Fatty acid oxidation pathway control state

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MitoPedia

Fatty acid oxidation pathway control state

Description

F-junction

In the fatty acid oxidation pathway control state (F, FAO), one or several fatty acids are supplied to feed electrons into the F-junction through fatty acyl CoA dehydrogenase (reduced form FADH2), to electron transferring flavoprotein (CETF), and further through the Q-junction to Complex III (CIII). FAO not only depends on electron transfer through the F-junction (which is typically rate-limiting), but simultaneously generates FADH2 and NADH and thus depends on N-junction throughput. Hence FAO can be inhibited completely by inhibition of Complex I (CI). In addition and independent of this source of NADH, the type N substrate malate is required as a co-substrate for FAO in mt-preparations, since accumulation of AcetylCo inhibits FAO in the absence of malate. Malate is oxidized in a reaction catalyzed by malate dehydrogenase to oxaloacetate (yielding NADH), which then stimulates the entry of Acetyl CoA into the TCA cycle catalyzed by citrate synthase. Peroxysomal β-oxidation carries out few β-oxidation cycles, thus shortening very-long-chain fatty acids (>C20) for entry into mitochondrial β-oxidation. Oxygen consumption by peroxisomal acyl-CoA oxidase is considered as residual oxygen consumption rather than cell respiration.

Abbreviation: F, FAO

Reference: Electron transfer-pathway state, Gnaiger 2014 MitoPathways


MitoPedia concepts: Respiratory state, SUIT state, Recommended 


MitoPedia topics: EAGLE 

Communicated by Gnaiger E 2016-05-09, edited 2016-11-09, 2018-02-25.
More details
» O2k-Network discussion forum: fatty acids used in permeabilized fibre assays
» F-junction
» Fatty acid oxidation

FL

FAO pathway in the LEAK state can be evaluated in the following SUIT protocols:

FP

FAO pathway in the OXPHOS state can be evaluated in the following SUIT protocols:

FE

FAO pathway in the ET state can be evaluated in the following SUIT protocols:

Discussion

What is the difference between the abbreviations F, F(N) and FN?
  • F: Fatty acid oxidation with low concentration of Malate.
  • F(N): Fatty acid oxidation with low or high concentration of Malate. In the case of permeabilized fibers (pfi), high concentration of Malate is required.
  • FN: Fatty acid oxidation is combined with high concentration of N-linked substrates such as Pyruvate, Glutamate and Malate.


