Bioblast alert 2012

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Bioblasts - Richard Altmann and MiPArt by Odra Noel

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Bioblast alert 2012

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Bioblast alert 2012(01): 2012-02-27

Two exciting publications on mitochondrial p50, apparent excess capacity of cytochrome c oxidase, basal metabolic rate, P/O ratios and ergometric efficiency:

  1. Larsen FJ, Schiffer TA, Sahlin K, Ekblom B, Weitzberg E, Lundberg JO (2011) Mitochondrial oxygen affinity predicts basal metabolic rate in humans. FASEB J 25: 2843-52.
  2. Larsen FJ, Schiffer TA, Borniquel S, Sahlin K, Ekblom B, Lundberg JO, Weitzberg E (2011) Dietary inorganic nitrate improves mitochondrial efficiency in humans. Cell Metab 13: 149-59.

Bioblast alert 2012(02): 2012-03-06

  • 50 Years ago: Nick Holonyak, considered as the "father of the light-emitting diode", developed the first practical visible-spectrum LED in 1962. Which colour? What is a LED? >>> see MitoPedia: Fluorometry

Mitochondrial dys/function in obesity vs. anorexia:

  1. Lindfors C, Nilsson IA, Garcia-Roves PM, Zuberi AR, Karimi M, Donahue LR, Roopenian DC, Mulder J, Uhlén M, Ekström TJ, Davisson MT, Hökfelt TG, Schalling M, Johansen JE (2011) Hypothalamic mitochondrial dysfunction associated with anorexia in the anx/anx mouse. Proc Natl Acad Sci U S A 108: 18108-13.
  2. Holmstroem MH, Iglesias-Gutierrez E, Zierath JR, Garcia-Roves PM (2012) Tissue-specific control of mitochondrial respiration in obesity-related insulin resistance and diabetes. Am J Physiol Endocrinol Metab 302: E731-9.

Bioblast alert 2012(03): 2012-03-23 / 2012-04-03

Bioblast topic: Oxygen dependence of ROS production - are permeabilized fibres a valid model?

--> Discussion

Drosophila vs. sandworm: High-resolution respirometry in permeabilized muscle fibres

  1. Pichaud N, Rioux P, Blier PU (2012) In situ quantification of mitochondrial respiration in permeabilized fibers of a marine invertebrate with low aerobic capacity. Comp Biochem Physiol A Mol Integr Physiol 161: 429-35.
  2. Pichaud N, Ballard JW, Tanguay RM, Blier PU (2011) Thermal sensitivity of mitochondrial functions in permeabilized muscle fibers from two populations of Drosophila simulans with divergent mitotypes. Am J Physiol Regul Integr Comp Physiol 301: R48-9.

New from the Ballard lab:

Bioblast alert 2012(04): 2012-04-29

Votion DM, Gnaiger E, Lemieux H, Mouithys-Mickalad A, Serteyn D (2012) Physical fitness and mitochondrial respiratory capacity in horse skeletal muscle. PLoS One 7(4): e34890.

Bioblast alert 2012(05): 2012-06-05

Bioblast alert 2012(06): 2012-07-20

>> More information on MitoPedia: Substrates and metabolites
  • Bioblast terminology: State 3 - is [ADP] saturating? Not generally in State 3, but certainly in the OXPHOS state (P).
>> Update on the MitoPedia: Respiratory states

Bioblast alert 2012(07): 2012-10-24

  • Bioblast topic: Publications of historical interest are valued as milestones in science, as sources of understanding currently discussed concepts, and as a reminder that 'nothing' is new (something new is 'nothing'?) >> Mitochondria and bioblasts: Made history
  • Bioblast terminology: LEAK vs. State 2: The resting state of substrate supported respiration without ADP (LEAK state) in contrast to the substrate limited State 2 of residual oxygen consumption at high ADP concentration: >> Chance and Williams 1955.
MitoPedia: Respiratory states

Bioblast alert 2012(08): 2012-12-18

  • MitoPedia: Substrate control states in mitochondrial preparations versus intact cells - new perspectives in OXPHOS analysis.
  • Bioblast topic: The Mitochondrial Global Network (MitoGlobal) aims at providing a WorldWide information platform for scientific mitochondrial organizations.
  • MitoGlobal Events are listed by Mitochondrial Global Network, providing a comprehensive list of mitochondrial conferences, workshops, and educational programmes. Send us your event to be included in MitoGlobal Events.
  • We invite organizations with a focus on mitochondrial research and medicine to submit your contact details, to be included in the List of MitoGlobal Organizations.


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