Complex IV

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MitoPedia

Complex IV

Description

Complex IV or cytochrome c oxidase is the terminal oxidase of the mitochondrial ET-pathway, reducing oxygen to water, with reduced cytochrome c as a substrate. CIV is frequently abbreviated as COX or CcO. It is the 'ferment' (Atmungsferment) of Otto Warburg, shown to be related to the cytochromes discovered by David Keilin.

Abbreviation: CIV

Reference: MiPNet06.06


MitoPedia topics: Enzyme 

HRR protocol: Complex IV assay

Ascorbate and TMPD

Ascorbate (As; 2 mM) and TMPD (Tm; 0.5 mM) are added to mitochondrial preparations. It is important to add ascorbate before TMPD to avoid uncontrollable autoxidation. Ascorbate maintains TMPD in a reduced state. Electrons flow from TMPD to cytochrome c.
Cytochrome c oxidase (CIV) in intact mitochondra has a biphasic kinetics for TMPD (Gnaiger_2002_Biochem_Soc_Trans). Due to the high K'm of the low-affinity phase, TMPD cannot be added at saturating concentrations, since then autoxidation of TMPD would be strikingly high. The actually chosen TMPD concentration, therefore, is a compromise. Inhibitor titrations with cyanide or azide of ET-pathway pathway flux versus the single step of CIV reveal an apparent excess capacity of CIV. The optimum TMPD concentration, therefore, is adjusted to obtain a reaction velocity corresponding to the apparent excess capacity (Gnaiger_1998_J Exp Biol).


Correction for chemical O2 background

Due to autooxidation of ascorbate and TMPD, a chemical correction has to be applied on flux. Autooxidation is higher in the presence than in the absence of cytochrome c, and is dependent on oxygen concentration. The oxygen dependence is linear above c. 50 µM O2, but biphasic (linear+hyperbolic) below 50 µM O2. If you maintain oxygen in the linear dependence above 50 µM, you can use the automatic instrumental background correction in DatLab to also take care of the chemical background correction (in the ‘Edit Experiment’ window the instrumental background parameters are replaced by the combined background parameters). Cyanide is OK except if you use pyruvate as a substrate. Pyruvate particularly at high oxygen levels reverses the inhibition by cyanide (see Cyanide).

References

Publications:


SUITbrowser question: CIV

Work in progress


List of publications: Complex IV;cytochrome c oxidase

 YearReferenceMammal and modelTissue and cellStressDiseases
Zhao 2019 Basic Res Cardiol2019Zhao J, Gao JL, Zhu JX, Zhu HB, Peng X, Jiang M, Fu Y, Xu J, Mao XH, Hu N, Ma MH, Dong DL (2019) The different response of cardiomyocytes and cardiac fibroblasts to mitochondria inhibition and the underlying role of STAT3. Basic Res Cardiol 114:12.RatHeart
Fibroblast
Ischemia-reperfusion
Larsen 2019 Appl Physiol Nutr Metab2019Larsen S, Dandanell S, Kristensen KB, Jørgensen SD, Dela F, Helge JW (2019) Influence of exercise amount and intensity on long-term weight loss maintenance and skeletal muscle mitochondrial ROS production in humans. Appl Physiol Nutr Metab [Epub ahead of print].HumanSkeletal muscle
Chatfield 2019 JACC Basic Transl Sci2019Chatfield KC, Sparagna GC, Chau S, Phillips EK, Ambardekar AV, Aftab M, Mitchell MB, Sucharov CC, Miyamoto SD, Stauffer BL (2019) Elamipretide improves mitochondrial function in the failing human heart. JACC Basic Transl Sci 4:147-57.HumanHeartCardiovascular
Cesnekova 2019 Thesis2019Cesnekova J (2019) Functional characterization of LACE1 APTase and mitochondrial AAA proteases YME1L and AFG3L2 in mitochondrial protein homeostasis. PhD Thesis 133.HumanHEK
Zverova 2019 Neuropsychiatr Dis Treat2019Zvěřová M, Hroudová J, Fišar Z, Hansíková H, Kališová L, Kitzlerová E, Lambertová A, Raboch J (2019) Disturbances of mitochondrial parameters to distinguish patients with depressive episode of bipolar disorder and major depressive disorder. Neuropsychiatr Dis Treat 15:233-40.HumanPlateletOther
Lauridsen 2019 Mitochondrion2019Lauridsen PE, Rasmussen LJ, Desler C (2019) Mitochondrial oxidative phosphorylation capacity of cryopreserved cells. Mitochondrion [Epub ahead of print].HumanOther cell linesCryopreservation
Chang 2019 Br J Anaesth2019Chang L, Daly C, Miller DM, Allen PD, Boyle JP, Hopkins PM, Shaw MA (2019) Permeabilised skeletal muscle reveals mitochondrial deficiency in malignant hyperthermia-susceptible individuals. Br J Anaesth 122:613-21.HumanSkeletal muscleTemperature
Desmoulins 2019 Mol Metab2019Desmoulins L, Chrétien C, Paccoud R, Collins S, Cruciani-Guglielmacci C, Galinier A, Liénard F, Quinault A, Grall S, Allard C, Fenech C, Carneiro L, Mouillot T, Fournel A, Knauf C, Magnan C, Fioramonti X, Pénicaud L, Leloup C (2019) Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing. Mol Metab 20:166-77.RatNervous system
Trefts 2019 Thesis2019Trefts E (2019) Integrin linked kinase is critical for hepatic cellular organization, metabolism, and glucoregulation. PhD Thesis 164.MouseLiverOther
Vaka 2019 Am J Physiol Regul Integr Comp Physiol2019Vaka VR, Mcmasters KM, Cornelius DC, Ibrahim T, Jayaram A, Usry N, Cunningham MW Jr, Amaral LM, LaMarca BD (2019) Natural killer cells contribute to mitochondrial dysfunction in response to placental ischemia in Reduced Uterine Perfusion Pressure (RUPP) rats. Am J Physiol Regul Integr Comp Physiol 316:R441-R447.Human
Rat
Endothelial;epithelial;mesothelial cell
Genital
Ischemia-reperfusion
Oxidative stress;RONS
Alvarez 2019 Chem Biol Interact2019Álvarez Santos MR, Duarte YB, Güiza FM, Romero Bohórquez AR, Mendez-Sanchez SC (2019) Effects of new tetrahydroquinoline-isoxazole hybrides on bioenergetics of hepatocarcinoma Hep-G2 cells and rat liver mitochondria. Chem Biol Interact 302:164-71.HumanLiverCancer
Stepanova 2019 Antioxid Redox Signal2019Stepanova A, Sosunov S, Niatsetskaya Z, Konrad C, Starkov AA, Manfredi G, Wittig I, Ten V, Galkin A (2019) Redox-dependent loss of flavin by mitochondrial complex I in brain ischemia/reperfusion injury. Antioxid Redox Signal [Epub ahead of print].MouseNervous systemIschemia-reperfusion
Trefts 2019 Am J Physiol Endocrinol Metab2019Trefts E, Hughey CC, Lantier L, Lark DS, Boyd KL, Pozzi A, Zent R, Wasserman DH (2019) Energy metabolism couples hepatocyte integrin-linked kinase to liver glucoregulation and the postabsorptive response of mice in an age-dependent manner. Am J Physiol Endocrinol Metab [Epub ahead of print].MouseLiver
Spinazzi 2019 Proc Natl Acad Sci U S A2019Spinazzi M, Radaelli E, Horré K, Arranz AM, Gounko NV, Agostinis P, Maia TM, Impens F, Morais VA, Lopez-Lluch G, Serneels L, Navas P, De Strooper B (2019) PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome. Proc Natl Acad Sci U S A 116:277-86.MouseNervous systemNeurodegenerative
Munro 2019 Aging Cell2019Munro D, Baldy C, Pamenter ME, Treberg JR (2019) The exceptional longevity of the naked mole-rat may be explained by mitochondrial antioxidant defenses. Aging Cell 18:e12916.Mouse
Other mammals
Heart
Skeletal muscle
Oxidative stress;RONSAging;senescence
Laouafa 2019 Acta Physiol (Oxf)2019Laouafa S, Roussel D, Marcouiller F, Soliz J, Gozal D, Bairam A, Joseph V (2019) Roles of oestradiol receptor alpha and beta against hypertension and brain mitochondrial dysfunction under intermittent hypoxia in female rats. Acta Physiol (Oxf) 226:e13255.RatNervous systemHypoxia
Hafen 2019 J Appl Physiol (1985)2019Hafen PS, Abbott K, Bowden JA, Lopiano R, Hancock CR, Hyldahl RD (2019) Daily heat treatment maintains mitochondrial function and attenuates atrophy in human skeletal muscle subjected to immobilization. J Appl Physiol (1985) [Epub ahead of print].HumanSkeletal muscleTemperature
Doig 2019 bioRxiv2019Doig CD, Zelinska AE, Oakey LA, Fletcher RS, El Hassan Y, Garten A, Cartwright D, Heising S, Tennant DA, Watson D, Adamski J, Lavery GG (2019) Induction of the nicotinamide riboside kinase NAD+ salvage pathway in skeletal muscle of H6PDH KO mice. bioRxiv doi: https://doi.org/10.1101/567297 .MouseSkeletal muscle
Cree-Green 2018 Diabetes2018Cree-Green M, Scalzo RL, Harrall K, Newcomer BR, Schauer IE, Huebschmann AG, McMillin S, Brown MS, Orlicky D, Knaub L, Nadeau KJ, Mcclatchey PM, Bauer TA, Regensteiner JG, Reusch JEB (2018) Supplemental oxygen improves in-vivo mitochondrial oxidative phosphorylation flux in sedentary obese adults with type 2 diabetes. Diabetes 67:1369-79.HumanSkeletal muscleDiabetes
Obesity
Qu 2018 FASEB J2018Qu C, Zhang S, Wang W, Li M, Wang Y, van der Heijde-Mulder M, Shokrollahi E, Hakim MS, Raat NJH, Peppelenbosch MP, Pan Q (2018) Mitochondrial electron transport chain complex III sustains hepatitis E virus replication and represents an antiviral target. FASEB J 33:1008-19.HumanLiverInfectious
Barca 2018 Hum Mol Genet2018Barca E, Ganetzky RD, Potluri P, Juanola-Falgarona M, Gai X, Li D, Jalas C, Hirsch Y, Emmanuele V, Tadesse S, Ziosi M, Akman HO, Chung WK, Tanji K, McCormick E, Place E, Consugar M, Pierce EA, Hakonarson H, Wallace DC, Hirano M, Falk MJ (2018) USMG5 Ashkenazi Jewish founder mutation impairs mitochondrial complex V dimerization and ATP synthesis. Hum Mol Genet 27:3305-12.HumanFibroblastOther
Neurodegenerative
Trewin 2018 Am J Physiol Regul Integr Comp Physiol2018Trewin AJ, Parker L, Shaw CS, Hiam D, Garnham AP, Levinger I, McConell GK, Stepto NK (2018) Acute HIIE elicits similar changes in human skeletal muscle mitochondrial H2O2 release, respiration and cell signaling as endurance exercise even with less work. Am J Physiol Regul Integr Comp Physiol 315:R1003-R1016.HumanSkeletal muscle
Lobo-Jarne 2018 Cell Rep2018Lobo-Jarne T, Nývltová E, Pérez-Pérez R, Timón-Gómez A, Molinié T, Choi A, Mourier A, Fontanesi F, Ugalde C, Barrientos A (2018) Human COX7A2L regulates complex III biogenesis and promotes supercomplex organization remodeling without affecting mitochondrial bioenergetics. Cell Rep 25:1786-99.HumanHEK
Guitart-Mampel 2018 Biochim Biophys Acta2018Guitart-Mampel M, Gonzalez-Tendero A, Niñerola S, Morén C, Catalán-Garcia M, González-Casacuberta I, Juárez-Flores DL, Ugarteburu O, Matalonga L, Cascajo MV, Tort F, Cortés A, Tobias E, Milisenda JC, Grau JM, Crispi F, Gratacós E, Garrabou G, Cardellach F (2018) Cardiac and placental mitochondrial characterization in a rabbit model of intrauterine growth restriction. Biochim Biophys Acta 1862:1157-67.RabbitHeart
Genital
Other
Roy Chowdhury 2018 Mol Cell Neurosci2018Roy Chowdhury S, Djordjevic J, Thomson E, Smith DR, Albensi BC, Fernyhough P (2018) Depressed mitochondrial function and electron transport Complex II-mediated H2O2 production in the cortex of type 1 diabetic rodents. Mol Cell Neurosci 90:49-59.Mouse
Rat
Nervous systemDiabetes
Stepanova 2018 J Cereb Blood Flow Metab2018Stepanova A, Konrad C, Guerrero-Castillo S, Manfredi G, Vannucci S, Arnold S, Galkin A (2018) Deactivation of mitochondrial complex I after hypoxia-ischemia in the immature brain. J Cereb Blood Flow Metab [Epub ahead of print].RatNervous systemHypoxia
Ischemia-reperfusion
Takahashi 2018 Sci Rep2018Takahashi K, Miura Y, Ohsawa I, Shirasawa T, Takahashi M (2018) In vitro rejuvenation of brain mitochondria by the inhibition of actin polymerization. Sci Rep 8:15585.MouseNervous systemAging;senescence
De Paula Martins 2018 Free Radic Biol Med2018de Paula Martins R, Ghisoni K, Lim CK, Aguiar AS Jr, Guillemin GJ, Latini A (2018) Neopterin preconditioning prevents inflammasome activation in mammalian astrocytes. Free Radic Biol Med 115:371-82.RatNervous system
Goncalves 2018 Neurotoxicology2018Gonçalves DF, Courtes AA, Hartmann DD, da Rosa PC, Oliveira DM, Soares FAA, Dalla Corte CL (2018) 6-Hydroxydopamine induces different mitochondrial bioenergetics response in brain regions of rat. Neurotoxicology 70:1-11.RatNervous systemParkinson's
Neurodegenerative
Belosludtsev 2018 Biochim Biophys Acta2018Belosludtsev KN, Belosludtseva NV, Talanov EY, Tenkov KS, Starinets VS, Agafonov AV, Pavlik LL, Dubinin MV (2018) Effect of bedaquiline on the functions of rat liver mitochondria. Biochim Biophys Acta 1861:288-97.RatLiver
Souza 2018 Sci Rep2018Souza RWA, Alves CRR, Medeiros A, Rolim N, Silva GJJ, Moreira JBN, Alves MN, Wohlwend M, Gebriel M, Hagen L, Sharma A, Koch LG, Britton SL, Slupphaug G, Wisløff U, Brum PC (2018) Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity. Sci Rep 8:17772.RatHeart
Skeletal muscle
Geffroy 2018 Biochim Biophys Acta2018Geffroy G, Benyahia R, Frey S, Desquiret-Dumas V, Gueguen N, Bris C, Belal S, Inisan A, Renaud A, Chevrollier A, Henrion D, Bonneau D, Letournel F, Lenaers G, Reynier P, Procaccio V (2018) The accumulation of assembly intermediates of the mitochondrial complex I matrix arm is reduced by limiting glucose uptake in a neuronal-like model of MELAS syndrome. Biochim Biophys Acta 1864:1596-1608.HumanNervous system
Other cell lines
Hafen 2018 J Appl Physiol (1985)2018Hafen PS, Preece CN, Sorensen JR, Hancock CR, Hyldahl RD (2018) Repeated exposure to heat stress induces mitochondrial adaptation in human skeletal muscle. J Appl Physiol (1985) 125:1447-55.HumanSkeletal muscleTemperature
Keller 2018 Oxid Med Cell Longev2018Keller AC, Knaub LA, Scalzo RL, Hull SE, Johnston AE, Walker LA, Reusch JEB (2018) Sepiapterin improves vascular reactivity and insulin-stimulated glucose in wistar rats. Oxid Med Cell Longev 2018:7363485.RatEndothelial;epithelial;mesothelial cellCardiovascular
Kauppila 2018 Nucleic Acids Res2018Kauppila JHK, Bonekamp NA, Mourier A, Isokallio MA, Just A, Kauppila TES, Stewart JB, Larsson NG (2018) Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice. Nucleic Acids Res 46:6642-69.MouseAging;senescence
Ryan 2018 JCI Insight2018Ryan TE, Yamaguchi DJ, Schmidt CA, Zeczycki TN, Shaikh SR, Brophy P, Green TD, Tarpey MD, Karnekar R, Goldberg EJ, Sparagna GC, Torres MJ, Annex BH, Neufer PD, Spangenburg EE, McClung JM (2018) Extensive skeletal muscle cell mitochondriopathy distinguishes critical limb ischemia patients from claudicants. JCI Insight 3:123235.HumanSkeletal muscleCardiovascular
Hedges 2018 J Appl Physiol (1985)2018Hedges CP, Woodhead JST, Wang HW, Mitchell CJ, Cameron-Smith D, Hickey AJR, Merry TL (2018) Peripheral blood mononuclear cells do not reflect skeletal muscle mitochondrial function or adaptation to high-intensity interval training in healthy young men. J Appl Physiol (1985) 126:454-61.HumanSkeletal muscle
Blood cells
Cunatova 2018 Thesis2018Čunátová K (2018) The role of tissue specific isoforms of subunit 4 in assembly and function of cytochrome c oxidase. PhD Thesis p107.HumanHEK
Pamenter 2018 PLoS One2018Pamenter ME, Lau GY, Richards JG (2018) Effects of cold on murine brain mitochondrial function. PLoS One 13:e0208453.MouseNervous system
Fouret 2018 Br J Nutr2018Fouret G, Gaillet S, Lecomte J, Bonafos B, Djohan F, Barea B, Badia E, Coudray C, Feillet-Coudray C (2018) 20-Week follow-up of hepatic steatosis installation and liver mitochondrial structure and activity and their interrelation in rats fed a high-fat-high-fructose diet. Br J Nutr 119:368-80.RatLiverDiabetes
Obesity
Li 2018 Gene2018Li Y, Wen S, Li D, Xie J, Wei X, Li X, Liu Y, Fang H, Yang Y, Lyu J (2018) SURF1 mutations in Chinese patients with Leigh syndrome: Novel mutations, mutation spectrum, and the functional consequences. Gene 674:15-24.HumanBlood cellsMitochondrial disease
Paech 2018b Toxicology2018Paech F, Abegg VF, Duthaler U, Terracciano L, Bouitbir J, Krähenbühl S (2018) Sunitinib induces hepatocyte mitochondrial damage and apoptosis in mice. Toxicology 409:13-23.MouseLiverCell death
Cryopreservation
Friederich 2018 Nat Commun2018Friederich MW, Timal S, Powell CA, Dallabona C, Kurolap A, Palacios-Zambrano S, Bratkovic D, Derks TGJ, Bick D, Bouman K, Chatfield KC, Damouny-Naoum N, Dishop MK, Falik-Zaccai TC, Fares F, Fedida A, Ferrero I, Gallagher RC, Garesse R, Gilberti M, González C, Gowan K, Habib C, Halligan RK, Kalfon L, Knight K, Lefeber D, Mamblona L, Mandel H, Mory A, Ottoson J, Paperna T, Pruijn GJM, Rebelo-Guiomar PF, Saada A, Sainz B Jr, Salvemini H, Schoots MH, Smeitink JA, Szukszto MJ, Ter Horst HJ, van den Brandt F, van Spronsen FJ, Veltman JA, Wartchow E, Wintjes LT, Zohar Y, Fernández-Moreno MA, Baris HN, Donnini C, Minczuk M, Rodenburg RJ, Van Hove JLK (2018) Pathogenic variants in glutamyl-tRNAGln amidotransferase subunits cause a lethal mitochondrial cardiomyopathy disorder. Nat Commun 9:4065.HumanFibroblastMyopathy
Juarez-Flores 2018 J Transl Med2018Juárez-Flores DL, González-Casacuberta I, Ezquerra M, Bañó M, Carmona-Pontaque F, Catalán-García M, Guitart-Mampel M, Rivero JJ, Tobias E, Milisenda JC, Tolosa E, Marti MJ, Fernández-Santiago R, Cardellach F, Morén C, Garrabou G (2018) Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2G2019S -Parkinson's disease. J Transl Med 16:160.HumanFibroblastParkinson's