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»Publications: FAO, F-pathway control state
Publications in the MiPMap
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 YearReferenceCouplingPathwayPreparationOrganismTissue;cell
Wang 2019 J Biol Chem2019Wang H, Lu J, Kulkarni S, Zhang W, Gorka JE, Mandel JA, Goetzman ES, Prochownik EV (2019) Metabolic and oncogenic adaptations to pyruvate dehydrogenase inactivation in fibroblasts. J Biol Chem 294:5466-86.ROUTINE
OXPHOS
ET
F
N
S
NS
Intact cells
Permeabilized cells
Isolated mitochondria
RatFibroblast
Halle 2019 Am J Physiol Regul Integr Comp Physiol2019Halle JL, Pena GS, Paez HG, Castro AJ, Rossiter HB, Visavadiya NP, Whitehurst MA, Khamoui AV (2019) Tissue-specific dysregulation of mitochondrial respiratory capacity and coupling control in colon-26 tumor-induced cachexia. Am J Physiol Regul Integr Comp Physiol [Epub ahead of print].LEAK
OXPHOS
ET
F
N
S
NS
ROX
Intact cells
Permeabilized tissue
MouseSkeletal muscle
Liver
Fat
Driescher 2019 Heliyon2019Driescher N, Joseph DE, Human VR, Ojuka E, Cour M, Hadebe N, Bester D, Marnewick JL, Lecour S, Lochner A, Essop MF (2019) The impact of sugar-sweetened beverage intake on rat cardiac function. Heliyon 5:e01357.LEAK
OXPHOS
ET
F
N
CIV
ROX
Permeabilized tissueRatHeart
Scheiber 2019 Exp Mol Med2019Scheiber D, Jelenik T, Zweck E, Horn P, Schultheiss HP, Lassner D, Boeken U, Saeed D, Kelm M, Roden M, Westenfeld R, Szendroedi J (2019) High-resolution respirometry in human endomyocardial biopsies shows reduced ventricular oxidative capacity related to heart failure. Exp Mol Med 51:16.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissue
Isolated mitochondria
HumanHeart
McCoin 2019 Am J Physiol Endocrinol Metab2019McCoin CS, Von Schulze A, Allen J, Fuller KN, Xia Q, Koestler DC, Houchen CJ, Maurer A, Dorn Ii GW, Shankar K, Morris EM, Thyfault JP (2019) Sex modulates hepatic mitochondrial adaptations to high fat diet and physical activity. Am J Physiol Endocrinol Metab [Epub ahead of print].LEAK
OXPHOS
ET
F
N
NS
Isolated mitochondriaMouseLiver
Chao 2019 J Appl Physiol (1985)2019Chao T, Burmeister DM, Corona BT, Greising SM (2019) Oxidative pathophysiology following volumetric muscle loss injury in a porcine model. J Appl Physiol (1985) [Epub ahead of print].LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissuePigSkeletal muscle
Gnaiger 2019 MitoFit Preprint Arch2019Gnaiger E, Aasander Frostner E, Abdul Karim N, Abumrad NA, Acuna-Castroviejo D, Adiele RC, et al (2019) Mitochondrial respiratory states and rates. MitoFit Preprint Arch doi:10.26124/mitofit:190001.v4.LEAK
OXPHOS
ET
F
N
S
Gp
DQ
CIV
NS
Other combinations
ROX
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Fisher-Wellman 2019 Cell Rep2019Fisher-Wellman KH, Draper JA, Davidson MT, Williams AS, Narowski TM, Slentz DH, Ilkayeva OR, Stevens RD, Wagner GR, Najjar R, Hirschey MD, Thompson JW, Olson DP, Kelly DP, Koves TR, Grimsrud PA, Muoio DM (2019) Respiratory phenomics across multiple models of protein hyperacylation in cardiac mitochondria reveals a marginal impact on bioenergetics. Cell Rep 26:1557-72.LEAK
OXPHOS
ET
F
N
S
Gp
Isolated mitochondriaMouseHeart
Skeletal muscle
Petrick 2019 Biochem J2019Petrick HL, Holloway GP (2019) High intensity exercise inhibits carnitine palmitoyltransferase-I sensitivity to L-carnitine. Biochem J 476:547-58.OXPHOS
LEAK
F
N
NS
Permeabilized tissueMouseSkeletal muscle
Nakajima 2019 Sci Rep2019Nakajima T, Yokota T, Shingu Y, Yamada A, Iba Y, Ujihira K, Wakasa S, Ooka T, Takada S, Shirakawa R, Katayama T, Furihata T, Fukushima A, Matsuoka R, Nishihara H, Dela F, Nakanishi K, Matsui Y, Kinugawa S (2019) Impaired mitochondrial oxidative phosphorylation capacity in epicardial adipose tissue is associated with decreased concentration of adiponectin and severity of coronary atherosclerosis. Sci Rep 9:3535.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueHumanFat
Kakimoto 2019 PLoS One2019Kakimoto PA, Chausse B, Caldeira da Silva CC, Donato Júnior J, Kowaltowski AJ (2019) Resilient hepatic mitochondrial function and lack of iNOS dependence in diet-induced insulin resistance. PLoS One 14:e0211733.LEAK
OXPHOS
F
NS
Isolated mitochondriaMouseLiver
McBride 2019 Arch Biochem Biophys2019McBride S, Wei-LaPierre L, McMurray F, MacFarlane M, Qiu X, Patten DA, Dirksen RT, Harper ME (2019) Skeletal muscle mitoflashes, pH, and the role of uncoupling protein-3. Arch Biochem Biophys 663:239-48.LEAK
OXPHOS
F
N
CIV
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Kwak 2019 Int J Environ Res Public Health2019Kwak HB, Woodlief TL, Green TD, Cox JH, Hickner RC, Neufer PD, Cortright RN (2019) Overexpression of long-chain acyl-CoA synthetase 5 increases fatty acid oxidation and free radical formation while attenuating insulin signaling in primary human skeletal myotubes. Int J Environ Res Public Health 16:E1157.LEAK
OXPHOS
ET
F
N
NS
Permeabilized cellsHumanSkeletal muscle
Doig 2019 bioRxiv2019Doig CD, Zelinska AE, Oakey LA, Fletcher RS, El Hassan Y, Garten A, Cartwright D, Heising S, Tennant DA, Watson D, Adamski J, Lavery GG (2019) Induction of the nicotinamide riboside kinase NAD+ salvage pathway in skeletal muscle of H6PDH KO mice. bioRxiv doi: https://doi.org/10.1101/567297 .ET
LEAK
OXPHOS
F
N
NS
ROX
S
Permeabilized tissueMouseSkeletal muscle
Maresch 2019 Hepatol Commun2019Maresch LK, Benedikt P, Feiler U, Eder S, Zierler KA, Taschler U, Kolleritsch S, Eichmann TO, Schoiswohl G, Leopold C, Wieser B, Lackner C, Rülicke T, van Klinken J, Kratky D, Moustafa T, Hoefler G, Haemmerle G (2019) Intestine‐specific overexpression of carboxylesterase 2c protects mice from diet‐induced liver steatosis and obesity. Hepatol Commun 3:227-45.LEAK
OXPHOS
FHomogenateMouseEndothelial;epithelial;mesothelial cell
Paumelle 2019 J Hepatol2019Paumelle R, Haas J, Hennuyer N, Bauge E, Deleye Y, Mesotten D, Langouche L, Vanhoutte J, Cudejko C, Wouters K, Hannou SA, Legry V, Lancel S, Lalloyer F, Polizzi A, Smati S, Gourdy P, Vallez E, Bouchaert E, Derudas B, Dehondt H, Gheeraert C, Fleury S, Tailleux A, Montagner A, Wahli W, Van Den Berghe G, Guillou H, Dombrowicz D, Staels B (2019) Hepatic PPARα is critical in the metabolic adaptation to sepsis. J Hepatol 70:963-73.OXPHOSF
N
HomogenateHumanLiver
Koop 2019 Int J Cardiol2019Koop AMC, Hagdorn QAJ, Bossers GPL, van Leusden T, Gerding A, van Weeghel M, Vaz FM, Koonen DPY, Silljé HHW, Berger RMF, Bartelds B (2019) Right ventricular pressure overload alters cardiac lipid composition. Int J Cardiol 287:96-105.OXPHOSF
N
Isolated mitochondriaRatHeart
MiPNet21.06 SUIT RP2018-06-25
O2k-Protocols
SUIT reference protocol for OXPHOS analysis by high-resolution respirometry.
LEAK
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
MiPNet21.17 BloodCellsIsolation2018-04-09
O2k-Protocols
O2k-Protocols: Isolation of blood cells for HRR.
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Lymphocyte
Platelet
Monaco 2018 Diabetologia2018Monaco CMF, Proudfoot R, Miotto PM, Herbst EAF, MacPherson REK, Holloway GP (2018) α-linolenic acid supplementation prevents exercise-induced improvements in white adipose tissue mitochondrial bioenergetics and whole-body glucose homeostasis in obese Zucker rats. Diabetologia 61:433-44.F
N
Permeabilized tissueRatSkeletal muscle
Fat
Miotto 2018 Thesis2018Miotto PM (2018) The influence of exercise and high fat feeding on the regulation of mitochondrial substrate sensitivity in skeletal muscle. PhD Thesis p185.OXPHOSF
N
NS
Permeabilized cellsMouseSkeletal muscle
Hoffmann 2018 Sci Rep2018Hoffmann C, Höckele S, Kappler L, Hrabĕ de Angelis M, Häring HU, Weigert C (2018) The effect of differentiation and TGFβ on mitochondrial respiration and mitochondrial enzyme abundance in cultured primary human skeletal muscle cells. Sci Rep 8:737.OXPHOS
ET
F
N
S
NS
ROX
Permeabilized cellsHumanSkeletal muscle
Fisher-Wellman 2018 Cell Rep2018Fisher-Wellman KH, Davidson MT, Narowski TM, Lin CT, Koves TR, Muoio DM (2018) Mitochondrial diagnostics: A multiplexed assay platform for comprehensive assessment of mitochondrial energy fluxes. Cell Rep 24:3593-606.LEAK
OXPHOS
F
N
S
Isolated mitochondriaMouseHeart
Skeletal muscle
Lima 2018 Biochem Cell Biol2018Lima T, Silveira L (2018) A microplate assay for measuring cell death in C2C12 cells. Biochem Cell Biol 96:702-6.LEAK
ET
FIntact cellsMouseSkeletal muscle
Other cell lines
Cardinale 2018 Acta Physiol (Oxf)2018Cardinale DA, Larsen FJ, Jensen-Urstad M, Rullman E, Søndergaard H, Morales-Alamo D, Ekblom B, Calbet JAL, Boushel R (2018) Muscle mass and inspired oxygen influence oxygen extraction at maximal exercise: Role of mitochondrial oxygen affinity. Acta Physiol (Oxf) 225:e13110.OXPHOSF
N
NS
Permeabilized tissue
Isolated mitochondria
HumanSkeletal muscle
Manakov 2018 J Physiol Biochem2018Manakov D, Kolar D, Zurmanova J, Pravenec M, Novotny J (2018) Changes in the activity of some metabolic enzymes in the heart of SHR rat incurred by transgenic expression of CD36. J Physiol Biochem 74:479-89.ET
LEAK
OXPHOS
F
N
NS
ROX
S
Isolated mitochondriaRatHeart
Robach 2018 Scand J Med Sci Sports2018Robach P, Hansen J, Pichon A, Meinild Lundby AK, Dandanell S, Slettaløkken Falch G, Hammarström D, Pesta DH, Siebenmann C, Keiser S, Kérivel P, Whist JE, Rønnestad BR, Lundby C (2018) Hypobaric live high-train low does not improve aerobic performance more than live low-train low in cross-country skiers. Scand J Med Sci Sports 28:1636-52.OXPHOS
ET
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Dandanell 2018 Scand J Med Sci Sports2018Dandanell S, Meinild-Lundby AK, Andersen AB, Lang PF, Oberholzer L, Keiser S, Robach P, Larsen S, Rønnestad BR, Lundby C (2018) Determinants of maximal whole-body fat oxidation in elite cross-country skiers: role of skeletal muscle mitochondria. Scand J Med Sci Sports 28:2494-504.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Gratl 2018 Thesis2018Gratl A (2018) High-resolution respirometry for measurement of mitochondrial function in PAD patients before and after revascularisation. PhD Thesis 69.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Kappler 2018 Thesis2018Kappler L (2018) Method development for valid high‐resolution profiling of mitochondria and Omics investigation of mitochondrial adaptions to excess energy intake and physical exercise. Dissertation p181.LEAK
OXPHOS
ET
F
N
S
CIV
NS
ROX
Permeabilized cells
Homogenate
Isolated mitochondria
Human
Mouse
Skeletal muscle
Liver
Other cell lines
Chicco 2018 J Biol Chem2018Chicco AJ, Le CH, Gnaiger E, Dreyer HC, Muyskens JB, D'Alessandro A, Nemkov T, Hocker AD, Prenni JE, Wolfe LM, Sindt NM, Lovering AT, Subudhi AW, Roach RC (2018) Adaptive remodeling of skeletal muscle energy metabolism in high-altitude hypoxia: Lessons from AltitudeOmics. J Biol Chem 293:6659-71.LEAK
OXPHOS
ET
F
N
S
Permeabilized tissueHumanSkeletal muscle
Hancock 2018 Elife2018Hancock M, Hafstad AD, Nabeebaccus AA, Catibog N, Logan A, Smyrnias I, Hansen SS, Lanner J, Schröder K, Murphy MP, Shah AM, Zhang M (2018) Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise. Elife 7:e41044.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Isolated mitochondriaMouseHeart
Chung 2018 J Exp Biol2018Chung DJ, Sparagna GC, Chicco AJ, Schulte PM (2018) Patterns of mitochondrial membrane remodeling parallel functional adaptations to thermal stress. J Exp Biol 221. pii: jeb174458.LEAK
OXPHOS
ET
F
N
S
CIV
NS
ROX
Isolated mitochondriaFishesLiver
Wefers 2018 Proc Natl Acad Sci U S A2018Wefers J, van Moorsel D, Hansen J, Connell NJ, Havekes B, Hoeks J, van Marken Lichtenbelt WD, Duez H, Phielix E, Kalsbeek A, Boekschoten MV, Hooiveld GJ, Hesselink MKC, Kersten S, Staels B, Scheer FAJL, Schrauwen P (2018) Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle. Proc Natl Acad Sci U S A 115:7789-94.OXPHOS
ET
F
N
Intact cellsHumanSkeletal muscle
Distefano 2018 J Cachexia Sarcopenia Muscle2018Distefano G, Standley RA, Zhang X, Carnero EA, Yi F, Cornnell HH, Coen PM (2018) Physical activity unveils the relationship between mitochondrial energetics, muscle quality, and physical function in older adults. J Cachexia Sarcopenia Muscle 9:279-94.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Cooper 2018 Exp Physiol2018Cooper MA, McCoin C, Pei D, Thyfault JP, Koestler D, Wright DE (2018) Reduced mitochondrial reactive oxygen species production in peripheral nerves of mice fed a ketogenic diet. Exp Physiol 103:1206-12.OXPHOS
ET
F
N
NS
Permeabilized tissueMouseNervous system
Smenes 2018 Interact Cardiovasc Thorac Surg2018Smenes BT, Bækkerud FH, Slagsvold KH, Hassel E, Wohlwend M, Pinho M, Høydal M, Wisløff U, Rognmo Ø, Wahba A (2018) Acute exercise is not cardioprotective and may induce apoptotic signalling in heart surgery: a randomized controlled trial. Interact Cardiovasc Thorac Surg 27:95-101.LEAK
OXPHOS
ET
F
N
S
CIV
NS
ROX
Permeabilized tissueHumanHeart
Wilmanns 2018 Mol Metab2018Wilmanns JC, Pandey R, Hon O, Chandran A, Schilling JM, Forte E, Wu Q, Cagnone G, Bais P, Philip V, Coleman D, Kocalis H, Archer SK, Pearson JT, Ramialison M, Heineke J, Patel HH, Rosenthal NA, Furtado MB, Costa MW (2018) Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease. Mol Metab 20:102-14.LEAK
OXPHOS
ET
F
N
NS
ROX
Permeabilized tissueMouseHeart
Weber 2018 Int J Mol Sci2018Weber A, Klocker H, Oberacher H, Gnaiger E, Neuwirt H, Sampson N, Eder IE (2018) Succinate accumulation is associated with a shift of mitochondrial respiratory control and HIF-1α upregulation in PTEN negative prostate cancer cells. Int J Mol Sci 19:2129.ET
OXPHOS
ROUTINE
F
N
NS
Other combinations
ROX
S
Intact cells
Permeabilized cells
HumanGenital
Musi 2018 Aging Cell2018Musi N, Valentine JM, Sickora KR, Baeuerle E, Thompson CS, Shen Q, Orr ME (2018) Tau protein aggregation is associated with cellular senescence in the brain. Aging Cell 17:e12840.LEAK
OXPHOS
ET
F
N
S
NS
HomogenateMouseNervous system
Setz 2018 Hear Res2018Setz C, Benischke AS, Pinho Ferreira Bento AC, Brand Y, Levano S, Paech F, Leitmeyer K, Bodmer D (2018) Induction of mitophagy in the HEI-OC1 auditory cell line and activation of the Atg12/LC3 pathway in the organ of Corti. Hear Res 361:52-65.OXPHOS
ET
F
N
S
NS
ROX
Permeabilized cellsMouseOther cell lines
Van Den Brink 2018 PLoS Genet2018Van Den Brink DM, Cubizolle A, Chatelain G, Davoust N, Girard V, Johansen S, Napoletano F, Dourlen P, Guillou L, Angebault-Prouteau C, Bernoud-Hubac N, Guichardant M, Brabet P, Mollereau B (2018) Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina. PLoS Genet 14:e1007627.LEAK
OXPHOS
F
N
S
NS
Permeabilized cellsMouseEndothelial;epithelial;mesothelial cell
Van Erp 2018 Sci Rep2018Van Erp AC, Rebolledo RA, Hoeksma D, Jespersen NR, Ottens PJ, Nørregaard R, Pedersen M, Laustsen C, Burgerhof JGM, Wolters JC, Ciapaite J, Bøtker HE, Leuvenink HGD, Jespersen B (2018) Organ-specific responses during brain death: increased aerobic metabolism in the liver and anaerobic metabolism with decreased perfusion in the kidneys. Sci Rep 8:4405.OXPHOS
ET
F
N
S
NS
Isolated mitochondriaRatLiver
Kidney
Apostolopoulou 2018 Thesis2018Apostolopoulou M (2018) Determinants of insulin sensitivity in obesity and recent-onset type 2 diabetes mellitus. PhD Thesis 77.OXPHOS
ET
F
N
NS
Homogenate
Isolated mitochondria
HumanLiver
Toledo 2018 Obesity (Silver Spring)2018Toledo FGS, Dubé JJ, Goodpaster BH, Stefanovic-Racic M, Coen PM, DeLany JP (2018) Mitochondrial respiration is associated with lower energy expenditure and lower aerobic capacity in African American women. Obesity (Silver Spring) 26:903-9.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueHumanSkeletal muscle
De Medeiros 2018 Biochim Biophys Acta2018de Medeiros WA, da Silva LA, Dall'Igna DM, Michels M, Manfredini A, Dos Santos Cardoso J, Constantino L, Scaini G, Vuolo F, Streck EL, Ritter C, Dal-Pizzol F (2018) N-acetylcysteine effects on a murine model of chronic critical limb ischemia. Biochim Biophys Acta 1864:454-63.OXPHOSF
N
NS
Rat
Jelenik 2018 Mol Metab2018Jelenik T, Dille M, Müller-Lühlhoff S, Kabra DG, Zhou Z, Binsch C, Hartwig S, Lehr S, Chadt A, Peters EMJ, Kruse J, Roden M, Al-Hasani H, Castañeda TR (2018) FGF21 regulates insulin sensitivity following long-term chronic stress. Mol Metab 16:126-38.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueMouseSkeletal muscle
Doerrier 2018 Methods Mol Biol2018Doerrier C, Garcia-Souza LF, Krumschnabel G, Wohlfarter Y, Mészáros AT, Gnaiger E (2018) High-Resolution FluoRespirometry and OXPHOS protocols for human cells, permeabilized fibers from small biopsies of muscle, and isolated mitochondria. Methods Mol Biol 1782:31-70.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Intact cells
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Human
Mouse
Rat
Saccharomyces cerevisiae
Heart
Skeletal muscle
Endothelial;epithelial;mesothelial cell
Blood cells
HEK
Platelet
McLaughlin 2018 Biochem Biophys Res Commun2018McLaughlin KL, McClung JM, Fisher-Wellman KH (2018) Bioenergetic consequences of compromised mitochondrial DNA repair in the mouse heart. Biochem Biophys Res Commun 504:742-48.N
S
F
Isolated mitochondriaMouseHeart
Komlodi 2018 Methods Mol Biol2018Komlodi T, Sobotka O, Krumschnabel G, Bezuidenhout N, Hiller E, Doerrier C, Gnaiger E (2018) Comparison of mitochondrial incubation media for measurement of respiration and hydrogen peroxide production. Methods Mol Biol 1782:137-55.LEAK
OXPHOS
ET
F
N
S
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
Human
Mouse
Skeletal muscle
HEK
MitoEAGLE blood cells 12018MitoEAGLE blood cells group (2018) An interlaboratory guide through procedures for mitochondrial respiratory studies with intact and permeabilized peripheral blood mononuclear cells and platelets. - Updated: 2018-02-23LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Platelet
Barbeau 2018 Biochem J2018Barbeau PA, Miotto PM, Holloway GP (2018) Mitochondrial derived reactive oxygen species influence ADP sensitivity, but not CPT-I substrate sensitivity. Biochem J 475:2997-3008.OXPHOSF
N
NS
Permeabilized tissueMouseSkeletal muscle
Boutoual 2018 Sci Rep2018Boutoual R, Meseguer S, Villarroya M, Martín-Hernández E, Errami M, Martín MA, Casado M, Armengod ME (2018) Defects in the mitochondrial-tRNA modification enzymes MTO1 and GTPBP3 promote different metabolic reprogramming through a HIF-PPARγ-UCP2-AMPK axis. Sci Rep 8:1163.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Intact cells
Permeabilized cells
HumanFibroblast
Park 2018 J Clin Invest2018Park H, He A, Tan M, Johnson JM, Dean JM, Pietka TA, Chen Y, Zhang X, Hsu FF, Razani B, Funai K, Lodhi IJ (2018) Peroxisome-derived lipids regulate adipose thermogenesis by mediating cold-induced mitochondrial fission. J Clin Invest 129:694-711.OXPHOS
ET
F
N
NS
Permeabilized tissueMouseFat
Scheiber 2018 J Cardiovasc Transl Res2018Scheiber D, Zweck E, Jelenik T, Horn P, Albermann S, Masyuk M, Boeken U, Saeed D, Kelm M Roden M, Szendroedi J, Westenfeld R (2018) Reduced myocardial mitochondrial ROS production in mechanically unloaded hearts. J Cardiovasc Transl Res 12:107-15.LEAK
OXPHOS
ET
F
N
NS
ROX
Permeabilized tissueHumanHeart
Stein 2018 Cell Rep2018Stein CS, Jadiya P, Zhang X, McLendon JM, Abouassaly GM, Witmer NH, Anderson EJ, Elrod JW, Boudreau RL (2018) Mitoregulin: A lncRNA-encoded microprotein that supports mitochondrial supercomplexes and respiratory efficiency. Cell Rep 23:3710-20.LEAK
OXPHOS
F
N
Permeabilized tissueHumanHeart
Skeletal muscle
Burney 2018 Thesis2018Burney E (2018) Characterization of mitochondrial metabolism in L6 rat myoblasts. Bachelor's Thesis p50.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
NS
Other combinations
ROX
Intact cells
