Gen Comp Endocrinol 121:205-213.
Wieser 2001 Biochem J2001Wieser W, Krumschnabel G (2001) Hierarchies of ATP-consuming processes: direct compared with indirect measurements, and comparative aspects. Biochem J 355:389-395.
Krumschnabel 2001 Physiol Biochem Zool2001Krumschnabel G, Manzl C, Schwarzbaum PJ (2001) Importance of glycolysis for the energetics of anoxia-tolerant and anoxia-intolerant teleost hepatocytes. Physiol Biochem Zool 74:413-419.
Krumschnabel 2000b J Exp Biol2000bKrumschnabel G, Biasi C, Wieser W (2000b) Action of adenosine on energetics, protein synthesis and K(+) homeostasis in teleost hepatocytes. J Exp Biol 203:2657-2665.
Krumschnabel 2000a J Exp Biol2000aKrumschnabel G, Schwarzbaum PJ, Lisch J, Biasi C, Wieser W (2000a) Oxygen-dependent energetics of anoxia-tolerant and anoxia-intolerant hepatocytes. J Exp Biol 203:951-959.
Krumschnabel 1999 Comp Biochem Physiol C Pharmacol Toxicol Endocrinol1999Krumschnabel G, Schwarzbaum PJ, Wieser W (1999) Energetics of trout hepatocytes during A23187-induced disruption of Ca2+ homeostasis. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 124:187-195.
Schwarzbaum 1998 Am J Physiol1998Schwarzbaum PJ, Frischmann ME, Krumschnabel G, Rossi RC, Wieser W (1998) Functional role of ecto-ATPase activity in goldfish hepatocytes. Am J Physiol 274: R1031-R1038.
Krumschnabel 1998 Arch Biochem Biophys1998Krumschnabel G, Frischmann ME, Schwarzbaum PJ, Wieser W (1998) Loss of K+ homeostasis in trout hepatocytes during chemical anoxia: a screening study for potential causes and mechanisms. Arch Biochem Biophys 353: 199-206.
Krumschnabel 1997 J Comp Physiol B1997Krumschnabel G, Biasi C, Schwarzbaum PJ, Wieser W (1997) Acute and chronic effects of temperature, and of nutritional state, on ion homeostasis and energy metabolism in teleost hepatocytes. J Comp Physiol B 167:280-6.
Krumschnabel 1997 Am J Physiol1997Krumschnabel G, Schwarzbaum PJ, Biasi C, Dorigatti M, Wieser W (1997) Effects of energy limitation on Ca2+ and K+ homeostasis in anoxia-tolerant and anoxia-intolerant hepatocytes. Am J Physiol 273:R307-316.
Schwarzbaum 1996 J Exp Biol1996Schwarzbaum P, Bernabeu R, Krumschnabel G, Wieser C (1996) Effect of chemical anoxia on protein kinase C and Na+, K+-ATPase in hepatocytes of goldfish (Carassius auratus) and rainbow trout (Oncorhynchus mykiss). J Exp Biol 199: 1515-1521.
Krumschnabel 1996 Am J Physiol1996Krumschnabel G, Biasi C, Schwarzbaum PJ, Wieser W (1996) Membrane-metabolic coupling and ion homeostasis in anoxia-tolerant and anoxia-intolerant hepatocytes. Am J Physiol 270:R614-620.
Krumschnabel 1994 J Exp Biol1994Krumschnabel G, Malle S, Schwarzbaum PJ, Wieser W (1994) Glycolytic function in goldfish hepatocytes at different temperatures: relevance for Na+ pump activity and protein synthesis. J Exp Biol 193:285-90.
Krumschnabel 1994 Physiol Zool1994Krumschnabel G, Schwarzbaum PJ, Wieser W (1994) Coupling of energy supply and energy demand in isolated goldfish hepatocytes. Physiol Zool 67:438-448.
Krumschnabel 1994 Experientia1994Krumschnabel G, Wieser W (1994) Inhibition of the sodium pump does not cause a stoichiometric decrease of ATP-production in energy limited fish hepatocytes. Experientia 50:483-5.


Krumschnabel 2016b Abstract MitoFit Science Camp 20162016O2k-MultiSensor: Mitochondrial respiration media for HRR and simultaneous O2k-Fluorometry.
Sumbalova 2016 Abstract Mito Xmas Meeting Innsbruck2016Methods for evaluation of mitochondrial membrane potential with multi-sensor high-resolution respirometry: potentiometry vs fluorometry.
Lamberti 2016 Abstract MitoFit Science Camp 20162016Development of a reference sample for HRR.
Doerrier 2016a Abstract Mito Xmas Meeting Innsbruck2016
MitoFit and MITOEAGLE – towards a global data bank on mitochondrial physiology.
Krumschnabel 2016a Abstract MitoFit Science Camp 20162016O2k-Protocols: Mitochondrial preparations for HRR.
Krumschnabel 2016 Abstract Mito Xmas Meeting Innsbruck2016Establishment of a reference sample for high-resolution respirometry.
Doerrier 2016 Abstract MitoFit Science Camp 20162016Development of a SUIT reference protocol for OXPHOS analysis by high-resolution respirometry.
Sumbalova 2016a Abstract MitoFit Science Camp 20162016Optimizing strategies on the malate concentration in SUIT protocols.
Gnaiger 2016 Abstract EBEC Riva del Garda 20162016MitoFit and MITOEAGLE – towards a global data bank on mitochondrial physiology.
Sumbalova 2016b Abstract MitoFit Science Camp 20162016Human blood cells: isolation and HRR.
Gnaiger 2015 Abstract MiP20152015Mitochondrial function of cyropreserved HEK 293T cells: development of a reference sample for high-resolution respirometry.
Sumbalova 2014 Abstract MiP20142014Optimization of malate concentration for high-resolution respirometry: mitochondria from rat liver and brain.
Krumschnabel 2014 Abstract MiP20142014Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production.
Krumschnabel 2013 Abstract MiP20132013Krumschnabel G, Eigentler A, Fontana-Ayoub M, Draxl A, Fasching M, Gnaiger E (2013) Tissue homogenates for respiratory OXPHOS analysis in comparative mitochondrial physiology: mouse and trout – heart and liver. Mitochondr Physiol Network 18.08.