Maurya 2018 Cell Rep2018Maurya SK, Herrera JL, Sahoo SK, Reis FCG, Vega RB, Kelly DP, Periasamy M (2018) Sarcolipin signaling promotes mitochondrial biogenesis and oxidative metabolism in skeletal muscle. Cell Rep 24:2919-31.MouseSkeletal muscle
Bombaca 2018 Free Radic Biol Med2018Bombaça ACS, Viana PG, Santos ACC, Silva TL, Rodrigues ABM, Guimarães ACR, Goulart MOF, Da Silva Júnior EN, Menna-Barreto RFS (2018) Mitochondrial disfunction and ROS production are essential for anti-Trypanosoma cruzi activity of β-lapachone-derived naphthoimidazoles. Free Radic Biol Med 130:408-18.ProtistsInfectious
Eimre 2018 Oxid Med Cell Longev2018Eimre M, Paju K, Peet N, Kadaja L, Tarrend M, Kasvandik S, Seppet J, Ivask M, Orlova E, Kõks S (2018) Increased mitochondrial protein levels and bioenergetics in the musculus rectus femoris of Wfs1-deficient mice. Oxid Med Cell Longev 2018:3175313.MouseSkeletal muscleDiabetes
Inherited
Meinild Lundby 2018 Acta Physiol (Oxf)2018Meinild Lundby AK, Jacobs RA, Gehrig S, de Leur J, Hauser M, Bonne TC, Flück D, Dandanell S, Kirk N, Kaech A, Ziegler U, Larsen S, Lundby C (2018) Exercise training increases skeletal muscle mitochondrial volume density by enlargement of existing mitochondria and not de novo biogenesis. Acta Physiol (Oxf) 222, e12905.HumanSkeletal muscle
Miotto 2018 Thesis2018Miotto PM (2018) The influence of exercise and high fat feeding on the regulation of mitochondrial substrate sensitivity in skeletal muscle. PhD Thesis p185.MouseSkeletal muscle
Angebault 2018 Sci Signal2018Angebault C, Fauconnier J, Patergnani S, Rieusset J, Danese A, Affortit CA, Jagodzinska J, Mégy C, Quiles M, Cazevieille C, Korchagina J, Bonnet-Wersinger D, Milea D, Hamel C, Pinton P, Thiry M, Lacampagne A, Delprat B, Delettre C (2018) ER-mitochondria cross-talk is regulated by the Ca2+ sensor NCS1 and is impaired in Wolfram syndrome. Sci Signal 11:eaaq1380.HumanFibroblastNeurodegenerative
Allard 2018 J Clin Endocrinol Metab2018Allard NAE, Schirris TJJ, Verheggen RJ, Russel FGM, Rodenburg RJ, Smeitink JAM, Thompson PD, Hopman MTE, Timmers S (2018) Statins affect skeletal muscle performance: evidence for disturbances in energy metabolism. J Clin Endocrinol Metab 103:75-84.HumanSkeletal muscleMyopathy
Thompson 2018 EMBO Mol Med2018Thompson K, Mai N, Oláhová M, Scialó F, Formosa LE, Stroud DA, Garrett M, Lax NZ, Robertson FM, Jou C, Nascimento A, Ortez C, Jimenez-Mallebrera C, Hardy SA, He L, Brown GK, Marttinen P, McFarland R, Sanz A, Battersby BJ, Bonnen PE, Ryan MT, Chrzanowska-Lightowlers ZM, Lightowlers RN, Taylor RW (2018) OXA1L mutations cause mitochondrial encephalopathy and a combined oxidative phosphorylation defect. EMBO Mol Med 10:e9060.Drosophila
Perks 2018 Cell Rep2018Perks KL, Rossetti G, Kuznetsova I, Hughes LA, Ermer JA, Ferreira N, Busch JD, Rudler DL, Spahr H, Schöndorf T, Shearwood AJ, Viola HM, Siira SJ, Hool LC, Milenkovic D, Larsson NG, Rackham O, Filipovska A (2018) PTCD1 is required for 16S rRNA maturation complex stability and mitochondrial ribosome assembly. Cell Rep 23:127-42.MouseHeart
Casal 2018 J Anim Sci2018Casal A, Garcia-Roche M, Navajas EA, Cassina A, Carriquiry M (2018) Hepatic mitochondrial function in Hereford steers with divergent residual feed intake phenotypes. J Anim Sci 96:4431-43.BovinesLiver
Havird 2018 bioRxiv2018Havird JC, Noe GR, Link L, Torres A, Logan DC, Sloan DB, Chicco AJ (2018) Assessing mitochondrial function in angiosperms with highly divergent mitochondrial genomes. bioRxiv doi: https://doi.org/10.1101/448902.Plants
Stein 2018 Cell Rep2018Stein CS, Jadiya P, Zhang X, McLendon JM, Abouassaly GM, Witmer NH, Anderson EJ, Elrod JW, Boudreau RL (2018) Mitoregulin: A lncRNA-encoded microprotein that supports mitochondrial supercomplexes and respiratory efficiency. Cell Rep 23:3710-20.HumanHeart
Skeletal muscle
Giacco 2018 FASEB J2018Giacco A, Delli Paoli G, Senese R, Cioffi F, Silvestri E, Moreno M, Ruoppolo M, Caterino M, Costanzo M, Lombardi A, Goglia F, Lanni A, de Lange P (2018) The saturation degree of fatty acids and their derived acylcarnitines determines the direct effect of metabolically active thyroid hormones on insulin sensitivity in skeletal muscle cells. FASEB J 33:1811-23.RatSkeletal muscle
Monzio Compagnoni 2018 Biochim Biophys Acta Mol Basis Dis2018Monzio Compagnoni G, Kleiner G, Bordoni A, Fortunato F, Ronchi D, Salani S, Guida M, Corti C, Pichler I, Bergamini C, Fato R, Pellecchia MT, Vallelunga A, Del Sorbo F, Elia A, Reale C, Garavaglia B, Mora G, Albanese A, Cogiamanian F, Ardolino G, Bresolin N, Corti S, Comi GP, Quinzii CM, Di Fonzo A (2018) Mitochondrial dysfunction in fibroblasts of multiple system atrophy. Biochim Biophys Acta Mol Basis Dis 1864:3588-97.HumanFibroblastNeurodegenerative
Aparicio-Trejo 2018 Free Radic Biol Med2018Aparicio-Trejo OE, Reyes-Fermín LM, Briones-Herrera A, Tapia E, León-Contreras JC, Hernández-Pando R, Sánchez-Lozada LG, Pedraza-Chaverri J (2018) Protective effects of N-acetyl-cysteine in mitochondria bioenergetics, oxidative stress, dynamics and S-glutathionylation alterations in acute kidney damage induced by folic acid. Free Radic Biol Med 130:379-96.RatKidneyOxidative stress;RONSOther
Lim 2018 Sci Rep2018Lim SC, Tajika M, Shimura M, Carey KT, Stroud DA, Murayama K, Ohtake A, McKenzie M (2018) Loss of the mitochondrial fatty acid β-oxidation protein medium-chain acyl-Coenzyme A dehydrogenase disrupts oxidative phosphorylation protein complex stability and function. Sci Rep 8:153.HumanOther cell linesCancer
McLaughlin 2018 Biochem Biophys Res Commun2018McLaughlin KL, McClung JM, Fisher-Wellman KH (2018) Bioenergetic consequences of compromised mitochondrial DNA repair in the mouse heart. Biochem Biophys Res Commun 504:742-48.MouseHeart
Boutoual 2018 Scientific Reports2018Boutoual, R., Meseguer, S., Villarroya, M., Martin-Hernandez, E., Errami, M., Martin, M. A., Casado, M., and Armengod, M. E. (2018) Defects in the mitochondrial-tRNA modification enzymes MTO1 and GTPBP3 promote different metabolic reprogramming through a HIF-PPARgamma-UCP2-AMPK axis. Scientific reports 8, 1163HumanOther cell lines
Fibroblast
Mitochondrial diseaseCardiovascular
Kahl 2018 Stroke2018Kahl A, Stepanova A, Konrad C, Anderson C, Manfredi G, Zhou P, Iadecola C, Galkin A (2018) Critical role of flavin and glutathione in complex I-mediated bioenergetic failure in brain ischemia/reperfusion injury. Stroke 49:1223-31.MouseNervous systemIschemia-reperfusion
Rocha 2018 J Physiol Biochem2018Rocha C, Koury OH, Scheede-Bergdahl C, Bergdahl A (2018) Cardiac mitochondrial respiration following a low-carbohydrate, high-fat diet in apolipoprotein E-deficient mice. J Physiol Biochem 75:65-72.MouseHeart
Walczak 2018 FASEB J2018Walczak J, Dębska-Vielhaber G, Vielhaber S, Szymański J, Charzyńska A, Duszyński J, Szczepanowska J (2018) Distinction of sporadic and familial forms of ALS based on mitochondrial characteristics. FASEB J 33:4388-403.HumanFibroblastNeurodegenerative
Wefers 2018 Proc Natl Acad Sci U S A2018Wefers J, van Moorsel D, Hansen J, Connell NJ, Havekes B, Hoeks J, van Marken Lichtenbelt WD, Duez H, Phielix E, Kalsbeek A, Boekschoten MV, Hooiveld GJ, Hesselink MKC, Kersten S, Staels B, Scheer FAJL, Schrauwen P (2018) Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle. Proc Natl Acad Sci U S A 115:7789-94.HumanSkeletal muscleDiabetes
Wang 2018 Cell Physiol Biochem2018Wang P, Hu Y, Yao D, Li Y (2018) Omi/HtrA2 regulates a aitochondria-dependent apoptotic pathway in a murine model of septic encephalopathy. Cell Physiol Biochem 49:2163-73.RatNervous systemOxidative stress;RONS
Cell death
Neurodegenerative
Sepsis
Tyagi 2018 Sci Rep2018Tyagi A, Nguyen CU, Chong T, Michel CR, Fritz KS, Reisdorph N, Knaub L, Reusch JEB, Pugazhenthi S (2018) SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain. Sci Rep 8:17547.MouseNervous system
Seite 2018 Sci Rep2018Seite S, Mourier A, Camougrand N, Salin B, Figueiredo-Silva AC, Fontagne-Dicharry S, Panserat S, Seiliez I (2018) Dietary methionine deficiency affects oxidative status, mitochondrial integrity and mitophagy in the liver of rainbow trout (Oncorhynchus mykiss). Sci Rep 8:10151.FishesLiver
Kjeld 2018 PLoS One2018Kjeld T, Stride N, Gudiksen A, Hansen EG, Arendrup HC, Horstmann PF, Zerahn B, Jensen LT, Nordsborg N, Bejder J, Halling JF (2018) Oxygen conserving mitochondrial adaptations in the skeletal muscles of breath hold divers. PLoS One 13:e0201401.HumanSkeletal muscle
Zhou 2018 Cell Death Dis2018Zhou C, Sun H, Zheng C, Gao J, Fu Q, Hu N, Shao X, Zhou Y, Xiong J, Nie K, Zhou H, Shen L, Fang H, Lyu J (2018) Oncogenic HSP60 regulates mitochondrial oxidative phosphorylation to support Erk1/2 activation during pancreatic cancer cell growth. Cell Death Dis 9:161.HumanIslet cell;pancreas;thymus
Other cell lines
Cancer
JanssenDuijghuijsen 2018 Thesis2018JanssenDuijghuijsen LM (2018) Good, Bad, or Risky? Intestinal permeability to protein: Human and in vitro studies. Doctoral Thesis p154.HumanEndothelial;epithelial;mesothelial cell
Monaco 2018 Diabetologia2018Monaco CMF, Proudfoot R, Miotto PM, Herbst EAF, MacPherson REK, Holloway GP (2018) α-linolenic acid supplementation prevents exercise-induced improvements in white adipose tissue mitochondrial bioenergetics and whole-body glucose homeostasis in obese Zucker rats. Diabetologia 61:433-44.RatSkeletal muscle
Fat
Obesity
Pape 2018 Nutrients2018Pape JA, Newey CR, Burrell HR, Workman A, Perry K, Bikman BT, Bridgewater LC, Grose JH (2018) Per-Arnt-Sim kinase (PASK) deficiency increases cellular respiration on a standard diet and decreases liver triglyceride accumulation on a western high-fat high-sugar diet. Nutrients 10:1990.MouseSkeletal muscle
Liver
McFarlane 2017 Am J Physiol Regul Integr Comp Physiol2017McFarlane SV, Mathers KE, Staples JF (2017) Reversible temperature-dependent differences in brown adipose tissue respiration during torpor in a mammalian hibernator. Am J Physiol Regul Integr Comp Physiol 312:R434-42.Other mammalsFatTemperature
Volani 2017 Metallomics2017Volani C, Doerrier C, Demetz E, Haschka D, Paglia G, Lavdas AA, Gnaiger E, Weiss G (2017) Dietary iron loading negatively affects liver mitochondrial function. Metallomics 9:1634-44.MouseLiver
Mueller 2017 Orphanet J Rare Dis2017Mueller SM, Gehrig SM, Petersen JA, Frese S, Mihaylova V, Ligon-Auer M, Khmara N, Nuoffer JM, Schaller A, Lundby C, Toigo M, Jung HH (2017) Effects of endurance training on skeletal muscle mitochondrial function in Huntington disease patients. Orphanet J Rare Dis 12:184.HumanSkeletal muscleNeurodegenerative
Rowley 2017 J Nutr Biochem2017Rowley TJ, Bitner BF, Ray JD, Lathen DR, Smithson AT, Dallon BW, Plowman CJ, Bikman BT, Hansen JM, Dorenkott MR, Goodrich KM, Ye L, O'Keefe SF, Neilson AP, Tessem JS (2017) Monomeric cocoa catechins enhance β-cell function by increasing mitochondrial respiration. J Nutr Biochem 49:30-41.RatIslet cell;pancreas;thymusDiabetes
Scheede-Bergdahl 2017 Can J Physiol Pharmacol2017Scheede-Bergdahl C, Bergdahl A (2017) Adaptation of mitochondrial expression and ATP production in dedifferentiating vascular smooth muscle cells. Can J Physiol Pharmacol 95:1473-9.MouseEndothelial;epithelial;mesothelial cellCardiovascular
Haegler 2017 PLOS ONE2017Haegler P, Grünig D, Berger B, Terracciano L, Krähenbühl S, Bouitbir J (2017) Hepatic effects of pharmacological doses of hydroxy-cobalamin[c-lactam] in mice. PLOS ONE 12:e0171026.MouseLiver
Bohanon 2017 Shock2017Bohanon FJ, Lopez ON, Herndon DN, Wang X, Bhattarai N, Ayadi AE, Prasai A, Jay JW, Rojas-Khalil Y, Toliver-Kinsky TE, Finnerty CC, Radhakrishnan RS, Porter C (2017) Burn trauma acutely increases the respiratory capacity and function of liver mitochondria. Shock 49:466-73.MouseLiver
Hals 2017 Physiol Rep2017Hals I, Ohki T, Singh R, Ma Z, Björklund A, Balasuriya C, Scholz H, Grill V (2017) Hyperoxia reduces insulin release and induces mitochondrial dysfunction with possible implications for hyperoxic treatment of neonates. Physiol Rep 5. pii: e13447.Human
Mouse
Islet cell;pancreas;thymusHypoxia
Newsom 2017 Am J Physiol Endocrinol Metab2017Newsom SA, Miller BF, Hamilton KL, Ehrlicher SE, Stierwalt HD, Robinson MM (2017) Long-term rates of mitochondrial protein synthesis are increased in mouse skeletal muscle with high fat feeding regardless of insulin sensitizing treatment. Am J Physiol Endocrinol Metab 313:552-62.MouseSkeletal muscleDiabetes
Obesity
Ruiz 2017 Brain Pathol2017Ruiz M, Bégou M, Launay N, Ranea-Robles P, Bianchi P, López-Erauskin J, Morató L, Guilera C, Petit B, Vaurs-Barriere C, Guéret-Gonthier C, Bonnet-Dupeyron MN, Fourcade S, Auwerx J, Boespflug-Tanguy O, Pujol A (2017) Oxidative stress and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease. Brain Pathol 28:611-30.Human
Mouse
Nervous system
Fibroblast
Oxidative stress;RONSInherited
Neurodegenerative
Friederich 2017 Hum Mol Genet2017Friederich MW, Erdogan AJ, Coughlin CR 2nd, Elos MT, Jiang H, O'Rourke CP, Lovell MA, Wartchow E, Gowan K, Chatfield KC, Chick WS, Spector EB, Van Hove JLK, Riemer J (2017) Mutations in the accessory subunit NDUFB10 result in isolated complex I deficiency and illustrate the critical role of intermembrane space import for complex I holoenzyme assembly. Hum Mol Genet 26:702-16.HumanFibroblastMyopathy
Mathers 2017 J Comp Physiol B2017Mathers KE, McFarlane SV, Zhao L, Staples JF (2017) Regulation of mitochondrial metabolism during hibernation by reversible suppression of electron transport system enzymes. J Comp Physiol B 187:227-34.Other mammalsLiverTemperature
Dechandt 2017 J Bioenerg Biomembr2017Dechandt CRP, Zuccolotto-Dos-Reis FH, Teodoro BG, Fernandes AMAP, Eberlin MN, Kettelhut IC, Curti C, Alberici LC (2017) Triacsin C reduces lipid droplet formation and induces mitochondrial biogenesis in primary rat hepatocytes. J Bioenerg Biomembr 49:399-411.RatLiverOther
Comelli 2017 J Bioenerg Biomembr2017Comelli M, Pretis I, Buso A, Mavelli I (2017) Mitochondrial energy metabolism and signalling in human glioblastoma cell lines with different PTEN gene status. J Bioenerg Biomembr 50:33-52.HumanNervous systemCancer
Profilo 2017 Biochim Biophys Acta2017Profilo E, Peña-Altamira LE, Corricelli M, Castegna A, Danese A, Agrimi G, Petralla S, Giannuzzi G, Porcelli V, Sbano L, Viscomi C, Massenzio F, Palmieri EM, Giorgi C, Fiermonte G, Virgili M, Palmieri L, Zeviani M, Pinton P, Monti B, Palmieri F, Lasorsa FM (2017) Down-regulation of the mitochondrial aspartate-glutamate carrier isoform 1 AGC1 inhibits proliferation and N-acetylaspartate synthesis in Neuro2A cells. Biochim Biophys Acta 1863:1422-35.MouseNervous system