Permeabilized cells
RatOther cell lines
Lund 2018 Acta Physiol (Oxf)2018Lund MT, Larsen S, Hansen M, Courraud J, Floyd AK, Støckel M, Helge JW, Dela F (2018) Mitochondrial respiratory capacity remains stable despite a comprehensive and sustained increase in insulin sensitivity in obese patients undergoing gastric bypass surgery. Acta Physiol (Oxf) 223:e13032.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Merz 2018 Intensive Care Med Exp2018Merz T, Wepler M, Nußbaum B, Vogt J, Calzia E, Wang R, Szabo C, Radermacher P, McCook O (2018) Cystathionine-γ-lyase expression is associated with mitochondrial respiration during sepsis-induced acute kidney injury in swine with atherosclerosis. Intensive Care Med Exp 6:43.ET
LEAK
OXPHOS
F
N
NS
ROX
S
HomogenatePigKidney
Chen 2018 Hum Mol Genet2018Chen A, Tiosano D, Guran T, Baris HN, Bayram Y, Mory A, Shapiro-Kulnane L, Hodges CA, Coban Akdemir Z, Turan S, Jhangiani SN, van den Akker F, Hoppel CL, Salz HK, Lupski JR, Buchner DA (2018) Mutations in the mitochondrial ribosomal protein MRPS22 lead to primary ovarian insufficiency. Hum Mol Genet 27:1913-26.OXPHOS
ET
F
N
S
DQ
CIV
NS
Isolated mitochondriaHumanEndothelial;epithelial;mesothelial cell
Fibroblast
Stanford 2018 Cell Metab2018Stanford KI, Lynes MD, Takahashi H, Baer LA, Arts PJ, May FJ, Lehnig AC, Middelbeek RJW, Richard JJ, So K, Chen EY, Gao F, Narain NR, Distefano G, Shettigar VK, Hirshman MF, Ziolo MT, Kiebish MA, Tseng YH, Coen PM, Goodyear LJ (2018) 12,13-diHOME: an exercise-induced lipokine that increases skeletal muscle fatty acid uptake. Cell Metab 27:1111-20.LEAK
OXPHOS
ET
F
ROX
Permeabilized tissueHuman
Mouse
Skeletal muscle
Scalzo 2018 Physiol Rep2018Scalzo RL, Knaub LA, Hull SE, Keller AC, Hunter K, Walker LA, Reusch JEB (2018) Glucagon-like peptide-1 receptor antagonism impairs basal exercise capacity and vascular adaptation to aerobic exercise training in rats. Physiol Rep 6:e13754.LEAK
OXPHOS
ET
F
NS
Other combinations
Permeabilized tissueRatHeart
Tsuda 2018 J Cachexia Sarcopenia Muscle2018Tsuda M, Fukushima A, Matsumoto J, Takada S, Kakutani N, Nambu H, Yamanashi K, Furihata T, Yokota T, Okita K, Kinugawa S, Anzai T (2018) Protein acetylation in skeletal muscle mitochondria is involved in impaired fatty acid oxidation and exercise intolerance in heart failure. J Cachexia Sarcopenia Muscle 9:844-59.OXPHOS
LEAK
F
N
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Bryant 2018 Thesis2018Bryant HJ (2018) The role of mitochondrial uncoupling in temperature responses in Atlantic killifish, Fundulus heteroclitus. Master's Thesis p126.LEAK
OXPHOS
ET
F
S
Isolated mitochondriaFishesNervous system
Liver
Fat
Cardinale 2018 Thesis2018Cardinale DA (2018) The significance of mitochondrial respiratory function in regulating oxygen uptake and performance in humans. PhD Thesis 99.LEAK
OXPHOS
F
N
NS
Isolated mitochondria
Permeabilized tissue
HumanSkeletal muscle
Thrush 2018 Int J Obes (Lond)2018Thrush AB, Antoun G, Nikpay M, Patten DA, DeVlugt C, Mauger JF, Beauchamp BL, Lau P, Reshke R, Doucet É, Imbeault P, Boushel R, Gibbings D, Hager J, Valsesia A, Slack R, Al-Dirbashi OY, Dent R, McPherson R, Harper ME (2018) Diet-resistant obesity is characterized by a distinct plasma proteomic signature and impaired muscle fiber metabolism. Int J Obes (Lond) 42:353-62.LEAK
OXPHOS
ET
F
N
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Martins 2018 Comp Biochem Physiol B Biochem Mol Biol2018Martins EL, Ricardo JC, de-Souza-Ferreira E, Camacho-Pereira J, Ramos-Filho D, Galina A (2018) Rapid regulation of substrate use for oxidative phosphorylation during a single session of high intensity interval or aerobic exercises in different rat skeletal muscles. Comp Biochem Physiol B Biochem Mol Biol 217:40-50.ET
LEAK
OXPHOS
F
N
NS
ROX
Permeabilized tissueRatSkeletal muscle
Brouwers 2018 Front Physiol2018Brouwers B, Stephens NA, Costford SR, Hopf ME, Ayala JE, Yi F, Xie H, Li JL, Gardell SJ, Sparks LM, Smith SR (2018) Elevated nicotinamide phosphoribosyl transferase in skeletal muscle augments exercise performance and mitochondrial respiratory capacity following exercise training. Front Physiol 9:704.OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Leckey 2018 FASEB J2018Leckey JJ, Hoffman NJ, Parr EB, Devlin BL, Trewin AJ, Stepto NK, Morton JP, Burke LM, Hawley JA (2018) High dietary fat intake increases fat oxidation and reduces skeletal muscle mitochondrial respiration in trained humans. FASEB J 32:2979-91.LEAK
OXPHOS
ET
F
N
S
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Konopka 2018 Aging Cell2018Konopka AR, Laurin JL, Schoenberg HM, Reid JJ, Castor WM, Wolff CA, Musci RV, Safairad OD, Linden MA, Biela LM, Bailey SM, Hamilton KL, Miller BF (2018) Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults. Aging Cell 18:e12880.ET
OXPHOS
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Becker 2018 EMBO Rep2018Becker C, Kukat A, Szczepanowska K, Hermans S, Senft K, Brandscheid CP, Maiti P, Trifunovic A (2018) CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis. EMBO Rep 19. pii: e45126.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Isolated mitochondriaMouseLiver
Fat
Barca 2018 Hum Mol Genet2018Barca E, Ganetzky RD, Potluri P, Juanola-Falgarona M, Gai X, Li D, Jalas C, Hirsch Y, Emmanuele V, Tadesse S, Ziosi M, Akman HO, Chung WK, Tanji K, McCormick E, Place E, Consugar M, Pierce EA, Hakonarson H, Wallace DC, Hirano M, Falk MJ (2018) USMG5 Ashkenazi Jewish founder mutation impairs mitochondrial complex V dimerization and ATP synthesis. Hum Mol Genet 27:3305-12.LEAK
ROUTINE
OXPHOS
ET
F
N
S
DQ
NS
ROX
Intact cells
Permeabilized cells
HumanFibroblast
Johnson 2018 J Mol Cell Cardiol2018Johnson JM, Ferrara PJ, Verkerke ARP, Coleman CB, Wentzler EJ, Neufer PD, Kew KA, de Castro Brás LE, Funai K (2018) Targeted overexpression of catalase to mitochondria does not prevent cardioskeletal myopathy in Barth syndrome. J Mol Cell Cardiol 121:94-102.OXPHOS
ET
F
N
S
NS
Isolated mitochondriaMouseHeart
Skeletal muscle
Rocha 2018 J Physiol Biochem2018Rocha C, Koury OH, Scheede-Bergdahl C, Bergdahl A (2018) Cardiac mitochondrial respiration following a low-carbohydrate, high-fat diet in apolipoprotein E-deficient mice. J Physiol Biochem 75:65-72.LEAK
OXPHOS
ET
F
N
CIV
NS
ROX
Permeabilized tissueMouseHeart
Cruz 2018 Lipids Health Dis2018Cruz MM, Lopes AB, Crisma AR, de Sá RCC, Kuwabara WMT, Curi R, de Andrade PBM, Alonso-Vale MIC (2018) Palmitoleic acid (16:1n7) increases oxygen consumption, fatty acid oxidation and ATP content in white adipocytes. Lipids Health Dis 17:55.ETFIntact cellsMouseFat
Other cell lines
Ravasz 2018 Biochim Biophys Acta2018Ravasz D, Kacso G, Fodor V, Horvath K, Adam-Vizi V, Chinopoulos C (2018) Reduction of 2-methoxy-1,4-naphtoquinone by mitochondrially-localized Nqo1 yielding NAD+ supports substrate-level phosphorylation during respiratory inhibition. Biochim Biophys Acta 1859:909-24.LEAK
OXPHOS
DQ
F
N
Isolated mitochondriaMouseLiver
Allard 2018 J Clin Endocrinol Metab2018Allard NAE, Schirris TJJ, Verheggen RJ, Russel FGM, Rodenburg RJ, Smeitink JAM, Thompson PD, Hopman MTE, Timmers S (2018) Statins affect skeletal muscle performance: evidence for disturbances in energy metabolism. J Clin Endocrinol Metab 103:75-84.OXPHOSF
N
S
Gp
CIV
NS
Permeabilized tissueHumanSkeletal muscle
Britto 2018 BMC Biol2018Britto FA, Cortade F, Belloum Y, Blaquière M, Gallot YS, Docquier A, Pagano AF, Jublanc E, Bendridi N, Koechlin-Ramonatxo C, Chabi B, Francaux M, Casas F, Freyssenet D, Rieusset J, Giorgetti-Peraldi S, Carnac G, Ollendorff V, Favier FB (2018) Glucocorticoid-dependent REDD1 expression reduces muscle metabolism to enable adaptation under energetic stress. BMC Biol 16:65.LEAK
OXPHOS
F
N
NS
Other combinations
Isolated mitochondria
Permeabilized cells
MouseSkeletal muscle
Jelenik 2018 Diabetes2018Jelenik T, Flögel U, Álvarez-Hernández E, Scheiber D, Zweck E, Ding Z, Rothe M, Mastrototaro L, Kohlhaas V, Kotzka J, Knebel B, Müller-Wieland D, Moellendorf S, Gödecke A, Kelm M, Westenfeld R, Roden M, Szendroedi J (2018) Insulin resistance and vulnerability to cardiac ischemia. Diabetes 67:2695-702.LEAK
OXPHOS
F
N
NS
ROX
Permeabilized tissue
Isolated mitochondria
Human
Mouse
Heart
Szelechowski 2018 Sci Rep2018Szelechowski M, Amoedo N, Obre E, Léger C, Allard L, Bonneu M, Claverol S, Lacombe D, Oliet S, Chevallier S, Le Masson G, Rossignol R (2018) Metabolic reprogramming in amyotrophic lateral sclerosis. Sci Rep 8:3953.LEAK
ROUTINE
ET
F
ROX
Intact cellsHumanEndothelial;epithelial;mesothelial cell
Fibroblast
Larsen 2018 Physiol Rep2018Larsen S, Lundby AM, Dandanell S, Oberholzer L, Keiser S, Andersen AB, Haider T, Lundby C (2018) Four days of bed rest increases intrinsic mitochondrial respiratory capacity in young healthy males. Physiol Rep 6:e13793.OXPHOS
ET
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Bjoerndal 2018 Nutr Metab (Lond)2018Bjørndal B, Alterås EK, Lindquist C, Svardal A, Skorve J, Berge RK (2018) Associations between fatty acid oxidation, hepatic mitochondrial function, and plasma acylcarnitine levels in mice. Nutr Metab (Lond) 15:10.OXPHOS
ET
F
N
ROX
HomogenateMouseLiver
Valentine 2018 J Gerontol A Biol Sci Med Sci2018Valentine JM, Li ME, Shoelson SE, Zhang N, Reddick RL, Musi N (2018) NFκB regulates muscle development and mitochondrial function. J Gerontol A Biol Sci Med Sci [Epub ahead of print].LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized tissueMouseSkeletal muscle
Rajkumar 2018 Metabolism2018Rajkumar A, Liaghati A, Chan J, Lamothe G, Dent R, Doucet É, Rabasa-Lhoret R, Prud'homme D, Harper ME, Tesson F (2018) ACSL5 genotype influence on fatty acid metabolism: a cellular, tissue, and whole-body study. Metabolism 83:271-9.OXPHOS
ET
F
N
CIV
NS
Permeabilized cellsHuman
Mouse
Skeletal muscle
Other cell lines
Gam 2018 Acta Diabetol2018Gam CMBF, Mortensen OH, Larsen LH, Poulsen SS, Qvortrup K, Mathiesen ER, Damm P, Quistorff B (2018) Diabetes, myometrium, and mitochondria in pregnant women at term. Acta Diabetol 55:999-1010.LEAK
OXPHOS
F
N
NS
S
Isolated mitochondriaHumanGenital
Von Schulze 2018 J Physiol2018Von Schulze A, McCoin CS, Onyekere C, Allen J, Geiger P, Dorn GW, Morris EM, Thyfault JP (2018) Hepatic mitochondrial adaptations to physical activity: impact of sexual dimorphism, PGC1α, and BNIP3 mediated mitophagy. J Physiol 596:6157-71.OXPHOS
ET
F
N
NS
Isolated mitochondriaMouseLiver
Oemer 2018 Proc Nat Acad Sci U S A2018Oemer G, Lackner L, Muigg K, Krumschnabel G, Watschinger K, Sailer S, Lindner H, Gnaiger E, Wortmann SB, Werner ER, Zschocke J, Keller MA (2018) The molecular structural diversity of mitochondrial cardiolipins. Proc Nat Acad Sci U S A 115:4158-63.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanHeLa
Zhang 2018 J Gerontol A Biol Sci Med Sci2018Zhang X, Trevino MB, Wang M, Gardell SJ, Ayala JE, Han X, Kelly DP, Goodpaster BH, Vega RB, Coen PM (2018) Impaired mitochondrial energetics characterize poor early recovery of muscle mass following hind limb unloading in old mice. J Gerontol A Biol Sci Med Sci 73:1313-22.LEAK
OXPHOS
F
N
NS
MouseSkeletal muscle
Bytautiene 2018 J Dev Orig Health Dis2018Bytautiene Prewit E, Porter C, La Rosa M, Bhattarai N, Yin H, Gamble P, Kechichian T, Sidossis LS (2018) Adipose tissue uncoupling protein 1 levels and function are increased in a mouse model of developmental obesity induced by maternal exposure to high-fat diet. J Dev Orig Health Dis 9:401-8.LEAKF
N
Permeabilized tissueMouseFat
Nacarelli 2018 Geroscience2018Nacarelli T, Azar A, Altinok O, Orynbayeva Z, Sell C (2018) Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts. Geroscience [Epub ahead of print].OXPHOSF
N
S
NS
Isolated mitochondriaHumanHeart
Fibroblast
Cardinale 2018 Physiol Rep2018Cardinale DA, Gejl KD, Ørtenblad N, Ekblom B, Blomstrand E, Larsen FJ (2018) Reliability of maximal mitochondrial oxidative phosphorylation in permeabilized fibers from the vastus lateralis employing high-resolution respirometry. Physiol Rep 6. doi: 10.14814/phy2.13611.LEAK
OXPHOS
F
N
Permeabilized tissueHumanSkeletal muscle
Keller 2018 Oxid Med Cell Longev2018Keller AC, Knaub LA, Scalzo RL, Hull SE, Johnston AE, Walker LA, Reusch JEB (2018) Sepiapterin improves vascular reactivity and insulin-stimulated glucose in wistar rats. Oxid Med Cell Longev 2018:7363485.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueRatEndothelial;epithelial;mesothelial cell
Hsiao 2018 Anal Biochem2018Hsiao CP, Hoppel C (2018) Analyzing mitochondrial function in human peripheral blood mononuclear cells. Anal Biochem 549:12-20.OXPHOS
ET
F
N
S
DQ
CIV
NS
ROX
Intact cellsHumanBlood cells
Boutoual 2018 Scientific Reports2018Boutoual, R., Meseguer, S., Villarroya, M., Martin-Hernandez, E., Errami, M., Martin, M. A., Casado, M., and Armengod, M. E. (2018) Defects in the mitochondrial-tRNA modification enzymes MTO1 and GTPBP3 promote different metabolic reprogramming through a HIF-PPARgamma-UCP2-AMPK axis. Scientific reports 8, 1163LEAK
ROUTINE
OXPHOS
ET
F
S
Gp
Intact cells
Permeabilized cells
HumanOther cell lines
Fibroblast
Koit 2018 US Patent2018Koit A, Kaambre T (2018) Method for selecting patients responsive for cancer treatments. US Patent US20180017547A1.OXPHOSF
N
NS
Permeabilized cellsHuman
Cardinale 2018 Front Physiol2018Cardinale DA, Larsen FJ, Schiffer TA, Morales-Alamo D, Ekblom B, Calbet JAL, Holmberg HC, Boushel R (2018) Superior intrinsic mitochondrial respiration in women than in men. Front Physiol 9:1133.OXPHOSF
N
NS
Isolated mitochondriaHumanSkeletal muscle
Meinild Lundby 2018 Acta Physiol (Oxf)2018Meinild Lundby AK, Jacobs RA, Gehrig S, de Leur J, Hauser M, Bonne TC, Flück D, Dandanell S, Kirk N, Kaech A, Ziegler U, Larsen S, Lundby C (2018) Exercise training increases skeletal muscle mitochondrial volume density by enlargement of existing mitochondria and not de novo biogenesis. Acta Physiol (Oxf) 222, e12905.OXPHOS
LEAK
ET
NS
F
N
CIV
Permeabilized tissueHumanSkeletal muscle
Fernandes-Siqueira 2018 mSphere2018Fernandes-Siqueira LO, Zeidler JD, Sousa BG, Ferreira T, Da Poian AT (2018) Anaplerotic role of glucose in the oxidation of endogenous fatty acids during Dengue virus infection. mSphere 3.pii: e00458-17.LEAK
ET
F
ROX
Intact cellsHumanLiver
Other cell lines
Lu 2018 Cell Discov2018Lu Z, Wei X, Sun F, Zhang H, Gao P, Pu Y, Wang A, Chen J, Tong W, Li Q, Zhou X, Yan Z, Zheng H, Yang G, Huang Y, Liu D, Zhu Z (2018) Non-insulin determinant pathways maintain glucose homeostasis upon metabolic surgery. Cell Discov 4:58.OXPHOS
ET
F
N
ROX
Isolated mitochondriaRatSkeletal muscle
Cree-Green 2018 Diabetes2018Cree-Green M, Scalzo RL, Harrall K, Newcomer BR, Schauer IE, Huebschmann AG, McMillin S, Brown MS, Orlicky D, Knaub L, Nadeau KJ, Mcclatchey PM, Bauer TA, Regensteiner JG, Reusch JEB (2018) Supplemental oxygen improves in-vivo mitochondrial oxidative phosphorylation flux in sedentary obese adults with type 2 diabetes. Diabetes 67:1369-79.ET
LEAK
OXPHOS
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Chou 2018 Int J Cardiol2018Chou CH, Fu TC, Tsai HH, Hsu CC, Wang CH, Wang JS (2018) High-intensity interval training enhances mitochondrial bioenergetics of platelets in patients with heart failure. Int J Cardiol 274:214-20.LEAK
ROUTINE
OXPHOS
ET
F
N
S
NS
ROX
Intact cells
Permeabilized cells
HumanPlatelet
Van Schaardenburgh 2017 J Vasc Surg2017Van Schaardenburgh M, Wohlwend M, Rognmo Ø, Mattsson E (2017) Calf raise exercise increases walking performance in patients with intermittent claudication. J Vasc Surg 65:1473-82.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Jelenik 2017 Diabetes2017Jelenik T, Kaul K, Séquaris G, Flögel U, Phielix E, Kotzka J, Knebel B, Fahlbusch P, Hörbelt T, Lehr S, Reinbeck AL, Müller-Wieland D, Esposito I, Shulman GI, Szendroedi J, Roden M (2017) Mechanisms of insulin resistance in primary and secondary nonalcoholic fatty liver. Diabetes 66:2241-53.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueMouseSkeletal muscle
Liver
Tueller 2017 Biochem Biophys Res Commun2017Tueller DJ, Harley JS, Hancock CR (2017) Effects of curcumin and ursolic acid on the mitochondrial coupling efficiency and hydrogen peroxide emission of intact skeletal myoblasts. Biochem Biophys Res Commun 492:368-72.LEAK
ROUTINE
OXPHOS
F
N
NS
ROX
Intact cells
Permeabilized cells
Skeletal muscle
Nabben 2017 Am J Physiol Regul Integr Comp Physiol2017Nabben M, Schmitz JP, Ciapaite J, Le Clercq CM, van Riel NA, Haak HR, Nicolay K, de Coo IF, Smeets HJ, Praet SF, van Loon LJ, Prompers JJ (2017) Dietary nitrate does not reduce oxygen cost of exercise or improve muscle mitochondrial function in mitochondrial myopathy patients. Am J Physiol Regul Integr Comp Physiol 312:689-701.LEAK
OXPHOS
ET
F
N
S
Permeabilized tissueHumanSkeletal muscle
Kyhl 2017 Peptides2017Kyhl K, Lønborg J, Hartmann B, Kissow H, Poulsen SS, Ali HE, Kjær A, Dela F, Engstrøm T, Treiman M (2017) Lack of effect of prolonged treatment with liraglutide on cardiac remodeling in rats after acute myocardial infarction. Peptides 93:1-12.OXPHOSF
N
S
NS
ROX
Permeabilized tissueRatHeart
Electron transfer-pathway state2017Gnaiger E (2017) ET-pathway states. Mitochondr Physiol Network 2016-08-12, edited 2016-11-08, 2017-02-17, 2017-10-10.LEAK
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
SMP
Trewin 2017 PLOS ONE2017Trewin AJ, Levinger I, Parker L, Shaw CS, Serpiello FR, Anderson MJ, McConell GK, Hare DL, Stepto NK (2017) Acute exercise alters skeletal muscle mitochondrial respiration and H2O2 emission in response to hyperinsulinemic-euglycemic clamp in middle-aged obese men. PLOS ONE 12:e0188421.LEAK
OXPHOS
ET
F
N
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Warren 2017 J Nutr Metab2017Warren JL, Gower BA, Hunter GR, Windham ST, Moellering DR, Fisher G (2017) Associations of mitochondrial fatty acid oxidation with body fat in premenopausal women. J Nutr Metab 2017:7832057.LEAK
OXPHOS
F
N
Permeabilized tissueHumanSkeletal muscle
Darrell 2017 US Patent2017Neufer PD, Anderson EJ, Szeto HH (2017) Methods for preventing or treating insulin resistance. US Patent US20170100450 A1.LEAK
OXPHOS
F
N
S
ROX
Permeabilized tissueHuman
Rat
Skeletal muscle
Nabeebaccus 2017 JCI Insight2017Nabeebaccus AA, Zoccarato A, Hafstad AD, Santos CX, Aasum E, Brewer AC, Zhang M, Beretta M, Yin X, West JA, Schröder K, Griffin JL, Eykyn TR, Abel ED, Mayr M, Shah AM (2017) Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation. JCI Insight 2:96184.LEAK
ET
F
N
Isolated mitochondriaMouseHeart
Joergensen 2017 Physiol Rep2017Jørgensen W, Rud KA, Mortensen OH, Frandsen L, Grunnet N, Quistorff B (2017) Your mitochondria are what you eat: a high-fat or a high-sucrose diet eliminates metabolic flexibility in isolated mitochondria from rat skeletal muscle. Physiol Rep 5. pii: e13207.LEAK
OXPHOS
F
N
NS
Isolated mitochondriaRatSkeletal muscle
Zeidler 2017 J Biol Chem2017Zeidler JD, Fernandes-Siqueira LO, Carvalho AS, Cararo-Lopes E, Dias MH, Ketzer LA, Galina A, Da Poian AT (2017) Short-term starvation is a strategy to unravel the cellular capacity of oxidizing specific exogenous/endogenous substrates in mitochondria. J Biol Chem 292:14176-87.LEAK
ROUTINE
ET
F
N
ROX
Intact cellsMouse
Kudin 2017 Int J Mol Sci2017Kudin AP, Mawasi H, Eisenkraft A, Elger CE, Bialer M, Kunz WS (2017) Mitochondrial liver toxicity of valproic acid and its acid derivatives is related to inhibition of α-lipoamide dehydrogenase. Int J Mol Sci 18. pii: E1912.OXPHOSF
N
Isolated mitochondriaRatNervous system
Liver
Chavanelle 2017 Sci Rep2017Chavanelle V, Boisseau N, Otero YF, Combaret L, Dardevet D, Montaurier C, Delcros G, Peltier SL, Sirvent P (2017) Effects of high-intensity interval training and moderate-intensity continuous training on glycaemic control and skeletal muscle mitochondrial function in db/db mice. Sci Rep 7:204.ET
