Durand 2018 Blood Purif

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Publications in the MiPMap
Durand PY, Nicco C, Serteyn D, Attaf D, Edeas M (2018) Microbiota quality and mitochondrial activity link with occurrence of muscle cramps in hemodialysis patients using citrate dialysate: a pilot study. Blood Purif 46:301-8.

» PMID: 30048977

Durand PY, Nicco C, Serteyn D, Attaf D, Edeas M (2018) Blood Purif

Abstract: Hemodialysis-associated muscle cramp (HAMC) is a common complication under citrate dialysate (CD) occurring in 30% of cases. Our objectives were to assess the gut microbiota quality, mitochondrial activity, and to investigate their possible relationship with HAMC.

Ten end-stage renal disease patients (78.9 ± 2.1 years) treated by hemodialysis (HD) with CD were enrolled and then classified according to the frequency of HAMCs: "frequent HAMCs group" (n = 5) and "absence of HAMCs group" (n = 5). Gut microbiota quality, mitochondrial activity, and some markers of oxidative stress (OS) were investigated.

In patients with cramps, gut microbiota diversity seemed lower and some genera including Helicobacter, Lachnospira, Roseburia, and Haemophilus seemed over-expressed, a significant increase of citratemia and significant lowering mitochondrial function were observed. No difference was observed on the OS markers.

This first clinical study revealed a possible dysbiosis of microbiota and a mitochondrial dysfunction into HD patients with cramps under CD compared to patients without cramp.


Bioblast editor: Plangger M, Kandolf G


Labels: MiParea: Respiration, Patients 


Organism: Human  Tissue;cell: Platelet  Preparation: Intact cells 


Coupling state: LEAK, ROUTINE, OXPHOS, ET  Pathway: S, ROX  HRR: Oxygraph-2k 

Labels, 2018-08