Other cell lines
Neuroblastoma
Lemieux 2017 bioRxiv 1514802017Lemieux H, Subarsky P, Doblander C, Wurm M, Troppmair J, Gnaiger E (2017) Impairment of mitochondrial respiratory function as an early biomarker of apoptosis induced by growth factor removal. bioRxiv doi: https://doi.org/10.1101/151480 .MouseBlood cellsCell deathCancer
Mahalingam 2017 J Physiol2017Mahalingam S, McClelland GB, Scott GR (2017) Evolved changes in the intracellular distribution and physiology of muscle mitochondria in high-altitude native deer mice. J Physiol 595:4785-801.MouseSkeletal muscleHypoxia
Blecha 2017 Free Radic Biol Med2017Blecha J, Novais SM, Rohlenova K, Novotna E, Lettlova S, Schmitt S, Zischka H, Neuzil J, Rohlena J (2017) Antioxidant defense in quiescent cells determines selectivity of electron transport chain inhibition-induced cell death. Free Radic Biol Med 112:253-66.Endothelial;epithelial;mesothelial cellOxidative stress;RONSCancer
Lin 2017 Dis Model Mech2017Lin H, Magrane J, Rattelle A, Stepanova A, Galkin A, Clark EM, Dong YN, Halawani SM, Lynch DR (2017) Early cerebellar deficits in mitochondrial biogenesis and respiratory chain complexes in the KIKO mouse model of Friedreich ataxia. Dis Model Mech 10(11):1343-52.MouseNervous systemInherited
Dent 2017 Mol Metab2017Dent JR, Martins VF, Svensson K, LaBarge SA, Schlenk NC, Esparza MC, Buckner EH, Meyer GA, Hamilton DL, Schenk S, Philp A (2017) Muscle-specific knockout of general control of amino acid synthesis 5 (GCN5) does not enhance basal or endurance exercise-induced mitochondrial adaptation. Mol Metab 6:1574-84.MouseSkeletal muscle
Gusdon 2017 Exp Gerontol2017Gusdon AM, Callio J, Distefano G, O'Doherty RM, Goodpaster BH, Coen PM, Chu CT (2017) Exercise increases mitochondrial complex I activity and DRP1 expression in the brains of aged mice. Exp Gerontol 90:1-13.MouseNervous systemOxidative stress;RONSAging;senescence
Asiri 2017 Thesis2017Asiri A (2017) Effects of asiatic acid on neurite outgrowth in Neuro-2a cells. Master's Thesis p42.MouseNervous systemCancer
Bombaca 2017 Free Radic Biol Med2017Bombaça ACS, Dias FA, Ennes-Vidal V, Garcia-Gomes ADS, Sorgine MHF, d'Avila-Levy CM, Menna-Barreto RFS (2017) Hydrogen peroxide resistance in Strigomonas culicis: Effects on mitochondrial functionality and Aedes aegypti interaction. Free Radic Biol Med 113:255-66.Protists
Takahashi 2017 Exp Gerontol2017Takahashi K, Ohsawa I, Shirasawa T, Takahashi M (2017) Optic atrophy 1 mediates coenzyme Q-responsive regulation of respiratory complex IV activity in brain mitochondria. Exp Gerontol 98:217-223.MouseNervous systemAging;senescence
Ma 2017 Int J Cancer2017Ma L, Fu Q, Xu B, Zhou H, Gao J, Shao X, Xiong J, Gu Q, Wen S, Li F, Shen L, Chen G, Fang H, Lyu J (2017) Breast cancer-associated mitochondrial DNA haplogroup promotes neoplastic growth via ROS-mediated AKT activation. Int J Cancer 142:1786-96.HumanCancer
Buso 2017 Thesis2017Buso A (2017) Mitochondrial oxidative phosphorylation plasticity/adaptation triggered by disturbances and stresses and targeted by therapies. PhD Thesis p110.MouseSkeletal muscleAging;senescence
Koit 2017 Oxid Med Cell Longev2017Koit A, Shevchuk I, Ounpuu L, Klepinin A, Chekulayev V, Timohhina N, Tepp K, Puurand M,Truu L, Heck K, Valvere V, Guzun R, Kaambre T (2017) Mitochondrial respiration in human colorectal and breast cancer clinical material is regulated differently. Oxid Med Cell Longev 2017:1372640.HumanEndothelial;epithelial;mesothelial cellCancer
Zhou 2017 Biochim Biophys Acta2017Zhou L, Wang W, Hoppel C, Liu J, Zhu X (2017) Parkinson's disease-associated pathogenic VPS35 mutation causes complex I deficits. Biochim Biophys Acta 1863:2791-5.HumanFibroblastParkinson's
Greggio 2017 Cell Metab2017Greggio C, Jha P, Kulkarni SS, Lagarrigue S, Broskey NT, Boutant M, Wang X, Conde Alonso S, Ofori E, Auwerx J, Cantó C, Amati F (2017) Enhanced respiratory chain supercomplex formation in response to exercise in human skeletal muscle. Cell Metab 25:301-11.HumanSkeletal muscle
JanssenDuijghuijsen 2017 Front Physiol2017JanssenDuijghuijsen LM, Grefte S, de Boer VCJ, Zeper L, van Dartel DAM, van der Stelt I, Bekkenkamp-Grovenstein M, van Norren K, Wichers HJ, Keijer J (2017) Mitochondrial ATP depletion disrupts Caco-2 monolayer integrity and internalizes Claudin 7. Front Physiol 8:794.HumanEndothelial;epithelial;mesothelial cell
Lopez 2017 Sci Rep2017Lopez Sanchez MIG, Waugh HS, Tsatsanis A, Wong BX, Crowston JG, Duce JA, Trounce IA (2017) Amyloid precursor protein drives down-regulation of mitochondrial oxidative phosphorylation independent of amyloid beta. Sci Rep 7:9835.HumanAlzheimer's
Cancer
Ferens 2017 Biochem Cell Biol2017Ferens FG, Spicer V, Krokhin OV, Motnenko A, Summers WA, Court DA (2017) A deletion variant partially complements a porin-less strain of Neurospora crassa. Biochem Cell Biol 95:318-27.Fungi
Singhal 2017 Mol Biol Cell2017Singhal RK, Kruse C, Heidler J, Strecker V, Zwicker K, Düsterwald L, Westermann B, Herrmann JM, Wittig I, Rapaport D (2017) Coi1 is a novel assembly factor of the yeast complex III-complex IV supercomplex. Mol Biol Cell [Epub ahead of print].Saccharomyces cerevisiae
Lores-Arnaiz 2017 J Neurochem2017Lores-Arnaiz S, Karadayian AG, Gutnisky A, Rodríguez de Lores Arnaiz G (2017) The low affinity neurotensin receptor antagonist levocabastine impairs brain nitric oxide synthesis and mitochondrial function by independent mechanisms. J Neurochem 143:684-96.RatNervous system
Schmidt 2017 J Vasc Surg2017Schmidt CA, Ryan TE, Lin CT, Inigo MM, Green TD, Brault JJ, Spangenburg EE, McClung JM (2017) Diminished force production and mitochondrial respiratory deficits are strain-dependent myopathies of subacute limb ischemia. J Vasc Surg 65:1504-1514.MouseSkeletal muscleHypoxiaMyopathy
Other
Xu 2017 J Hum Genet2017Xu B, Li X, Du M, Zhou C, Fang H, Lyu J, Yang Y (2017) Novel mutation of ND4 gene identified by targeted next-generation sequencing in patient with Leigh syndrome. J Hum Genet 62:291-7.HumanBlood cells
Platelet
Neurodegenerative
Zhang 2017 J Biol Chem2017Zhang Y, Bharathi SS, Rardin MJ, Lu J, Maringer KV, Sims-Lucas S, Prochownik EV, Gibson BW, Goetzman ES (2017) Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain. J Biol Chem 292:10239-49.HumanLiver
HEK
Welker 2017 Thesis2017Welker L (2017) Metabolic and morphologic shifts in Neuro2a cells cultured in galactose medium. Master's Thesis p26.MouseCancer
Linden 2017 Am J Physiol Gastrointest Liver Physiol2017Linden MA, Fletcher JA, Meers GM, Thyfault JP, Laughlin MH, Rector RS (2017) A return to ad libitum feeding following caloric restriction promotes hepatic steatosis in hyperphagic OLETF rats. Am J Physiol Gastrointest Liver Physiol 311:G387-95.RatLiverObesity
Nogueira 2017 Free Radic Biol Med2017Nogueira NP, Saraiva FMS, Oliveira MP, Mendonca APM, Inacio JDF, Almeida-Amaral EE, Menna-Barreto RF, Laranja GAT, Lopes Torres EJ, Oliveira MF, Paes MC (2017) Heme modulates Trypanosoma cruzi bioenergetics inducing mitochondrial ROS production. Free Radic Biol Med 108:183-91.ProtistsOxidative stress;RONS
Schatton 2017 J Cell Biol2017Schatton D, Pla-Martin D, Marx MC, Hansen H, Mourier A, Nemazanyy I, Pessia A, Zentis P, Corona T, Kondylis V, Barth E, Schauss AC, Velagapudi V, Rugarli EI (2017) CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs. J Cell Biol 216:675-93.MouseLiver
Rowley 2017 Thesis2017Rowley TJ (2017) The effect of cocoa flavanols on β-cell mass and function. Master's Thesis p131.RatIslet cell;pancreas;thymusDiabetes
Obesity
Doerrier 2016 Mitochondrion2016Doerrier C, García JA, Volt H, Díaz-Casado ME, Luna-Sánchez M, Fernández-Gil B, Escames G, López LC, Acuña-Castroviejo D (2016) Permeabilized myocardial fibers as model to detect mitochondrial dysfunction during sepsis and melatonin effects without disruption of mitochondrial network. Mitochondrion 27:56-63.MouseHeartSepsis
Fisar 2016 Curr Alzheimer Res2016Fišar Z, Hroudová J, Hansíková H, Spáčilová J, Lelková P, Wenchich L, Jirák R, Zvěřová M, Zeman J, Martásek P, Raboch J (2016) Mitochondrial respiration in the platelets of patients with Alzheimer's disease. Curr Alzheimer Res 13:930-41.HumanBlood cells
Platelet
Alzheimer's
Milerova 2016 Mol Cell Biochem2016Milerová M, Drahota Z, Chytilová A, Tauchmannová K, Houštěk J, Ošťádal B (2016) Sex difference in the sensitivity of cardiac mitochondrial permeability transition pore to calcium load. Mol Cell Biochem 412:147-54.RatHeartIschemia-reperfusion
Bernardo 2015 J Nutr Biochem2016Bernardo AF, Cortez E, Neves FA, Vieira AKG, Soares V, Rodrigues-Cunha AC, Andrade DC, Thole AA, Gabriel-Costa D, Brum PC, Moura AS, Garcia-Souza EP (2015) Overnutrition during lactation leads to impairment in insulin signaling, upregulation of GLUT1 and increased mitochondrial carbohydrate oxidation in heart of weaned mice. J Nutr Biochem 29:124-32.MouseHeartDiabetes
Obesity
Levchenko 2016 Biochim Biophys Acta2016Levchenko M, Wuttke JM, Römpler K, Schmidt B, Neifer K, Juris L, Wissel M, Rehling P, Deckers M (2016) Cox26 is a novel stoichiometric subunit of the yeast cytochrome c oxidase. Biochim Biophys Acta 1863:1624-32.Saccharomyces cerevisiae
Siewiera 2016 Life Sci2016Siewiera K, Kassassir H, Talar M, Wieteska L, Watala C (2016) Higher mitochondrial potential and elevated mitochondrial respiration are associated with excessive activation of blood platelets in diabetic rats. Life Sci 148:293-304.RatBlood cells
Platelet
Diabetes
Bombicino 2016 Arch Biochem Biophys2016Bombicino SS, Iglesias DE, Zaobornyj T, Boveris A, Valdez LB (2016) Mitochondrial nitric oxide production supported by reverse electron transfer. Arch Biochem Biophys 607:8-19.RatHeart
Bratic 2016 PLoS Genet2016Bratic A, Clemente P, Calvo-Garrido J, Maffezzini C, Felser A, Wibom R, Wedell A, Freyer C, Wredenberg A (2016) Mitochondrial polyadenylation is a one-step process required for mRNA integrity and tRNA maturation. PLoS Genet 12:e1006028.Drosophila
Sobotka 2016 J Bioenerg Biomembr2016Sobotka O, Endlicher R, Drahota Z, Kučera O, Rychtrmoc D, Raad M, Hakeem K, Červinková Z (2016) Impaired mitochondrial functions contribute to 3-bromopyruvate toxicity in primary rat and mouse hepatocytes. J Bioenerg Biomembr 48:363-73.Mouse
Rat
LiverCell death
Oxidative stress;RONS
Melenovsky 2016 Eur J Heart Fail2016Melenovsky V, Petrak J, Mracek T, Benes J, Borlaug BA, Nuskova H, Pluhacek T, Spatenka J, Kovalcikova J, Drahota Z, Kautzner J, Pirk J, Houstek J (2016) Myocardial iron content and mitochondrial function in human heart failure: a direct tissue analysis. Eur J Heart Fail 19:522-30.HumanHeartCardiovascular
Gerber 2016 J Med Genet2016Gerber S, Ding MG, Gérard X, Zwicker K, Zanlonghi X, Rio M, Serre V, Hanein S, Munnich A, Rotig A, Bianchi L, Amati-Bonneau P, Elpeleg O, Kaplan J, Brandt U, Rozet JM (2016) Compound heterozygosity for severe and hypomorphic NDUFS2 mutations cause non-syndromic LHON-like optic neuropathy. J Med Genet 54:346-56.HumanEndothelial;epithelial;mesothelial cell
Fibroblast
Saben 2016 Cell Rep2016Saben JL, Boudoures AL, Asghar Z, Thompson A, Drury A, Zhang W, Chi M, Cusumano A, Scheaffer S, Moley KH (2016) Maternal metabolic syndrome programs mitochondrial dysfunction via germline changes across three generations. Cell Rep 16:1-8.MouseSkeletal muscleObesity
Safiedeen 2016 Antioxid Redox Signal2016Safiedeen Z, Rodríguez-Gómez I, Vergori L, Soleti R, Vaithilingam D, Douma I, Agouni A, Leiber D, Dubois S, Simard G, Zibara K, Andriantsitohaina R, Martínez MC (2016) Temporal cross talk between endoplasmic reticulum and mitochondria regulates oxidative stress and mediates microparticle-induced endothelial dysfunction. Antioxid Redox Signal 26:15-27.HumanEndothelial;epithelial;mesothelial cellOxidative stress;RONSDiabetes
Obesity
Other
Reijne 2016 PLOS ONE2016Reijne AC, Ciapaite J, van Dijk TH, Havinga R, van der Zee EA, Groen AK, Reijngoud DJ, Bakker BM, van Dijk G (2016) Whole-body vibration partially reverses aging-induced increases in visceral adiposity and hepatic lipid storage in mice. PLOS ONE 11:e0149419.MouseSkeletal muscle
Liver
Aging;senescence
Wuest 2016 Cardiovasc Res2016Wüst RC, de Vries HJ, Wintjes LT, Rodenburg RJ, Niessen HW, Stienen GJ (2016) Mitochondrial complex I dysfunction and altered NAD(P)H kinetics in rat myocardium in cardiac right ventricular hypertrophy and failure. Cardiovasc Res 111:362-72.RatHeartCardiovascular
Rackham 2016 Cell Rep2016Rackham O, Busch JD, Matic S, Siira SJ, Kuznetsova I, Atanassov I, Ermer JA, Shearwood AM, Richman TR, Stewart JB, Mourier A, Milenkovic D, Larsson NG, Filipovska A (2016) Hierarchical RNA processing is required for mitochondrial ribosome assembly. Cell Rep 16:1874-90.MouseHeart
Van Hoose 2016 J Nutr Biochem2016Van Hoose PM, Kelm NQ, Piell KM, Cole MP (2016) Conjugated linoleic acid and nitrite attenuate mitochondrial dysfunction during myocardial ischemia. J Nutr Biochem 34:8-16.MouseHeartIschemia-reperfusionCardiovascular
Oliveira 2016 PLOS ONE2016Oliveira MP, Correa Soares JB, Oliveira MF (2016) Sexual preferences in nutrient utilization regulate oxygen consumption and reactive oxygen species generation in Schistosoma mansoni: potential implications for parasite redox biology. PLOS ONE 11:e0158429.Other invertebratesOxidative stress;RONS
Wang 2016 J Biol Chem2016Wang H, Lu J, Edmunds LR, Kulkarni S, Dolezal J, Tao J, Ranganathan S, Jackson L, Fromherz M, Stolz DB, Uppala R, Bharathi S, Monga SP, Goetzman ES, Prochownik EV (2016) Coordinated activities of multiple Myc-dependent and Myc-independent biosynthetic pathways in Hepatoblastoma. J Biol Chem 291:26241-51.MouseLiverCancer
Volt 2016 J Pineal Res2016Volt H, García JA, Doerrier C, Díaz-Casado ME, Guerra-Librero A, López LC, Escames G, Tresguerres JA, Acuña-Castroviejo D (2016) Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin. J Pineal Res 60:193-205.MouseHeartAging;senescence
Sepsis
Hartmannova 2016 Hum Mol Genet2016Hartmannová H, Piherová L, Tauchmannová K, Kidd K, Acott PD, Crocker JF, Oussedik Y, Mallet M, Hodaňová K, Stránecký V, Přistoupilová A, Barešová V, Jedličková I, Živná M, Sovová J, Hůlková H, Robins V, Vrbacký M, Pecina P, Kaplanová V, Houštěk J, Mráček T, Thibeault Y, Bleyer AJ, Kmoch S (2016) Acadian variant of Fanconi syndrome is caused by mitochondrial respiratory chain complex I deficiency due to a non-coding mutation in complex I assembly factor NDUFAF6. Hum Mol Genet 25:4062-79.HumanFibroblastInherited