LEAK
OXPHOS
F
N
NS
ROX
S
Permeabilized tissueMouseSkeletal muscle
Svensson 2017 Acta Physiol (Oxf)2017Svensson K, LaBarge SA, Martins VF, Schenk S (2017) Temporal overexpression of SIRT1 in skeletal muscle of adult mice does not improve insulin sensitivity or markers of mitochondrial biogenesis. Acta Physiol (Oxf) 221:193-203.OXPHOS
ET
LEAK
F
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Nelskylae 2017 Resuscitation2017Nelskylä A, Nurmi J, Jousi M, Schramko A, Mervaala E, Ristagno G, Skrifvars MB (2017) The effect of 50% compared to 100% inspired oxygen fraction on brain oxygenation and post cardiac arrest mitochondrial function in experimental cardiac arrest. Resuscitation 116:1-7.OXPHOS
ET
F
N
S
NS
HomogenatePigHeart
Litt 2017 Thesis2017Litt MJ (2017) Identification and characterization of a cardiomyopathy syndrome resulting from loss of the melanocortin 4 receptor. Dissertation p172.OXPHOS
ET
F
N
NS
Permeabilized tissueMouseHeart
Edgett 2017 Thesis2017Edgett B (2017) Regulation of SIRT1, SIRT3, PGC-1α, and LRP130 in response to energetic stress in human skeletal muscle. Doctoral Dissertation p145.LEAK
OXPHOS
F
N
NS
S
Permeabilized tissueHumanSkeletal muscle
Desprat 2017 Comp Biochem Physiol A Mol Integr Physiol2017Desprat JL, Teulier L, Puijalon S, Dumet A, Romestaing C, Tattersall GJ, Lengagne T, Mondy N (2017) Doping for sex: Bad for mitochondrial performances? Case of testosterone supplemented Hyla arborea during the courtship period. Comp Biochem Physiol A Mol Integr Physiol 209:74-83.OXPHOS
ET
F
N
NS
Permeabilized tissueAmphibiansSkeletal muscle
Permer 2017 Bachelor Thesis2017Permer M (2017) Respirometrische Charakterisierung kryopräservierter HEK 239T Zellen. Bachelor Thesis 1-56.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanOther cell lines
HEK
Boudoures 2017 Thesis2017Boudoures AL (2017) Mitochondrial damage accumulation in oocytes – a potential link between maternal obesity and increased cardiometabolic disease risk in offspring. PhD Thesis p179.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueMouseHeart
Schoenfeld 2017 Neurochem Int2017Schönfeld P, Reiser G (2017) Brain energy metabolism spurns fatty acids as fuel due to their inherent mitotoxicity and potential capacity to unleash neurodegeneration. Neurochem Int 109:68-77.OXPHOSF
N
RatNervous system
Liver
Sobotka 2017 Thesis2017Sobotka O (2017) Pharmacological and metabolic influence on liver mitochondrial functions. PhD Thesis p127.LEAK
OXPHOS
ET
F
N
NS
Intact cells
Homogenate
Isolated mitochondria
Mouse
Rat
Liver
Mueller 2017 Orphanet J Rare Dis2017Mueller SM, Gehrig SM, Petersen JA, Frese S, Mihaylova V, Ligon-Auer M, Khmara N, Nuoffer JM, Schaller A, Lundby C, Toigo M, Jung HH (2017) Effects of endurance training on skeletal muscle mitochondrial function in Huntington disease patients. Orphanet J Rare Dis 12:184.LEAK
OXPHOS
ET
F
N
S
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Galambo 2017 Thesis2017Galambo D (2017) The effect of cardiolipin on vascular smooth muscle cell dedifferentiation, function, and mitochondrial respiration. Master's Thesis p.90.LEAK
OXPHOS
F
N
CIV
NS
ROX
Permeabilized tissueMouseEndothelial;epithelial;mesothelial cell
Horscroft 2017 Proc Natl Acad Sci U S A2017Horscroft JA, Kotwica AO, Laner V, West JA, Hennis PJ, Levett DZH, Howard DJ, Fernandez BO, Burgess SL, Ament Z, Gilbert-Kawai ET, Vercueil A, Landis BD, Mitchell K, Mythen MG, Branco C, Johnson RS, Feelisch M, Montgomery HE, Griffin JL, Grocott MPW, Gnaiger E, Martin DS, Murray AJ (2017) Metabolic basis to Sherpa altitude adaptation. Proc Natl Acad Sci U S A 114:6382–7.LEAK
OXPHOS
ET
F
N
S
NS
Other combinations
Permeabilized tissueHumanSkeletal muscle
Van Schaardenburgh 2017 J Transl Med2017van Schaardenburgh M, Wohlwend M, Rognmo Ø, Mattsson EJR (2017) Exercise in claudicants increase or decrease walking ability and the response relates to mitochondrial function. J Transl Med 15:130.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Scheede-Bergdahl 2017 Can J Physiol Pharmacol2017Scheede-Bergdahl C, Bergdahl A (2017) Adaptation of mitochondrial expression and ATP production in dedifferentiating vascular smooth muscle cells. Can J Physiol Pharmacol 95:1473-9.LEAK
OXPHOS
F
N
CIV
NS
ROX
Permeabilized tissueMouseEndothelial;epithelial;mesothelial cell
Porras 2017 Stem Cells2017Porras DP, Abbaszadeh M, Bhattacharya D, D'Souza NC, Edjiu NR, Perry CG, Scimè A (2017) p107 determines a metabolic checkpoint required for adipocyte lineage fates. Stem Cells 35:1378-91.OXPHOSF
N
Intact cellsMouseFat
Fibroblast
De Carvalho 2017 Toxicol Research2017de Carvalho NR, Rodrigues NR, Macedo GE, Boligon AA, de Campos MM, Posser T, Cunha FAB, Coutinho HD, Klamt F, Bristot IJ, Merritt TJS, Franco JL (2017) Eugenia uniflora leaves essential oil promotes mitochondrial dysfunction in Drosophila melanogaster through the inhibition of oxidative phosphorylation. Toxicol Research 6:526-34 .LEAK
ROUTINE
OXPHOS
ET
F
N
NS
ROX
Isolated mitochondriaDrosophila
Jang 2017 Clin Toxicol (Phila)2017Jang DH, Kelly M, Hardy K, Lambert DS, Shofer FS, Eckmann DM (2017) A preliminary study in the alterations of mitochondrial respiration in patients with carbon monoxide poisoning measured in blood cells. Clin Toxicol (Phila) 55:579-84.LEAK
ROUTINE
OXPHOS
ET
F
S
CIV
NS
ROX
Intact cellsBlood cells
Dent 2017 Mol Metab2017Dent JR, Martins VF, Svensson K, LaBarge SA, Schlenk NC, Esparza MC, Buckner EH, Meyer GA, Hamilton DL, Schenk S, Philp A (2017) Muscle-specific knockout of general control of amino acid synthesis 5 (GCN5) does not enhance basal or endurance exercise-induced mitochondrial adaptation. Mol Metab 6:1574-84.ET
LEAK
OXPHOS
F
N
NS
ROX
S
Permeabilized tissueMouseSkeletal muscle
Jespersen 2017 J Physiol2017Jespersen NR, Yokota T, Støttrup NB, Bergdahl A, Paelestik KB, Povlsen JA, Dela F, Bøtker HE (2017) Pre-ischaemic mitochondrial substrate constraint by inhibition of malate-aspartate shuttle preserves mitochondrial function after ischaemia-reperfusion. J Physiol 595:3765-80.LEAK
OXPHOS
F
N
NS
ROX
S
Permeabilized tissueRatHeart
Lalia 2017 Aging (Albany NY)2017Lalia AZ, Dasari S, Robinson MM, Abid H, Morse DM, Klaus KA, Lanza IR (2017) Influence of omega-3 fatty acids on skeletal muscle protein metabolism and mitochondrial bioenergetics in older adults. Aging (Albany NY) 9:1096-1129.OXPHOS
LEAK
ET
F
N
NS
ROX
S
Isolated mitochondriaHumanSkeletal muscle
Bohanon 2017 Shock2017Bohanon FJ, Lopez ON, Herndon DN, Wang X, Bhattarai N, Ayadi AE, Prasai A, Jay JW, Rojas-Khalil Y, Toliver-Kinsky TE, Finnerty CC, Radhakrishnan RS, Porter C (2017) Burn trauma acutely increases the respiratory capacity and function of liver mitochondria. Shock 49:466-73.LEAK
OXPHOS
ET
F
N
ROX
Intact cellsMouseLiver
Most 2017 Eur J Clin Nutr2017Most J, Penders J, Lucchesi M, Goossens GH, Blaak EE (2017) Gut microbiota composition in relation to the metabolic response to 12-week combined polyphenol supplementation in overweight men and women. Eur J Clin Nutr 71:1040-5.OXPHOSFPermeabilized tissueHumanSkeletal muscle
Zholobenko 2017 PLOS ONE2017Zholobenko AV, Mouithys-Mickalad A, Dostal Z, Serteyn D, Modriansky M (2017) On the causes and consequences of the uncoupler-like effects of quercetin and dehydrosilybin in H9c2 cells. PLOS ONE 12:e0185691.LEAK
OXPHOS
ET
ROUTINE
F
N
S
NS
ROX
Intact cells
Permeabilized cells
RatHeart
Liu 2017 Physiol Rep2017Liu A, Philip J, Vinnakota KC, Van den Bergh F, Tabima DM, Hacker T, Beard DA, Chesler NC (2017) Estrogen maintains mitochondrial content and function in the right ventricle of rats with pulmonary hypertension. Physiol Rep 5:e13157.OXPHOS
ROUTINE
F
N
Isolated mitochondriaRatHeart
Holland 2017 Placenta2017Holland OJ, Hickey AJR, Alvsaker A, Moran S, Hedges C, Chamley LW, Perkins AV (2017) Changes in mitochondrial respiration in the human placenta over gestation. Placenta 57:102-12.LEAK
ROUTINE
OXPHOS
F
N
CIV
NS
ROX
Intact cells
Permeabilized cells
Genital
Dechandt 2017 J Bioenerg Biomembr2017Dechandt CRP, Zuccolotto-Dos-Reis FH, Teodoro BG, Fernandes AMAP, Eberlin MN, Kettelhut IC, Curti C, Alberici LC (2017) Triacsin C reduces lipid droplet formation and induces mitochondrial biogenesis in primary rat hepatocytes. J Bioenerg Biomembr 49:399-411.LEAK
ROUTINE
ET
F
N
ROX
Intact cells
Permeabilized cells
RatLiver
Makrecka-Kuka 2017 Toxicol Lett2017Makrecka-Kuka M, Volska K, Antone U, Vilskersts R, Grinberga S, Bandere D, Liepinsh E, Dambrova M (2017) Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria. Toxicol Lett 267:32-8.LEAK
OXPHOS
ET
F
N
S
CIV
NS
ROX
Permeabilized tissueMouseHeart
Warren 2017 Metabolism2017Warren JL, Bulur S, Ovalle F, Windham ST, Gower BA, Fisher G (2017) Effects of acute hyperinsulinemia on skeletal muscle mitochondrial function, reactive oxygen species production, and metabolism in premenopausal women. Metabolism 77:1-12.LEAK
OXPHOS
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Newsom 2017 Am J Physiol Endocrinol Metab2017Newsom SA, Miller BF, Hamilton KL, Ehrlicher SE, Stierwalt HD, Robinson MM (2017) Long-term rates of mitochondrial protein synthesis are increased in mouse skeletal muscle with high fat feeding regardless of insulin sensitizing treatment. Am J Physiol Endocrinol Metab 313:552-62.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Isolated mitochondriaMouseSkeletal muscle
Yu 2017 Free Radic Biol Med2017Yu Y, Wang L, Delguste F, Durand A, Guilbaud A, Rousselin C, Schmidt AM, Tessier F, Boulanger E, Neviere R (2017) Advanced glycation end products receptor RAGE controls myocardial dysfunction and oxidative stress in high-fat fed mice by sustaining mitochondrial dynamics and autophagy-lysosome pathway. Free Radic Biol Med 112:397-410.LEAK
OXPHOS
F
N
CIV
ROX
Permeabilized tissueMouseHeart
McFarlane 2017 Am J Physiol Regul Integr Comp Physiol2017McFarlane SV, Mathers KE, Staples JF (2017) Reversible temperature-dependent differences in brown adipose tissue respiration during torpor in a mammalian hibernator. Am J Physiol Regul Integr Comp Physiol 312:R434-42.LEAK
ROUTINE
OXPHOS
F
N
Intact cells
Isolated mitochondria
Other mammalsFat
Zeng 2017 J Biol Chem2017Zeng J, Deng S, Wang Y, Li P, Tang L, Pang Y (2017) Specific inhibition of acyl-CoA oxidase-1 by an acetylenic acid improves hepatic lipid and reactive oxygen species (ROS) metabolism in rats fed a high fat diet. J Biol Chem 292:3800-9.FOxidase;biochemical oxidationLiver
Anderson 2017 Cell Metab2017Anderson KA, Huynh FK, Fisher-Wellman K, Stuart JD, Peterson BS, Douros JD, Wagner GR, Thompson JW, Madsen AS, Green MF, Sivley RM, Ilkayeva OR, Stevens RD, Backos DS, Capra JA, Olsen CA, Campbell JE, Muoio DM, Grimsrud PA, Hirschey MD (2017) SIRT4 is a lysine deacylase that controls leucine metabolism and insulin secretion. Cell Metab 25:838-55.OXPHOS
LEAK
F
N
NS
Other combinations
Isolated mitochondriaMouseHeart
Liver
Heim 2017 Am J Physiol Regul Integr Comp Physiol2017Heim AB, Chung D, Florant GL, Chicco AJ (2017) Tissue-specific seasonal changes in mitochondrial function of a mammalian hibernator. Am J Physiol Regul Integr Comp Physiol 313:R180-90.LEAK
OXPHOS
F
NS
Isolated mitochondriaOther mammalsHeart
Skeletal muscle
Liver
Fat
Kenny 2017 Diabetologia2017Kenny HC, Rudwill F, Breen L, Salanova M, Blottner D, Heise T, Heer M, Blanc S, O'Gorman DJ (2017) Bed rest and resistive vibration exercise unveil novel links between skeletal muscle mitochondrial function and insulin resistance. Diabetologia 60:1491-501.LEAK
OXPHOS
ET
N
S
CIV
NS
F
Permeabilized tissueHumanSkeletal muscle
Wollenman 2017 PLOS ONE2017Wollenman LC, Vander Ploeg MR, Miller ML, Zhang Y, Bazil JN (2017) The effect of respiration buffer composition on mitochondrial metabolism and function. PLOS ONE 12:e0187523.ET
LEAK
OXPHOS
F
N
NS
S
Isolated mitochondriaGuinea pigHeart
Liver
Chung 2017 Sci Rep2017Chung DJ, Morrison PR, Bryant HJ, Jung E, Brauner CJ, Schulte PM (2017) Intraspecific variation and plasticity in mitochondrial oxygen binding affinity as a response to environmental temperature. Sci Rep 7:16238.OXPHOSF
N
NS
Isolated mitochondriaFishesLiver
Cardinale 2017 Front Physiol2017Cardinale DA, Lilja M, Mandić M, Gustafsson T, Larsen FJ, Lundberg TR (2017) Resistance training with co-ingestion of anti-inflammatory drugs attenuates mitochondrial function. Front Physiol 8:1074.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Wolff 2017 Thesis2017Wolff C (2017) Impact of lipid metabolism on skeletal muscle mitochondrial function in type 2 diabetes mellitus patients. Dissertation p68.ET
LEAK
OXPHOS
F
N
NS
Permeabilized tissueHorseSkeletal muscle
Merz 2017 Intensive Care Med Exp2017Merz T, Vogt JA, Wachter U, Calzia E, Szabo C, Wang R, Radermacher P, McCook O (2017) Impact of hyperglycemia on cystathionine-γ-lyase expression during resuscitated murine septic shock. Intensive Care Med Exp 5:30.LEAK
OXPHOS
ET
F
N
S
NS
ROX
HomogenateMouseLiver
Da Silva 2017 Thesis2017da Silva LA (2017) Efeito do tratamento com N-acetilcisteína sobre dinâmica mitocondrial em modelo animal de isquemia crônica de membros inferiores. Dissertation p54.OXPHOSF
N
NS
RatSkeletal muscle
Goedecke 2017 JMIR Res Protoc2017Goedecke JH, Mendham AE, Clamp L, Nono Nankam PA, Fortuin-de Smidt MC, Phiri L, Micklesfield LK, Keswell D, Woudberg NJ, Lecour S, Alhamud A, Kaba M, Lutomia FM, van Jaarsveld PJ, de Villiers A, Kahn SE, Chorell E, Hauksson J, Olsson T (2017) An exercise intervention to unravel the mechanisms underlying insulin resistance in a cohort of black South African women: Protocol for a randomized controlled trial. JMIR Res Protoc 03/10/2017:9098.LEAK
OXPHOS
ET
F
N
S
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Fat
Categories of SUIT protocols2017Gnaiger E (2017) Categories of SUIT protocols and ETS pathway control states. MiPNet 2017-03-12; original 2016-03-20; edited 2016-08-21.F
N
S
Gp
CIV
NS
Other combinations
ROX
Miller 2017 PLOS ONE2017Miller B, Hamilton K, Boushel R, Williamson K, Laner V, Gnaiger E, Davis M (2017) Mitochondrial respiration in highly aerobic canines in the non-raced state and after a 1600-km sled dog race. PLOS ONE 12:e0174874.OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueDogSkeletal muscle
Lou 2017 Physiol Rep2017Lou PH, Lucchinetti E, Scott KY, Huang Y, Gandhi M, Hersberger M, Clanachan AS, Lemieux H, Zaugg M (2017) Alterations in fatty acid metabolism and sirtuin signaling characterize early type-2 diabetic hearts of fructose-fed rats. Physiol Rep 5 pii: e13388.LEAK
OXPHOS
F
N
CIV
NS
RatHeart
Buck 2017 PLOS ONE2017Buck E, Zügel M, Schumann U, Merz T, Gumpp AM, Witting A, Steinacker JM, Landwehrmeyer GB, Weydt P, Calzia E, Lindenberg KS (2017) High-resolution respirometry of fine-needle muscle biopsies in pre-manifest Huntington's disease expansion mutation carriers shows normal mitochondrial respiratory function. PLOS ONE 12:e0175248.LEAK
OXPHOS
ET
F
N
S
NS
ROX
HomogenateHuman
Mouse
Heart
Skeletal muscle
Nervous system
Liver
Asping 2017 Eur J Clin Pharmacol2017Asping M, Stride N, Søgaard D, Dohlmann TL, Helge JW, Dela F, Larsen S (2017) The effects of 2 weeks of statin treatment on mitochondrial respiratory capacity in middle-aged males: the LIFESTAT study. Eur J Clin Pharmacol 73:679-87.LEAK
ET
F
N
S
CIV
NS
ROX
Permeabilized tissueHuman
Torres 2017 Cell Metab2017Torres MJ, Kew KA, Ryan TE, Pennington ER, Lin CT, Buddo KA, Fix AM, Smith CA, Gilliam LA, Karvinen S, Lowe DA, Spangenburg EE, Zeczycki TN, Shaikh SR, Neufer PD (2017) 17β-estradiol directly lowers mitochondrial membrane microviscosity and improves bioenergetic function in skeletal muscle. Cell Metab 27:167-79.OXPHOS
ET
LEAK
F
N
S
CIV
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Rontoyanni 2017 Shock2017Rontoyanni VG, Malagaris I, Herndon DN, Rivas E, Capek KD, Delgadillo AD, Bhattarai N, Elizondo A, Voigt CD, Finnerty CC, Suman OE, Porter C (2017) Skeletal muscle mitochondrial function is determined by burn severity, sex and sepsis, and is associated with glucose metabolism and functional capacity in burned children. Shock 50:141-48.LEAK
OXPHOS
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Emmett 2017 Nature2017Emmett MJ, Lim HW, Jager J, Richter HJ, Adlanmerini M, Peed LC, Briggs ER, Steger DJ, Ma T, Sims CA, Baur JA, Pei L, Won KJ, Seale P, Gerhart-Hines Z, Lazar MA (2017) Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge. Nature 546:544-8.LEAK
OXPHOS
F
N
S
CIV
ROX
HomogenateMouseFat
Wetzel 2017 Thesis2017Wetzel MD (2017) Mechanism of metformin action in dermal fibroblasts. PhD Thesis 125.LEAK
OXPHOS
F
N
NS
ROX
Intact cellsHumanFibroblast
Konopka 2017 J Appl Physiol (1985)2017Konopka AR, Castor WM, Wolff CA, Musci RV, Reid JJ, Laurin JL, Valenti ZJ, Hamilton KL, Miller BF (2017) Case studies in physiology: skeletal muscle mitochondrial protein synthesis and respiration in response to the energetic stress of an ultra-endurance race. J Appl Physiol (1985) 123:1516-24.OXPHOS
ET
F
N
NS
Permeabilized tissueHumanSkeletal muscle
MiPNet21.07 MitoFit DatLab PT2016-07-20
O2k-Protocols
MitoFit DatLab proficiency test.
LEAK
OXPHOS
ET
F
N
S
Gp
CIV
Other combinations
ROX
Permeabilized cellsHuman
Tsai 2016 Sci Rep2016Tsai HH, Chang SC, Chou CH, Weng TP, Hsu CC, Wang JS (2016) Exercise training alleviates hypoxia-induced mitochondrial dysfunction in the lymphocytes of sedentary males. Sci Rep 6:35170.LEAK
ROUTINE
OXPHOS
ET
F
N
S
NS
Other combinations
ROX
Intact cells
Permeabilized cells
HumanLymphocyte
Blood cells
Williams 2016 Diabetes2016Williams AS, Trefts E, Lantier L, Grueter C, Bracy DP, James FD, Pozzi A, Zent R, Wasserman DH (2016) Integrin-linked kinase is necessary for the development of diet-induced hepatic insulin resistance. Diabetes 66:325-34.OXPHOS
LEAK
F
N
Isolated mitochondriaMouseLiver
Sadhukhan 2016 Proc Natl Acad Sci U S A2016Sadhukhan S, Liu X, Ryu D, Nelson OD, Stupinski JA, Li Z, Chen W, Zhang S, Weiss RS, Locasale JW, Auwerx J, Lin H (2016) Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function. Proc Natl Acad Sci U S A 113:4320-5.LEAK
OXPHOS
F
N
Permeabilized tissueMouseHeart
Teulier 2016 Proc Biol Sci2016Teulier L, Weber JM, Crevier J, Darveau CA (2016) Proline as a fuel for insect flight: enhancing carbohydrate oxidation in hymenopterans. Proc Biol Sci 283: 20160333.OXPHOSF
Gp
N
NS
Other combinations
ROX
S
Permeabilized tissueHexapodsSkeletal muscle
Duteil 2016 Cell Rep2016Duteil D, Tosic M, Lausecker F, Nenseth HZ, Müller JM, Urban S, Willmann D, Petroll K, Messaddeq N, Arrigoni L, Manke T, Kornfeld JW, Brüning JC, Zagoriy V, Meret M, Dengjel J, Kanouni T, Schüle R (2016) Lsd1 ablation triggers metabolic reprogramming of brown adipose tissue. Cell Rep 17:1008-21.ETF
N
S
NS
Permeabilized tissueMouseFat
Kancirova 2016 Physiol Res2016Kancirová I, Jašová M, Muráriková M, Sumbalová Z, Uličná O, Ravingerová T, Waczulíková I, Ziegelhöffer A, Ferko M (2016) Cardioprotection induced by remote ischemic preconditioning preserves the mitochondrial respiratory function in acute diabetic myocardium. Physiol Res 65:S611-19.LEAK
OXPHOS
F
N
Isolated mitochondriaRatHeart
Timmers 2016 Diabetes Care2016Timmers S, de Ligt M, Phielix E, van de Weijer T, Hansen J, Moonen-Kornips E, Schaart G, Kunz I, Hesselink MK, Schrauwen-Hinderling VB, Schrauwen P (2016) Resveratrol as add-on therapy in subjects with well-controlled type 2 diabetes: a randomized controlled trial. Diabetes Care 39:2211-17.LEAK
ET
OXPHOS
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Schoepf 2016 FEBS J2016Schöpf B, Schäfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E (2016) Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells. FEBS J 283:2181-96.LEAK
OXPHOS
ET
F
N
S
NS
Other combinations
ROX
Permeabilized cells
Permeabilized tissue
HumanEndothelial;epithelial;mesothelial cell
Genital
Other cell lines
Fibroblast
Gilliam 2016 Am J Physiol Endocrinol Metab2016Gilliam LA, Lark DS, Reese LR, Torres MJ, Ryan TE, Lin CT, Cathey BL, Neufer PD (2016) Targeted overexpression of mitochondrial catalase protects against cancer chemotherapy-induced skeletal muscle dysfunction. Am J Physiol Endocrinol Metab 311:E293-301.LEAK
OXPHOS
F
N
NS
Other combinations
Permeabilized tissueMouseSkeletal muscle
Hamilton 2016 Physiol Rep2016Hamilton DJ, Minze LJ, Kumar T, Cao TN, Lyon CJ, Geiger PC, Hsueh WA, Gupte AA (2016) Estrogen receptor alpha activation enhances mitochondrial function and systemic metabolism in high-fat-fed ovariectomized mice. Physiol Rep 4. pii: e12913.LEAK
OXPHOS
F
N
NS
Isolated mitochondriaMouseHeart
Van Eunen 2016 BMC Biol2016van Eunen K, Volker-Touw CM, Gerding A, Bleeker A, Wolters JC, van Rijt WJ, Martines AM, Niezen-Koning KE, Heiner RM, Permentier H, Groen AK, Reijngoud DJ, Derks TG, Bakker BM (2016) Living on the edge: substrate competition explains loss of robustness in mitochondrial fatty-acid oxidation disorders. BMC Biol 14:107.ETF
N
Isolated mitochondriaMouseLiver
Newell 2016 Physiol Entomol2016Newell C, Kane CL, Kane DC (2016) Mitochondrial substrate specificity in beetle flight muscle: assessing respiratory oxygen flux in small samples from Dermestes maculatus and Tenebrio molitor. Physiol Entomol p7.OXPHOSF
Gp
N
Other combinations
Permeabilized tissueHexapodsSkeletal muscle
Heinonen 2016 Hum Exp Toxicol2016Heinonen JA, Schramko AA, Skrifvars MB, Litonius E, Backman JT, Mervaala E, Rosenberg PH (2016) The effects of intravenous lipid emulsion on hemodynamic recovery and myocardial cell mitochondrial function after bupivacaine toxicity in anesthetized pigs. Hum Exp Toxicol 36:365-75.LEAK
OXPHOS
ET
F
N
S
NS
HomogenatePigHeart
Kacso 2016 Biochem J2016Kacso G, Ravasz D, Doczi J, Németh B, Madgar O, Saada A, Ilin P, Miller C, Ostergaard E, Iordanov I, Adams D, Vargedo Z, Araki M, Araki K, Nakahara M, Ito H, Gál A, Molnár MJ, Nagy Z, Patocs A, Adam-Vizi V, Chinopoulos C (2016) Two transgenic mouse models for β-subunit components of succinate-CoA ligase yielding pleiotropic metabolic alterations. Biochem J 473:3463-85.LEAK
OXPHOS
F
N
Other combinations
Isolated mitochondriaMouseHeart
Nervous system
Liver
MiPNet21.14 Reference sample HRR2016
O2k-Protocols
Development of a reference sample for HRR.
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Intact cells
Permeabilized cells
HumanHEK
Talati 2016 Am J Respir Crit Care Med2016Talati MH, Brittain EL, Fessel JP, Penner N, Atkinson J, Funke M, Grueter C, Jerome WG, Freeman M, Newman JH, West J, Hemnes AR (2016) Mechanisms of lipid accumulation in the bone morphogenetic protein receptor type 2 mutant right ventricle. Am J Respir Crit Care Med 194:719-28.LEAKF
N
Permeabilized tissueMouseHeart
Gorbacheva 2016 International Symposium Mitochondrial Motility2016Gorbacheva OS, Strutynskyi RB, Khmil NV, Belosludtseva NV, Murzaeva SV, Korobeynikova MO, Alilova GA, Lezhnev EI, Mironova GD (2016) Study of the influence of flocalin on the energy and ion exchanges in rat liver mitochondria. International Symposium Mitochondrial Motility 73-7.LEAKF
N
S
RatLiver
Ojuka 2016 Am J Physiol Endocrinol Metab2016Ojuka E, Andrew B, Bezuidenhout N, George S, Maarman G, Madlala HP, Mendham A, Osiki PO (2016) Measurement of β-oxidation capacity of biological samples by respirometry: a review of principles and substrates. Am J Physiol Endocrinol Metab 310:E715-23.LEAK
OXPHOS
ET
FPermeabilized tissue
Isolated mitochondria
Human
Mouse
Rat
Skeletal muscle
Liver
Gemmink 2016 Diabetologia2016Gemmink A, Bosma M, Kuijpers HJ, Hoeks J, Schaart G, van Zandvoort MA, Schrauwen P, Hesselink MK (2016) Decoration of intramyocellular lipid droplets with PLIN5 modulates fasting-induced insulin resistance and lipotoxicity in humans. Diabetologia 59:1040-8.ET
OXPHOS
F
NS
Other combinations
Permeabilized tissueHumanSkeletal muscle
Van Zutphen 2016 J Hepatol2016van Zutphen T, Ciapaite J, Bloks VW, Ackereley C, Gerding A, Jurdzinski A, Allgayer de Moraes R, Zhang L, Wolters JC, Bischoff R, Wanders RJ, Houten SM, Bronte-Tinkew D, Shatseva T, Lewis GF, Groen AK, Reijngoud DJ, Bakker BM, Jonker JW, Kim PK, Bandsma RH (2016) Malnutrition-associated liver steatosis and ATP depletion is caused by peroxisomal and mitochondrial dysfunction. J Hepatol 65:1198-1208.ET
LEAK
OXPHOS
F
N
NS
Other combinations
Isolated mitochondriaRatLiver
Porter 2016 Cell Metab2016Porter C, Herndon DN, Chondronikola M, Chao T, Annamalai P, Bhattarai N, Saraf MK, Capek KD, Reidy PT, Daquinag AC, Kolonin MG, Rasmussen BB, Borsheim E, Toliver-Kinsky T, Sidossis LS (2016) Human and mouse brown adipose tissue mitochondria have comparable UCP1 function. Cell Metab 24:246-55.LEAK
OXPHOS
ET
F
N
NS
Other combinations
Permeabilized tissueHuman
Mouse
Skeletal muscle
Fat
Schoenfeld 2016 J Cereb Blood Flow Metab2016Schönfeld P, Reiser G (2016) Inhibition of b-oxidation is not a valid therapeutic tool for reducing oxidative stress in conditions of neurodegeneration. J Cereb Blood Flow Metab 37:848-54.OXPHOSF
Other combinations
Isolated mitochondriaRatNervous system
Lashbrook 2016 Thesis2016Lashbrook M (2016) Functional responses of cardiac and skeletal muscle mitochondria to short-term obesity: are all obesities the same? Master's Thesis 63pp.LEAK
OXPHOS
F
N
NS
Permeabilized tissue
Isolated mitochondria
Mouse
Other mammals
Heart
Skeletal muscle
Jacobs 2016 J Physiol2016Jacobs RA, Lundby AM, Fenk S, Gehrig S, Siebenmann C, Flück D, Kirk N, Hilty MP, Lundby C (2016) Twenty-eight days of exposure to 3,454 m increases mitochondrial volume density in human skeletal muscle. J Physiol 594:1151-66.LEAK
OXPHOS
ET
F
N
S
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Chorner 2016 Am J Physiol Regul Integr Comp Physiol2016Chorner Z, Barbeau PA, Castellani L, Wright DC, Chabowski A, Holloway GP (2016) Dietary α-linolenic acid supplementation alters skeletal muscle plasma membrane lipid composition, sarcolemmal FAT/CD36 abundance, and palmitate transport rates. Am J Physiol Regul Integr Comp Physiol 311:R1234-42.LEAK
OXPHOS
F
N
NS
Isolated mitochondriaRatSkeletal muscle
Speijer 2016 Biochem J2016Speijer D (2016) Being right on Q: shaping eukaryotic evolution. Biochem J 473:4103-27.F
N
ROX
Zabielski 2016 Diabetes2016Zabielski P, Lanza IR, Gopala S, Holtz Heppelmann CJ, Bergen HR 3rd, Dasari S, Nair KS (2016) Altered skeletal muscle mitochondrial proteome as the basis of disruption of mitochondrial function in diabetic mice. Diabetes 65:561-73.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized cellsMouseSkeletal muscle
Christensen 2016 J Appl Physiol (1985)2016Christensen PM, Jacobs RA, Bonne T, Flück D, Bangsbo J, Lundby C (2016) A short period of high-intensity interval training improves skeletal muscle mitochondrial function and pulmonary oxygen uptake kinetics. J Appl Physiol (1985) 120:1319-27.LEAK
OXPHOS
ET
F
N
S
CIV
NS
Other combinations
ROX
Permeabilized tissueHumanSkeletal muscle
Pravenec 2016 Physiol Genomics2016Pravenec M, Mlejnek P, Zídek V, Landa V, Šimáková M, Šilhavý J, Strnad H, Eigner S, Eigner Henke K, Škop V, Malínská H, Trnovská J, Kazdová L, Drahota Z, Mráček T, Houštěk J (2016) Autocrine effects of transgenic resistin reduce palmitate and glucose oxidation in brown adipose tissue. Physiol Genomics 48:420-7.ETF
N
Isolated mitochondriaRatFat
Pambianco 2016 Cell Rep2016Pambianco S, Giovarelli M, Perrotta C, Zecchini S, Cervia D3, Di Renzo I, Moscheni C, Ripolone M, Violano R, Moggio M, Bassi MT, Puri PL, Latella L, Clementi E, De Palma C (2016) Reversal of defective mitochondrial biogenesis in limb-girdle muscular dystrophy 2D by independent modulation of histone and PGC-1α acetylation. Cell Rep 17:3010-23.LEAK
OXPHOS
F
N
S
NS
ROX
Permeabilized cells
Isolated mitochondria
Permeabilized tissue
MouseSkeletal muscle
Sparks 2016 Diabetologia2016Sparks LM, Gemmink A, Phielix E, Bosma M, Schaart G, Moonen-Kornips E, Jörgensen JA, Nascimento EB, Hesselink MK, Schrauwen P, Hoeks J (2016) ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity. Diabetologia 59:1030-9.LEAK
OXPHOS
ET
F
N
NS
Other combinations
Permeabilized tissue
Isolated mitochondria
Human
Mouse
Rat
Skeletal muscle
Other cell lines
Most 2016 Am J Clin Nutr2016Most J, Timmers S, Warnke I, Jocken JW, van Boekschoten M, de Groot P, Bendik I, Schrauwen P, Goossens GH, Blaak EE (2016) Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: a randomized controlled trial. Am J Clin Nutr 104:215-27.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueHumanSkeletal muscle
McFarlane 2016 Thesis2016McFarlane SV (2016) Temperature-dependent alterations of brown adipose tissue metabolism during hibernation in the thirteen-lined ground squirrel, Ictidomys tridecemlineatus. Dissertation p74.LEAK
ROUTINE
OXPHOS
ET
F
N
Intact cells
Isolated mitochondria
Other mammalsFat
Assmann 2016 Cell Rep2016Assmann N, Dettmer K, Simbuerger JM, Broeker C, Nuernberger N, Renner K, Courtneidge H, Klootwijk ED, Duerkop A, Hall A, Kleta R, Oefner PJ, Reichold M, Reinders J (2016) Renal fanconi syndrome is caused by a mistargeting-based mitochondriopathy. Cell Rep 15:1423-9.LEAK
OXPHOS
ET
F
N
S
NS
Other combinations
ROX
Intact cellsPigKidney
Other cell lines
Moon 2016 J Biol Chem2016Moon SH, Mancuso DJ, Sims HF, Liu X, Nguyen AL, Yang K, Guan S, Dilthey BG, Jenkins CM, Weinheimer CJ, Kovacs A, Abendschein D, Gross RW (2016) Cardiac myocyte-specific knock-out of calcium-independent phospholipase A2γ (iPLA2γ) decreases oxidized fatty acids during ischemia/reperfusion and reduces infarct size. J Biol Chem 291:19687-700.LEAK
OXPHOS
F
N
NS
Other combinations
ROX
S
Isolated mitochondriaMouseHeart
Osiki 2016 FASEB J2016Osiki PO, Ojuka E, Marmaan G (2016) An investigation of the suitability of using octanoylcarnitine together with malate as a substrate combination for assessing Beta-oxidation using High Resolution Respirometry. FASEB J 30: 1015.12 .LEAK
OXPHOS
ET
FPermeabilized tissueRatSkeletal muscle
Schoenenberger 2016 Cancer Res2016Schönenberger D, Harlander S, Rajski M, Jacobs RA, Lundby AK, Adlesic M, Hejhal T, Wild PJ, Lundby C, Frew IJ (2016) Formation of renal cysts and tumors in Vhl/Trp53-deficient mice requires HIF1α and HIF2α. Cancer Res 76:2025-36.OXPHOS
ET
F
N
S
CIV
NS
ROX
Permeabilized tissueMouseNervous system
McCurdy 2016 JCI Insight2016McCurdy CE, Schenk S, Hetrick B, Houck J, Drew BG, Kaye S, Lashbrook M, Bergman BC, Takahashi DL, Dean TA, Nemkov T, Gertsman I, Hansen KC, Philp A, Hevener AL, Chicco AJ, Aagaard KM, Grove KL, Friedman JE (2016) Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques. JCI Insight 1:e86612.LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized tissueOther mammalsSkeletal muscle
Reijne 2016 PLOS ONE2016Reijne AC, Ciapaite J, van Dijk TH, Havinga R, van der Zee EA, Groen AK, Reijngoud DJ, Bakker BM, van Dijk G (2016) Whole-body vibration partially reverses aging-induced increases in visceral adiposity and hepatic lipid storage in mice. PLOS ONE 11:e0149419.LEAK
OXPHOS
F
N
Other combinations
Isolated mitochondriaMouseSkeletal muscle
Liver
Jiroutkova 2016 JPEN J Parenter Enteral Nutr2016Jiroutková K, Krajčová A, Žiak J, Fric M, Gojda J, Džupa V, Kalous M, Tůmová J, Trnka J, Duška F (2016) Mitochondrial function in an in vitro model of skeletal muscle of patients with protracted critical illness and intensive care unit-acquired weakness. JPEN J Parenter Enteral Nutr 41:1213-21.LEAK
ET
F
ROX
HumanSkeletal muscle
Other cell lines
Smith 2016 Diabetes2016Smith BK, Ford RJ, Desjardins EM, Green AE, Hughes MC, Houde VP, Day EA, Marcinko K, Crane JD, Mottillo EP, Perry CG, Kemp BE, Tarnopolsky MA, Steinberg GR (2016) Salsalate (Salicylate) uncouples mitochondria, improves glucose homeostasis, and reduces liver lipids independent of AMPK β1. Diabetes 65:3352-61.ET
LEAK
OXPHOS
F
N
NS
Other combinations
ROX
Isolated mitochondria
Permeabilized cells
Permeabilized tissue
MouseFat
Liver
Skeletal muscle
Bernardo 2015 J Nutr Biochem2016Bernardo AF, Cortez E, Neves FA, Vieira AKG, Soares V, Rodrigues-Cunha AC, Andrade DC, Thole AA, Gabriel-Costa D, Brum PC, Moura AS, Garcia-Souza EP (2015) Overnutrition during lactation leads to impairment in insulin signaling, upregulation of GLUT1 and increased mitochondrial carbohydrate oxidation in heart of weaned mice. J Nutr Biochem 29:124-32.LEAK
OXPHOS
F
N
NS
Permeabilized tissueMouseHeart
Gehrig 2016 Orphanet J Rare Dis2016Gehrig SM, Mihaylova V, Frese S, Mueller SM, Ligon-Auer M, Spengler CM, Petersen JA, Lundby C, Jung HH (2016) Altered skeletal muscle (mitochondrial) properties in patients with mitochondrial DNA single deletion myopath. Orphanet J Rare Dis 11:105.LEAK
OXPHOS
F
N
S
CIV
NS
Other combinations
ROX
Permeabilized tissueHumanSkeletal muscle
LaBarge 2016 FASEB J2016LaBarge SA, Migdal CW, Buckner EH, Okuno H, Gertsman I, Stocks B, Barshop BA, Nalbandian SR, Philp A, McCurdy CE, Schenk S (2016) p300 is not required for skeletal muscle metabolic adaptation to endurance exercise training. FASEB J 30:1623-33.LEAK
OXPHOS
ET
F
N
NS
ROX
S
Other combinations
Permeabilized tissueMouseSkeletal muscle
Holzem 2016 FASEB J2016Holzem KM, Vinnakota KC, Ravikumar VK, Madden EJ, Ewald GA, Dikranian K, Beard DA, Efimov IR (2016) Mitochondrial structure and function are not different between nonfailing donor and end-stage failing human hearts. FASEB J 30:2698-707.OXPHOS
LEAK
F
N
Permeabilized tissue
Isolated mitochondria
HumanHeart
Lund 2016 J Physiol2016Lund MT, Kristensen M, Hansen M, Tveskov L, Floyd AK, Støckel M, Vainer B, Poulsen SS, Helge JW, Prats C, Dela F (2016) Hepatic mitochondrial oxidative phosphorylation is normal in obese patients with and without type 2 diabetes. J Physiol 594:4351-8.LEAK
OXPHOS
ET
F
N
S
CIV
NS
ROX
Permeabilized tissueHumanLiver
Oliveira 2016 PLOS ONE2016Oliveira MP, Correa Soares JB, Oliveira MF (2016) Sexual preferences in nutrient utilization regulate oxygen consumption and reactive oxygen species generation in Schistosoma mansoni: potential implications for parasite redox biology. PLOS ONE 11:e0158429.LEAK
ROUTINE
F
ROX
Intact organismOther invertebrates
Van Schaardenburgh 2016 PLOS ONE2016van Schaardenburgh M, Wohlwend M, Rognmo Ø, Mattsson EJ (2016) Mitochondrial respiration after one session of calf raise exercise in patients with peripheral vascular disease and healthy older adults. PLOS ONE 11:e0165038.ET
LEAK
OXPHOS
F
N
NS
S
Permeabilized tissueHumanSkeletal muscle
Scott 2016 Thesis2016Scott KY (2016) Evaluation of cardiac mitochondrial function in the fructose-fed rat. Master's Thesis p98.LEAK
OXPHOS
ET
F
N
S
CIV
ROX
Isolated mitochondriaRatHeart
Hamilton 2016 Am J Physiol Heart Circ Physiol2016Hamilton DJ, Zhang A, Li S, Cao TN, Smith JA, Vedula I, Cordero-Reyes AM, Youker KA, Torre-Amione G, Gupte AA (2016) Combination of angiotensin II and l-NG-nitroarginine methyl ester exacerbates mitochondrial dysfunction and oxidative stress to cause heart failure. Am J Physiol Heart Circ Physiol 310:H667-80.LEAK
OXPHOS
F
N
S
NS
Other combinations
ROX
Permeabilized tissue
Isolated mitochondria
MouseHeart
Edgett 2016 Exp Physiol2016Edgett BA, Hughes MC, Matusiak JB, Perry CG, Simpson CA, Gurd BJ (2016) SIRT3 gene expression but not SIRT3 subcellular localization is altered in response to fasting and exercise in human skeletal muscle. Exp Physiol 101:1101-13.OXPHOSF
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Heim 2016 Thesis2016Heim A (2016) Tissue-specific seasonal changes in mitochondrial respiratory function and membrane composition in the golden-matled ground squirrel. Master's Thesis p77.LEAK
OXPHOS
F
N
NS
Other combinations
Isolated mitochondriaOther mammalsHeart
Skeletal muscle
Liver
Fat
Porter 2015 Am J Physiol Endocrinol Metab2015Porter C, Hurren NM, Cotter MV, Bhattarai N, Reidy PT, Dillon EL, Durham WJ, Tuvdendorj D, Sheffield-Moore M, Volpi E, Sidossis LS, Rasmussen BB, Børsheim E (2015) Mitochondrial respiratory capacity and coupling control decline with age in human skeletal muscle. Am J Physiol Endocrinol Metab 309:E224-32.LEAK
OXPHOS
ET
F
N
NS
Other combinations
Permeabilized tissueHumanSkeletal muscle
Saraf 2015 J Burn Care Res2015Saraf MK, Herndon DN, Porter C, Toliver-Kinsky T, Radhakrishnan R, Chao T, Chondronikola M, Sidossis LS (2015) Morphological changes in subcutaneous white adipose tissue after severe burn injury. J Burn Care Res 37:e96-e103.LEAK
OXPHOS
F
N
Other combinations
Permeabilized tissueHumanFat
Christiansen 2015 J Vet Med Sci2015Christiansen LB, Dela F, Koch J, Yokota T (2015) Tissue-specific and substrate-specific mitochondrial bioenergetics in feline cardiac and skeletal muscles. J Vet Med Sci 77:669-75.LEAK
OXPHOS
ET
F
N
S
CIV
NS
Other combinations
ROX
Permeabilized tissueCatHeart
Skeletal muscle
Katunga 2015 Mol Metab2015Katunga LA, Gudimella P, Efird JT, Abernathy S, Mattox TA, Beatty C, Darden TM, Thayne KA, Alwair H, Kypson AP, Virag JA, Anderson EJ (2015) Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy. Mol Metab 4:493-506.LEAK
OXPHOS
FPermeabilized tissueMouseHeart
Assmann 2014 PhD Thesis2015Assmann N (2015) Impact of Fanconi-associated protein on the mitochonrial proteome. PhD Thesis 1-111.LEAK
ROUTINE
OXPHOS
ET
F
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
PigKidney
Other cell lines
Hagve 2015 Am J Physiol Endocrinol Metab2015Hagve M, Gjessing PF, Fuskevåg OM, Larsen TS, Irtun Ø (2015) Skeletal muscle mitochondria exhibit decreased pyruvate oxidation capacity and increased ROS emission during surgery-induced acute insulin resistance. Am J Physiol Endocrinol Metab 308:E613-20.LEAK
OXPHOS
F
N
Isolated mitochondriaPigSkeletal muscle
Liver
Sidossis 2015 Cell Metab2015Sidossis LS, Porter C, Saraf MK, Børsheim E, Radhakrishnan RS, Chao T, Ali A, Chondronikola M, Mlcak R, Finnerty CC, Hawkins HK, Toliver-Kinsky T, Herndon DN (2015) Browning of subcutaneous white adipose tissue in humans after severe adrenergic stress. Cell Metab 22:219-27.LEAKF
N
NS
Other combinations
Permeabilized cellsHuman
Mouse
Fat
Schrauwen-Hinderling 2015 Antioxid Redox Signal2015Schrauwen-Hinderling VB, Kooi ME, Schrauwen P (2015) Mitochondrial function and diabetes; consequences for skeletal and cardiac muscle metabolism. Antioxid Redox Signal 24:39-51.LEAK
OXPHOS
F
N
S
CIV
Permeabilized tissue
Isolated mitochondria
HumanHeart
Skeletal muscle
Grevengoed 2015 J Lipid Res2015Grevengoed TJ, Martin SA, Katunga L, Cooper DE, Anderson EJ, Murphy RC, Coleman RA (2015) Acyl-CoA synthetase 1 deficiency alters cardiolipin species and impairs mitochondrial function. J Lipid Res 56:1572-82.LEAK
OXPHOS
F
N
NS
ROX
Permeabilized tissueMouseHeart
Other cell lines
HEK
Boushel 2015 Scand J Med Sci Sports2015Boushel R, Gnaiger E, Larsen FJ, Helge JW, Gonzalez-Alonso J, Ara I, Munch-Andersen T, van Hall G, Søndergaard H, Saltin B, Calbet JAL (2015) Maintained peak leg and pulmonary VO2 despite substantial reduction in muscle mitochondrial capacity. Scand J Med Sci Sports 25 (Suppl 4):135–43.OXPHOSF
N
S
NS
Intact organ
Permeabilized tissue
HumanSkeletal muscle
Patil 2015 J Nutr Biochem2015Patil YN, Dille KN, Burk DH, Cortez CC, Gettys TW (2015) Cellular and molecular remodeling of inguinal adipose tissue mitochondria by dietary methionine restriction. J Nutr Biochem 26:1235-47.LEAK
OXPHOS
ET
F
N
S
Gp
ROX
Isolated mitochondriaMouseSkeletal muscle
Liver
Fat