Chang 2016 Transl Res2016Chang JC, Wu SL, Liu KH, Chen YH, Chuang CS, Cheng FC, Su HL, Wei YH, Kuo SJ, Liu CS (2016) Allogeneic/xenogeneic transplantation of peptide-labeled mitochondria in Parkinson's disease: restoration of mitochondria functions and attenuation of 6-hydroxydopamine-induced neurotoxicity. Transl Res 170:40-56.RatNervous system
Other cell lines
Parkinson's
Most 2016 Am J Clin Nutr2016Most J, Timmers S, Warnke I, Jocken JW, van Boekschoten M, de Groot P, Bendik I, Schrauwen P, Goossens GH, Blaak EE (2016) Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: a randomized controlled trial. Am J Clin Nutr 104:215-27.HumanSkeletal muscleDiabetes
Obesity
Stepanova 2016 Biochim Biophys Acta2016Stepanova A, Shurubor Y, Valsecchi F, Manfredi G, Galkin A (2016) Differential susceptibility of mitochondrial complex II to inhibition by oxaloacetate in brain and heart. Biochim Biophys Acta 1857:1561-8.MouseHeart
Nervous system
McFarlane 2016 Thesis2016McFarlane SV (2016) Temperature-dependent alterations of brown adipose tissue metabolism during hibernation in the thirteen-lined ground squirrel, Ictidomys tridecemlineatus. Dissertation p74.Other mammalsFatTemperature
Iglesias-Gonzalez 2016 Mol Neurobiol2016Iglesias-González J, Sánchez-Iglesias S, Beiras-Iglesias A, Méndez-Álvarez E, Soto-Otero R (2016) Effects of aluminium on rat brain mitochondria bioenergetics: an in vitro and in vivo study. Mol Neurobiol 54:563-70.RatNervous systemAlzheimer's
Neurodegenerative
Parkinson's
Hagl 2016 Neuromolecular Med2016Hagl S, Asseburg H, Heinrich M, Sus N, Blumrich EM, Dringen R, Frank J, Eckert GP (2016) Effects of long-term rice bran extract supplementation on survival, cognition and brain mitochondrial function in aged NMRI mice. Neuromolecular Med 18:347-63.MouseNervous systemAging;senescence
Alzheimer's
Neurodegenerative
Bastian 2016 Cancer Lett2016Bastian A, Matsuzaki S, Humphries KM, Pharaoh GA, Doshi A, Zaware N, Gangjee A, Ihnat MA (2016) AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization. Cancer Lett pii: S0304-3835(16)30745-5.MouseCell deathCancer
Li 2016 Neurochem Int2016Li H, Liu Y, Lin LT, Wang XR, Du SQ, Yan CQ, He T, Yang JW, Liu CZ (2016) Acupuncture reversed hippocampal mitochondrial dysfunction in vascular dementia rats. Neurochem Int 92:35-42.RatNervous systemNeurodegenerative
Wolter 2016 J Thromb Haemost2016Wolter J, Schild L, Bock F, Hellwig A, Gadi I, Al-Dabet MM, Ranjan S, Rönicke R, Nawroth PP, Petersen KU, Mawrin C, Shahzad K, Isermann B (2016) Thrombomodulin-dependent protein C activation is required for mitochondrial function and myelination in the central nervous system. J Thromb Haemost 14:2212-26.MouseNervous systemNeurodegenerative
Bareth 2016 Mol Biol Cell2016Bareth B, Nikolov M, Lorenzi I, Hildenbeutel M, Mick DU, Helbig C, Urlaub Z, Ott M, Rehling P, Dennerlein S (2016) Oms1 associates with cytochrome c oxidase assembly intermediates to stabilize newly synthesized Cox1. Mol Biol Cell 27:1570-80.Saccharomyces cerevisiae
Richman 2016 Nat Commun2016Richman TR, Spåhr H, Ermer JA, Davies SM, Viola HM, Bates KA, Papadimitriou J, Hool LC, Rodger J, Larsson NG, Rackham O, Filipovska A (2016) Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice. Nat Commun 7:11884.MouseHeart
Liver
Mitochondrial disease
Cacabelos 2016 Acta Neuropathol Commun2016Cacabelos D, Ramírez-Núñez O, Granado-Serrano AB, Torres P, Ayala V, Moiseeva V, Povedano M, Ferrer I, Pamplona R, Portero-Otin M, Boada J (2016) Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS. Acta Neuropathol Commun 4:3.MouseNervous system
Other cell lines
Neurodegenerative
Leucci 2016 Nature2016Leucci E, Vendramin R, Spinazzi M, Laurette P, Fiers M, Wouters J, Radaelli E, Eyckerman S, Leonelli C, Vanderheyden K, Rogiers A, Hermans E, Baatsen P, Aerts S, Amant F, Van Aelst S, van den Oord J, de Strooper B, Davidson I, Lafontaine DL, Gevaert K, Vandesompele J, Mestdagh P, Marine JC (2016) Melanoma addiction to the long non-coding RNA SAMMSON. Nature 531:518-22.HumanEndothelial;epithelial;mesothelial cell
Other cell lines
Cancer
Ryan 2016 Diabetes2016Ryan TE, Schmidt CA, Green TD, Spangenburg EE, Neufer PD, McClung JM (2016) Targeted expression of catalase to mitochondria protects against ischemic myopathy in high fat fed mice. Diabetes 65:2553-68.MouseSkeletal muscleIschemia-reperfusionDiabetes
Davuluri 2016 J Physiol2016Davuluri G, Allawy A, Thapaliya S, Rennison JH, Singh D, Kumar A, Sandlers Y, Van Wagoner DR, Flask CA, Hoppel C, Kasumov T, Dasarathy S (2016) Hyperammonaemia-induced skeletal muscle mitochondrial dysfunction results in cataplerosis and oxidative stress. J Physiol 594:7341-60.MouseSkeletal muscle
Other cell lines
Oxidative stress;RONS
Davoudi 2016 PLOS ONE2016Davoudi M, Kotarsky H, Hansson E, Kallijärvi J, Fellman V (2016) COX7A2L/SCAFI and pre-complex III modify respiratory chain supercomplex formation in different mouse strains with a Bcs1l mutation. PLOS ONE 11:e0168774.MouseLiverOther
Castellano-Gonzalez 2016 Oncotarget2016Castellano-González G, Pichaud N, Ballard JW, Bessede A, Marcal H, Guillemin GJ (2016) Epigallocatechin-3-gallate induces oxidative phosphorylation by activating cytochrome c oxidase in human cultured neurons and astrocytes. Oncotarget 7:7426-40HumanNervous system
Amaral 2016 Biochim Biophys Acta2016Amaral AU, Cecatto C, da Silva JC, Wajner A, Godoy KD, Ribeiro RT, Wajner M (2016) cis-4-Decenoic and decanoic acids impair mitochondrial energy, redox and Ca2+ homeostasis and induce mitochondrial permeability transition pore opening in rat brain and liver: Possible implications for the pathogenesis of MCAD deficiency. Biochim Biophys Acta 1857:1363-72.RatNervous system
Liver
Miotto 2016 Biochem J2016Miotto PM, Holloway GP (2016) In the absence of phosphate shuttling, exercise reveals the in vivo importance of creatine-independent mitochondrial ADP transport. Biochem J 473:2831-43.MouseSkeletal muscle
Szczepanowska 2016 EMBO J2016Szczepanowska K, Maiti P, Kukat A, Hofsetz E, Nolte H, Senft K, Becker C, Ruzzenente B, Hornig-Do HT, Wibom R, Wiesner RJ, Krüger M, Trifunovic A (2016) CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels. EMBO J 35:2566-83.MouseHeart
Singh 2016 Mol Neurobiol2016Singh N, Hroudová J, Fišar Z (2016) In vitro effects of cognitives and nootropics on mitochondrial respiration and monoamine oxidase activity. Mol Neurobiol 54:5894-904.PigNervous systemAlzheimer's
Lund 2016 J Physiol2016Lund MT, Kristensen M, Hansen M, Tveskov L, Floyd AK, Støckel M, Vainer B, Poulsen SS, Helge JW, Prats C, Dela F (2016) Hepatic mitochondrial oxidative phosphorylation is normal in obese patients with and without type 2 diabetes. J Physiol 594:4351-8.HumanLiverDiabetes
Obesity
Gomez 2016 Thesis2016Gomez CR (2016) Mitochondrial responses to anoxia exposure in red eared sliders (Trachemys scripta). Master's Thesis p102.ReptilesHeart
Nervous system
Oxidative stress;RONS
Amigo 2016 Aging Cell2016Amigo I, Menezes-Filho SL, Luévano-Martínez LA, Chausse B, Kowaltowski AJ (2016) Caloric restriction increases brain mitochondrial calcium retention capacity and protects against excitotoxicity. Aging Cell 16:73-81.MouseNervous system
Schinagl 2016 PLoS One2016Schinagl CW, Vrabl P, Burgstaller W (2016) Adapting high-resolution respirometry to glucose-limited steady state mycelium of the filamentous fungus Penicillium ochrochloron: method development and standardisation. PLoS One 11:e0146878.Fungi
Scott 2016 Thesis2016Scott KY (2016) Evaluation of cardiac mitochondrial function in the fructose-fed rat. Master's Thesis p98.RatHeartDiabetes
Bal 2016 J Biol Chem2016Bal NC, Maurya SK, Singh S, Wehrens XH, Periasamy M (2016) Increased reliance on muscle based thermogenesis upon acute minimization of brown adipose tissue function. J Biol Chem 291:17247-57.MouseSkeletal muscleTemperature
Schiffer 2016 Am J Physiol Cell Physiol2016Schiffer TA, Peleli M, Sundqvist ML, Ekblom B, Lundberg JO, Weitzberg E, Larsen FJ (2016) Control of human energy expenditure by cytochrome c oxidase subunit IV-2. Am J Physiol Cell Physiol 311:C452-61.HumanHEK
Skeletal muscle
Hypoxia
Oxidative stress;RONS
Lores-Arnaiz 2016 Neurochem Res2016Lores-Arnaiz S, Lombardi P, Karadayian AG, Orgambide F, Cicerchia D, Bustamante J (2016) Brain cortex mitochondrial bioenergetics in synaptosomes and non-synaptic mitochondria during aging. Neurochem Res 41:353-63.MouseNervous systemAging;senescence
Rohlenova 2016 Antioxid Redox Signal2016Rohlenova K, Sachaphibulkij K, Stursa J, Bezawork-Geleta A, Blecha J, Endaya B, Werner L, Cerny J, Zobalova R, Goodwin J, Spacek T, Alisadeh E, Yan B, Nguyen M, Vondrusova M, Sobol M, Jezek P, Hozak P, Truksa J, Rohlena J, Dong L, Neuzil J (2016) Selective disruption of respiratory supercomplexes as a new strategy to suppress Her2high breast cancer. Antioxid Redox Signal 26:84-103.Human
Mouse
Liver
Genital
Other cell lines
Oxidative stress;RONSCancer
Frey 2016 Biochim Biophys Acta2016Frey S, Geffroy G, Desquiret-Dumas V, Gueguen N, Bris C, Belal S, Amati-Bonneau P, Chevrollier A, Barth M, Henrion D, Lenaers G, Bonneau D, Reynier P, Procaccio V (2016) The addition of ketone bodies alleviates mitochondrial dysfunction by restoring complex I assembly in a MELAS cellular model. Biochim Biophys Acta 1863:284-91.HumanNervous systemOther
Strifler 2016 PLOS ONE2016Strifler G, Tuboly E, Szél E, Kaszonyi E, Cao C, Kaszaki J, Mészáros A, Boros M, Hartmann P (2016) Inhaled methane limits the mitochondrial electron transport chain dysfunction during experimental liver ischemia-reperfusion injury. PLOS ONE 11:e0146363.RatLiverIschemia-reperfusion
Distefano 2016 J Gerontol A Biol Sci Med Sci2016Distefano G, Standley RA, Dubé JJ, Carnero EA, Ritov VB, Stefanovic-Racic M, Toledo FG, Piva SR, Goodpaster BH, Coen PM (2016) Chronological age does not influence ex-vivo mitochondrial respiration and quality control in skeletal muscle. J Gerontol A Biol Sci Med Sci 72:535-42.HumanSkeletal muscleAging;senescence
Thomas 2016 Neurodegeneration Therapeutics2016Thomas RR, Keeney PM, Berr SB, Khan SM, Portell FR, Shakenov MZ, Antkowiak PF, Kundu B, Tustison N, Brohawn DG, Bennett JP (2016) Recombinant human TFAM stimulates rat brain, rat cervical spinal cord and human neural stem cell mitochondrial bioenergetics. Neurodegeneration Therapeutics p41.RatNervous systemMitochondrial disease
Khattar 2016 J Neurosci Methods2016Khattar NK, Yablonska S, Baranov SV, Baranova OV, Kretz ES, Larkin TM, Carlisle DL, Richardson RM, Friedlander RM (2016) Isolation of functionally active and highly purified neuronal mitochondria from human cortex. J Neurosci Methods 263:1-6.Human
Mouse
Nervous system
Lim 2016 FASEB J2016Lim SC, Hroudová J, Van Bergen NJ, Lopez Sanchez MI, Trounce IA, McKenzie M (2016) Loss of mitochondrial DNA-encoded protein ND1 results in disruption of complex I biogenesis during early stages of assembly. FASEB J 30:2236-48.HumanOther cell linesCancer
Van Zutphen 2016 J Hepatol2016van Zutphen T, Ciapaite J, Bloks VW, Ackereley C, Gerding A, Jurdzinski A, Allgayer de Moraes R, Zhang L, Wolters JC, Bischoff R, Wanders RJ, Houten SM, Bronte-Tinkew D, Shatseva T, Lewis GF, Groen AK, Reijngoud DJ, Bakker BM, Jonker JW, Kim PK, Bandsma RH (2016) Malnutrition-associated liver steatosis and ATP depletion is caused by peroxisomal and mitochondrial dysfunction. J Hepatol 65:1198-1208.RatLiver
MiPNet06.06 Chemical O2 background2015-04-27
O2k-Protocols
Oxygraph assay of cytochrome c oxidase activity: chemical background correction.
Van Hoose 2015 Thesis2015Van Hoose P (2015) Co-treatment with conjugated linoleic acid and nitrite modulates mitochondrial respiration and electron transport chain activity in vivo and attenuates mitochondrial dysfunction during cardiac injury. Dissertations p128.MouseHeartIschemia-reperfusionCardiovascular
Paglialunga 2015 Diabetologia2015Paglialunga S, Ludzki A, Root-McCaig J, Holloway GP (2015) In adipose tissue, increased mitochondrial emission of reactive oxygen species is important for short-term high-fat diet-induced insulin resistance in mice. Diabetologia 58:1071-80.MouseFatOxidative stress;RONSDiabetes
Lantier 2015 Diabetes2015Lantier L, Williams AS, Williams IM, Yang KK, Bracy DP, Goelzer M, James FD, Gius D, Wasserman DH (2015) SIRT3 is crucial for maintaining skeletal muscle insulin action and protects against severe insulin resistance in high fat fed mice. Diabetes 64:3081-92.MouseSkeletal muscleDiabetes
Patil 2015 J Nutr Biochem2015Patil YN, Dille KN, Burk DH, Cortez CC, Gettys TW (2015) Cellular and molecular remodeling of inguinal adipose tissue mitochondria by dietary methionine restriction. J Nutr Biochem 26:1235-47.MouseSkeletal muscle
Liver
Fat
Caito 2015 Antioxid Redox Signal2015Caito SW, Aschner M (2015) Mitochondrial redox dysfunction and environmental exposures. Antioxid Redox Signal 23:578-95.Human
Mouse
Rat
Bovines
Drosophila
Fishes
Hexapods
Heart
Nervous system
Liver
Kidney
Lung;gill
Endothelial;epithelial;mesothelial cell
Cell death
Ischemia-reperfusion
Oxidative stress;RONS
COPD
Ydfors 2015 J Physiol2015Ydfors M, Hughes MC, Laham R, Schlattner U, Norrbom J, Perry CG (2015) Modelling in vivo creatine/phosphocreatine in vitro reveal divergent adaptations in human muscle mitochondrial respiratory control by ADP after acute and chronic exercise. J Physiol 594:3127-40.HumanSkeletal muscle
Harris 2015 Diabetes2015Harris LA, Skinner JR, Shew TM, Pietka TA, Abumrad NA, Wolins NE (2015) Perilipin 5-driven lipid droplet accumulation in skeletal muscle stimulates the expression of fibroblast growth factor 21. Diabetes 64:2757-68.MouseSkeletal muscle
Van Rahden 2015 Am J Hum Genet2015van Rahden VA, Fernandez-Vizarra E, Alawi M, Brand K, Fellmann F, Horn D, Zeviani M, Kutsche K (2015) Mutations in NDUFB11, encoding a complex I component of the mitochondrial respiratory chain, cause microphthalmia with linear skin defects syndrome. Am J Hum Genet 96:640-50.HumanHeLaCell deathOther
Senyilmaz 2015 Nature2015Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA (2015) Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature 525:124-8.DrosophilaParkinson's
Kruse 2015 Aging Cell2015Kruse SE, Karunadharma PP, Basisty N, Johnson R, Beyer RP, MacCoss MJ, Rabinovitch PS, Marcinek DJ (2015) Age modifies respiratory complex I and protein homeostasis in a muscle type-specific manner. Aging Cell 15:89-99.MouseSkeletal muscleOxidative stress;RONSAging;senescence
Kang 2015 Int J Clin Exp Med2015Kang M, Zhao L, Ren M, Deng M, Li C (2015) Reduced metallothionein expression induced by Zinc deficiency results in apoptosis in hepatic stellate cell line LX-2. Int J Clin Exp Med 8:20603-9.HumanLiver
Other cell lines
Cell death
Beauchamp 2015 Biosci Rep2015Beauchamp B, Thrush AB, Quizi J, Antoun G, McIntosh N, Al-Dirbashi OY, Patti ME, Harper ME (2015) Undernutrition during pregnancy in mice leads to dysfunctional cardiac muscle respiration in adult offspring. Biosci Rep 35. pii:e00200.MouseHeart
Liver
Cardiovascular
Diabetes
Obesity
Ikaga 2015 Biochem Biophys Rep2015Ikaga R, Namekatac I, Kotiadisd VN, Ogawab H, Duchend MR, Tanakac H, Iida-Tanakab N (2015) Knockdown of aquaporin-8 induces mitochondrial dysfunction in 3T3-L1 cells. Biochem Biophys Rep 4:187–95.MouseFat
Other cell lines
Richman 2015 PLoS Genet2015Richman TR, Ermer JA, Davies SM, Perks KL, Viola HM, Shearwood AM, Hool LC, Rackham O, Filipovska A (2015) Mutation in MRPS34 compromises protein synthesis and causes mitochondrial dysfunction. PLoS Genet 11:e1005089.MouseHeart
Liver
Mitochondrial diseaseAging;senescence
Cardiovascular
Other
Teh 2015 Oncogene2015Teh JT, Zhu WL, Ilkayeva OR, Li Y, Gooding J, Casey PJ, Summers SA, Newgard CB, Wang M (2015) Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism. Oncogene 34:3296-304.HumanOther cell linesCancer
Rodrigues 2016 Biochem J2015Rodrigues MF, Obre E, Melo FH, Santos-Jr GC, Galina A, Jasiulionis MG, Rossignol R, Rumjanek FD, Amoedo ND (2016) Enhanced OXPHOS, glutaminolysis and beta-oxidation constitute the metastatic phenotype of melanoma cells. Biochem J 473:703-15.MouseEndothelial;epithelial;mesothelial cell
Other cell lines
Cancer
Lim 2015 Am J Cancer Res2015Lim SC, Carey KT, McKenzie M (2015) Anti-cancer analogues ME-143 and ME-344 exert toxicity by directly inhibiting mitochondrial NADH: ubiquinone oxidoreductase (Complex I). Am J Cancer Res 5:689-701.HumanKidney
Other cell lines
HEK
HeLa
Fibroblast
Cancer
Kishita 2015 Am J Hum Genet2015Kishita Y, Pajak A, Bolar NA, Marobbio CM, Maffezzini C, Miniero DV, Monné M, Kohda M, Stranneheim H, Murayama K, Naess K, Lesko N, Bruhn H, Mourier A, Wibom R, Nennesmo I, Jespers A, Govaert P, Ohtake A, Van Laer L, Loeys BL, Freyer C, Palmieri F, Wredenberg A, Okazaki Y, Wedell A (2015) Intra-mitochondrial methylation deficiency due to mutations in SLC25A26. Am J Hum Genet 97:761-8.HumanSkeletal muscle
Fibroblast
Inherited
Other
Dungel 2015 Free Radic Biol Med2015Dungel P, Perlinger M, Weidinger A, Redl H, Kozlov AV (2015) The cytoprotective effect of nitrite is based on the formation of dinitrosyl iron complexes. Free Radic Biol Med 89:300-10.RatLiverIschemia-reperfusion
Oxidative stress;RONS
Vincent 2015 Front Physiol2015Vincent G, Lamon S, Gant N, Vincent PJ, MacDonald JR, Markworth JF, Edge JA, Hickey AJ (2015) Changes in mitochondrial function and mitochondria associated protein expression in response to 2-weeks of high intensity interval training. Front Physiol 6:51.HumanSkeletal muscle
Agil 2015 J Pineal Res2015Agil A, El-Hammadi M, Jiménez-Aranda A, Tassi M, Abdo W, Fernández-Vázquez G, Reiter RJ (2015) Melatonin reduces hepatic mitochondrial dysfunction in diabetic obese rats. J Pineal Res 59:70-9.RatLiverDiabetes
Obesity
Martinez 2015 Thesis2015Martínez Gasca B (2015) Generacion de modelos celulares para el estudio del efecto fenotipico de la variacion genetica en el mtDNA. Thesis 1-35.HumanLiver
Other cell lines
Soares 2015 PLoS One2015Soares JB, Gaviraghi A, Oliveira MF (2015) Mitochondrial physiology in the major arbovirus vector Aedes aegypti: substrate preferences and sexual differences define respiratory capacity and superoxide production. PLoS One 10:e0120600.HexapodsSkeletal muscleOxidative stress;RONS
Angebault 2015 Am J Hum Genet2015Angebault C, Guichet PO, Talmat-Amar Y, Charif M, Gerber S, Fares-Taie L, Gueguen N, Halloy F, Moore D, Amati-Bonneau P, Manes G, Hebrard M, Bocquet B, Quiles M, Piro-Mégy C, Teigell M, Delettre C, Rossel M, Meunier I, Preising M, Lorenz B, Carelli V, Chinnery PF, Yu-Wai-Man P, Kaplan J, Roubertie A, Barakat A, Bonneau D, Reynier P, Rozet JM, Bomont P, Hamel CP, Lenaers G (2015) Recessive mutations in RTN4IP1 cause isolated and syndromic optic neuropathies. Am J Hum Genet 97:754-60.HumanEndothelial;epithelial;mesothelial cell
Fibroblast
Other
Mourier 2015 J Cell Biol2015Mourier A, Motori E, Brandt T, Lagouge M, Atanassov I, Galinier A, Rappl G, Brodesser S, Hultenby K, Dieterich C, Larsson NG (2015) Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels. J Cell Biol 208:429-42.MouseHeart
Fibroblast
Blatzer 2015 Antioxid Redox Signal2015Blatzer M, Jukic E, Posch W, Schöpf B, Binder U, Steger M, Blum G, Hackl H, Gnaiger E, Lass-Flörl C, Wilflingseder D (2015) Amphotericin B resistance in Aspergillus terreus is overpowered by co-application of pro-oxidants. Antioxid Redox Signal 23:1424-38.FungiOxidative stress;RONS
Llobet 2015 Dis Model Mech2015Llobet L, Toivonen JM, Montoya J, Ruiz-Pesini E, López-Gallardo E (2015) OXPHOS xenobiotics alter adipogenic differentiation at concentrations found in human blood. Dis Model Mech 8:1441-55.HumanFat
Stem cells
Jiroutkova 2015 Crit Care2015Jiroutková K, Krajčová A, Ziak J, Fric M, Waldauf P, Džupa V, Gojda J, Němcova-Fürstová V, Kovář J, Elkalaf M, Trnka J, Duška F (2015) Mitochondrial function in skeletal muscle of patients with protracted critical illness and ICU-acquired weakness. Crit Care 19:448.HumanSkeletal muscleOther
Ludzki 2015 Diabetes2015Ludzki A, Paglialunga S, Smith BK, Herbst EA, Allison MK, Heigenhauser GJ, Neufer PD, Holloway GP (2015) Rapid repression of ADP transport by palmitoyl-CoA is attenuated by exercise training in humans; a potential mechanism to decrease oxidative stress and improve skeletal muscle insulin signaling. Diabetes 64:2769-79.Human
Mouse
Skeletal muscleDiabetes
Flatters 2015 Prog Mol Biol Transl Sci2015Flatters SJ (2015) The contribution of mitochondria to sensory processing and pain. Prog Mol Biol Transl Sci 131:119-46.RatNervous systemDiabetes
Other
Schrauwen-Hinderling 2015 Antioxid Redox Signal2015Schrauwen-Hinderling VB, Kooi ME, Schrauwen P (2015) Mitochondrial function and diabetes; consequences for skeletal and cardiac muscle metabolism. Antioxid Redox Signal 24:39-51.HumanHeart
Skeletal muscle
Diabetes
Other
Hanssen 2015 Nat Med2015Hanssen MJ, Hoeks J, Brans B, van der Lans AA, Schaart G, van den Driessche JJ, Jörgensen JA, Boekschoten MV, Hesselink MK, Havekes B, Kersten S, Mottaghy FM, van Marken Lichtenbelt WD, Schrauwen P (2015) Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus. Nat Med 21:863-5.HumanSkeletal muscleTemperatureDiabetes
Czerniczyniec 2015 J Bioenerg Biomembr2015Czerniczyniec A, Lanza EM, Karadayian AG, Bustamante J, Lores-Arnaiz S (2015) Impairment of striatal mitochondrial function by acute paraquat poisoning. J Bioenerg Biomembr 47:395-408.RatNervous system
Ramos-Filho 2015 PLoS One2015Ramos-Filho D, Chicaybam G, de-Souza-Ferreira E, Guerra Martinez C, Kurtenbach E, Casimiro-Lopes G, Galina A (2015) High intensity interval training (HIIT) induces specific changes in respiration and electron leakage in the mitochondria of different rat skeletal muscles. PLoS One 10:e0131766.RatSkeletal muscle
Blanchet 2015 Sci Rep2015Blanchet L, Smeitink JA, van Emst-de Vries SE, Vogels C, Pellegrini M, Jonckheere AI, Rodenburg RJ, Buydens LM, Beyrath J, Willems PH, Koopman WJ (2015) Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning. Sci Rep 5:8035.HumanEndothelial;epithelial;mesothelial cell
Fibroblast
Mitochondrial disease
Whitfield 2015 J Physiol2015Whitfield J, Ludzki A, Heigenhauser GJ, Senden JM, Verdijk LB, van Loon LJ, Spriet LL, Holloway GP (2015) Beetroot juice supplementation reduces whole body oxygen consumption but does not improve indices of mitochondrial efficiency in human skeletal muscle. J Physiol 594:421-35.HumanSkeletal muscleOxidative stress;RONS
Luevano-Martinez 2015 Biochim Biophys Acta2015Luévano-Martínez LA, Forni MF, Dos Santos VT, Souza-Pinto NC, Kowaltowski AJ (2015) Cardiolipin is a key determinant for mtDNA stability and segregation during mitochondrial stress. Biochim Biophys Acta 1847:587-98.Saccharomyces cerevisiae
Fungi
Temperature
Gaude 2014 Cancer Metab2014Gaude E, Frezza C (2014) Defects in mitochondrial metabolism and cancer. Cancer Metab 2:10.HumanCancer
D'Erchia 2014 Mitochondrion2014D'Erchia AM, Atlante S, Gadaleta G, Pavesi G, Chiara M, De Virgilio C, Manzari C, Mastropasqua F, Prazzoli GM, Picardi E, Gissi C, Horner D, Reyes A, Sbisa E, Tullo A, Pesole G (2014) Tissue-specific mtDNA abundance from exome data and its correlation 2 with mitochondrial transcription, mass and respiratory activity. Mitochondrion 970:1-9.Human
Kelly 2014 J Appl Physiol2014Kelly NA, Ford MP, Standaert DG, Watts RL, Bickel CS, Moellering DR, Tuggle SC, Williams JY, Lieb L, Windham ST, Bamman MM (2014) Novel, high-intensity exercise prescription improves muscle mass, mitochondrial function, and physical capacity in individuals with Parkinson's disease. J Appl Physiol 116:582-92.HumanSkeletal muscleNeurodegenerative
Parkinson's
Van Bergen 2014 Mitochondrion2014Van Bergen NJ, Blake RE, Crowston JG, Trounce IA (2014) Oxidative phosphorylation measurement in cell lines and tissues. Mitochondrion 15:24-33.Human
Mouse
Nervous system
Blood cells
Lymphocyte
Boczek 2014 Biomed Res Int2014Boczek T, Lisek M, Ferenc B, Kowalski A, Wiktorska M, Zylinska L (2014) Silencing of plasma membrane Ca2+-ATPase isoforms 2 and 3 impairs energy metabolism in differentiating PC12 cells. Biomed Res Int 2014:735106.RatNervous system
Other cell lines
Pulliam 2014 Biochem J2014Pulliam DA, Deepa SS, Liu Y, Hill S, Lin AL, Bhattacharya A, Shi Y, Sloane L, Viscomi C, Zeviani M, Van Remmen H (2014) Complex IV-deficient Surf1(-/-) mice initiate mitochondrial stress responses. Biochem J 462:359-71.MouseHeart
Skeletal muscle
Mitochondrial disease
Quoilin 2014 Dissertation2014Quoilin C (2014) Les effets délétères métaboliques et oxydants induits lors d'un sepsis sur la fonction rénale. Dissertation 1-195.Kidney
Endothelial;epithelial;mesothelial cell
Cell death
Ischemia-reperfusion
Oxidative stress;RONS
Sepsis
De Lucas 2014 J Sports Sci2014De Lucas DR, Caputo F, Mendes de Souza K, Sigwalt AR, Ghisoni K, Lock Silveira PC, Remor AP, da Luz Scheffer D, Antonacci Guglielmo LG, Latini A (2014) Increased platelet oxidative metabolism, blood oxidative stress and neopterin levels after ultraendurance exercise. J Sports Sci 32:22-30HumanBlood cells
Platelet
Oxidative stress;RONS
Mourier 2014 Hum Mol Genet2014Mourier A, Ruzzenente B, Brandt T, Kühlbrandt W, Larsson NG (2014) Loss of LRPPRC causes ATP synthase deficiency. Hum Mol Genet 23:2580-92.MouseHeartOxidative stress;RONSNeurodegenerative
Paradies 2014 Biochim Biophys Acta2014Paradies G, Paradies V, De Benedictis V, Ruggiero FM, Petrosillo G (2014) Functional role of cardiolipin in mitochondrial bioenergetics. Biochim Biophys Acta 1837:408-17.Cell death
Permeability transition
Spinazzi 2014 Neuropathol Appl Neurobiol2014Spinazzi M, Sghirlanzoni A, Salviati L, Angelini C (2014) Impaired copper and iron metabolism in blood cells and muscles of patients affected by copper deficiency myeloneuropathy. Neuropathol Appl Neurobiol 40:888-98.HumanOxidative stress;RONSNeurodegenerative
Other
Lapuente-Brun 2013 Science2013Lapuente-Brun E, Moreno-Loshuertos R, Acín-Pérez R, Latorre-Pellicer A, Colás C, Balsa E, Perales-Clemente E, Quirós PM, Calvo E, Rodríguez-Hernández MA, Navas P, Cruz R, Carracedo Á, López-Otín C, Pérez-Martos A, Fernández-Silva P, Fernández-Vizarra E, Enríquez JA (2013) Supercomplex assembly determines electron flux in the mitochondrial electron transport chain. Science 340:1567-70.
Stride 2013 Eur J Heart Fail2013Stride N, Larsen S, Hey-Mogensen M, Sander K, Lund JT, Gustafsson F, Kober L, Dela F (2013) Decreased mitochondrial oxidative phosphorylation capacity in the human heart with left ventricular systolic dysfunction. Eur J Heart Fail 15:150-7.HumanHeartMitochondrial disease
Segalés 2013 Am J Physiol Endocrinol Metab2013Segalés J, Paz JC, Hernández-Alvarez MI, Sala D, Muñoz JP, Noguera E, Pich S, Palacín M, Enríquez JA, Zorzano A (2013) A form of mitofusin 2 (Mfn2) lacking the transmembrane domains and the COOH-terminal end stimulates metabolism in muscle and liver cells. Am J Physiol Endocrinol Metab 305:1208-21.MouseSkeletal muscle
Liver
Other cell lines
Kaambre 2013 Front Physiol2013Kaambre T, Chekulayev V, Shevchuk I, Tepp K, Timohhina N, Varikmaa M, Bagur R, Klepinin A, Anmann T, Koit A, Kaldma A, Guzun R, Valvere V, Saks V (2013) Metabolic control analysis of respiration in human cancer tissue. Front Physiol 4:151.HumanEndothelial;epithelial;mesothelial cellCell deathCancer
Kiebish 2013 J Lipid Res2013Kiebish MA, Yang K, Liu X, Mancuso DJ, Guan S, Zhao Z, Sims HF, Cerqua R, Cade WT, Han X, Gross RW (2013) Dysfunctional cardiac mitochondrial bioenergetic, lipidomic, and signaling in a murine model of Barth syndrome. J Lipid Res 54:1312-25.MouseHeartMitochondrial diseaseOther
Leadsham 2013 Cell Metab2013Leadsham JE, Sanders G, Giannaki S, Bastow EL, Hutton R, Naeimi WR, Breitenbach M, Gourlay CW (2013) Loss of cytochrome c oxidase promotes RAS-dependent ROS production from the ER resident NADPH oxidase, Yno1p, in yeast. Cell Metab 18:279-86.Saccharomyces cerevisiaeOxidative stress;RONS
Ye 2013 Anal Biochem2013Ye F, Hoppel CL (2013) Measuring oxidative phosphorylation in human skin fibroblasts. Anal Biochem 437:52-8.HumanSkeletal muscle
Fibroblast
Chacko 2013 Lab Invest2013Chacko BK, Kramer PA, Ravi S, Johnson MS, Hardy RW, Ballinger SW, Darley-Usmar VM (2013) Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and neutrophils, and the oxidative burst from human blood. Lab Invest 93:690-700.HumanBlood cells
Other cell lines
Lymphocyte
Platelet
Strobel 2013 Comp Biochem Physiol B Biochem Mol Biol2013Strobel A, Leo E, Pörtner HO, Mark FC (2013) Elevated temperature and PCO2 shift metabolic pathways in differentially oxidative tissues of Notothenia rossii. Comp Biochem Physiol B Biochem Mol Biol 166:48-57.FishesHeart
Skeletal muscle
Liver
Temperature