Lantier 2015 Diabetes2015Lantier L, Williams AS, Williams IM, Yang KK, Bracy DP, Goelzer M, James FD, Gius D, Wasserman DH (2015) SIRT3 is crucial for maintaining skeletal muscle insulin action and protects against severe insulin resistance in high fat fed mice. Diabetes 64:3081-92.LEAK
OXPHOS
F
N
Permeabilized tissueMouseSkeletal muscle
Ofer 2015 Mol Endocrinol2015Ofer P, Heidegger I, Eder IE, Schöpf B, Neuwirt H, Geley S, Klocker H, Massoner P (2015) Both IGF1R and INSR knockdown exert anti-tumorigenic effects in prostate cancer in vitro and in vivo. Mol Endocrinol 29:1694-707.ROUTINE
OXPHOS
ET
F
N
NS
Intact cells
Permeabilized cells
HumanGenital
Other cell lines
Rodrigues 2016 Biochem J2015Rodrigues MF, Obre E, Melo FH, Santos-Jr GC, Galina A, Jasiulionis MG, Rossignol R, Rumjanek FD, Amoedo ND (2016) Enhanced OXPHOS, glutaminolysis and beta-oxidation constitute the metastatic phenotype of melanoma cells. Biochem J 473:703-15.LEAK
ROUTINE
OXPHOS
ET
F
N
S
ROX
Intact cells
Permeabilized cells
MouseEndothelial;epithelial;mesothelial cell
Other cell lines
Conner 2015 FASEB J2015Conner B, Hetrik B, Chicco A, McCurdy C (2015) Maternal obesity alters offspring muscle mitochondrial function in nonhuman primates. FASEB J 29:1036.7.LEAK
OXPHOS
FPermeabilized tissueOther mammalsSkeletal muscle
Cappel 2015 PLoS One2015Cappel DA, Lantier L, Palmisano BT, Wasserman DH, Stafford JM (2015) CETP expression protects female mice from obesity-induced decline in exercise capacity. PLoS One 10:e0136915.OXPHOSF
N
Permeabilized tissueMouseSkeletal muscle
Guadalupe-Grau 2015 J Sports Sci2015Guadalupe-Grau A, Plenge U, Helbo S, Kristensen M, Andersen PR, Fago A, Belhage B, Dela F, Helge JW (2015) Effects of an 8-weeks erythropoietin treatment on mitochondrial and whole body fat oxidation capacity during exercise in healthy males. J Sports Sci 33:570-8.LEAK
OXPHOS
F
N
NS
Other combinations
ROX
Permeabilized tissueHumanSkeletal muscle
Seillier 2015 EMBO Mol Med2015Seillier M, Pouyet L, N'Guessan P, Nollet M, Capo F, Guillaumond F, Peyta L, Dumas JF, Varrault A, Bertrand G, Bonnafous S, Tran A, Meur G, Marchetti P, Ravier MA, Dalle S, Gual P, Muller D, Rutter GA, Servais S, Iovanna JL, Carrier A (2015) Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1. EMBO Mol Med 7:802-18.ET
LEAK
OXPHOS
ROUTINE
CIV
F
NS
ROX
Intact cells
Permeabilized cells
Human
Mouse
Fibroblast
Dueregger 2015 PLoS One2015Dueregger A, Schöpf B, Eder T, Höfer J, Gnaiger E, Aufinger A, Kenner L, Perktold B, Ramoner R, Klocker H, Eder IE (2015) Differential utilization of dietary fatty acids in benign and malignant cells of the prostate. PLoS One 10(8):e0135704.LEAK
ROUTINE
OXPHOS
ET
F
N
NS
ROX
Permeabilized cells
Permeabilized tissue
HumanGenital
Other cell lines
Coen 2015 Diabetes2015Coen PM, Menshikova EV, Distefano G, Zheng D, Tanner CJ, Standley RA, Helbling NL, Dubis GS, Ritov VB, Xie H, Desimone ME, Smith SR, Stefanovic-Racic M, Toledo FG, Houmard JA, Goodpaster BH (2015) Exercise and weight loss improve muscle mitochondrial respiration, lipid partitioning, and insulin sensitivity after gastric bypass surgery. Diabetes 64:3737-50.ET
LEAK
OXPHOS
F
N
NS
Other combinations
Permeabilized tissueHumanSkeletal muscle
Janssens 2015 Nutr Metab (Lond)2015Janssens S, Heemskerk MM, van den Berg SA, van Riel NA, Nicolay K, Willems van Dijk K, Prompers JJ (2015) Effects of low-stearate palm oil and high-stearate lard high-fat diets on rat liver lipid metabolism and glucose tolerance. Nutr Metab (Lond) 12:57.LEAK
OXPHOS
F
N
Isolated mitochondriaRatLiver
Den Besten 2015 Diabetes2015den Besten G, Bleeker A, Gerding A, van Eunen K, Havinga R, van Dijk TH, Oosterveer MH, Jonker JW, Groen AK, Reijngoud DJ, Bakker BM (2015) Short-chain fatty acids protect against high-fat diet-induced obesity via a PPARγ-dependent switch from lipogenesis to fat oxidation. Diabetes 64:2398-408.LEAK
OXPHOS
FIsolated mitochondriaMouseLiver
De Andrade 2015 Exp Cell Res2015de Andrade DC, de Carvalho SN, Pinheiro D, Thole AA, Moura AS, de Carvalho L, Cortez EA (2015) Bone marrow mononuclear cell transplantation improves mitochondrial bioenergetics in the liver of cholestatic rats. Exp Cell Res 336:15-22.LEAK
OXPHOS
F
NS
Permeabilized tissueRatLiver
Siewiera 2015 Platelets2015Siewiera K, Kassassir H, Talar M, Wieteska L, Watala C (2015) Long-term untreated streptozotocin-diabetes leads to increased expression and elevated activity of prostaglandin H2 synthase in blood platelets. Platelets 27:203-11.F
ROX
RatBlood cells
Platelet
Hanssen 2015 Diabetologia2015Hanssen MJ, Wierts R, Hoeks J, Gemmink A, Brans B, Mottaghy FM, Schrauwen P, van Marken Lichtenbelt WD (2015) Glucose uptake in human brown adipose tissue is impaired upon fasting-induced insulin resistance. Diabetologia 58:586-95.LEAK
ET
FIsolated mitochondriaHumanSkeletal muscle
Koliaki 2015 Cell Metab2015Koliaki C, Szendroedi J, Kaul K, Jelenik T, Nowotny P, Jankowiak F, Herder C, Carstensen M, Krausch M, Knoefel WT, Schlensak M, Roden M (2015) Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis. Cell Metab 21:739-46.LEAK
OXPHOS
ET
F
N
NS
Other combinations
ROX
Homogenate
Isolated mitochondria
HumanLiver
Grabez 2015 J Anim Sci2015Grabež V, Kathri M, Phung V, Moe KM, Slinde E, Skaugen M, Saarem K, Egelandsdal B (2015) Protein expression and oxygen consumption rate of early postmortem mitochondria relate to meat tenderness. J Anim Sci 93:1967-79.LEAK
OXPHOS
ET
F
N
S
NS
Other combinations
ROX
Permeabilized tissueBovinesSkeletal muscle
Hanssen 2015 Nat Med2015Hanssen MJ, Hoeks J, Brans B, van der Lans AA, Schaart G, van den Driessche JJ, Jörgensen JA, Boekschoten MV, Hesselink MK, Havekes B, Kersten S, Mottaghy FM, van Marken Lichtenbelt WD, Schrauwen P (2015) Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus. Nat Med 21:863-5.LEAK
OXPHOS
ET
F
N
NS
Other combinations
Permeabilized tissueHumanSkeletal muscle
Van Ewijk 2015 Obesity (Silver Spring)2015van Ewijk PA, Paglialunga S, Kooi ME, Nunes PM, Gemmink A, Slenter J, Kornips E, Jörgensen JA, Hoeks J, Wildberger JE, Hesselink MK, Glatz JF, Heerschap A, Kersten S, Schrauwen P, Schrauwen-Hinderling VB (2015) Effects of high-fat feeding on ectopic fat storage and postprandial lipid metabolism in mouse offspring. Obesity (Silver Spring) 23:2242-50.LEAK
OXPHOS
F
N
Isolated mitochondriaMouseHeart
Liver
Hanssen 2015 Diabetes2015Hanssen MJ, van der Lans AA, Brans B, Hoeks J, Jardon KM, Schaart G, Mottaghy FM, Schrauwen P, van Marken Lichtenbelt WD (2015) Short-term cold acclimation recruits brown adipose tissue in obese humans. Diabetes 65:1179-89.LEAK
OXPHOS
ET
F
N
NS
Other combinations
Permeabilized tissueHumanSkeletal muscle
Joergensen 2015 J Cereb Blood Flow Metab2015Jørgensen T, Grunnet N, Quistorff B (2015) One-year high fat diet affects muscle-but not brain mitochondria. J Cereb Blood Flow Metab 35:943-50.LEAK
OXPHOS
F
N
S
Other combinations
Isolated mitochondriaRatSkeletal muscle
Nervous system
Johnson 2015 Aging Cell2015Johnson ML, Lalia AZ, Dasari S, Pallauf M, Fitch M, Hellerstein MK, Lanza IR (2015) Eicosapentaenoic acid but not docosahexaenoic acid restores skeletal muscle mitochondrial oxidative capacity in old mice. Aging Cell 14:734-43.LEAK
OXPHOS
F
N
S
NS
ROX
Isolated mitochondriaMouseSkeletal muscle
Antoun 2015 JIMD Rep2015Antoun G, McBride S, Vanstone JR, Naas T, Michaud J, Redpath S, McMillan HJ, Brophy J, Daoud H, Chakraborty P, Dyment D, Holcik M, Harper ME, Lines MA (2015) Detailed biochemical and bioenergetic characterization of FBXL4-related encephalomyopathic mitochondrial DNA depletion. JIMD Rep 27:1-9.LEAK
OXPHOS
ET
F
N
S
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Williams 2015 J Biol Chem2015Williams AS, Kang L, Zheng J, Grueter CA, Bracy DP, James FD, Pozzi A, Wasserman DH (2015) Integrin α1-null mice exhibit improved fatty liver when fed a high fat diet despite severe hepatic insulin resistance. J Biol Chem 290:6546-57.LEAK
OXPHOS
F
N
Permeabilized tissueMouseLiver
Other cell lines
Porter 2015 Shock2015Porter C, Herndon DN, Bhattarai N, Ogunbileje JO, Szczesny B, Szabo C, Toliver-Kinsky T, Sidossis LS (2015) Severe burn injury induces thermogenically functional mitochondria in murine white adipose tissue. Shock 44:258-64.LEAKF
N
NS
Other combinations
S
Permeabilized tissueMouseFat
Wessels 2015 Am J Physiol2015Wessels B, van den Broek NM, Ciapaite J, Houten SM, Wanders RJ, Nicolay K, Prompers JJ (2015) Carnitine supplementation in high-fat diet-fed rats does not ameliorate lipid-induced skeletal muscle mitochondrial dysfunction in vivo. Am J Physiol 309(7):E670-8.LEAK
OXPHOS
ET
F
N
Isolated mitochondriaRatSkeletal muscle
Ludzki 2015 Diabetes2015Ludzki A, Paglialunga S, Smith BK, Herbst EA, Allison MK, Heigenhauser GJ, Neufer PD, Holloway GP (2015) Rapid repression of ADP transport by palmitoyl-CoA is attenuated by exercise training in humans; a potential mechanism to decrease oxidative stress and improve skeletal muscle insulin signaling. Diabetes 64:2769-79.LEAK
OXPHOS
F
N
NS
Permeabilized tissueHuman
Mouse
Skeletal muscle
Schoettl 2015 Mol Metab2015Schöttl T, Kappler L, Fromme T, Klingenspor M (2015) Limited OXPHOS capacity in white adipocytes is a hallmark of obesity in laboratory mice irrespective of the glucose tolerance status. Mol Metab 4:631-42.LEAK
ROUTINE
OXPHOS
ET
F
N
S
ROX
Intact cells
Isolated mitochondria
MouseFat
Other cell lines
Paglialunga 2015 Diabetologia2015Paglialunga S, Ludzki A, Root-McCaig J, Holloway GP (2015) In adipose tissue, increased mitochondrial emission of reactive oxygen species is important for short-term high-fat diet-induced insulin resistance in mice. Diabetologia 58:1071-80.LEAK
OXPHOS
F
N
Permeabilized tissueMouseFat
Aroor 2015 Diabetes2015Aroor AR, Habibi J, Ford DA, Nistala R, Lastra G, Manrique C, Dunham MM, Ford KD, Thyfault JP, Parks EJ, Sowers JR, Rector RS (2015) Dipeptidyl peptidase-4 inhibition ameliorates western diet-induced hepatic steatosis and insulin resistance through hepatic lipid remodeling and modulation of hepatic mitochondrial function. Diabetes 64:1988-2001.ET
LEAK
OXPHOS
ROUTINE
F
N
NS
S
Isolated mitochondriaMouseLiver
Desprat 2015 Thesis2015Desprat JL, Teulier L, Puijalon S, Romestaing C, Dumet A, Lengagne T, Mondy N (2015) Caloric restriction and testosterone affect mitochondrial functioning and contractile properties of calling muscles in Hyla arborea.. Doctoral Thesis p153.LEAK
OXPHOS
F
NS
Permeabilized tissueAmphibiansSkeletal muscle
Van de Weijer 2015 Diabetes2015van de Weijer T, Phielix E, Bilet L, Williams EG, Ropelle ER, Bierwagen A, Livingstone R, Nowotny P, Sparks LM, Paglialunga S, Szendroedi J, Havekes B, Moullan N, Pirinen E, Hwang JH, Schrauwen-Hinderling VB, Hesselink MK, Auwerx J, Roden M, Schrauwen P (2015) Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans. Diabetes 64:1193-201.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Ramos-Filho 2015 PLoS One2015Ramos-Filho D, Chicaybam G, de-Souza-Ferreira E, Guerra Martinez C, Kurtenbach E, Casimiro-Lopes G, Galina A (2015) High intensity interval training (HIIT) induces specific changes in respiration and electron leakage in the mitochondria of different rat skeletal muscles. PLoS One 10:e0131766.LEAK
OXPHOS
ET
F
N
S
Gp
NS
ROX
Permeabilized tissueRatSkeletal muscle
Hansen 2015 Obesity (Silver Spring)2015Hansen M, Lund MT, Gregers E, Kraunsøe R, Van Hall G, Helge JW, Dela F (2015) Adipose tissue mitochondrial respiration and lipolysis before and after a weight loss by diet and RYGB. Obesity (Silver Spring) 23:2022-9.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueHumanFat
Beauchamp 2015 Biosci Rep2015Beauchamp B, Thrush AB, Quizi J, Antoun G, McIntosh N, Al-Dirbashi OY, Patti ME, Harper ME (2015) Undernutrition during pregnancy in mice leads to dysfunctional cardiac muscle respiration in adult offspring. Biosci Rep 35. pii:e00200.LEAK
OXPHOS
F
NS
Other combinations
ROX
HomogenateMouseHeart
Liver
Larsen 2015 Physiol Rep2015Larsen S, Scheede-Bergdahl C, Whitesell T, Boushel R, Bergdahl A (2015) Increased intrinsic mitochondrial respiratory capacity in skeletal muscle from rats with streptozotocin-induced hyperglycemia. Physiol Rep 3 pii:e12467.LEAK
OXPHOS
F
N
CIV
NS
Other combinations
ROX
Permeabilized tissueRatSkeletal muscle
Wessels 2015 Diabetes Obes Metab2015Wessels B, Ciapaite J, van den Broek NM, Houten SM, Nicolay K, Prompers JJ (2015) Pioglitazone treatment restores in vivo muscle oxidative capacity in a rat model of diabetes. Diabetes Obes Metab 17:52-60.LEAK
OXPHOS
ET
F
N
S
Isolated mitochondriaRatSkeletal muscle
Christiansen 2015 Am J Physiol Heart Circ Physiol2015Christiansen LB, Dela F, Koch J, Hansen CN, Leifsson PS, Yokota T (2015) Impaired cardiac mitochondrial oxidative phosphorylation and enhanced mitochondrial oxidative stress in feline hypertrophic cardiomyopathy. Am J Physiol Heart Circ Physiol 308:H1237-47.ET
LEAK
OXPHOS
CIV
F
N
NS
ROX
S
Isolated mitochondria
Permeabilized tissue
CatHeart
Skeletal muscle
Gnaiger 2015 Scand J Med Sci Sports2015Gnaiger E, Boushel R, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet JAL, Christiansen M, Helge JW, Saltin B (2015) Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and caucasians in the arctic winter. Scand J Med Sci Sports 25 (Suppl 4):126–34.ET
LEAK
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Permeabilized tissueHumanSkeletal muscle
Cedikova 2014 Evid Based Complement Alternat Med2014Cedikova M, Miklikova M, Stachova L, Grundmanova M, Tuma Z, Vetvicka V, Zech N, Kralickova M, Kuncova J (2014) Effects of the Czech propolis on sperm mitochondrial function. Evid Based Complement Alternat Med 248768.LEAK
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N
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Permeabilized cellsHumanGenital
Robach 2014 Med Sci Sports Exerc2014Robach P, Bonne T, Flück D, Bürgi S, Toigo M, Jacobs R, Lundby C (2014) Hypoxic training: effect on mitochondrial function and aerobic performance in hypoxia. Med Sci Sports Exerc 46:1936-45.FPermeabilized tissueHumanSkeletal muscle
Rauchova 2014 Int J Biochem Cell Biol2014Rauchová H, Vokurková M, Drahota Z (2014) Inhibition of mitochondrial glycerol-3-phosphate dehydrogenase by α-tocopheryl succinate. Int J Biochem Cell Biol 53:409-13.F
S
Isolated mitochondriaRat
Other mammals
Fat
Littlejohns 2014 PLoS One2014Littlejohns B, Pasdois P, Duggan S, Bond AR, Heesom K, Jackson CL, Angelini GD, Halestrap AP, Suleiman MS (2014) Hearts from mice fed a non-obesogenic high-fat diet exhibit changes in their oxidative state, calcium and mitochondria in parallel with increased susceptibility to reperfusion injury. PLoS One 9:e100579.LEAK
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Isolated mitochondriaMouseHeart
Kancirova 2014 Cardiovascular Research Supplements2014Kancirova I, Jasova M, Murarikova M, Carnicka S, Sumbalova Z, Ulicna O, Vancova O, Waczulikova I. Ziegelhoffer A, Ferko M (2014) Adaptive changes of rat heart mitochondrial respiration: response of remote ischemic preconditioning. Cardiovascular Research Supplements 103:57–94.OXPHOSF
N
Isolated mitochondriaRatHeart
Montaigne 2014 Circulation2014Montaigne D, Marechal X, Coisne A, Debry N, Modine T, Fayad G, Potelle C, El Arid JM, Mouton S, Sebti Y, Duez H, Preau S, Remy-Jouet I, Zerimech F, Koussa M, Richard V, Neviere R, Edme JL, Lefebvre P, Staels B (2014) Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in Type 2 Diabetic but not in obese patients. Circulation 130:554-64.LEAK
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Permeabilized tissueHumanHeart
Lou 2014b PLoS One2014Lou PH, Lucchinetti E, Zhang L, Affolter A, Gandhi M, Hersberger M, Warren BE, Lemieux H, Sobhi HF, Clanachan AS, Zaugg M (2014) Loss of Intralipid®- but not sevoflurane-mediated cardioprotection in early type-2 diabetic hearts of fructose-fed rats: importance of ROS signaling. PLoS One 9:e104971.LEAKF
N
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Permeabilized tissueRatHeart
Ferko 2014 Physiol Res2014Ferko M, Kancirová I, Jašová M, Čarnická S, Muráriková M, Waczulíková I, Sumbalová Z, Kucharská J, Uličná O, Ravingerová T, Ziegelhöffer A (2014) Remote ischemic preconditioning of the heart: protective responses in functional and biophysical properties of cardiac mitochondria. Physiol Res 63:469-78.LEAK
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Isolated mitochondriaRatHeart
Ost 2014 PLoS One2014Ost M, Werner F, Dokas J, Klaus S, Voigt A (2014) Activation of AMPKa2 is not crucial for mitochondrial uncoupling-induced metabolic effects but required to maintain skeletal muscle integrity. PLoS One 14:e94689.LEAK
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Permeabilized tissueMouseSkeletal muscle
Frederick 2014 J Biol Chem2014Frederick DW, Davis JG, Dávila A Jr, Agarwal B, Michan S, Puchowicz MA, Nakamaru-Ogiso E, Baur JA (2014) Increasing NAD synthesis in muscle via nicotinamide phosphoribosyltransferase is not sufficient to promote oxidative metabolism.. J Biol Chem. 290:1546-58.LEAK
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F
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Isolated mitochondriaMouseSkeletal muscle
Gjessing 2014 Thesis University of Tromso2014Gjessing PF (2014) Postoperative insulin resistance and the metabolic and cellular responses to single-dose preoperative oral carbohydrate supplementation. Thesis University of Tromso 102 pp.LEAK
OXPHOS
F
N
Isolated mitochondriaPigSkeletal muscle
Liver
Guadalupe-Grau 2014 J Sports Sci2014Guadalupe-Grau A, Plenge U, Helbo S, Kristensen M, Andersen PR, Fago A, Belhage B, Dela F, Helge JW (2014) Effects of an 8-weeks erythropoietin treatment on mitochondrial and whole body fat oxidation capacity during exercise in healthy males. J Sports Sci 26:1-9.LEAK
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Permeabilized tissueHumanSkeletal muscle
Kancirova 2014 Cardiovasc Res2014Kancirova I, Jasova M, Murarikova M, Carnicka S, Sumbalova Z, Ulicna O, Vancova O, Waczulikova I, Ziegelhoffer A, Ferko M (2014) P406Adaptive changes of rat heart mitochondrial respiration: response of remote ischemic preconditioning. Cardiovasc Res 103 Suppl 1:S74-5.OXPHOSF
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Isolated mitochondriaRatHeart
Slinde 2014 freepatentsonline.com2014Slinde E, Egelandsdal B (2014) Meat treatment and preservation method. Freepatentsonline.com 14/128207.LEAK
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Permeabilized tissueBovinesSkeletal muscle
Garratt 2014 Proc Natl Acad Sci U S A2014Garratt M, Pichaud N, Glaros EN, Kee AJ, Brooks RC (2014) Superoxide dismutase deficiency impairs olfactory sexual signaling and alters bioenergetic function in mice. Proc Natl Acad Sci U S A 111:8119-24.LEAK
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Permeabilized tissueMouseLiver
Larsen 2014 World J Diabetes2014Larsen S, Skaaby S, Helge JW, Dela F (2014) Effects of exercise training on mitochondrial function in patients with type 2 diabetes. World J Diabetes 5:482-92.OXPHOSFPermeabilized tissueHumanSkeletal muscle
Rudnicki 2014 United States Patent Application Publication2014Rudnicki MA, Yin Hang (2014) MICRORNA INHIBITORS. United States Patent Application Publication 1-49.LEAK
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Intact cells
Permeabilized cells
MouseSkeletal muscle
Fat
Ambrosio 2014 Free Radic Biol Med2014Ambrosio F, Brown E, Stolz D, Ferrari R, Goodpaster BH, Deasy B, Distefano G, Roperti A, Cheikhi A, Garciafigueroa Y, Barchowsky A (2014) Arsenic induces sustained impairment of skeletal muscle and muscle progenitor cell ultrastructure and bioenergetics. Free Radic Biol Med 74C:64-73.LEAK
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Permeabilized tissueMouseSkeletal muscle
Koenemann 2014 Dissertation2014Koenemann B (2014) Einfluss der Hyperglykämie auf die mitochondriale Atmung von Leberzellen septischer Mäuse mit und ohne Imeglimin. PhD Thesis 1-61.LEAK
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ROX
HomogenateMouseLiver
Cavalcanti-de-Albuquerque 2014 J Appl Physiol2014Cavalcanti-de-Albuquerque JP, Salvador IC, Martins EL, Jardim-Messeder D, Werneck-de-Castro JP, Galina A, Carvalho DP (2014) Role of estrogen on skeletal muscle mitochondrial function in ovariectomized rats: a time course study in different fiber types. J Appl Physiol 116:779-89.LEAK
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Permeabilized tissueRatSkeletal muscle
Kivelae 2014 EMBO Mol Med2014Kivelä R, Bry M, Robciuc MR, Räsänen M, Taavitsainen M, Silvola JM, Saraste A, Hulmi JJ, Anisimov A, Mäyränpää MI, Lindeman JH, Eklund L, Hellberg S, Hlushchuk R, Zhuang ZW, Simons M, Djonov V, Knuuti J, Mervaala E, Alitalo K (2016) VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart. EMBO Mol Med 6:307-21.LEAK
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HomogenateRatHeart
Van Bree 2014 PhD Thesis2014van Bree B (2014) Mitochondria, lipotoxicity and skeletal muscle metabolism: implications for type 2 diabetes mellitus. PhD Thesis 1-150.LEAK
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Isolated mitochondriaMouseSkeletal muscle
Williams 2014 PLoS One2014Williams CB, Hughes MC, Edgett BA, Scribbans TD, Simpson CA, Perry CG, Gurd BJ (2014) An examination of resveratrol's mechanisms of action in human tissue: impact of a single dose in vivo and dose responses in skeletal muscle ex vivo. PLoS One 9:e102406.OXPHOSF
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Permeabilized tissueHumanSkeletal muscle
Divakaruni 2014 Curr Protoc Toxicol2014Divakaruni AS, Rogers GW, Murphy AN (2014) Measuring mitochondrial function in permeabilized cells using the Seahorse XF Analyzer or a clark-type oxygen electrode. Curr Protoc Toxicol 60:25.2.1-25.2.16.LEAK
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Permeabilized cellsMouseSkeletal muscle
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Ludzki 2014 Thesis2014Ludzki AC (2014) Palmitoyl-CoA inhibition of mitochondrial ADP sensitivity is attenuated by exercise training in human skeletal muscle. Master's Thesis 1-86.LEAK
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Permeabilized tissueHuman
Mouse
Skeletal muscle
Chicco 2014 J Exp Biol2014Chicco AJ, Le CH, Schlater AE, Nguyen AD, Kaye SD, Beals JW, Scalzo RL, Bell C, Gnaiger E, Costa DP, Crocker DE, Kanatous SB (2014) High fatty acid oxidation capacity and phosphorylation control despite elevated leak and reduced respiratory capacity in northern elephant seal muscle mitochondria. J Exp Biol 217:2947-55.LEAK
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Permeabilized tissueHuman
Other mammals
Skeletal muscle
Abdurrachim 2014 Biochim Biophys Acta2014Abdurrachim D, Ciapaite J, Wessels B, Nabben M, Luiken JJ, Nicolay K, Prompers JJ (2014) Cardiac diastolic dysfunction in high-fat diet fed mice is associated with lipotoxicity without impairment of cardiac energetics in vivo. Biochim Biophys Acta 1842:1525-37.LEAK
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Isolated mitochondriaMouseHeart
Gnaiger 2014 MitoPathways2014
O2k-Protocols
Gnaiger E (2014) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 4th ed. Mitochondr Physiol Network 19.12. Oroboros MiPNet Publications, Innsbruck:80 pp.
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Permeabilized cells
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Homogenate
Isolated mitochondria
Human
Mouse
Heart
Skeletal muscle
Fibroblast
Boushel 2014 Acta Physiol (Oxf)2014Boushel RC, Ara I, Gnaiger E, Helge JW, Gonzalez-Alonzo J, Munck-Andersen T, Sondergaard H, Damsgaard R, van Hall G, Saltin B, Calbet JA (2014) Low intensity training increases peak arm VO2 by enhancing both convective and diffusive O2 delivery. Acta Physiol (Oxf) 211:122-34.LEAK
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Permeabilized tissueHumanSkeletal muscle
Cahova 2014 Appl Physiol Nutr Metab2014Cahova M, Chrastina P, Hansikova H, Drahota Z, Trnovska J, Skop V, Spacilova J, Malinska HOliyarnyk O, Papackova Z, Palenickova E,Kazdova L (2014) Carnitine supplementation alleviates lipid metabolism derangements and protects against oxidative stress in non-obese hereditary hypertriglyceridemic rats. Appl Physiol Nutr Metab 40:280-91.OXPHOSF
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Isolated mitochondriaRatLiver
Ryan 2014 J Physiol2014Ryan TE, Brophy P, Lin CT, Hickner RC, Neufer PD (2014) Assessment of in vivo skeletal muscle mitochondrial respiratory capacity in humans by near-infrared spectroscopy: a comparison with in situ measurements. J Physiol 592:3231-41.LEAK
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Permeabilized tissueHumanSkeletal muscle
Casanova 2014 J Nutr Biochem2014Casanova E, Baselga-Escudero L, Ribas-Latre A, Cedó L, Arola-Arnal A, Pinent M, Bladé C, Arola L, Salvadó MJ (2014) Chronic intake of proanthocyanidins and docosahexaenoic acid improves skeletal muscle oxidative capacity in diet-obese rats. J Nutr Biochem 25:1003–10.LEAK
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Isolated mitochondriaRatSkeletal muscle
Yin 2013 Cell Metab2013Yin H, Pasut A, Soleimani VD, Bentzinger CF, Antoun G, Thorn S, Seale P, Fernando P, van Ijcken W, Grosveld F, Dekemp RA, Boushel RC, Harper ME, Rudnicki MA (2013) MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16. Cell Metab 17:210-24.FIntact cells
Permeabilized tissue
MouseSkeletal muscle
Fat
Jacobs 2013 J Gerontol A Biol Sci Med Sci2013Jacobs R, Diaz V, Soldini L, Haider T, Thomassen M, Nordsborg NB, Gassmann M, Lundby C (2013) Fast-twitch glycolytic skeletal muscle is predisposed to age-induced impairments in mitochondrial function. J Gerontol A Biol Sci Med Sci 68:1010-22.LEAK
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Permeabilized tissueMouseSkeletal muscle
Roy 2013 PLoS One2013Roy C, Paglialunga S, Schaart G, Moonen-Kornips E, Meex RC, Phielix E, Hoeks J, Hesselink MK, Cianflone K, Schrauwen P (2013) Relationship of C5L2 receptor to skeletal muscle substrate utilization. PLoS One 8:e57494.F
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Isolated mitochondriaHuman
Mouse
Skeletal muscle
Van Eunen 2013 PLoS Comput Biol2013van Eunen K, Simons SM, Gerding A, Bleeker A, den Besten G, Touw CM, Houten SM, Groen BK, Krab K, Reijngoud DJ, Bakker BM (2013) Biochemical competition makes fatty-acid β-oxidation vulnerable to substrate overload. PLoS Comput Biol 9:e1003186.ETF
N
Isolated mitochondriaRatLiver
Jaburek 2013 Int J Biochem Cell Biol2013Jabůrek M, Ježek J, Zelenka J, Ježek P (2013) Antioxidant activity by a synergy of redox-sensitive mitochondrial phospholipase A2 and uncoupling protein-2 in lung and spleen. Int J Biochem Cell Biol 45:816-25.F
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Isolated mitochondriaMouse
Wohlwend 2013 Thesis2013Wohlwend M (2013) Mitochondrial function in health and disease - high-resolution respirometry in rats inbred for high vs. low running capacity. Thesis Norwegian University of Science and Technology - Trondheim: 44pp.LEAK
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Permeabilized tissueRatHeart
Skeletal muscle
Kiebish 2013 J Lipid Res2013Kiebish MA, Yang K, Liu X, Mancuso DJ, Guan S, Zhao Z, Sims HF, Cerqua R, Cade WT, Han X, Gross RW (2013) Dysfunctional cardiac mitochondrial bioenergetic, lipidomic, and signaling in a murine model of Barth syndrome. J Lipid Res 54:1312-25.LEAK
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Isolated mitochondriaMouseHeart
Felser 2013 Toxicol Sci2013Felser A, Blum K, Lindinger PW, Bouitbir J, Kraehenbuehl S (2013) Mechanisms of hepatocellular toxicity associated with dronedarone - a comparison to amiodarone. Toxicol Sci 131:480-90.F
N
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Isolated mitochondriaHuman
Rat
Liver
Jacobs 2013 J Appl Physiol2013Jacobs R, Flück D, Bonne TC, Bürgi S, Christensen PM, Toigo M, Lundby C (2013) Improvements in exercise performance 1 with high-intensity interval training 2 coincide with an increase in skeletal muscle mitochondrial content and function. J Appl Physiol 115:785-93.LEAK
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CIV
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Permeabilized tissueHumanSkeletal muscle
Wone 2013 Comp Biochem Physiol A Mol Integr Physiol2013Wone BW, Donovan ER, Cushman JC, Hayes JP (2013) Metabolic rates associated with membrane fatty acids in mice selected for increased maximal metabolic rate. Comp Biochem Physiol A Mol Integr Physiol 165:70-8.FMouse
Jacobs 2013 Am J Physiol Endocrinol Metab2013Jacobs R, Meinild AK, Nordsborg NB, Lundby C (2013) Lactate oxidation in human skeletal muscle mitochondria. Am J Physiol Endocrinol Metab 304:686-94.LEAK
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Permeabilized tissueHumanSkeletal muscle
Lanza 2013 Am J Physiol Endocrinol Metab2013Lanza IR, Blachnio-Zabielska A, Johnson ML, Schimke JM, Jakaitis DR, Lebrasseur NK, Jensen MD, Sreekumaran Nair K, Zabielski P (2013) Influence of fish oil on skeletal muscle mitochondrial energetics and lipid metabolites during high-fat diet. Am J Physiol Endocrinol Metab 304:E1391-403.LEAK
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Isolated mitochondriaMouseSkeletal muscle
Jacobs 2013 Exp Physiol2013Jacobs R, Boushel RC, Wright-Paradis C, Calbet JA, Robach P, Gnaiger E, Lundby C (2013) Mitochondrial function in human skeletal muscle following high altitude exposure. Exp Physiol 98:245-55.LEAK
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Permeabilized tissueHumanSkeletal muscle
Larsen 2012 J Physiol2012Larsen S, Nielsen J, Neigaard Nielsen C, Nielsen LB, Wibrand F, Stride N, Schroder HD, Boushel RC, Helge JW, Dela F, Hey-Mogensen M (2012) Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects. J Physiol 590:3349-60.LEAK
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Permeabilized tissueHumanSkeletal muscle
Kwak 2012 Free Radic Biol Med2012Kwak HB, Thalacker-Mercer A, Anderson EJ, Lin CT, Kane DA, Lee NS, Cortright RN, Bamman MM, Neufer PD (2012) Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes. Free Radic Biol Med 52:198-207.LEAK
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HumanSkeletal muscle
Other cell lines
Stephenson 2012 J Appl Physiol (1985)2012Stephenson EJ, Stepto NK, Koch LG, Britton SL, Hawley JA (2012) Divergent skeletal muscle respiratory capacities in rats artificially selected for high and low running ability: a role for Nor1? J Appl Physiol (1985) 113:1403-12.LEAK
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ROX
Permeabilized tissueRatSkeletal muscle
Pesta 2012 Methods Mol Biol2012
O2k-Protocols
Pesta D, Gnaiger E (2012) High-resolution respirometry. OXPHOS protocols for human cells and permeabilized fibres from small biopsies of human muscle. Methods Mol Biol 810:25-58.
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HumanFibroblast
HEK
HUVEC
Other cell lines
Skeletal muscle
Lou 2012 Cardiovasc Res2012Lou PH, Zhang L, Lucchinetti E, Heck M, Affolter A, Gandhi M, Kienesberger PC, Hersberger M, Clanachan AS, Zaugg M (2012) Infarct-remodeled hearts with limited oxidative capacity boost fatty acid oxidation after conditioning against ischemia/reperfusion injury. Cardiovasc Res 97:251-61.OXPHOSF
N
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Permeabilized tissueRatHeart
Stride 2012 Front Physiol2012Stride N, Larsen S, Treebak JT, Hansen CN, Hey-Mogensen M, Speerschneider T, Jensen TE, Jeppesen J, Wojtaszewski JF, Richter EA, Køber L, Dela F (2012) 5'-AMP activated protein kinase is involved in the regulation of myocardial β-oxidative capacity in mice. Front Physiol 3:33.OXPHOSFPermeabilized tissueMouseHeart
Hoeks 2012 J Cell Physiol2012Hoeks J, Arany Z, Phielix E, Moonen-Kornips E, Hesselink MK, Schrauwen P (2012) Enhanced lipid -but not carbohydrate- supported mitochondrial respiration in skeletal muscle of PGC-1α overexpressing mice. J Cell Physiol 227:1026-33.LEAK
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Isolated mitochondriaMouseSkeletal muscle
Joergensen 2012 Am J Physiol Endocrinol Metab2012Jørgensen W, Jelnes P, Rud KA, Hansen LL, Grunnet N, Quistorff B (2012) Progression of type 2 diabetes in GK rats affects muscle and liver mitochondria differently: pronounced reduction of Complex II flux is observed in liver only. Am J Physiol Endocrinol Metab 303:E515-23.LEAK
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RatLiver
Skeletal muscle
Pajuelo-Reguera 2011 Br J Nutr2011Pajuelo-Reguera D, Quesada H, Díaz S, Fernández-Iglesias A, Arola-Arnal A, Bladé C, Salvadó J, Arola L (2011) Chronic dietary supplementation of proanthocyanidins corrects the mitochondrial dysfunction of brown adipose tissue caused by diet-induced obesity in Wistar rats. Br J Nutr 28:1-9.LEAK
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Isolated mitochondriaRatFat
Pesta 2011 Am J Physiol Regul Integr Comp Physiol2011Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Similar qualitative and quantitative changes of mitochondrial respiration following strength and endurance training in normoxia and hypoxia in sedentary humans. Am J Physiol Regul Integr Comp Physiol 301:R1078–87.ET
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Permeabilized tissueHumanSkeletal muscle
Witkowski 2011 J Biol Chem2011Witkowski A, Thweatt J, Smith S (2011) Mammalian ACSF3 protein is a malonyl-CoA synthetase that supplies the chain extender units for mitochondrial fatty acid synthesis. J Biol Chem 286:33729-36.FIsolated mitochondriaHumanHEK
Lemieux 2011 Int J Biochem Cell Biol2011Lemieux H, Semsroth S, Antretter H, Höfer D, Gnaiger E (2011) Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heart. Int J Biochem Cell Biol 43:1729–38.LEAK
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Permeabilized tissueHumanHeart
Boyle 2011 Int J Obes2011Boyle KE, Zheng D, Anderson EJ, Neufer PD, Houmard JA (2011) Mitochondrial lipid oxidation is impaired in cultured myotubes from obese humans. Int J Obes 36:1025-31.FPermeabilized cellsHumanSkeletal muscle
Jacobs 2011 J Appl Physiol2011Jacobs R, Rasmussen P, Siebenmann C, Díaz V, Pesta D, Gnaiger E, Nordsborg NB, Robach P, Lundby C (2011) Determinants of time trial performance and maximal incremental exercise in highly trained endurance athletes. J Appl Physiol 111:1422–30.LEAK
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Permeabilized tissueHumanSkeletal muscle
Timmers 2011 Cell Metab2011Timmers S, Konings E, Bilet L, Houtkooper RH, van de Weijer T, Goossens GH, Hoeks J, van der Krieken S, Ryu D, Kersten S, Moonen-Kornips E, Hesselink MK, Kunz I, Schrauwen-Hinderling VB, Blaak EE, Auwerx J, Schrauwen P (2011) Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab 14:612-22.ET
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Permeabilized tissueHumanSkeletal muscle
Remels 2010 Mol Cell Endocrinol2010Remels AH, Langen RC, Schrauwen P, Schaart G, Schols AM, Gosker HR (2010) Regulation of mitochondrial biogenesis during myogenesis. Mol Cell Endocrinol 315:113-20.ROUTINE
OXPHOS
ET
FPermeabilized cellsMouse
Rat
Skeletal muscle
Other cell lines
Hoeks 2010 Diabetes2010Hoeks J, van Herpen NA, Mensink M, Moonen-Kornips E, van Beurden D, Hesselink MK, Schrauwen P (2010) Prolonged fasting identifies skeletal muscle mitochondrial dysfunction as consequence rather than cause of human insulin resistance. Diabetes 59:2117-25.LEAK
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Permeabilized tissueHumanSkeletal muscle
Henique 2010 J Biol Chem2010Henique C, Mansouri A, Fumey G, Lenoir V, Girard J, Bouillaud F, Prip-Buus C, Cohen I (2010) Increased mitochondrial fatty acid oxidation is sufficient to protect skeletal muscle cells from palmitate-induced apoptosis. J Biol Chem 285:36818-27.FIntact cellsMouseSkeletal muscle
Other cell lines
Tahara 2009 Free Radic Biol Med2009Tahara EB, Navarete FD, Kowaltowski AJ (2009) Tissue-, substrate-, and site-specific characteristics of mitochondrial reactive oxygen species generation. Free Radic Biol Med 46:1283-97.LEAK
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Isolated mitochondriaRatHeart
Skeletal muscle
Nervous system
Liver
Kidney
Kwon 2009 Thesis2009Kwon OS (2009) Effect of acute exercise or fasting on mitochondrial function and high fat diet-induced insulin resistance. PhD Thesis 46.LEAK
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Permeabilized tissueRatSkeletal muscle
Flamment 2009 Am J Physiol Endocrinol Metab2009Flamment M, Gueguen N, Wetterwald C, Simard G, Malthièry Y, Ducluzeau PH (2009) Effects of the cannabinoid CB1 antagonist rimonabant on hepatic mitochondrial function in rats fed a high-fat diet. Am J Physiol Endocrinol Metab 297:E1162-70.LEAK
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Isolated mitochondriaRatLiver
Hoeks 2008 FEBS Lett2008Hoeks J, Briedé JJ, de Vogel J, Schaart G, Nabben M, Moonen-Kornips E, Hesselink MK, Schrauwen P (2008) Mitochondrial function, content and ROS production in rat skeletal muscle: Effect of high-fat feeding. FEBS Lett 582:510-16.ROUTINE
OXPHOS
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Isolated mitochondriaRatSkeletal muscle
Cervinkova 2008 Physiol Res2008Cervinková Z, Rauchová H, Kriváková P, Drahota Z (2008) Inhibition of palmityl carnitine oxidation in rat liver mitochondria by tert-butyl hydroperoxide. Physiol Res 57:133-6.F
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Giulivi 2008 Biochem J2008Giulivi C, Ross-Inta C, Horton AA, Luckhart S (2008) Metabolic pathways in Anopheles stephensi mitochondria. Biochem J 415:309-16.LEAK
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ROX
Isolated mitochondriaHuman
Rat
Birds
Hexapods
Skeletal muscle
Gnaiger 2007 MitoPathways2007
O2k-Protocols
Gnaiger E ed (2007) Mitochondrial Pathways and Respiratory Control. Oroboros MiPNet Publications, Innsbruck:96 pp. Electronic 1st ed ISBN 978-3-9502399-0-4 (see 4th edition: Gnaiger 2014 MitoPathways).
F
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Toleikis 2005 Biosci Rep2005Toleikis A, Trumbeckaite S, Majiene D (2005) Cytochrome C effect on respiration of heart mitochondria: influence of various factors. Biosci Rep 25:387-97.LEAK
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Rat
Rabbit
Heart
Rasmussen 2001 Am J Physiol Endocrinol Metab2001Rasmussen UF, Rasmussen HN, Krustrup P, Quistorff B, Saltin B, Bangsbo J (2001) Aerobic metabolism of human quadriceps muscle: in vivo data parallel measurements on isolated mitochondria. Am J Physiol Endocrinol Metab 280:E301-7.LEAK
OXPHOS
ET
F
N
S
Gp
NS
Isolated mitochondriaHumanSkeletal muscle
Moyes 1990 Am J Physiol1990Moyes CD, Buck LT, Hochachka PW (1990) Mitochondrial and peroxisomal fatty acid oxidation in elasmobranchs. Am J Physiol 258:R756-62.OXPHOSFIsolated mitochondriaFishesHeart
Skeletal muscle
Moyes 1989 J Exp Biol1989Moyes CD, Buck LT, Hochachka PW, Suarez RK (1989) Oxidative properties of carp red and white muscle. J Exp Biol 143:321-31.OXPHOSF
N
Gp
Isolated mitochondriaSkeletal muscle
Vamecq 1987 Biochem J1987Vamecq J, Schepers L, Parmentier G, Mannaerts GP (1987) Inhibition of peroxisomal fatty acyl-CoA oxidase by antimycin A. Biochem J 248:603-7.F
ROX
Oxidase;biochemical oxidation
Boveris 1973 Biochem J1973Boveris A, Chance B (1973) The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem J 134:707-16.LEAK
OXPHOS
ET
F
N
S
NS
Isolated mitochondriaRat
Birds
Heart