Glancy 2013 Biochemistry2013Glancy B, Willis WT, Chess DJ, Balaban RS (2013) Effect of calcium on the oxidative phosphorylation cascade in skeletal muscle mitochondria. Biochemistry 52:2793-809.Skeletal muscle
Alandijany 2013 J Neurovirol2013Alandijany T, Kammouni W, Roy Chowdhury SK, Fernyhough P, Jackson AC (2013) Mitochondrial dysfunction in rabies virus infection of neurons. J Neurovirol 19:537-49.RatNervous systemOxidative stress;RONSInfectious
Kristensen 2013 PLoS One2013Kristensen JM, Larsen S, Helge JW, Dela F, Wojtaszewski JFP (2013) Two weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type mice. PLoS One 8:e53533.MouseSkeletal muscleDiabetes
Weber 2013 Thesis East Carolina University2013Weber T (2013) The effect of contractile activity and substrate challenges on metabolic flexibility in human primary myotubes. Thesis East Carolina University - USA:105 pp.HumanSkeletal muscle
Other cell lines
Obesity
Freyer 2012 Nat Genet2012Freyer C, Cree LM, Mourier A, Stewart JB, Koolmeister C, Milenkovic D, Wai T, Floros VI, Hagström E, Chatzidaki EE, Wiesner RJ, Samuels DC, Larsson NG, Chinnery PF (2012) Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission. Nat Genet 44:1282-5.MouseHeart
Liver
Larsen 2012 J Physiol2012Larsen S, Nielsen J, Neigaard Nielsen C, Nielsen LB, Wibrand F, Stride N, Schroder HD, Boushel RC, Helge JW, Dela F, Hey-Mogensen M (2012) Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects. J Physiol 590:3349-60.HumanSkeletal muscle
Mark 2012 PLoS One2012Mark FC, Lucassen M, Strobel A, Barrera-Oro E, Koschnick N, Zane L, Patarnello T, Pörtner HO, Papetti C (2012) Mitochondrial function in Antarctic Nototheniids with ND6 translocation. PLoS One 7:e31860FishesLiver
Hroudova 2012 European Psychiatry2012Hroudova J, Fisar Z, Korabecny J, Kuca K, Jirak R, Raboch J (2012) P-451 - changes of cellular respiration in patients with Alzheimer's disease. European Psychiatry 27:01.HumanBlood cells
Platelet
Alzheimer's
Neurodegenerative
Lanza 2012 Cell Metab2012Lanza IR, Zabielski P, Klaus KA, Morse DM, Heppelmann CJ, Bergen HR 3rd, Dasari S, Walrand S, Short KR, Johnson ML, Robinson MM, Schimke JM, Jakaitis DR, Asmann YW, Sun Z, Nair KS (2012) Chronic caloric restriction preserves mitochondrial function in senescence without increasing mitochondrial biogenesis. Cell Metab 16:777-88.MouseSkeletal muscleAging;senescence
Aoun 2012 Br J Nutr2012Aoun M, Feillet-Coudray C, Fouret G, Chabi B, Crouzier D, Ferreri C, Chatgilialoglu C, Wrutniak-Cabello C, Cristol JP, Carbonneau MA, Coudray C (2012) Rat liver mitochondrial membrane characteristics and mitochondrial functions are more profoundly altered by dietary lipid quantity than by dietary lipid quality: effect of different nutritional lipid patterns. Br J Nutr 107:647-59.RatLiverOther
Gutierrez 2012 Hum Mutat2012Gutiérrez Cortés N, Pertuiset C, Dumon E, Börlin M, Hebert-Chatelain E, Pierron D, Feldmann D, Jonard L, Marlin S, Letellier T, Rocher C (2012) Novel mitochondrial DNA mutations responsible for maternally inherited non-syndromic hearing loss. Hum Mutat 33:681-9HumanInherited
Kucera 2012 J Gastroenterol Hepatol2012Kucera O, Rousar T, Stankova P, Hanackova L, Lotkova H, Podhola M, Cervinkova Z (2012) Susceptibility of rat non-alcoholic fatty liver to the acute toxic effect of acetaminophen. J Gastroenterol Hepatol 27:323-30.RatLiverOxidative stress;RONS
Picard 2012 PLoS One2012Picard M, Wright KJ, Ritchie D, Thomas MM, Hepple RT (2012) Mitochondrial function in permeabilized cardiomyocytes is largely preserved in the senescent rat myocardium. PLoS One 7:e43003.RatHeartOxidative stress;RONSAging;senescence
Oellermann 2012 J Exp Biol2012Oellermann M, Poertner HO, Mark FC (2012) Mitochondrial dynamics underlying thermal plasticity of cuttlefish (Sepia officinalis) hearts. J Exp Biol 215:2992-3000.MolluscsHeartIschemia-reperfusion
Pereira 2012 BMC Cancer2012Pereira L, Soares P, Máximo V, Samuels DC (2012) Somatic mitochondrial DNA mutations in cancer escape purifying selection and high pathogenicity mutations lead to the oncocytic phenotype: pathogenicity analysis of reported somatic mtDNA mutations in tumors. BMC Cancer 12:53.Cancer
Wuest 2012 Am J Physiol Heart Circ Physiol2012Wuest RC, Myers DS, Stones R, Benoist D, Robinson PA, Boyle JP, Peers C, White E, Rossiter HB (2012) Regional skeletal muscle remodeling and mitochondrial dysfunction in right ventricular heart failure. Am J Physiol Heart Circ Physiol 302: H402-H411.RatSkeletal muscleCryopreservation
Galli 2012 J Therm Biol2012Galli GL, Richards JG (2012) The effect of temperature on mitochondrial respiration in permeabilized cardiac fibres from the freshwater turtle, Trachemys scripta. J Ther Bio 37:195–200.ReptilesHeart
Simonin 2012 Biochem J2012Simonin V, Galina A (2012) Nitric oxide inhibits succinate dehydrogenase-driven oxygen consumption in potato tuber mitochondria in an oxygen tension-independent manner. Biochem J 449:263-73.Plants
Welchen 2012 Biochim Biophys Acta2012Welchen E, Hildebrandt TM, Lewejohann D, Gonzalez DH, Braun HP (2012) Lack of cytochrome c in Arabidopsis decreases stability of Complex IV and modifies redox metabolism without affecting Complexes I and III. Biochim Biophys Acta 1817:990-1001.PlantsOxidative stress;RONS
Vuda 2012 Innate Immun2012Vuda M, Brander L, Schröder R, Jakob SM, Takala J, Djafarzadeh S (2012) Effects of catecholamines on hepatic and skeletal muscle mitochondrial respiration after prolonged exposure to faecal peritonitis in pigs. Innate Immun 18:217-30.PigSkeletal muscle
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Groeger 2012 Shock2012Groeger M, Matallo J, McCook O, Wagner F, Wachter U, Bastian O, Gierer S, Reich V, Stahl B, Huber-Lang M, Szabó C, Georgieff M, Radermacher P, Calzia E, Wagner K (2012) Temperature and cell-type dependency of sulfide effects on mitochondrial respiration. Shock 38:367-74.Macrophage-derived
Moon 2012 J Biol Chem2012Moon SH, Jenkins CM, Kiebish MA, Sims HF, Mancuso DJ, Gross RW (2012) Genetic ablation of calcium-independent phospholipase A (iPLA) attenuates calcium-induced opening of the mitochondrial permeability transition pore and resultant cytochrome c release. J Biol Chem 287:29837-50.MouseLiverCell death
Permeability transition
Acuña-Castroviejo 2012 Age (Dordr)2012Acuña-Castroviejo D, Carretero M, Doerrier C, López LC, García-Corzo L, Tresguerres JA, Escames G (2012) Melatonin protects lung mitochondria from aging. Age (Dordr) 34(3):681-92.MouseLung;gillAging;senescence
Bustamante 2012 Alcohol2012Bustamante J, Karadayian AG, Lores-Arnaiz S, Cutrera RA (2012) Alterations of motor performance and brain cortex mitochondrial function during ethanol hangover. Alcohol 46:473-9.MouseNervous systemOxidative stress;RONS
Iglesias-Gonzalez 2012 Neurochem Res2012Iglesias-Gonzalez J, Sanchez-Iglesias S, Mendez-Alvarez E, Rose S, Hikima A, Jenner P, Soto-Otero R (2012) Differential toxicity of 6-hydroxydopamine in SH-SY5Y human neuroblastoma cells and rat brain mitochondria: protective role of catalase and superoxide dismutase. Neurochem Res 37:2150-60.RatNervous systemOxidative stress;RONS
Mitochondrial disease
Neurodegenerative
Parkinson's
Goo 2012 PLoS One2012Goo CK, Lim HY, Ho QS, Too HP, Clement MV, Wong KP (2012) PTEN/Akt signaling controls mitochondrial respiratory capacity through 4E-BP1. PLoS One 7:e45806.MouseFibroblast
Aoun 2012 J Bioenerg Biomembr2012Aoun M, Fouret G, Michel F, Bonafos B, Ramos J, Cristol JP, Carbonneau MA, Coudray C, Feillet-Coudray C (2012) Dietary fatty acids modulate liver mitochondrial cardiolipin content and its fatty acid composition in rats with non alcoholic fatty liver disease. J Bioenerg Biomembr 44:439-52.RatLiverOther
Strub 2011 FASEB J2011Strub GM, Paillard M, Liang J, Gomez L, Allegood JC, Hait NC, Maceyka M, Price MM, Chen Q, Simpson DC, Kordula T, Milstien S, Lesnefsky EJ, Spiegel S (2011) Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate Complex IV assembly and respiration. FASEB J 25:600-12.MouseHeart
Djafarzadeh 2011 Mitochondrion2011Djafarzadeh S, Vuda M, Takala J, Ochs M, Jakob SM (2011) Toll-like receptor-3-induced mitochondrial dysfunction in cultured human hepatocytes. Mitochondrion 11:83-8.HumanLiver
Niehusmann 2011 Epilepsy Behav2011Niehusmann P, Surges R, von Wrede RD, Elger CE, Wellmer J, Reimann J, Urbach H, Vielhaber S, Bien CG, Kunz WS (2011) Mitochondrial dysfunction due to Leber's hereditary optic neuropathy as a cause of visual loss during assessment for epilepsy surgery. Epilepsy Behav 20:38-43.HumanSkeletal muscle
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Naimi 2011 Clin Physiol Funct Imaging2011Naimi AI, Bourbeau J, Perrault H, Baril J, Wright-Paradis C, Rossi A, Taivassalo T, Sheel AW, Rabøl R, Dela F, Boushel RC (2011) Altered mitochondrial regulation in quadriceps muscles of patients with COPD. Clin Physiol Funct Imaging 31:124-31.HumanSkeletal muscleMitochondrial diseaseCOPD
Bratic 2011 PLoS Genet2011Bratic A, Wredenberg A, Grönke S, Stewart JB, Mourier A, Ruzzenente B, Kukat C, Wibom R, Habermann B, Partridge L, Larsson NG (2011) The bicoid stability factor controls polyadenylation and expression of specific mitochondrial mRNAs in Drosophila melanogaster. PLoS Genet 7:e1002324.Drosophila
Pasdois 2011 Biochem J2011Pasdois P, Parker JE, Griffiths EJ, Halestrap AP (2011) The role of oxidized cytochrome c in regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia. Biochem J 436:493-505.RatHeartIschemia-reperfusion
Oxidative stress;RONS
Rosca 2011 Biochim Biophys Acta2011Rosca M, Minkler P, Hoppel CL (2011) Cardiac mitochondria in heart failure: Normal cardiolipin profile and increased threonine phosphorylation of Complex IV. Biochim Biophys Acta 1807:1373-82.Rat
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Viader 2011 J Neurosci2011Viader A, Golden JP, Baloh RH, Schmidt RE, Hunter DA, Milbrandt J (2011) Schwann cell mitochondrial metabolism supports long-term axonal survival and peripheral nerve function. J Neurosci 31:10128-40.MouseNervous systemNeurodegenerative
Guillet 2011 FASEB J2011Guillet V, Gueguen N, Cartoni R, Chevrollier A, Desquiret V, Angebault C, Amati-Bonneau P, Procaccio V, Bonneau D, Martinou JC, Reynier P (2011) Bioenergetic defect associated with mKATP channel opening in a mouse model carrying a mitofusin 2 mutation. FASEB J 25:1618-27.MouseNervous system
Oliva 2011 PloS One2011Oliva CR, Moellering DR, Gillespie GY, Griguer CE (2011) Acquisition of chemoresistance in gliomas is associated with increased mitochondrial coupling and decreased ROS production. PloS One 6:e24665.HumanNervous systemOxidative stress;RONSCancer
Tweedie 2011 Am J Physiol Regul Integr Comp Physiol2011Kane C, Romestaing C, Burelle Y, Safdar A, Tarnopolsky MA, Seadon S, Britton SL, Koch LG, Hepple RT (2011) Lower oxidative DNA damage despite greater ROS production in muscles from rats selectively bred for high running capacity. Am J Physiol Regul Integr Comp Physiol 300:R544-53.RatSkeletal muscleOxidative stress;RONS
Robin 2011 J Bacteriol2011Robin S, Arese M, Forte E, Sarti P, Giuffrè A, Soulimane T (2011) A sulfite respiration pathway from Thermus thermophilus and the key role of newly identified cytochrome c550. J Bacteriol 193:3988-97.Eubacteria
Van Bergen 2011 PLoS One2011Van Bergen NJ, Crowston JG, Kearns LS, Staffieri SE, Hewitt AW, Cohn AC, Mackey DA, Trounce IA (2011) Mitochondrial oxidative phosphorylation compensation may preserve vision in patients with OPA1-linked autosomal dominant optic atrophy. PLoS One 6:e21347.HumanNervous system
Islet cell;pancreas;thymus
Mitochondrial disease
Sarti 2011 Biochim Biophys Acta2011Sarti P, Forte E, Mastronicola D, Giuffrè A, Arese M (2011) Cytochrome c oxidase and nitric oxide in action: Molecular mechanisms and pathophysiological implications. Biochim Biophys Acta 1817:610-19
Wang 2010 Stem Cells2010Wang W, Osenbroch P, Skinnes R, Esbensen Y, Bjoeraas M, Eide L (2010) Mitochondrial DNA integrity is essential for mitochondrial maturation during differentiation of neural stem cells. Stem Cells 28:2195-204.Nervous system
Stem cells
Dikov 2010 Exp Gerontol2010Dikov D, Aulbach A, Muster B, Dröse S, Jendrach M, Bereiter-Hahn J (2010) Do UCP2 and mild uncoupling improve longevity? Exp Gerontol 45:586-95.HeLa
Fibroblast
HUVEC
Oxidative stress;RONSAging;senescence
Freyer 2010 Nucleic Acids Res2010Freyer C, Park CB, Ekstrand MI, Shi Y, Khvorostova J, Wibom R, Falkenberg M, Gustafsson CM, Larsson NG (2010) Maintenance of respiratory chain function in mouse hearts with severely impaired mtDNA transcription. Nucleic Acids Res 38:6577–88.MouseHeartCardiovascular
Pichaud 2010 J Exp Biol2010Pichaud N, Chatelain HE, Ballard JWO, Tanguay R, Morrow G, Blier PU (2010)Thermal sensitivity of mitochondrial metabolism in two distinct mitotypes of Drosophila simulans: Evaluation of mitochondrial plasticity. J Exp Biol 213:1665-75.DrosophilaSkeletal muscle
Lim 2010 Proteomics2010Lim YA, Rhein V, Baysang G, Meier F, Poljak A, Raftery MJ, Guilhaus M, Ittner LM, Eckert A, Goetz J (2010) Abeta and human amylin share a common toxicity pathway via mitochondrial dysfunction. Proteomics 10:1621-33.HumanNervous systemOxidative stress;RONSAging;senescence
Alzheimer's
Diabetes
Neurodegenerative
Fornunskova 2010 Biochem J2010Fornuskova D, Stiburek L, Wenchich L, Vinsova K, Hansikova H, Zeman J (2010) Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4, 5a, 6a, 7a and 7b. Biochem J 428:363-74.HumanHEK
Chowdhury 2010 Am J Physiol Endocrinol Metab2010Chowdhury SK, Sangle GV, Xie X, Stelmack GL, Halayko AJ, Shen GX (2010) Effects of extensively oxidized low-density lipoprotein on mitochondrial function and reactive oxygen species in porcine aortic endothelial cells. Am J Physiol Endocrinol Metab 298:E89-98.PigEndothelial;epithelial;mesothelial cellOxidative stress;RONS
Mitochondrial disease
Fernyhough 2010 Expert Rev Endocrinol Metab2010Fernyhough P, Roy Chowdhury SK, Schmidt RE (2010) Mitochondrial stress and the pathogenesis of diabetic neuropathy. Expert Rev Endocrinol Metab 5:39-49.RatNervous systemDiabetes
Nuskova 2010 J Bioenerg Biomembr2010Nůsková H, Vrbacký M, Drahota Z, Houštěk J (2010) Cyanide inhibition and pyruvate-induced recovery of cytochrome c oxidase. J Bioenerg Biomembr 42:395-403.
Rhein 2010 PloS One2010Rhein V, Giese M, Baysang G, Meier F, Rao S, Schulz KL, Hamburger M, Eckert A (2010) Ginkgo biloba extract ameliorates oxidative phosphorylation performance and rescues abeta-induced failure. PloS One 5:e12359.NeuroblastomaAging;senescence