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»Abstracts: FAO, F-pathway control state
Publications in the MiPMap
Sort in ascending/descending order by a click on one of the small symbols in squares below.
 YearReferenceCouplingPathwayPreparationOrganismTissue;cell
Kandel 2019 Biophys J2019Kandel SM, Tomar N, Zheleznova N, Audi SH, Cowley Jr AW, Dash RK (2019) Calcium stimulation of mitochondrial respiration is substrate dependent and tissue specific. Biophys J.LEAK
OXPHOS
F
N
S
Isolated mitochondriaRatHeart
Kidney
Nemec 2018 MiP20182018
Michal Nemec
Aerobic/strength exercise intervention modulates skeletal muscle mitochondrial function in seniors.
LEAKF
N
NS
Other combinations
Permeabilized tissueHumanSkeletal muscle
Schoepf 2018 33rd Annual EAU Congress Copenhagen2018Shift of mitochondrial oxidative phosphorylation is associated with mtDNA mutational load in primary prostate cancer tissue.LEAK
OXPHOS
ET
F
N
NS
Other combinations
ROX
Permeabilized cells
Permeabilized tissue
HumanGenital
Gnaiger 2018 MiP20182018
Erich Gnaiger
Mitochondrial respiratory control by fuel substrates and specific inhibitors of respiratory enzymes: Building blocks of mitochondrial physiology Part 2.
OXPHOSN
F
S
Gp
DQ
CIV
NS
Other combinations
Chicco 2018 MiP2018b2018
Adam J Chicco
Defective cardiolipin remodeling and cardiac mitochondrial dysfunction: supercomplexes or just complex?
OXPHOSF
N
NS
Permeabilized tissueMouseHeart
Doerrier 2018 ESCI20182018
Carolina Anneliese Doerrier
High-resolution respirometry, two techniques combined in one to explore mitochondrial function in health and disease
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
ROX
CIV
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Skeletal muscle
Nervous system
Blood cells
HEK
Doerrier 2018 MiP2018b2018
Carolina Doerrier
Evaluation of anaplerotic pathways to avoid artefacts in respirometric measurement of fatty acid oxidation.
OXPHOSF
N
Homogenate
Isolated mitochondria
Permeabilized cells
Human
Mouse
Blood cells
HEK
Heart
Nervous system
Platelet
Votion 2018 MiP20182018
Dominique-Marie Votion
Functional diagnosis of mitochondrial defects in equine atypical myopathy and targeted mitochondrial therapy: a preliminary study.
OXPHOSF
N
S
NS
Intact cellsHorseSkeletal muscle
Doerrier 2018 EBEC20182018
Carolina Anneliese Doerrier
Respiratory mapping of mitochondrial pathways for establishing a database of mitochondrial physiology.
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Permeabilized cells
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Nervous system
Blood cells
HEK
Platelet
Gnaiger 2018 MiPschool Tromso A12018
Erich Gnaiger
Mitochondrial states and rates: 1. Electron transfer pathways and respiratory control. 2. Coupling control.
LEAK
ET
OXPHOS
F
N
S
Gp
DQ
CIV
NS
Other combinations
Keller 2018 MiP20182018
Markus A Keller
The structural molecular diversity of mitochondrial cardiolipins.
F
N
Intact cellsMouseHeart
Nervous system
Stankova 2018 MiP20182018
Pavla Krivakova-Stankova
Impact of western diet on energy metabolism in mouse liver.
OXPHOS
ET
S
F
N
HomogenateMouseLiver
Konopka 2018 FASEB J2018Konopka AR, Castor WM, Reid J, Schoenberg H, Laurin J, Wolff C, Hamilton K, Miller B (2018) Metformin blunts exercise-induced improvements in skeletal muscle mitochondrial respiration independent of changes in mitochondrial biogenesis. FASEB J.OXPHOS
ET
F
N
NS
Permeabilized tissueHumanSkeletal muscle
McCurdy 2018 Endocrine Reviews2018McCurdy CE, True C, Takahashi D, Hetrick B, Varlamov O, Roberts CT (2018) Chronic hyperandrogenemia impairs oxidative metabolism in skeletal muscle from adolescent female rhesus macaques. Endocrine Reviews.ETFPermeabilized tissueOther mammalsSkeletal muscle
Pereira da Silva Grilo da Silva 2018 MiP20182018
Filomena Pereira da Silva Grilo da Silva
The unspecific effect of etomoxir on mitochondrial respiration.
OXPHOS
ET
F
N
S
NS
Other combinations
Permeabilized cells
Isolated mitochondria
Human
Mouse
Nervous system
Liver
Other cell lines
Chang 2018 Life Sciences Meeting 2018 Innsbruck AT2018pH dependence of mitochondrial respiration and H2O2 production in oral cancer cells – a pilot study.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Permeabilized cellsHumanHEK
Kidney
Makrecka-Kuka 2018 MiP20182018
Marina Makrecka-Kuka
Fatty acid oxidation in brain: from aging to ischemia and sepsis.
OXPHOSFHomogenateMouse
Rat
Nervous system
Gnaiger 2017 MiPschool A42017
Gnaiger Erich.jpg
Respiratory pathway control in mitochondrial core energy metabolism: from bioenergetics to mitochondrial physiology.
F
N
S
Gp
CIV
NS
Other combinations
ROX
Permeabilized cells
Permeabilized tissue
Isolated mitochondria
Collins 2017 MiPschool Obergurgl2017
COST Action MitoEAGLE
The effects of a Mediterranean versus Western diet on nonhuman primate skeletal muscle bioenergetics.
OXPHOSF
N
S
Gp
CIV
NS
ROX
Intact cells
Dubouchaud 2017 Abstract MITOEAGLE Barcelona2017
COST Action MITOEAGLE
Impact of high-fat diet or PUFAs consumption on the mitochondrial function.
OXPHOSF
N
Permeabilized tissue
Isolated mitochondria
RatSkeletal muscle
Liver
Urban 2017 MiP20172017
MiPsociety
Kinetics of inhibition of energy metabolism pathways by propofol in human skeletal muscle homogenates.
F
N
NS
HomogenateHumanSkeletal muscle
Doerrier 2017 MiPschool C22017
DoerrierC.JPG
Substrate-uncoupler-inhibitor titration (SUIT) protocols – fundamental principles.
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
Permeabilized cells
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Nervous system
HEK
Distefano 2017 MiPschool Obergurgl2017
Giovanna Distefano
Effects of calorie restriction-induced weight loss and exercise on skeletal muscle mitochondrial energetics of older obese subjects.
LEAK
OXPHOS
ET
F
NS
Permeabilized tissueHumanSkeletal muscle
Nemec 2017 Abstract MITOEAGLE Barcelona2017
COST Action MITOEAGLE
Functional state of mitochondria in patients with preclinical cognitive deficit.
OXPHOS
ET
FPermeabilized tissueHumanSkeletal muscle
Doerrier 2017 MiP2017 C12017
Carolina Anneliese Doerrier
Effects of warm ischemia on cardiac mitochondria to detect specific targets by high-resolution respirometry (HRR)
LEAK
ET
F
N
S
CIV
NS
Isolated mitochondriaMouseHeart
Scheiber 2017 Europ Heart J2017High-resolution respirometry in human endomyocardial biopsies to assess myocardial mitochondrial function.OXPHOSF
N
NS
Permeabilized tissueHumanHeart
O'Brien 2017 Abstract IOC1222017PPARα independent effects of nitrate supplementation on skeletal muscle mitochondrial function in hypoxia.LEAK
OXPHOS
FMouseSkeletal muscle
Doerrier 2017 Abstract MitoEAGLE Barcelona2017
COST Action MitoEAGLE
SUIT reference protocol for comparative mitochondrial physiology.
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
Permeabilized cells
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Nervous system
HEK
Hoppel 2017 MiP20172017
Charles Hoppel
Pathways of mitochondrial fatty acid oxidation. Hoppel_Presentation
OXPHOSF
N
S
RatLiver
Nakajima 2017 Europ Heart J2017Mitochondrial dysfunction in epicardial adipose tissue; possible role in progression of coronary artery disease.OXPHOSF
N
NS
Permeabilized tissueHumanFat
Isola 2017 MiPschool Obergurgl2017
Isola Raffa recente piccola.jpg
Do mitochondria counteract diabetes impairment by means of morphological and physiological strategies?
OXPHOSF
N
Isolated mitochondriaRat
Holzknecht 2017 MiPschool Obergurgl2017
COST Action MitoEAGLE
Metabolic characterization of Fahd1 knock-out cardiomyocytes in a mammalian model organism - an outlook.
F
N
MouseHeart
Wu 2017 FASEB J2017Effects of eccentric and concentric cycling exercise regimens on hypoxia-mediated mitochondrial bioenergetics of platelets in sedentary males.F
N
S
Gp
HumanBlood cells
Platelet
Brazdova 2017 MiP20172017
Brazdova Andrea
Pleiotropic effects of biguanides on mitochondrial reactive oxygen species production.
F
N
NS
Isolated mitochondriaFat
Waldauf 2017 MITOEAGLE Obergurgl2017
COST Action MitoEAGLE
Effect of propofol on energy metabolism in an in vitro model of human skeletal muscle homogenates.
LEAK
OXPHOS
ET
F
N
S
CIV
NS
HomogenateHumanSkeletal muscle
Ukropec 2017 MITOEAGLE Obergurgl2017
COST Action MitoEAGLE
Could functional state of muscle mitochondria reflect exercise-induced changes in insulin sensitivity, glucose tolerance and cognitive performance in individuals with mild cognitive impairment?
LEAK
OXPHOS
ET
F
N
S
Gp
NS
Permeabilized cellsSkeletal muscle
Amick 2017 MiPschool Obergurgl2017
Amick picture.jpg
Bioenergetic profiling of mitochondria isolated from three distinct brain regions relevant to AD pathology in non-human primates.
LEAK
OXPHOS
F
N
Isolated mitochondriaOther mammalsNervous system
Sobotka 2017 Abstract MITOEAGLE Barcelona2017
COST Action MITOEAGLE
The effect of 24 weeks of high-fat and high-cholesterol diet on rat liver mitochondria. Sobotka_Presentation
OXPHOS
ET
F
N
S
Gp
ROX
Isolated mitochondriaRatLiver
Lemieux 2017 MiP20172017
Helene Lemieux
Compounding effects of age and sexual dimorphism on cardiac mitochondrial function in type 2 diabetes.
OXPHOSF
CIV
Permeabilized tissueRatHeart
Sumbalova 2016b Abstract MitoFit Science Camp 20162016Human blood cells: isolation and HRR.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Lymphocyte
Platelet
Makrecka-Kuka 2016 Abstract MitoFit Science Camp 20162016Long-chain acylCoAs vs acylcarnitines in mitochondrial bioenergetics: from in vitro to in vivo.OXPHOSFIsolated mitochondriaRatHeart
Garcia-Souza 2016 Abstract Mito Xmas Meeting Innsbruck2016Assessment of fatty acid oxidation in mouse brain and liver mitochondria.OXPHOSF
N
Homogenate
Isolated mitochondria
Nervous system
Liver
Chicco 2016b Abstract MitoFit Science Camp 20162016OXPHOS coupling efficiency of permeabilized muscle fibers predicts metabolic efficiency of subjects exercising at 5260 m.LEAK
OXPHOS
ET
F
N
Permeabilized tissueHumanSkeletal muscle
Lamberti 2016 Abstract MitoFit Science Camp 20162016Development of a reference sample for HRR.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
HumanKidney
HEK
Doerrier 2016b Abstract Mito Xmas Meeting Innsbruck2016Searching for specific targets of ischemic damage of cardiac mitochondria using O2k-Fluorometry.LEAK
OXPHOS
ET
F
N
S
Gp
CIV
ROX
Isolated mitochondriaMouseHeart
Osiki 2016 Abstract MitoFit Science Camp 20162016Suitability of octanoylcarnitine & malate for assessment of beta oxidation capacity by respirometry in aconitase-inhibited samples.OXPHOS
ET
F
N
Other combinations
RatSkeletal muscle
Sobotka 2016 Abstract IOC1162016Sobotka O, Kucera O, Stankova P, Endlicher R, Nozickova K, Banni A, Cervinkova Z (2016) Mitochondrial respiration in fatty liver. Mitochondr Physiol Network 21.11ET
LEAK
OXPHOS
CIV
F
Gp
N
NS
Other combinations
ROX
S
Isolated mitochondriaRatLiver
Doerrier 2016 Abstract MitoFit Science Camp 20162016Development of a SUIT reference protocol for OXPHOS analysis by high-resolution respirometry.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Blood cells
HEK
Platelet
Krajcova 2016 Abstract MitoFit Science Camp 20162016Mitochondrial pathogenesis of propofol infusion syndrome in an in vitro model of human skeletal muscle.LEAK
ET
FHomogenateHumanSkeletal muscle
Cecatto 2016 Abstract IOC1162016Cecatto C, Silva JC, Wajner A, Godoy KS, Ribeiro, RT, Amaral AU, Wajner M (2016) cis-4-Decenoic and decanoic acids impair mitochondrial energy, redox and Ca2+ homeostasis and induce mitochondrial permeability transition pore opening in rat brain and liver. Mitochondr Physiol Network 21.11LEAK
OXPHOS
ET
F
N
CIV
Other combinations
Permeabilized tissue
Isolated mitochondria
RatNervous system
Liver
Kane 2016 Abstract MitoFit Science Camp 20162016Effects of inhibiting myosin-ATPase on mitochondrial respiratory capacity in permeabilized skeletal muscle.OXPHOSF
N
Permeabilized tissueRatSkeletal muscle
Chicco 2016c Abstract MitoFit Science Camp 20162016Investigating the mechanism of cardiac mitochondrial respiratory impairment in Barth Syndrome.OXPHOSF
N
S
CIV
Other combinations
MouseHeart
Sumbalova 2016 Abstract Mito Xmas Meeting Innsbruck2016Methods for evaluation of mitochondrial membrane potential with multi-sensor high-resolution respirometry: potentiometry vs fluorometry.LEAK
OXPHOS
ET
F
N
S
NS
ROX
MouseNervous system
Gnaiger 2016 Abstract UMDF20162016Schöpf B, Schäfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E (2016) Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells.LEAK
OXPHOS
ET
F
N
NS
Permeabilized cells
Permeabilized tissue
HumanEndothelial;epithelial;mesothelial cell
Genital
Other cell lines
Fibroblast
Laner 2016 Abstract MitoFit Science Camp 20162016OXPHOS and ET-capacity in permeabilized fibres of canine superathletes. Analysis of HRR data presenting unexpected challenges.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueDogSkeletal muscle
Hoppel 2016a Abstract MitoFit Science Camp 20162016Skeletal muscle mitochondria in diagnostic studies.F
N
Other combinations
Isolated mitochondriaHumanSkeletal muscle
Liver
Laner 2016 Abstract Mito Xmas Meeting Innsbruck2016OXPHOS and ET capacity in permeabilized fibres of canine superathletes.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueDogSkeletal muscle
Pileggi 2016 Abstract MitoFit Science Camp 20162016Voluntary exercise prevents high fat diet-induced cardiac mitochondrial dysfunction in male rats.F
N
NS
Permeabilized tissueRatHeart
Sparks 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Sparks 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissueHuman
Mouse
Skeletal muscle
Chou 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Chou 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOXPHOS
ET
F
N
S
NS
ROX
Permeabilized cells
Permeabilized tissue
Blood cells
Lymphocyte
Platelet
Ali 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Ali 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFIntact cells
Wuest 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Wuest 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueRatHeart
Miller 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Miller 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissue
Goodpaster 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Goodpaster 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissue
Villena 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Villena 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFIntact cellsFat
Fontes-Oliveira 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Fontes-Oliveira 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFIntact cells
Permeabilized tissue
Makrecka 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Makrecka 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissue
Isolated mitochondria
Mouse
Rat
Heart
Skeletal muscle
Senyilmaz 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Senyilmaz 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissueDrosophilaSkeletal muscle
Gottlieb 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Gottlieb 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFMouseSkeletal muscle
Gorr 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Gorr 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissue
Chavanelle 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Chavanelle 2015 Fatty Acid Oxidation O2k-Network Discussion ForumLEAK
OXPHOS
F
N
Permeabilized tissueMouseSkeletal muscle
Chang 2015 Abstract EB20152015Different effects of interval and continuous exercise regimens on capacity of mitochondria oxidative phosphorylation in lymphocyte.F
N
NS
Intact cells
Permeabilized cells
HumanMacrophage-derived
Lemieux 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Lemieux 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissueHeart
Skeletal muscle
Palm 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Palm 2015 Fatty Acid Oxidation O2k-Network Discussion ForumF
Filippi 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Filippi 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFLiver
Coen 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Coen 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOXPHOSF
N
NS
Permeabilized tissue
Egelandsdal 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Egelandsdal 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissueBovinesSkeletal muscle
Kollberg 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Kollberg 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFIsolated mitochondria
Hickey 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Hickey 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissue
Isolated mitochondria
Rat
Fishes
Heart
Bouitbir 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Bouitbir 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissueHeart
Skeletal muscle
Smith 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Smith 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOXPHOS
ET
FPermeabilized tissue
Cortassa 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Cortassa 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFIntact cells
Isolated mitochondria
Skeletal muscle
Neviere 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Neviere 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissueHuman
Mouse
Ramsay 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Ramsay 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissue
Ljubkovic 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Ljubkovic 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOXPHOS
ET
F
N
NS
Permeabilized tissueHumanHeart
Krishnan 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Krishnan 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFLiver
Laner 2015 Abstract MiPschool Greenville 20152015Comparative mitochondrial physiology: OXPHOS and ET capacity in permeabilized fibres of canine superathletes.OXPHOS
ET
F
N
S
NS
Permeabilized tissueDogSkeletal muscle
Lund 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Lund 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFHomogenate
Isolated mitochondria
Essop 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Essop 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissue
Votion 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Votion 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissueMouse
Cabrera-Fuentes 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Cabrera-Fuentes 2015 Fatty Acid Oxidation O2k-Network Discussion ForumF
Pasdois 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissue
Isolated mitochondria
Moellering 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Moellering 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissueSkeletal muscle
Schauer 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Schauer 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOXPHOS
ET
FPermeabilized tissue
Hagland 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Hagland 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFIntact cells
Isolated mitochondria
Ost 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Ost 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissueMouseSkeletal muscle
Salin 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Salin 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissue
Homogenate
FishesSkeletal muscle
Wohlwend 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Wohlwend 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissueHuman
Rat
Skeletal muscle
Goetzman 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Goetzman 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFHomogenateLiver
Amoedo 2015 Abstract MiP20152015The energy requirement of metastatic cells.F
S
Mouse
Rat
Other cell lines
Hansson Fatty Acid Oxidation O2k-Network Discussion Forum2015Hansson 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissueHeart
McCurdy 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOXPHOSF
N
Permeabilized tissueOther mammalsSkeletal muscle
Kane 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Kane 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissue
Schoettl 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Schoettl 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFIsolated mitochondriaNervous system
Liver
Fat
HEK
Jelenik 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Jelenik 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissue
Gottschalk 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Gottschalk 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissue
Van Schaardenburgh 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Van Schaardenburgh 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissue
Mahdaviani 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Mahdaviani 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFIsolated mitochondriaFat
Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion ForumLEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHuman
Mouse
Skeletal muscle
Baekkerud 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Baekkerud 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissueMouse
Darveau 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Darveau 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissueHexapodsSkeletal muscle
Kaambre 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFHumanGenital
Laner 2015 Abstract MiP20152015Comparative mitochondrial physiology: OXPHOS and ET capacity in permeabilized fibres of canine superathletes.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueDogSkeletal muscle
Madlala 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Madlala 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOXPHOSFPermeabilized tissueRatSkeletal muscle
Ciapaite 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Ciapaite 2015 Fatty Acid Oxidation O2k-Network Discussion ForumLEAK
OXPHOS
ET
FPermeabilized tissueHuman
Rat
Skeletal muscle
Weber 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Weber 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFHuman
Mouse
Genital
Veksler 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Veksler 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissueHeart
Skeletal muscle
Chicco 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Chicco 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissue
Lesnefsky 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Lesnefsky 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissue
Trifunovic 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Trifunovic 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFIsolated mitochondriaHeart
West 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015West 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissue
Roden 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Roden 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissueHuman
Mouse
Skeletal muscle
Ojuka 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Ojuka 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOXPHOS
ET
FPermeabilized tissue
Robidoux 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Robidoux 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFIntact cellsFat
Wright 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Wright 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissue
Rodrigues 2014 Abstract MiP20142014Bioenergetics’ traits of tongue cancer metastatic cells.F
N
S
Permeabilized cellsMouseLymphocyte
Sumbalova 2014 Abstract MiP20142014Optimization of malate concentration for high-resolution respirometry: mitochondria from rat liver and brain.OXPHOS
ET
F
N
S
NS
Isolated mitochondriaRatNervous system
Liver
Horscroft 2014 Abstract MiP20142014Substrate utilisation in the hypoxic heart: a glycolysis/glucose oxidation mismatch?OXPHOSF
N
RatHeart
Amoedo 2014 Abstract MiP20142014The metabolic panorama during tumor progression towards malignancy.OXPHOSF
S
Permeabilized cellsOther cell lines
Larsen 2014 Abstract MiP20142014The effect of high intensity training on mitochondrial fat oxidation in skeletal muscle and subcutaneous adipose tissue.OXPHOSF
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Fat
Bresciani Martins de Andrade 2014 Abstract MiP20142014Mitochondrial function in white adipose tissue: palmitoleic acid (C16:1n7) treatment enhances white adipocyte oxygen consumption.FIntact cellsFat
Cavalcanti de Albuquerque 2013 Abstract MiP20132013Cavalcanti de Albuquerque JP, Salvador IC, Martins EG, Jardim-Messeder D; Werneck de Castro JPS; Carvalho DP; Galina A (2013) Skeletal muscle mitochondrial function in ovariectomized rats: A time course study and the role of estrogen replacement. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
F
N
S
Gp
NS
ROX
Intact organism
Permeabilized tissue
RatSkeletal muscle
Kotwica 2013 Abstract MiP20132013Kotwica AO, Horscroft JA, Murray AJ(2013) Mitochondrial respiration in heart and soleus of ob/ob mice. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
F
N
S
Permeabilized tissueMouseHeart
Skeletal muscle
Chicco 2013 Abstract IOC792013Chicco AJ (2013) Substrate-specific impairment of oxidative phosphorylation in Tafazzin-deficient cardiac mitochondria: potential role of CoA deficiency. Mitochondr Physiol Network 18.07OXPHOSF
N
S
Isolated mitochondria
Permeabilized cells
MouseHeart
Lemieux 2013 Abstract MiP20132013Lemieux H, Warren BE, Lucchinetti E, Lou PH, Zhang L, Gandhi M, Clanachan AS, Zaugg M(2013) Early mitochondrial dysfunction associated with type 2 diabetes mellitus in the heart and skeletal muscle. Mitochondr Physiol Network 18.08.OXPHOSF
N
S
CIV
NS
Other combinations
Permeabilized tissueRatHeart
Skeletal muscle
Gnaiger 2013 Abstract Mito20132013Gnaiger E, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet J, Christiansen M, Helge JW, Saltin B, Boushel R (2013) Conserved mitochondrial coupling efficiency and adaptive substrate control in Inuit and Caucasians: adaptation and acclimatization to the Arctic winter.LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Oliveira MF 2013 Abstract MiP20132013Oliveira MF (2013) Comparative mitochondrial physiology in blood feeding insect vectors and parasites. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
ROX
Intact organism
Intact organ
Intact cells
Permeabilized cells
Permeabilized tissue
Homogenate
Human
Drosophila
Hexapods
Other invertebrates
Skeletal muscle
Neuroblastoma
Gnaiger 2013 Abstract MiP20132013Gnaiger E, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet J, Christiansen M, Helge JW, Saltin B, Boushel R (2013) Biochemical coupling efficiency in permeabilized fibres from arm and leg muscle in Inuit versus Caucasians: A functional test of the uncoupling hypothesis in Greenland. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Quistorff 2013 Abstract MiP20132013Quistorff B (2013) With type 2 diabetes mitochondrial dysfunction develops earlier in liver than in skeletal muscle. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
F
S
Other combinations
RatSkeletal muscle
Liver
Chicco 2013 Abstract MiP20132013Chicco AJ, Le CH, Schlater A, Kanatous S (2013) Comparative muscle mitochondrial physiology of the northern elephant seal. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
F
N
Other combinations
Permeabilized tissueHuman
Other mammals
Skeletal muscle
Votion 2013 Abstract MiP20132013Votion DM, Mouithys-Mickalad A, Ceusters Justine D, Lemieux H, Tosi I, Franck T, Art T, Niesten A, Serteyn D (2013) The challenge of understanding myopathies in horses using permeabilized muscle cells. Mitochondr Physiol Network 18.08.ET
OXPHOS
F
N
NS
ROX
S
Permeabilized tissueHorseSkeletal muscle
Dzialowski 2013 Abstract MiP20132013Dzialowski EM, Ream S, Duquaine A, Sirsat TS, Goy Sirsat SK (2013) Mitochondrial function and the development of endothermy in the precocial Pekin duck (Anas pekin). Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
F
N
S
NS
Intact organism
Permeabilized tissue
BirdsSkeletal muscle
Gnaiger 2012 Abstract-FEPS-Santiago de Compostela2012Gnaiger E (2012) Aging and mitochondrial physiology. The effect of exercise and caloric balance on oxidative phosphorylation (OXPHOS). Abstract FEPS, Santiago de Compostela, Spain. Symposium: Advances in Aging and Mitochondria Research. September 08-12.F
N
S
NS
Human
Horse
Jacobs 2012 Abstract Bioblast2012Jacobs R, Lundby C (2012) Mitochondria express enhanced quality as well as quantity in parallel with aerobic fitness across recreationally active individuals up to elite athletes. Mitochondr Physiol Network 17.12.LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized cellsHumanSkeletal muscle
Pesta 2011Abstract Mitochondrial Medicine-Training2011Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Mitochondrial improvements after strength, endurance, and intermittend hypoxic training in sedentary humans. A respiratory study on permeabilized muscle fibres. Abstract Mitochondrial Medicine Chicago.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Gnaiger 2011 Abstract-Berlin2011Gnaiger E (2011) Fewer mitochondria - mitochondrial 'fever': Mitochondrial physiology and capacity of oxidative phosphorylation in active and sedentary life styles. Abstract Targeting Mitochondria Berlin.F
N
S
NS
Human
Pesta 2010 MiP Abstract2010Pesta D, Faulhaber M, Burtscher M, Gnaiger E, Schocke M (2010) Investigation of muscle metabolism of the M. quadriceps via 31P MRS and high-resolution respirometry in connection with 10 weeks of strength and endurance training in normoxia and hypoxia. MiP2010.LEAK
OXPHOS
ET
F
N
S
NS
Human
Gnaiger 2005 Abstract MiP20052005High-resolution respirometry in small biopsies of human muscle: correlations with body mass index and age.OXPHOS
ET
F
N
CIV
NS
Permeabilized tissueHumanSkeletal muscle