Alzheimer's
Neurodegenerative
Guillet 2010 Mitochondrion2010Guillet V, Chevrollier A, Cassereau J, Letournel F, Gueguen N, Richard L, Desquiret V, Verny C, Procaccio V, Amati-Bonneau P, Reynier P, Bonneau D (2010) Ethambutol-induced optic neuropathy linked to OPA1 mutation and mitochondrial toxicity. Mitochondrion 10:115-24.HumanFibroblastNeurodegenerative
Yang 2010 Cancer Biol Ther2010Yang D, Wang MT, Tang Y, Chen Y, Jiang H, Jones TT, Rao K, Brewer GJ, Singh KK, Nie D (2010) Impairment of mitochondrial respiration in mouse fibroblasts by oncogenic H-RAS(Q61L). Canc Biol Ther 9:122-33.MouseFibroblastCancer
Groeger 2010 Crit Care2010Groeger M, Wagner F, Baumgart K, Huber-Lang M, Knoeferl M, Georgieff M, Radermacher P, Szabo C, Calzia E (2010) Mitochondrial respiration and cytochrome c inhibition by sulfide in peritoneal macrophages in vitro: Effects of temperature and pH. Crit Care 14:P6.Macrophage-derived
Aguirre 2010 Biochim Biophys Acta2010Aguirre E, Rodríguez-Juárez F, Bellelli A, Gnaiger E, Cadenas S (2010) Kinetic model of the inhibition of respiration by endogenous nitric oxide in intact cells. Biochim Biophys Acta 1797:557-65.HEKOxidative stress;RONS
Jones 2010 Biochim Biophys Acta2010Jones TT, Brewer GJ (2010) Age-related deficiencies in Complex I endogenous substrate availability and reserve capacity of Complex IV in cortical neuron electron transport. Biochim Biophys Acta 1797:167-76.RatNervous systemAging;senescence
Neurodegenerative
Kotarsky 2010 Mitochondrion2010Kotarsky H, Karikoski R, Mörgelin M, Marjavaara S, Bergman P, Zhang DL, Smet J, van Coster R, Fellman V (2010) Characterization of complex III deficiency and liver dysfunction in GRACILE syndrome caused by a BCS1L mutation. Mitochondrion 10:497-509.HumanFibroblastInherited
Xie 2010 Acta Biochim Pol2010Xie X, Chowdhury SR, Sangle G, Shen GX (2010) Impact of diabetes-associated lipoproteins on oxygen consumption and mitochondrial enzymes in porcine aortic endothelial cells. Acta Biochim Pol 57:393-8.PigEndothelial;epithelial;mesothelial cellDiabetes
Ahting 2009 Biochim Biophys Acta2009Ahting U, Floss T, Uez N, Schneider-Lohmar I, Becker L, Kling E, Iuso A, Bender A, de Angelis MH, Gailus-Durner V, Fuchs H, Meitinger T, Wurst W, Prokisch H, Klopstock T (2009) Neurological phenotype and reduced lifespan in heterozygous Tim23 knockout mice, the first mouse model of defective mitochondrial import. Biochim Biophys Acta 1787:371-76.MouseStem cellsOther
Jones 2009 Exp Neurol2009Jones TT, Brewer GJ (2009) Critical age-related loss of cofactors of neuron cytochrome c oxidase reversed by estrogen. Exp Neurol 215:212-9.RatNervous systemMitochondrial disease
Osenbroch 2009 FEBS J2009Osenbroch Poe, Auk-Emblem P, Halsne R, Strand J, Forstroem RJ, van der Pluijm I, Eide L (2009) Accumulation of mitochondrial DNA damage and bioenergetic dysfunction in CSB defective cells. FEBS J 276:2811-21.MouseAging;senescence
Neurodegenerative
Flamment 2009 Am J Physiol Endocrinol Metab2009Flamment M, Gueguen N, Wetterwald C, Simard G, Malthièry Y, Ducluzeau PH (2009) Effects of the cannabinoid CB1 antagonist rimonabant on hepatic mitochondrial function in rats fed a high-fat diet. Am J Physiol Endocrinol Metab 297:E1162-70.RatLiver
Dalmonte 2009 J Biol Chem2009Dalmonte ME, Forte E, Genova ML, Giuffrè A, Sarti P, Lenaz G (2009) Control of respiration by cytochrome c oxidase in intact cells: role of the membrane potential. J Biol Chem 284:32331-5.Human
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Nouette-Gaulain 2009 Anesthesiology2009Nouette-Gaulain K, Bellance N, Prévost B, Passerieux E, Pertuiset C, Galbes O, Smolkova K, Masson F, Miraux S, Delage JP, Letellier T, Rossignol R, Capdevila X, Sztark F (2009) Erythropoietin protects against local anesthetic myotoxicity during continuous regional analgesia. Anesthesiology 110:648-59.Human
Rat
Skeletal muscle
Nervous system
Goncalves 2009 PLoS One2009Gonçalves RL, Machado AC, Paiva-Silva GO, Sorgine MH, Momoli MM, Oliveira JH, Vannier-Santos MA, Galina A, Oliveira PL, Oliveira MF (2009) Blood-feeding induces reversible functional changes in flight muscle mitochondria of Aedes aegypti mosquito. PLoS One 4:e7854.HexapodsSkeletal muscle
Rhein 2009 Cell Mol Neurobiol2009Rhein V, Baysang G, Rao S, Meier F, Bonert A, Müller-Spahn F, Eckert A (2009) Amyloid-beta leads to impaired cellular respiration, energy production and mitochondrial electron chain complex activities in human neuroblastoma cells. Cell Mol Neurobiol 29:1063-71.HumanNervous system
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Alzheimer's
Neurodegenerative
Gupte 2009 Diabetes2009Gupte AA, Bomhoff GL, Swerdlow RH, Geiger PC (2009) Heat treatment improves glucose tolerance and prevents skeletal muscle insulin resistance in rats fed a high-fat diet. Diabetes 58:567-78.RatSkeletal muscleDiabetes
Mortiboys 2008 Ann Neurol2008Mortiboys H, Thomas KJ, Koopman WJ, Klaffke S, Abou-Sleiman P, Olpin S, Wood NW, Willems PH, Smeitink JA, Cookson MR, Bandmann O (2008) Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts. Ann Neurol 64:555-65.HumanFibroblastParkinson's
Eimre 2008 Biochim Biophys Acta2008Eimre M, Paju K, Pelloux S, Beraud N, Roosimaa M, Kadaja L, Gruno M, Peet N, Orlova E, Remmelkoor R, Piirsoo A, Saks V, Seppet E (2008) Distinct organization of energy metabolism in HL-1 cardiac cell line and cardiomyocytes. Biochim Biophys Acta 1777:514-24.RatHeart
Juellig 2008 Proteomics2008Jüllig M, Hickey AJ, Chai CC, Skea GL, Middleditch MJ, Costa S, Choong SY, Philips AR, Cooper GJ (2008) Is the failing heart out of fuel or a worn engine running rich? A study of mitochondria in old spontaneously hypertensive rats. Proteomics 8:2556-72.RatHeartMitochondrial disease
Masci 2008 Biochim Biophys Acta2008Masci A, Mastronicola D, Arese M, Piane M, De Amicis A, Blanck TJ, Chessa L, Sarti P (2008) Control of cell respiration by nitric oxide in Ataxia Telangiectasia lymphoblastoid cells. Biochim Biophys Acta 1777:66-73.HumanNervous systemOxidative stress;RONS
Cizkova 2008 Nat Genet2008Cızkova A, Stranecky V, Mayr JA, Tesarova M, Havlıckova V, Paul J, Ivanek R, Kuss AW, Hansıkova H, Kaplanova W, Vrbacky M, Hartmannova H, Noskova L, Honzık T, Drahota Z, Magner M, Hejzlarova K, Sperl W, Zeman J, Houstek J, Kmoch S (2008) TMEM70 mutations cause isolated ATP synthase deficiency and neonatal mitochondrial encephalocardiomyopathy. Nat Genet 40:1288-90.Other
Brown 2008 Am J Physiol Endocrinol Metab2008Brown AE, Elstner M, Yeaman SJ, Turnbull DM, Walker M (2008) Does impaired mitochondrial function affect insulin signaling and action in cultured human skeletal muscle cells? Am J Physiol Endocrinol Metab 294:E97-102.HumanSkeletal muscleDiabetes
Pasdois 2007 Am J Physiol Heart Circ Physiol2007Pasdois P, Quinlan CL, Rissa A, Tariosse L, Vinassa B, Costa AD, Pierre SV, Dos Santos P, Garlid KD (2007) Ouabain protects rat hearts against ischemia-reperfusion injury via pathway involving src kinase, mitoKATP, and ROS. Am J Physiol Heart Circ Physiol 292:H1470-8.RatHeartIschemia-reperfusion
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McKenzie 2006 J Mol Biol2006McKenzie M, Lazarou M, Thorburn DR, Ryan MT (2006) Mitochondrial respiratory chain supercomplexes are destabilized in Barth Syndrome patients. J Mol Biol 361:462-9.LymphocyteCardiovascular
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Hervouet 2006 Biochem Biophys Res Commun2006Hervouet E, Pecina P, Demont J, Vojtíšková A, Simonnet H, Houštek J, Godinot C (2006) Inhibition of cytochrome c oxidase subunit 4 precursor processing by the hypoxia mimic cobalt chloride. Biochem Biophys Res Commun 344:1086-93.Human
Saccharomyces cerevisiae
Fungi
Cancer
Honzik 2006 Placenta2006Honzik T, Drahota Z, Bohm M, Jesina P, Mracek T, Paul J, Zeman J, Houstek J (2006) Specific properties of heavy fraction of mitochondria from human-term placenta - Glycerophosphate-dependent hydrogen peroxide production. Placenta 27:348-56.HumanOxidative stress;RONS
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Jarmuszkiewicz 2005 Biochim Biophys Acta2005Jarmuszkiewicz W, Czarna M, Sluse FE (2005) Substrate kinetics of the Acanthamoeba castellanii alternative oxidase and the effects of GMP. Biochim Biophys Acta 1708:71-8.Protists
Lee 2005 Am J Physiol Renal Physiol2005Lee WK, Bork U, Gholamrezaei F, Thévenod F (2005) Cd2+-induced cytochrome c release in apoptotic proximal tubule cells: role of mitochondrial permeability transition pore and Ca2+ uniporter. Am J Physiol Renal Physiol 288:F27-39.RatKidneyCell death
Winkler-Stuck 2005 J Neural Transm2005Winkler-Stuck K, Kirches E, Mawrin C, Dietzmann K, Lins H, Wallesch CW, Kunz WS, Wiedemann FR (2005) Re-evaluation of the dysfunction of mitochondrial respiratory chain in skeletal muscle of patients with Parkinson's disease. J Neural Transm 112:499-518.HumanSkeletal muscleMitochondrial diseaseParkinson's
Maneiro 2005 Ann Rheum Dis2005Maneiro E, López-Armada MJ, de Andres MC, Caramés B, Martín MA, Bonilla A, Del Hoyo P, Galdo F, Arenas J, Blanco FJ (2005) Effect of nitric oxide on mitochondrial respiratory activity of human articular chondrocyte. Ann Rheum Dis 64:388-95.HumanOxidative stress;RONS
Drahota 2005 Cell Biochem Biophys2005Drahota Z, Milerova M, Stieglerova A, Skarka L, Houstek J, Ostadal B (2005) Development of cytochrome-c oxidase in rat heart. Cell Biochem Biophys 43:87-94.RatHeart
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Pecina 2004 Am J Physiol Cell Physiol2004Pecina P, Gnaiger E, Zeman J, Pronicka E, Houstek J (2004) Decreased affinity to oxygen of cytochrome c oxidase in Leigh syndrome caused by SURF1 mutations. Am J Physiol Cell Physiol 287:C1384-8.HumanFibroblastInherited
Pecina 2004 Physiol Res2004Pecina P, Houstkova H, Hansikova H, Zeman J, Houstek J (2004) Genetic defects of cytochrome c oxidase assembly. Physiol Res 53 Suppl 1:S213-23.HumanSkeletal muscle
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Pecina 2003 Biochim Biophys Acta2003Pecina P, Capkova M, Chowdhury SK, Drahota Z, Dubot A, Vojtiskova A, Hansikova H, Houstekova H, Zeman J, Godinot C, Houstek J (2003) Functional alteration of cytochrome c oxidase by SURF1 mutations in Leigh syndrome. Biochim Biophys Acta 1639:53-63.HumanEndothelial;epithelial;mesothelial cell
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Rosenfeld 2003 Yeast2003Rosenfeld E, Beauvoit B (2003) Role of the non-respiratory pathways in the utilization of molecular oxygen by Saccharomyces cerevisiae. Yeast 20:1115-44.Saccharomyces cerevisiae
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Kudin 2002 Mol Biol Rep2002Kudin A, Vielhaber S, Elger CE, Kunz WS (2002) Differences in flux control and reserve capacity of cytochrome c oxidase (COX) in human skeletal muscle and brain suggest different metabolic effects of mild COX deficiencies. Mol Biol Rep 29:89-92.HumanSkeletal muscle
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Rosenfeld 2002 Yeast2002Rosenfeld E, Beauvoit B, Rigoulet M, Salmon JM (2002) Non-respiratory oxygen consumption pathways in anaerobically-grown Saccharomyces cerevisiae: evidence and partial characterization. Yeast 19:1299-321.Saccharomyces cerevisiae
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Schwerzmann 1986 J Cell Biol1986Schwerzmann K, Cruz-Orive LM, Eggman R, Sänger A, Weibel ER (1986) Molecular architecture of the inner membrane of mitochondria from rat liver: a combined biochemical and stereological study. J Cell Biol 102:97-103.Rat
Wikstroem 1979 Biochim Biophys Acta1979Wikstroem MKF, Krab K (1979) Proton-pumping cytochrome c oxidase. Biochim Biophys Acta 549:177-222.
Wikstroem 1977 Nature1977Wikstroem MKF (1977) Proton pump coupled to cytochrome c oxidase in mitochondria. Nature 266:271-3.
Hinkle 1972 J Biol Chem1972Hinkle PC, Kim JJ, Racker E (1972) Ion transport and respiratory control in vesicles formed from cytochrome oxidase and phospholipids. J Biol Chem 247:1338-9.BovinesHeart
Racker 1971 J Biol Chem1971Racker E, Kandrach A (1971) Reconstitution of the third site of oxidative phosphorylation. J Biol Chem 246:7069-71.Bovines
Saccharomyces cerevisiae
Fungi
Heart
Sottocasa 1967 J Cell Biol1967Sottocasa GL, Kuylenstierna, Ernster L, Bergstrand A (1967) An electron-transport system associated with the outer membrane of liver mitochondria. A biochemical and morphological study. J Cell Biol 32:415-38.RatLiver
Hatefi 1962 J Biol Chem-XLII1962Hatefi Y, Haavik AG, Fowler LR, Griffiths DE (1962) Studies on the Electron transfer-pathway XLII. Reconstitution of the Electron transfer-pathway. J Biol Chem 237:2661-9.BovinesHeart
Hatefi 1962 J Biol Chem-XLI1962Hatefi Y, Haavik AG, Griffiths DE (1962) Studies on the Electron transfer-pathway XLI. Reduced coenzyme Q (QH2)-cytochrome c reductase. J Biol Chem 237:1681-5.BovinesHeart
Kuboyama 1962 Biochem Biophys Res Commun-IX1962Kuboyama M, Takemori S, King TE (1962) Reconstitution of respiratory chain enzyme systems IX. Cytochrome c-cytochrome oxidase complex of heart muscle. Biochem Biophys Res Commun 9:534-9.Heart
Kuboyama 1962 Biochem Biophys Res Commun-X1962Kuboyama M, Takemori S, King TE (1962) Reconstitution of respiratory chain enzyme systems X. Reconstitution of succinate oxidase with cytochrome c-cytochrome oxidase of heart muscle. Biochem Biophys Res Commun 9:540-4.Heart
Hatefi 1961 Biochim Biophys Acta1961Hatefi Y, Haavik AG, Jurtshuk P (1961) Studies on the electron transport system XXXI. DPNH-cytochrome c reductase II. Biochim Biophys Acta 52:106-18.BovinesHeart
Crane 1956 Biochim Biophys Acta1956Crane FL, Glenn JL, Green DE (1956) Studies on the electron transfer-pathway IV. The electron transfer particle. Biochim Biophys Acta 22:475-87.BovinesHeart
Chance 1952 Nature1952Chance B (1952) Spectra and reaction kinetics of respiratory pigments of homogenized and intact cells. Nature 169:215-21.
Hogeboom 1946 J Biol Chem1946Hogeboom GH, Claude A, Hotchkiss RD (1946) The distribution of cytochrome oxidase and succinoxidase in the cytoplasm of the mammalian liver cell. J Biol Chem 165:615-29.RatLiver
Keilin 1929 Proc R Soc London Ser B1929Keilin D (1929) Cytochrome and respiratory enzymes. Proc R Soc London Ser B 104:206-52.
Keilin 1925 Proc R Soc Lond B Biol Sci1925Keilin D (1925) On cytochrome, a respiratory pigment, common to animals, yeast, and higher plants. Proc R Soc Lond B Biol Sci 98:312-39.Other mammals
Fungi
Plants
Eubacteria
Skeletal muscle